TY  - JOUR
AU  - Đurović, Saša
AU  - Vujanović, Milena
AU  - Radojković, Marija
AU  - Filipović, Jelena
AU  - Filipović, Vladimir
AU  - Gašić, Uroš
AU  - Tešić, Živoslav
AU  - Mašković, Pavle
AU  - Zeković, Zoran
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4067
AB  - Stinging nettle is an annual plant. This plant is known for applications in folk medicine, and as the human diet. The stinging nettle leaves has been used to obtain extracts, which are expected to be with a high content of biologically active compounds. Prepared microwave extracts were applied in the formulation of the functional products. The article completes preparation of the bread with addition of the stinging nettle leaves and its extract, and bread’s composition in phenolic acids, flavonoids, micro elements, and macro elements. The biological activity of the prepared bread samples showed significant antioxidant activity. This was especially true against DPPH radicals. It has been shown that it holds a high cytotoxic activity. Leaves themselves decreased the quality of the bread, while the extract improved the quality. It was sensorially confirmed. The article concluded that the extract substitutes leaves in bread as a product of a high benefit.
PB  - Elsevier Ltd
T2  - Food Chemistry
T1  - The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread
VL  - 312
DO  - 10.1016/j.foodchem.2019.126091
SP  - 126091
ER  - 

@article{
author = "Đurović, Saša and Vujanović, Milena and Radojković, Marija and Filipović, Jelena and Filipović, Vladimir and Gašić, Uroš and Tešić, Živoslav and Mašković, Pavle and Zeković, Zoran",
year = "2020",
abstract = "Stinging nettle is an annual plant. This plant is known for applications in folk medicine, and as the human diet. The stinging nettle leaves has been used to obtain extracts, which are expected to be with a high content of biologically active compounds. Prepared microwave extracts were applied in the formulation of the functional products. The article completes preparation of the bread with addition of the stinging nettle leaves and its extract, and bread’s composition in phenolic acids, flavonoids, micro elements, and macro elements. The biological activity of the prepared bread samples showed significant antioxidant activity. This was especially true against DPPH radicals. It has been shown that it holds a high cytotoxic activity. Leaves themselves decreased the quality of the bread, while the extract improved the quality. It was sensorially confirmed. The article concluded that the extract substitutes leaves in bread as a product of a high benefit.",
publisher = "Elsevier Ltd",
journal = "Food Chemistry",
title = "The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread",
volume = "312",
doi = "10.1016/j.foodchem.2019.126091",
pages = "126091"
}

Đurović, S., Vujanović, M., Radojković, M., Filipović, J., Filipović, V., Gašić, U., Tešić, Ž., Mašković, P.,& Zeković, Z.. (2020). The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread. in Food Chemistry
Elsevier Ltd., 312, 126091.
https://doi.org/10.1016/j.foodchem.2019.126091

Đurović S, Vujanović M, Radojković M, Filipović J, Filipović V, Gašić U, Tešić Ž, Mašković P, Zeković Z. The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread. in Food Chemistry. 2020;312:126091.
doi:10.1016/j.foodchem.2019.126091 .

Đurović, Saša, Vujanović, Milena, Radojković, Marija, Filipović, Jelena, Filipović, Vladimir, Gašić, Uroš, Tešić, Živoslav, Mašković, Pavle, Zeković, Zoran, "The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread" in Food Chemistry, 312 (2020):126091,
https://doi.org/10.1016/j.foodchem.2019.126091 . .

