TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Spasojević, Dragica
AU  - Orlovska, Irina
AU  - Kozyrovska, Natalia
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Dmitrović, Svetlana
AU  - Matović, Branko
AU  - Tasić, Nikola
AU  - Maksimović, Vuk
AU  - Sosnin, Mikhail
AU  - Radotić, Ksenija
PY  - 2018
UR  - https://doi.org/10.1016/j.ijbiomac.2018.06.067
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3102
AB  - Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.
T2  - International Journal of Biological Macromolecules
T1  - Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing
DO  - 10.1016/j.ijbiomac.2018.06.067
ER  - 

@article{
author = "Zmejkoski, Danica and Spasojević, Dragica and Orlovska, Irina and Kozyrovska, Natalia and Soković, Marina and Glamočlija, Jasmina and Dmitrović, Svetlana and Matović, Branko and Tasić, Nikola and Maksimović, Vuk and Sosnin, Mikhail and Radotić, Ksenija",
year = "2018",
abstract = "Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.",
journal = "International Journal of Biological Macromolecules",
title = "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing",
doi = "10.1016/j.ijbiomac.2018.06.067"
}

Zmejkoski, D., Spasojević, D., Orlovska, I., Kozyrovska, N., Soković, M., Glamočlija, J., Dmitrović, S., Matović, B., Tasić, N., Maksimović, V., Sosnin, M.,& Radotić, K.. (2018). Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules.
https://doi.org/10.1016/j.ijbiomac.2018.06.067

Zmejkoski D, Spasojević D, Orlovska I, Kozyrovska N, Soković M, Glamočlija J, Dmitrović S, Matović B, Tasić N, Maksimović V, Sosnin M, Radotić K. Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules. 2018;.
doi:10.1016/j.ijbiomac.2018.06.067 .

Zmejkoski, Danica, Spasojević, Dragica, Orlovska, Irina, Kozyrovska, Natalia, Soković, Marina, Glamočlija, Jasmina, Dmitrović, Svetlana, Matović, Branko, Tasić, Nikola, Maksimović, Vuk, Sosnin, Mikhail, Radotić, Ksenija, "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing" in International Journal of Biological Macromolecules (2018),
https://doi.org/10.1016/j.ijbiomac.2018.06.067 . .

TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Spasojević, Dragica
AU  - Orlovska, Irina
AU  - Kozyrovska, Natalia
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Dmitrović, Svetlana
AU  - Matović, Branko
AU  - Tasić, Nikola
AU  - Maksimović, Vuk
AU  - Sosnin, Mikhail
AU  - Radotić, Ksenija
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0141813018320919?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3101
AB  - Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.
T2  - International Journal of Biological Macromolecules
T1  - Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing.
IS  - Pt A
VL  - 118
DO  - 10.1016/j.ijbiomac.2018.06.067
SP  - 494
EP  - 503
ER  - 

@article{
author = "Zmejkoski, Danica and Spasojević, Dragica and Orlovska, Irina and Kozyrovska, Natalia and Soković, Marina and Glamočlija, Jasmina and Dmitrović, Svetlana and Matović, Branko and Tasić, Nikola and Maksimović, Vuk and Sosnin, Mikhail and Radotić, Ksenija",
year = "2018",
abstract = "Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.",
journal = "International Journal of Biological Macromolecules",
title = "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing.",
number = "Pt A",
volume = "118",
doi = "10.1016/j.ijbiomac.2018.06.067",
pages = "494-503"
}

Zmejkoski, D., Spasojević, D., Orlovska, I., Kozyrovska, N., Soković, M., Glamočlija, J., Dmitrović, S., Matović, B., Tasić, N., Maksimović, V., Sosnin, M.,& Radotić, K.. (2018). Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing.. in International Journal of Biological Macromolecules, 118(Pt A), 494-503.
https://doi.org/10.1016/j.ijbiomac.2018.06.067

Zmejkoski D, Spasojević D, Orlovska I, Kozyrovska N, Soković M, Glamočlija J, Dmitrović S, Matović B, Tasić N, Maksimović V, Sosnin M, Radotić K. Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing.. in International Journal of Biological Macromolecules. 2018;118(Pt A):494-503.
doi:10.1016/j.ijbiomac.2018.06.067 .

