TY  - JOUR
AU  - Hamad, Mohamad
AU  - AlKhamach, Dana M H
AU  - Alsayadi, Lujain Majed
AU  - Sarhan, Sirin Abdulkafi
AU  - Saeed, Balsam Qubais
AU  - Soković, Marina
AU  - Ben Hadda, Taibi
AU  - Soliman, Sameh S M
PY  - 2023
UR  - https://www.liebertpub.com/doi/10.1089/vim.2022.0122
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5466
AB  - Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initially emerged in December 2019 and has subsequently expanded globally, leading to the ongoing pandemic. The extensive spread of various SARS-CoV-2 variants possesses a serious public health threat. An extensive literature search along with deep analysis was performed to describe and evaluate the characteristics of SARS-CoV-2 variants of concern in relation to the effectiveness of the current vaccines and therapeutics. The obtained results showed that several significant mutations have evolved during the COVID-19 pandemic. The developed variants and their various structural mutations can compromise the effectiveness of several vaccines, escape the neutralizing antibodies, and limit the efficiency of available therapeutics. Furthermore, deep analysis of the available data enables the prediction of the future impact of virus mutations on the ongoing pandemic along with the selection of appropriate vaccines and therapeutics.
T2  - Viral Immunology
T1  - Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy
DO  - 10.1089/vim.2022.0122
ER  - 

@article{
author = "Hamad, Mohamad and AlKhamach, Dana M H and Alsayadi, Lujain Majed and Sarhan, Sirin Abdulkafi and Saeed, Balsam Qubais and Soković, Marina and Ben Hadda, Taibi and Soliman, Sameh S M",
year = "2023",
abstract = "Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initially emerged in December 2019 and has subsequently expanded globally, leading to the ongoing pandemic. The extensive spread of various SARS-CoV-2 variants possesses a serious public health threat. An extensive literature search along with deep analysis was performed to describe and evaluate the characteristics of SARS-CoV-2 variants of concern in relation to the effectiveness of the current vaccines and therapeutics. The obtained results showed that several significant mutations have evolved during the COVID-19 pandemic. The developed variants and their various structural mutations can compromise the effectiveness of several vaccines, escape the neutralizing antibodies, and limit the efficiency of available therapeutics. Furthermore, deep analysis of the available data enables the prediction of the future impact of virus mutations on the ongoing pandemic along with the selection of appropriate vaccines and therapeutics.",
journal = "Viral Immunology",
title = "Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy",
doi = "10.1089/vim.2022.0122"
}

Hamad, M., AlKhamach, D. M. H., Alsayadi, L. M., Sarhan, S. A., Saeed, B. Q., Soković, M., Ben Hadda, T.,& Soliman, S. S. M.. (2023). Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy. in Viral Immunology.
https://doi.org/10.1089/vim.2022.0122

Hamad M, AlKhamach DMH, Alsayadi LM, Sarhan SA, Saeed BQ, Soković M, Ben Hadda T, Soliman SSM. Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy. in Viral Immunology. 2023;.
doi:10.1089/vim.2022.0122 .

Hamad, Mohamad, AlKhamach, Dana M H, Alsayadi, Lujain Majed, Sarhan, Sirin Abdulkafi, Saeed, Balsam Qubais, Soković, Marina, Ben Hadda, Taibi, Soliman, Sameh S M, "Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy" in Viral Immunology (2023),
https://doi.org/10.1089/vim.2022.0122 . .