TY  - JOUR
AU  - Mašković, Pavle Z.
AU  - AC, Mira
AU  - Pavlović, Milan
AU  - Vujošević, Mladen
AU  - Blagojević, Jelena
AU  - Đurić, Milena
AU  - Vesković Modričanin, Slavica
AU  - Đukić, Dragutin A.
PY  - 2016
UR  - http://www.revistadechimie.ro/pdf/MASKOVIC P 12 16.pdf
UR  - http://www.revistadechimie.ro/article_eng.asp?ID=5344
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2594
AB  - This research studies the antioxidant activity and efficacy of the ethanolic extract of the plant species Onosma aucheriana DC. This plant growing wild in Serbia, in inhibiting the development of selected fungi and bacteria. The most sensitive to the ethanolic extracts were bacteria B. subtilis and S. aureus (MIC = 15.62 mg/mL), while the fungi, A. niger (MIC = 15.62 mg/mL) showed the highest susceptibility. Total phenolic, flavonoid, condensed tannin and gallotannin contents were 90.26 mg GA/g, 35.24 mg RU/g, 74.65 mg GA/g and 31.74 mg GA/g, respectively. Phenolic compounds are found as dominant in the extract of rosmarinic acid. Total antioxidant capacity was 78.45 mg AA/g. IC50 values were determined for each measurement: 21.45 mg/mL for DPPH free radical scavenging activity, 36.46 mg/mL for inhibitory activity against lipid peroxidation, 99.11 mg/mL for hydroxyl radical scavenging activity and 45.91 mg/mL for chelating ability. A potent inhibitor of cell growth to all three cell lines (Hep2c, RD, L2OB) is the ethanol extract of plant species O. aucheriana . Results of Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of O. aucheriana at concentrations of 62.5 mg/mL does not produce toxic or genotoxic effects.
T2  - Revista de Chimie
T1  - A Study on the Ethanolic Extract of Onosma aucheriana. Biological and toxicological evaluation
IS  - 12
VL  - 67
DO  - 10.37358/Rev.Chim.1949
SP  - 2511
EP  - 2518
ER  - 

@article{
author = "Mašković, Pavle Z. and AC, Mira and Pavlović, Milan and Vujošević, Mladen and Blagojević, Jelena and Đurić, Milena and Vesković Modričanin, Slavica and Đukić, Dragutin A.",
year = "2016",
abstract = "This research studies the antioxidant activity and efficacy of the ethanolic extract of the plant species Onosma aucheriana DC. This plant growing wild in Serbia, in inhibiting the development of selected fungi and bacteria. The most sensitive to the ethanolic extracts were bacteria B. subtilis and S. aureus (MIC = 15.62 mg/mL), while the fungi, A. niger (MIC = 15.62 mg/mL) showed the highest susceptibility. Total phenolic, flavonoid, condensed tannin and gallotannin contents were 90.26 mg GA/g, 35.24 mg RU/g, 74.65 mg GA/g and 31.74 mg GA/g, respectively. Phenolic compounds are found as dominant in the extract of rosmarinic acid. Total antioxidant capacity was 78.45 mg AA/g. IC50 values were determined for each measurement: 21.45 mg/mL for DPPH free radical scavenging activity, 36.46 mg/mL for inhibitory activity against lipid peroxidation, 99.11 mg/mL for hydroxyl radical scavenging activity and 45.91 mg/mL for chelating ability. A potent inhibitor of cell growth to all three cell lines (Hep2c, RD, L2OB) is the ethanol extract of plant species O. aucheriana . Results of Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of O. aucheriana at concentrations of 62.5 mg/mL does not produce toxic or genotoxic effects.",
journal = "Revista de Chimie",
title = "A Study on the Ethanolic Extract of Onosma aucheriana. Biological and toxicological evaluation",
number = "12",
volume = "67",
doi = "10.37358/Rev.Chim.1949",
pages = "2511-2518"
}

Mašković, P. Z., AC, M., Pavlović, M., Vujošević, M., Blagojević, J., Đurić, M., Vesković Modričanin, S.,& Đukić, D. A.. (2016). A Study on the Ethanolic Extract of Onosma aucheriana. Biological and toxicological evaluation. in Revista de Chimie, 67(12), 2511-2518.
https://doi.org/10.37358/Rev.Chim.1949

Mašković PZ, AC M, Pavlović M, Vujošević M, Blagojević J, Đurić M, Vesković Modričanin S, Đukić DA. A Study on the Ethanolic Extract of Onosma aucheriana. Biological and toxicological evaluation. in Revista de Chimie. 2016;67(12):2511-2518.
doi:10.37358/Rev.Chim.1949 .