Zmejkoski, Danica, Spasojević, Dragica, Orlovska, Irina, Kozyrovska, Natalia, Soković, Marina, Glamočlija, Jasmina, Dmitrović, Svetlana, Matović, Branko, Tasić, Nikola, Maksimović, Vuk, Sosnin, Mikhail, Radotić, Ksenija, "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing." in International Journal of Biological Macromolecules, 118, no. Pt A (2018):494-503,
https://doi.org/10.1016/j.ijbiomac.2018.06.067 . .

TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Petković, Branka
AU  - Pavković-Lučić, Sofija
AU  - Prolić, Zlatko
AU  - Anđelković, Marko
AU  - Savić, Tatjana
PY  - 2017
UR  - https://www.tandfonline.com/doi/full/10.1080/09553002.2017.1268281
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2548
AB  - Purpose: Extremely low frequency (ELF) magnetic fields as essential ecological factors may induce specific responses in genetically different lines. The object of this study was to investigate the impact of the ELF magnetic field on fitness components and locomotor activity of five Drosophila subobscura isofemale (IF) lines. Materials and methods: Each D. subobscura IF line, arbitrarily named: B16/1, B24/4, B39/1, B57/2 and B69/5, was maintained in five full-sib inbreeding generations. Their genetic structures were defined based on the mitochondrial DNA variability. Egg-first instar larvae and 1-day-old flies were exposed to an ELF magnetic field (50 Hz, 0.5 mT, 48 h) and thereafter, fitness components and locomotor activity of males and females in an open field test were observed for each selected IF line, respectively. Results: Exposure of egg-first instar larvae to an ELF magnetic field shortened developmental time, and did not affect the viability and sex ratio of D. subobscura IF lines. Exposure of 1-day-old males and females IF lines B16/1 and B24/4 to an ELF magnetic field significantly decreased their locomotor activity and this effect lasted longer in females than males. Conclusions: These results indicate various responses of D. subobscura IF lines to the applied ELF magnetic field depending on their genetic background.
T2  - International Journal of Radiation Biology
T1  - Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity
IS  - 5
VL  - 93
DO  - 10.1080/09553002.2017.1268281
SP  - 544
EP  - 552
ER  - 

@article{
author = "Zmejkoski, Danica and Petković, Branka and Pavković-Lučić, Sofija and Prolić, Zlatko and Anđelković, Marko and Savić, Tatjana",
year = "2017",
abstract = "Purpose: Extremely low frequency (ELF) magnetic fields as essential ecological factors may induce specific responses in genetically different lines. The object of this study was to investigate the impact of the ELF magnetic field on fitness components and locomotor activity of five Drosophila subobscura isofemale (IF) lines. Materials and methods: Each D. subobscura IF line, arbitrarily named: B16/1, B24/4, B39/1, B57/2 and B69/5, was maintained in five full-sib inbreeding generations. Their genetic structures were defined based on the mitochondrial DNA variability. Egg-first instar larvae and 1-day-old flies were exposed to an ELF magnetic field (50 Hz, 0.5 mT, 48 h) and thereafter, fitness components and locomotor activity of males and females in an open field test were observed for each selected IF line, respectively. Results: Exposure of egg-first instar larvae to an ELF magnetic field shortened developmental time, and did not affect the viability and sex ratio of D. subobscura IF lines. Exposure of 1-day-old males and females IF lines B16/1 and B24/4 to an ELF magnetic field significantly decreased their locomotor activity and this effect lasted longer in females than males. Conclusions: These results indicate various responses of D. subobscura IF lines to the applied ELF magnetic field depending on their genetic background.",
journal = "International Journal of Radiation Biology",
title = "Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity",
number = "5",
volume = "93",
doi = "10.1080/09553002.2017.1268281",
pages = "544-552"
}

Zmejkoski, D., Petković, B., Pavković-Lučić, S., Prolić, Z., Anđelković, M.,& Savić, T.. (2017). Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity. in International Journal of Radiation Biology, 93(5), 544-552.
https://doi.org/10.1080/09553002.2017.1268281

Zmejkoski D, Petković B, Pavković-Lučić S, Prolić Z, Anđelković M, Savić T. Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity. in International Journal of Radiation Biology. 2017;93(5):544-552.
doi:10.1080/09553002.2017.1268281 .

Zmejkoski, Danica, Petković, Branka, Pavković-Lučić, Sofija, Prolić, Zlatko, Anđelković, Marko, Savić, Tatjana, "Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity" in International Journal of Radiation Biology, 93, no. 5 (2017):544-552,
https://doi.org/10.1080/09553002.2017.1268281 . .

TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Petković, Branka
AU  - Pavković-Lučić, Sofija
AU  - Prolić, Zlatko
AU  - Anđelković, Marko
AU  - Savić, Tatjana
PY  - 2017
UR  - https://www.tandfonline.com/doi/full/10.1080/09553002.2017.1268281
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2548
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3781
AB  - Purpose: Extremely low frequency (ELF) magnetic fields as essential ecological factors may induce specific responses in genetically different lines. The object of this study was to investigate the impact of the ELF magnetic field on fitness components and locomotor activity of five Drosophila subobscura isofemale (IF) lines. Materials and methods: Each D. subobscura IF line, arbitrarily named: B16/1, B24/4, B39/1, B57/2 and B69/5, was maintained in five full-sib inbreeding generations. Their genetic structures were defined based on the mitochondrial DNA variability. Egg-first instar larvae and 1-day-old flies were exposed to an ELF magnetic field (50 Hz, 0.5 mT, 48 h) and thereafter, fitness components and locomotor activity of males and females in an open field test were observed for each selected IF line, respectively. Results: Exposure of egg-first instar larvae to an ELF magnetic field shortened developmental time, and did not affect the viability and sex ratio of D. subobscura IF lines. Exposure of 1-day-old males and females IF lines B16/1 and B24/4 to an ELF magnetic field significantly decreased their locomotor activity and this effect lasted longer in females than males. Conclusions: These results indicate various responses of D. subobscura IF lines to the applied ELF magnetic field depending on their genetic background.
T2  - International Journal of Radiation Biology
T1  - Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity
IS  - 5
VL  - 93
DO  - 10.1080/09553002.2017.1268281
SP  - 544
EP  - 552
ER  - 

@article{
author = "Zmejkoski, Danica and Petković, Branka and Pavković-Lučić, Sofija and Prolić, Zlatko and Anđelković, Marko and Savić, Tatjana",
year = "2017",
abstract = "Purpose: Extremely low frequency (ELF) magnetic fields as essential ecological factors may induce specific responses in genetically different lines. The object of this study was to investigate the impact of the ELF magnetic field on fitness components and locomotor activity of five Drosophila subobscura isofemale (IF) lines. Materials and methods: Each D. subobscura IF line, arbitrarily named: B16/1, B24/4, B39/1, B57/2 and B69/5, was maintained in five full-sib inbreeding generations. Their genetic structures were defined based on the mitochondrial DNA variability. Egg-first instar larvae and 1-day-old flies were exposed to an ELF magnetic field (50 Hz, 0.5 mT, 48 h) and thereafter, fitness components and locomotor activity of males and females in an open field test were observed for each selected IF line, respectively. Results: Exposure of egg-first instar larvae to an ELF magnetic field shortened developmental time, and did not affect the viability and sex ratio of D. subobscura IF lines. Exposure of 1-day-old males and females IF lines B16/1 and B24/4 to an ELF magnetic field significantly decreased their locomotor activity and this effect lasted longer in females than males. Conclusions: These results indicate various responses of D. subobscura IF lines to the applied ELF magnetic field depending on their genetic background.",
journal = "International Journal of Radiation Biology",
title = "Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity",
number = "5",
volume = "93",
doi = "10.1080/09553002.2017.1268281",
pages = "544-552"
}

Zmejkoski, D., Petković, B., Pavković-Lučić, S., Prolić, Z., Anđelković, M.,& Savić, T.. (2017). Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity. in International Journal of Radiation Biology, 93(5), 544-552.
https://doi.org/10.1080/09553002.2017.1268281

Zmejkoski D, Petković B, Pavković-Lučić S, Prolić Z, Anđelković M, Savić T. Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity. in International Journal of Radiation Biology. 2017;93(5):544-552.
doi:10.1080/09553002.2017.1268281 .

Zmejkoski, Danica, Petković, Branka, Pavković-Lučić, Sofija, Prolić, Zlatko, Anđelković, Marko, Savić, Tatjana, "Different responses of Drosophila subobscura isofemale lines to extremely low frequency magnetic field (50 Hz, 0.5 mT): fitness components and locomotor activity" in International Journal of Radiation Biology, 93, no. 5 (2017):544-552,
https://doi.org/10.1080/09553002.2017.1268281 . .

