TY  - CONF
AU  - Nešović, Marija
AU  - Garcia, Catarina
AU  - Stanković, Tijana
AU  - Dinić, Jelena
AU  - Podolski-Renić, Ana
AU  - Stojkovic Burić, Sonja
AU  - Dragoj, Miodrag
AU  - Jovanović, Mirna
AU  - Rijo, Patricia
AU  - Pešić, Milica
PY  - 2018
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6434
AB  - The genus Plectranthus has been widely used in traditional medicine to treat numerous diseases, including cancer. In this study, 31 extracts obtained from 16 Plectranthus spp. with medicinal potential were evaluated for their anticancer properties. The cytotoxic effects of all extracts were assessed in non-small cell lung carcinoma cell line NCI-H460. Five most promising Plectranthus spp. extracts (P. aliciae, P. japonicus, P. malvinus, P. stylesii and P. strigosus) were additionally tested for growth inhibition activity in multidrug resistant (MDR) cell lines with P-glycoprotein overexpression: NCI-H460/R (non-small cell lung carcinoma) and DLD1-TxR (colorectal adenocarcinoma), and compared to their sensitive counterparts, NCI-H460 and DLD1. P. strigosus acetonic extract was shown to be the most active. Parvifloron D, a diterpene identified in this extract, was tested in NCI-H460 and NCI-H460/R cells, as well as normal human embryonic bronchial fibroblasts (MRC-5) to evaluate its selectivity against cancer cells. It displayed the same efficacy in sensitive and MDR cancer cells, implying that parvifloron D is not a substrate for P-glycoprotein. Flow-cytometric analysis revealed that while parvifloron D is not exported via the P glycoprotein, it does not possess the potential to inhibit this transporter’s activity in NCI-H460/R cells. This study provides valuable information on the use of the Plectranthus genus as a source of therapeutically useful compounds against cancer cells including those with MDR phenotype, as well as compounds potentially responsible for their activity such as abietane diterpene parvifloron D. Additionally, the bioactivities of several Plectranthus spp. not previously described are reported.
PB  - Belgrade: Serbian Plant Physiology Society
C3  - Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia
T1  - Evaluation of anticancer activity of Plectranthus spp. extracts
SP  - 149
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6434
ER  - 

@conference{
author = "Nešović, Marija and Garcia, Catarina and Stanković, Tijana and Dinić, Jelena and Podolski-Renić, Ana and Stojkovic Burić, Sonja and Dragoj, Miodrag and Jovanović, Mirna and Rijo, Patricia and Pešić, Milica",
year = "2018",
abstract = "The genus Plectranthus has been widely used in traditional medicine to treat numerous diseases, including cancer. In this study, 31 extracts obtained from 16 Plectranthus spp. with medicinal potential were evaluated for their anticancer properties. The cytotoxic effects of all extracts were assessed in non-small cell lung carcinoma cell line NCI-H460. Five most promising Plectranthus spp. extracts (P. aliciae, P. japonicus, P. malvinus, P. stylesii and P. strigosus) were additionally tested for growth inhibition activity in multidrug resistant (MDR) cell lines with P-glycoprotein overexpression: NCI-H460/R (non-small cell lung carcinoma) and DLD1-TxR (colorectal adenocarcinoma), and compared to their sensitive counterparts, NCI-H460 and DLD1. P. strigosus acetonic extract was shown to be the most active. Parvifloron D, a diterpene identified in this extract, was tested in NCI-H460 and NCI-H460/R cells, as well as normal human embryonic bronchial fibroblasts (MRC-5) to evaluate its selectivity against cancer cells. It displayed the same efficacy in sensitive and MDR cancer cells, implying that parvifloron D is not a substrate for P-glycoprotein. Flow-cytometric analysis revealed that while parvifloron D is not exported via the P glycoprotein, it does not possess the potential to inhibit this transporter’s activity in NCI-H460/R cells. This study provides valuable information on the use of the Plectranthus genus as a source of therapeutically useful compounds against cancer cells including those with MDR phenotype, as well as compounds potentially responsible for their activity such as abietane diterpene parvifloron D. Additionally, the bioactivities of several Plectranthus spp. not previously described are reported.",
publisher = "Belgrade: Serbian Plant Physiology Society",
journal = "Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia",
title = "Evaluation of anticancer activity of Plectranthus spp. extracts",
pages = "149",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6434"
}

Nešović, M., Garcia, C., Stanković, T., Dinić, J., Podolski-Renić, A., Stojkovic Burić, S., Dragoj, M., Jovanović, M., Rijo, P.,& Pešić, M.. (2018). Evaluation of anticancer activity of Plectranthus spp. extracts. in Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia
Belgrade: Serbian Plant Physiology Society., 149.
https://hdl.handle.net/21.15107/rcub_ibiss_6434

Nešović M, Garcia C, Stanković T, Dinić J, Podolski-Renić A, Stojkovic Burić S, Dragoj M, Jovanović M, Rijo P, Pešić M. Evaluation of anticancer activity of Plectranthus spp. extracts. in Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia. 2018;:149.
https://hdl.handle.net/21.15107/rcub_ibiss_6434 .

Nešović, Marija, Garcia, Catarina, Stanković, Tijana, Dinić, Jelena, Podolski-Renić, Ana, Stojkovic Burić, Sonja, Dragoj, Miodrag, Jovanović, Mirna, Rijo, Patricia, Pešić, Milica, "Evaluation of anticancer activity of Plectranthus spp. extracts" in Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia (2018):149,
https://hdl.handle.net/21.15107/rcub_ibiss_6434 .