Mašković, Pavle Z., AC, Mira, Pavlović, Milan, Vujošević, Mladen, Blagojević, Jelena, Đurić, Milena, Vesković Modričanin, Slavica, Đukić, Dragutin A., "A Study on the Ethanolic Extract of Onosma aucheriana. Biological and toxicological evaluation" in Revista de Chimie, 67, no. 12 (2016):2511-2518,
https://doi.org/10.37358/Rev.Chim.1949 . .

TY  - JOUR
AU  - Mladenović, Milan
AU  - Mihailović, Mirjana
AU  - Bogojević, Desanka
AU  - Vuković, Nenad
AU  - Sukdolak, Slobodan
AU  - Matić, Sanja
AU  - Nićiforović, Neda
AU  - Mihailović, Vladimir
AU  - Mašković, Pavle
AU  - Vrvić, Miroslav M.
AU  - Solujić, Slavica
PY  - 2012
UR  - https://www.sciencedirect.com/science/article/pii/S0223523412002887?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3201
AB  - The objective of this study was to investigate in vitro and in vivo anticoagulant activity of sixteen 4-hydroxycoumarin derivatives bearing polar C-3 scaffolds. The activity was evaluated by measuring prothrombin time. Enhanced anticoagulant activity in vitro was observed for all tested compounds. Upon successive administration of 0.5 mg/kg of body weight to adult Wistar rats, over a period of five days, four derivatives (2b, 4c, 5c and 9c) presented anticoagulant activity in vivo. The most active compound was 2b, with PT = 30.0 s. Low or non-toxic effects in vivo were determined based on the catalytic activity of liver enzymes and the concentration of bilirubin, iron and proteins. Metabolic pathways of the most active compounds in vivo were determined after GC/MS analysis of collected rat urine samples. The excretion occurs by glucuronidation of 7-hydroxy forms of tested derivatives. In vivo results were described using PLS-based CoMFA and CoMSIA 3D-QSAR studies, which showed CoMFA-SE (q2 = 0.738) and CoMSIA-SEA (q2 = 0.763) to be the statistically most relevant models. Furthermore, molecular docking and DFT mechanistic studies performed on the rat VKORC1 homology model revealed interactions between the 4-OH coumarin group in the form of phenolic anion and the Cys135 catalytic site in the transition state.
T2  - European Journal of Medicinal Chemistry
T1  - Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
VL  - 54
DO  - 10.1016/J.EJMECH.2012.04.036
SP  - 144
EP  - 158
ER  - 

@article{
author = "Mladenović, Milan and Mihailović, Mirjana and Bogojević, Desanka and Vuković, Nenad and Sukdolak, Slobodan and Matić, Sanja and Nićiforović, Neda and Mihailović, Vladimir and Mašković, Pavle and Vrvić, Miroslav M. and Solujić, Slavica",
year = "2012",
abstract = "The objective of this study was to investigate in vitro and in vivo anticoagulant activity of sixteen 4-hydroxycoumarin derivatives bearing polar C-3 scaffolds. The activity was evaluated by measuring prothrombin time. Enhanced anticoagulant activity in vitro was observed for all tested compounds. Upon successive administration of 0.5 mg/kg of body weight to adult Wistar rats, over a period of five days, four derivatives (2b, 4c, 5c and 9c) presented anticoagulant activity in vivo. The most active compound was 2b, with PT = 30.0 s. Low or non-toxic effects in vivo were determined based on the catalytic activity of liver enzymes and the concentration of bilirubin, iron and proteins. Metabolic pathways of the most active compounds in vivo were determined after GC/MS analysis of collected rat urine samples. The excretion occurs by glucuronidation of 7-hydroxy forms of tested derivatives. In vivo results were described using PLS-based CoMFA and CoMSIA 3D-QSAR studies, which showed CoMFA-SE (q2 = 0.738) and CoMSIA-SEA (q2 = 0.763) to be the statistically most relevant models. Furthermore, molecular docking and DFT mechanistic studies performed on the rat VKORC1 homology model revealed interactions between the 4-OH coumarin group in the form of phenolic anion and the Cys135 catalytic site in the transition state.",
journal = "European Journal of Medicinal Chemistry",
title = "Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants",
volume = "54",
doi = "10.1016/J.EJMECH.2012.04.036",
pages = "144-158"
}