TY  - JOUR
AU  - Spasojević, Dragica
AU  - Zmejkoski, Danica
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Soković, Marina
AU  - Milošević, Verica
AU  - Jarić, Ivana
AU  - Stojanović, Marijana
AU  - Marinković, Emilija
AU  - Barisani-Asenbauer, Talin
AU  - Prodanović, Radivoje
AU  - Jovanović, Miloš
AU  - Radotić, Ksenija
PY  - 2016
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0924857916302679
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85000995852&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=5EA0B882AD39CF37A9F768C8B10917B5.wsnAw8kcdt7IPYLO0V48gA%3A1#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2480
AB  - Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP−Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
T2  - International Journal of Antimicrobial Agents
T1  - Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
IS  - 6
VL  - 48
DO  - 10.1016/j.ijantimicag.2016.08.014
SP  - 732
EP  - 735
ER  - 

@article{
author = "Spasojević, Dragica and Zmejkoski, Danica and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina and Milošević, Verica and Jarić, Ivana and Stojanović, Marijana and Marinković, Emilija and Barisani-Asenbauer, Talin and Prodanović, Radivoje and Jovanović, Miloš and Radotić, Ksenija",
year = "2016",
abstract = "Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP−Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.",
journal = "International Journal of Antimicrobial Agents",
title = "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment",
number = "6",
volume = "48",
doi = "10.1016/j.ijantimicag.2016.08.014",
pages = "732-735"
}

Spasojević, D., Zmejkoski, D., Glamočlija, J., Nikolić, M., Soković, M., Milošević, V., Jarić, I., Stojanović, M., Marinković, E., Barisani-Asenbauer, T., Prodanović, R., Jovanović, M.,& Radotić, K.. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents, 48(6), 732-735.
https://doi.org/10.1016/j.ijantimicag.2016.08.014

Spasojević D, Zmejkoski D, Glamočlija J, Nikolić M, Soković M, Milošević V, Jarić I, Stojanović M, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents. 2016;48(6):732-735.
doi:10.1016/j.ijantimicag.2016.08.014 .

Spasojević, Dragica, Zmejkoski, Danica, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, Milošević, Verica, Jarić, Ivana, Stojanović, Marijana, Marinković, Emilija, Barisani-Asenbauer, Talin, Prodanović, Radivoje, Jovanović, Miloš, Radotić, Ksenija, "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment" in International Journal of Antimicrobial Agents, 48, no. 6 (2016):732-735,
https://doi.org/10.1016/j.ijantimicag.2016.08.014 . .

TY  - JOUR
AU  - Pešić, Milica
AU  - Podolski-Renić, Ana
AU  - Stojković Burić, Sonja
AU  - Matovic, Branko
AU  - Zmejkoski, Danica
AU  - Kojic, Vesna
AU  - Bogdanovic, Gordana
AU  - Pavicevic, Aleksandra
AU  - Mojovic, Milos
AU  - Savic, Aleksandar
AU  - Milenkovic, Ivana
AU  - Kalauzi, Aleksandar
AU  - Radotic, Ksenija
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1957
AB  - Data on medical applications of cerium oxide nanoparticles CeO2 (CONP)
   are promising, yet information regarding their action in cells is
   incomplete and there are conflicting reports about in vitro toxicity.
   Herein, we have studied cytotoxic effect of CONP in several cancer and
   normal cell lines and their potential to change intracellular redox
   status. The IC50 was achieved only in two of eight tested cell lines,
   melanoma 518A2 and colorectal adenocarcinoma HT-29. Self-propagating
   room temperature method was applied to produce CONP with an average
   crystalline size of 4 nm. The results confirmed presence of Ce3+ and O2-
   vacancies. The induction of cell death by CONP and the production of
   reactive oxygen species (ROS) were analyzed by flow-cytometry. Free
   radicals related antioxidant capacity of the cells was studied by the
   reduction of stable free radical TEMPONE using electron spin resonance
   spectroscopy. CONP showed low or moderate cytotoxicity in cancer cell
   lines: adenocarcinoma DLD1 and multi-drug resistant DLD1-TxR, non-small
   cell lung carcinoma NCI-H460 and multi-drug resistant NCI-H460/R, while
   normal cell lines (keratinocytes HaCaT, lung fetal fibroblasts MRC-5)
   were insensitive. The most sensitive were 518A2 melanoma and HT-29
   colorectal adenocarcinoma cell lines, with the IC50 values being between
   100 and 200 mu M. Decreased rate of TEMPONE reduction and increased
   production of certain ROS species (peroxynitrite and hydrogen peroxide
   anion) indicates that free radical metabolism, thus redox status was
   changed, and antioxidant capacity damaged in the CONP treated 518A2 and
   HT-29 cells. In conclusion, changes in intracellular redox status
   induced by CONP are partly attributed to the prooxidant activity of the
   nanoparticles. Further, ROS induced cell damages might eventually lead
   to the cell death. However, low inhibitory potential of CONP in the
   other human cell lines tested indicates that CONP may be safe for human
   usage in industry and medicine. (C) 2015 Elsevier Ireland Ltd. All
   rights reserved.
T2  - Chemico-Biological Interactions
T1  - Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity
VL  - 232
DO  - 10.1016/j.cbi.2015.03.013
SP  - 85
EP  - 93
ER  - 

