TY  - JOUR
AU  - Šaponjić, Jasna
AU  - Mejías, Rebeca
AU  - Nikolovski, Neda
AU  - Dragic, Milorad
AU  - Canak, Asuman
AU  - Papoutsopoulou, Stamatia
AU  - Gürsoy-Özdemir, Yasemin
AU  - Fladmark, Kari
AU  - Ntavaroukas, Panagiotis
AU  - Bayar Muluk, Nuray
AU  - Zeljkovic Jovanovic, Milica
AU  - Fontán-Lozano, Ángela
AU  - Comi, Cristoforo
AU  - Marino, Franca
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6685
AB  - Parkinson’s disease (PD) is a chronic, age-related, progressive multisystem disease associated with neuroinflammation and immune dysfunction. This review discusses the methodological
approaches used to study the changes in central and peripheral immunity in PD, the advantages and
limitations of the techniques, and their applicability to humans. Although a single animal model
cannot replicate all pathological features of the human disease, neuroinflammation is present in
most animal models of PD and plays a critical role in understanding the involvement of the immune
system (IS) in the pathogenesis of PD. The IS and its interactions with different cell types in the
central nervous system (CNS) play an important role in the pathogenesis of PD. Even though culture
models do not fully reflect the complexity of disease progression, they are limited in their ability to
mimic long-term effects and need validation through in vivo studies. They are an indispensable tool
for understanding the interplay between the IS and the pathogenesis of this disease. Understanding
the immune-mediated mechanisms may lead to potential therapeutic targets for the treatment of PD.
We believe that the development of methodological guidelines for experiments with animal models
and PD patients is crucial to ensure the validity and consistency of the results.
PB  - Basel: MDPI
T2  - International Journal of Molecular Sciences
T1  - Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease
IS  - 8
VL  - 25
DO  - 10.3390/ijms25084330
SP  - 4330
ER  - 

@article{
author = "Šaponjić, Jasna and Mejías, Rebeca and Nikolovski, Neda and Dragic, Milorad and Canak, Asuman and Papoutsopoulou, Stamatia and Gürsoy-Özdemir, Yasemin and Fladmark, Kari and Ntavaroukas, Panagiotis and Bayar Muluk, Nuray and Zeljkovic Jovanovic, Milica and Fontán-Lozano, Ángela and Comi, Cristoforo and Marino, Franca",
year = "2024",
abstract = "Parkinson’s disease (PD) is a chronic, age-related, progressive multisystem disease associated with neuroinflammation and immune dysfunction. This review discusses the methodological
approaches used to study the changes in central and peripheral immunity in PD, the advantages and
limitations of the techniques, and their applicability to humans. Although a single animal model
cannot replicate all pathological features of the human disease, neuroinflammation is present in
most animal models of PD and plays a critical role in understanding the involvement of the immune
system (IS) in the pathogenesis of PD. The IS and its interactions with different cell types in the
central nervous system (CNS) play an important role in the pathogenesis of PD. Even though culture
models do not fully reflect the complexity of disease progression, they are limited in their ability to
mimic long-term effects and need validation through in vivo studies. They are an indispensable tool
for understanding the interplay between the IS and the pathogenesis of this disease. Understanding
the immune-mediated mechanisms may lead to potential therapeutic targets for the treatment of PD.
We believe that the development of methodological guidelines for experiments with animal models
and PD patients is crucial to ensure the validity and consistency of the results.",
publisher = "Basel: MDPI",
journal = "International Journal of Molecular Sciences",
title = "Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease",
number = "8",
volume = "25",
doi = "10.3390/ijms25084330",
pages = "4330"
}

Šaponjić, J., Mejías, R., Nikolovski, N., Dragic, M., Canak, A., Papoutsopoulou, S., Gürsoy-Özdemir, Y., Fladmark, K., Ntavaroukas, P., Bayar Muluk, N., Zeljkovic Jovanovic, M., Fontán-Lozano, Á., Comi, C.,& Marino, F.. (2024). Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease. in International Journal of Molecular Sciences
Basel: MDPI., 25(8), 4330.
https://doi.org/10.3390/ijms25084330

Šaponjić J, Mejías R, Nikolovski N, Dragic M, Canak A, Papoutsopoulou S, Gürsoy-Özdemir Y, Fladmark K, Ntavaroukas P, Bayar Muluk N, Zeljkovic Jovanovic M, Fontán-Lozano Á, Comi C, Marino F. Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease. in International Journal of Molecular Sciences. 2024;25(8):4330.
doi:10.3390/ijms25084330 .

Šaponjić, Jasna, Mejías, Rebeca, Nikolovski, Neda, Dragic, Milorad, Canak, Asuman, Papoutsopoulou, Stamatia, Gürsoy-Özdemir, Yasemin, Fladmark, Kari, Ntavaroukas, Panagiotis, Bayar Muluk, Nuray, Zeljkovic Jovanovic, Milica, Fontán-Lozano, Ángela, Comi, Cristoforo, Marino, Franca, "Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease" in International Journal of Molecular Sciences, 25, no. 8 (2024):4330,
https://doi.org/10.3390/ijms25084330 . .