Mladenović, M., Mihailović, M., Bogojević, D., Vuković, N., Sukdolak, S., Matić, S., Nićiforović, N., Mihailović, V., Mašković, P., Vrvić, M. M.,& Solujić, S.. (2012). Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants. in European Journal of Medicinal Chemistry, 54, 144-158.
https://doi.org/10.1016/J.EJMECH.2012.04.036

Mladenović M, Mihailović M, Bogojević D, Vuković N, Sukdolak S, Matić S, Nićiforović N, Mihailović V, Mašković P, Vrvić MM, Solujić S. Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants. in European Journal of Medicinal Chemistry. 2012;54:144-158.
doi:10.1016/J.EJMECH.2012.04.036 .

Mladenović, Milan, Mihailović, Mirjana, Bogojević, Desanka, Vuković, Nenad, Sukdolak, Slobodan, Matić, Sanja, Nićiforović, Neda, Mihailović, Vladimir, Mašković, Pavle, Vrvić, Miroslav M., Solujić, Slavica, "Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants" in European Journal of Medicinal Chemistry, 54 (2012):144-158,
https://doi.org/10.1016/J.EJMECH.2012.04.036 . .

TY  - JOUR
AU  - Mašković, Pavle
AU  - Dragišić Maksimović, Jelena
AU  - Maksimović, Vuk
AU  - Blagojević, Jelena
AU  - Vujošević, Mladen
AU  - Manojlović, Nedeljko T.
AU  - Radojković, Marija
AU  - Cvijović, Milica
AU  - Solujić, Slavica
PY  - 2012
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4675
AB  - The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was   exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of chemical constituents, genotoxic and antimicrobial activities of the endemic species, H.  sendtneri.
PB  - Warsaw: Versita
T2  - Central European Journal of Biology
T1  - Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri(Boiss) Dőrfler
IS  - 2
VL  - 7
DO  - 10.2478/s11535-012-0021-8
SP  - 327
EP  - 333
ER  - 

@article{
author = "Mašković, Pavle and Dragišić Maksimović, Jelena and Maksimović, Vuk and Blagojević, Jelena and Vujošević, Mladen and Manojlović, Nedeljko T. and Radojković, Marija and Cvijović, Milica and Solujić, Slavica",
year = "2012",
abstract = "The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was   exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of chemical constituents, genotoxic and antimicrobial activities of the endemic species, H.  sendtneri.",
publisher = "Warsaw: Versita",
journal = "Central European Journal of Biology",
title = "Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri(Boiss) Dőrfler",
number = "2",
volume = "7",
doi = "10.2478/s11535-012-0021-8",
pages = "327-333"
}

Mašković, P., Dragišić Maksimović, J., Maksimović, V., Blagojević, J., Vujošević, M., Manojlović, N. T., Radojković, M., Cvijović, M.,& Solujić, S.. (2012). Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri(Boiss) Dőrfler. in Central European Journal of Biology
Warsaw: Versita., 7(2), 327-333.
https://doi.org/10.2478/s11535-012-0021-8

Mašković P, Dragišić Maksimović J, Maksimović V, Blagojević J, Vujošević M, Manojlović NT, Radojković M, Cvijović M, Solujić S. Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri(Boiss) Dőrfler. in Central European Journal of Biology. 2012;7(2):327-333.
doi:10.2478/s11535-012-0021-8 .

Mašković, Pavle, Dragišić Maksimović, Jelena, Maksimović, Vuk, Blagojević, Jelena, Vujošević, Mladen, Manojlović, Nedeljko T., Radojković, Marija, Cvijović, Milica, Solujić, Slavica, "Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri(Boiss) Dőrfler" in Central European Journal of Biology, 7, no. 2 (2012):327-333,
https://doi.org/10.2478/s11535-012-0021-8 . .