@article{
author = "Pešić, Milica and Podolski-Renić, Ana and Stojković Burić, Sonja and Matovic, Branko and Zmejkoski, Danica and Kojic, Vesna and Bogdanovic, Gordana and Pavicevic, Aleksandra and Mojovic, Milos and Savic, Aleksandar and Milenkovic, Ivana and Kalauzi, Aleksandar and Radotic, Ksenija",
year = "2015",
abstract = "Data on medical applications of cerium oxide nanoparticles CeO2 (CONP)
   are promising, yet information regarding their action in cells is
   incomplete and there are conflicting reports about in vitro toxicity.
   Herein, we have studied cytotoxic effect of CONP in several cancer and
   normal cell lines and their potential to change intracellular redox
   status. The IC50 was achieved only in two of eight tested cell lines,
   melanoma 518A2 and colorectal adenocarcinoma HT-29. Self-propagating
   room temperature method was applied to produce CONP with an average
   crystalline size of 4 nm. The results confirmed presence of Ce3+ and O2-
   vacancies. The induction of cell death by CONP and the production of
   reactive oxygen species (ROS) were analyzed by flow-cytometry. Free
   radicals related antioxidant capacity of the cells was studied by the
   reduction of stable free radical TEMPONE using electron spin resonance
   spectroscopy. CONP showed low or moderate cytotoxicity in cancer cell
   lines: adenocarcinoma DLD1 and multi-drug resistant DLD1-TxR, non-small
   cell lung carcinoma NCI-H460 and multi-drug resistant NCI-H460/R, while
   normal cell lines (keratinocytes HaCaT, lung fetal fibroblasts MRC-5)
   were insensitive. The most sensitive were 518A2 melanoma and HT-29
   colorectal adenocarcinoma cell lines, with the IC50 values being between
   100 and 200 mu M. Decreased rate of TEMPONE reduction and increased
   production of certain ROS species (peroxynitrite and hydrogen peroxide
   anion) indicates that free radical metabolism, thus redox status was
   changed, and antioxidant capacity damaged in the CONP treated 518A2 and
   HT-29 cells. In conclusion, changes in intracellular redox status
   induced by CONP are partly attributed to the prooxidant activity of the
   nanoparticles. Further, ROS induced cell damages might eventually lead
   to the cell death. However, low inhibitory potential of CONP in the
   other human cell lines tested indicates that CONP may be safe for human
   usage in industry and medicine. (C) 2015 Elsevier Ireland Ltd. All
   rights reserved.",
journal = "Chemico-Biological Interactions",
title = "Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity",
volume = "232",
doi = "10.1016/j.cbi.2015.03.013",
pages = "85-93"
}

Pešić, M., Podolski-Renić, A., Stojković Burić, S., Matovic, B., Zmejkoski, D., Kojic, V., Bogdanovic, G., Pavicevic, A., Mojovic, M., Savic, A., Milenkovic, I., Kalauzi, A.,& Radotic, K.. (2015). Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity. in Chemico-Biological Interactions, 232, 85-93.
https://doi.org/10.1016/j.cbi.2015.03.013

Pešić M, Podolski-Renić A, Stojković Burić S, Matovic B, Zmejkoski D, Kojic V, Bogdanovic G, Pavicevic A, Mojovic M, Savic A, Milenkovic I, Kalauzi A, Radotic K. Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity. in Chemico-Biological Interactions. 2015;232:85-93.
doi:10.1016/j.cbi.2015.03.013 .

Pešić, Milica, Podolski-Renić, Ana, Stojković Burić, Sonja, Matovic, Branko, Zmejkoski, Danica, Kojic, Vesna, Bogdanovic, Gordana, Pavicevic, Aleksandra, Mojovic, Milos, Savic, Aleksandar, Milenkovic, Ivana, Kalauzi, Aleksandar, Radotic, Ksenija, "Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity" in Chemico-Biological Interactions, 232 (2015):85-93,
https://doi.org/10.1016/j.cbi.2015.03.013 . .