@conference{
author = "Šavikin, Katarina P. and Krstić Milošević, Dijana and Menković, Nebojša R. and Beara, Ivana N. and Mrkonjić, Zorica O. and Pljevljakušić, Dejan S.",
year = "2017",
abstract = "The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents.",
journal = "Natural Product Communications",
title = "Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity",
number = "2",
volume = "12",
doi = "10.1177/1934578x1701200204",
pages = "159-162"
}