TY  - JOUR
AU  - Stojanović, Ivana D.
AU  - Al-Abed, Yousef
AU  - Miljković, Đorđe
AU  - Maksimović-Ivanić, Danijela
AU  - Roth, Jesse
AU  - Bacher, Michael
AU  - Lan, Hui Y.
AU  - Nicoletti, Ferdinando
AU  - Stošić-Grujičić, Stanislava
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1699
AB  - Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a pivotal role in several immunoinflammatory and autoimmune diseases. In this study we examined the role of MIF in the development of immunoinflammatory diabetes induced in susceptible strains of mice by multiple low doses of streptozotocin. We found that MIF protein was significantly elevated in islet cells during the development of diabetes, and that targeting MIF activity with either neutralizing antibody or the pharmacological inhibitor (S, R)- 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester, markedly reduced clinical and histopathological features of the disease, such as hyperglycemia and insulitis. Lymphocytes from mice treated with the MIF inhibitors exhibited reduction of both islet antigen-specific proliferative responses and adhesive cell-cell interactions. Neutralization of MIF also down-regulated the ex vivo secretion of the proinflammatory mediators, TNF-alpha, interferon-gamma, and nitric oxide, while augmenting that of the antiinflammatory cytokine, IL-10. This study provides the first in vivo evidence for a critical role for MIF in the immune-mediated beta-cell destruction in an animal model of human type 1 diabetes mellitus and identifies a new therapeutic strategy for the prevention and treatment of this disease in humans that is based on the selective inhibition of MIF activity.
T2  - Endocrinology
T1  - Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes
IS  - 7
VL  - 146
DO  - 10.1210/en.2004-1393
SP  - 2942
EP  - 2951
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1699
ER  - 

@article{
author = "Stojanović, Ivana D. and Al-Abed, Yousef and Miljković, Đorđe and Maksimović-Ivanić, Danijela and Roth, Jesse and Bacher, Michael and Lan, Hui Y. and Nicoletti, Ferdinando and Stošić-Grujičić, Stanislava",
year = "2005",
abstract = "Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a pivotal role in several immunoinflammatory and autoimmune diseases. In this study we examined the role of MIF in the development of immunoinflammatory diabetes induced in susceptible strains of mice by multiple low doses of streptozotocin. We found that MIF protein was significantly elevated in islet cells during the development of diabetes, and that targeting MIF activity with either neutralizing antibody or the pharmacological inhibitor (S, R)- 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester, markedly reduced clinical and histopathological features of the disease, such as hyperglycemia and insulitis. Lymphocytes from mice treated with the MIF inhibitors exhibited reduction of both islet antigen-specific proliferative responses and adhesive cell-cell interactions. Neutralization of MIF also down-regulated the ex vivo secretion of the proinflammatory mediators, TNF-alpha, interferon-gamma, and nitric oxide, while augmenting that of the antiinflammatory cytokine, IL-10. This study provides the first in vivo evidence for a critical role for MIF in the immune-mediated beta-cell destruction in an animal model of human type 1 diabetes mellitus and identifies a new therapeutic strategy for the prevention and treatment of this disease in humans that is based on the selective inhibition of MIF activity.",
journal = "Endocrinology",
title = "Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes",
number = "7",
volume = "146",
doi = "10.1210/en.2004-1393",
pages = "2942-2951",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1699"
}

Stojanović, I. D., Al-Abed, Y., Miljković, Đ., Maksimović-Ivanić, D., Roth, J., Bacher, M., Lan, H. Y., Nicoletti, F.,& Stošić-Grujičić, S.. (2005). Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. in Endocrinology, 146(7), 2942-2951.
https://doi.org/10.1210/en.2004-1393
https://hdl.handle.net/21.15107/rcub_ibiss_1699

Stojanović ID, Al-Abed Y, Miljković Đ, Maksimović-Ivanić D, Roth J, Bacher M, Lan HY, Nicoletti F, Stošić-Grujičić S. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. in Endocrinology. 2005;146(7):2942-2951.
doi:10.1210/en.2004-1393
https://hdl.handle.net/21.15107/rcub_ibiss_1699 .

Stojanović, Ivana D., Al-Abed, Yousef, Miljković, Đorđe, Maksimović-Ivanić, Danijela, Roth, Jesse, Bacher, Michael, Lan, Hui Y., Nicoletti, Ferdinando, Stošić-Grujičić, Stanislava, "Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes" in Endocrinology, 146, no. 7 (2005):2942-2951,
https://doi.org/10.1210/en.2004-1393 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1699 .