TY  - JOUR
AU  - Stošić-Grujičić, Stanislava
AU  - Gruden-Movsesijan, Alisa
AU  - Radulović, Nataša
AU  - Mostarica-Stojković, Marija B
AU  - Milić, M
AU  - Sofronić-Milosavljević, Ljiljana
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1373
AB  - P>Trichinella spiralis is a helminth that provokes Th2 and anti-inflammatory type responses in an infected host. Our previous studies using Dark Agouti (DA) rats indicated that T. spiralis infection reduced experimental autoimmune encephalomyelitis (EAE) severity in rats. The aim of this study was to analyse the mechanisms underlying EAE suppression driven by T. spiralis infection. Reduced clinical and histological manifestations of the disease were accompanied by increased IL-4 and IL-10 production and decreased IFN-gamma and IL-17 production in draining lymph node cells. This indicates that T. spiralis infection successfully maintains a Th2 cytokine bias regardless of EAE induction. High IL-10 signifies parasite-induced anti-inflammatory and/or regulatory cell responses. Transfer of splenic T cell-enriched population of cells from T. spiralis-infected rats into EAE immunized rats caused amelioration of EAE and in some cases protection from disease development. This population of cells contained higher proportion of CD4+ CD25+ Foxp3+ regulatory cells and produced high level of IL-10 when compared with uninfected rats.
T2  - Parasite Immunology
T1  - Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats
IS  - 6
VL  - 32
EP  - 459
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1373
ER  - 

@article{
author = "Stošić-Grujičić, Stanislava and Gruden-Movsesijan, Alisa and Radulović, Nataša and Mostarica-Stojković, Marija B and Milić, M and Sofronić-Milosavljević, Ljiljana",
year = "2010",
abstract = "P>Trichinella spiralis is a helminth that provokes Th2 and anti-inflammatory type responses in an infected host. Our previous studies using Dark Agouti (DA) rats indicated that T. spiralis infection reduced experimental autoimmune encephalomyelitis (EAE) severity in rats. The aim of this study was to analyse the mechanisms underlying EAE suppression driven by T. spiralis infection. Reduced clinical and histological manifestations of the disease were accompanied by increased IL-4 and IL-10 production and decreased IFN-gamma and IL-17 production in draining lymph node cells. This indicates that T. spiralis infection successfully maintains a Th2 cytokine bias regardless of EAE induction. High IL-10 signifies parasite-induced anti-inflammatory and/or regulatory cell responses. Transfer of splenic T cell-enriched population of cells from T. spiralis-infected rats into EAE immunized rats caused amelioration of EAE and in some cases protection from disease development. This population of cells contained higher proportion of CD4+ CD25+ Foxp3+ regulatory cells and produced high level of IL-10 when compared with uninfected rats.",
journal = "Parasite Immunology",
title = "Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats",
number = "6",
volume = "32",
pages = "459",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1373"
}

Stošić-Grujičić, S., Gruden-Movsesijan, A., Radulović, N., Mostarica-Stojković, M. B., Milić, M.,& Sofronić-Milosavljević, L.. (2010). Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats. in Parasite Immunology, 32(6).
https://hdl.handle.net/21.15107/rcub_ibiss_1373

Stošić-Grujičić S, Gruden-Movsesijan A, Radulović N, Mostarica-Stojković MB, Milić M, Sofronić-Milosavljević L. Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats. in Parasite Immunology. 2010;32(6):null-459.
https://hdl.handle.net/21.15107/rcub_ibiss_1373 .

Stošić-Grujičić, Stanislava, Gruden-Movsesijan, Alisa, Radulović, Nataša, Mostarica-Stojković, Marija B, Milić, M, Sofronić-Milosavljević, Ljiljana, "Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats" in Parasite Immunology, 32, no. 6 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1373 .

TY  - JOUR
AU  - Gruden-Movsesijan, Alisa
AU  - Radulović, Nataša
AU  - Mostarica-Stojković, Marija B
AU  - Stošić-Grujičić, Stanislava
AU  - Milić, M
AU  - Sofronić-Milosavljević, Ljiljana
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1537
AB  - Helminth infection has a potent systemic immunomodulatory effect on the host immune response, which also affects the development of autoimmune diseases. We investigated the dose-dependent influence of Trichinella spiralis infection on experimental autoimmune encephalomyelitis (EAE). Our model of concomitant T. spiralis infection and EAE demonstrates that established infection of Dark Agouti (DA) rats with the parasite causes amelioration of the clinical course of induced EAE in a dose-dependent way. Infection with T spiralis L1 stage muscle larvae (TSL1) reduced the severity of the autoimmune disease as judged by lower maximal clinical score, cumulative index, duration of illness and degree of mononuclear cell infiltration in T spiralis infected animals compared to control, EAE-induced group. This study provides a valuable model of worm infection to investigate helminth-induced regulatory mechanisms for optimal benefit to the host. (c) 2008 Elsevier Inc. All rights reserved.
T2  - Experimental Parasitology
T1  - Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats
IS  - 4
VL  - 118
EP  - 647
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1537
ER  - 

@article{
author = "Gruden-Movsesijan, Alisa and Radulović, Nataša and Mostarica-Stojković, Marija B and Stošić-Grujičić, Stanislava and Milić, M and Sofronić-Milosavljević, Ljiljana",
year = "2008",
abstract = "Helminth infection has a potent systemic immunomodulatory effect on the host immune response, which also affects the development of autoimmune diseases. We investigated the dose-dependent influence of Trichinella spiralis infection on experimental autoimmune encephalomyelitis (EAE). Our model of concomitant T. spiralis infection and EAE demonstrates that established infection of Dark Agouti (DA) rats with the parasite causes amelioration of the clinical course of induced EAE in a dose-dependent way. Infection with T spiralis L1 stage muscle larvae (TSL1) reduced the severity of the autoimmune disease as judged by lower maximal clinical score, cumulative index, duration of illness and degree of mononuclear cell infiltration in T spiralis infected animals compared to control, EAE-induced group. This study provides a valuable model of worm infection to investigate helminth-induced regulatory mechanisms for optimal benefit to the host. (c) 2008 Elsevier Inc. All rights reserved.",
journal = "Experimental Parasitology",
title = "Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats",
number = "4",
volume = "118",
pages = "647",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1537"
}

Gruden-Movsesijan, A., Radulović, N., Mostarica-Stojković, M. B., Stošić-Grujičić, S., Milić, M.,& Sofronić-Milosavljević, L.. (2008). Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats. in Experimental Parasitology, 118(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1537

Gruden-Movsesijan A, Radulović N, Mostarica-Stojković MB, Stošić-Grujičić S, Milić M, Sofronić-Milosavljević L. Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats. in Experimental Parasitology. 2008;118(4):null-647.
https://hdl.handle.net/21.15107/rcub_ibiss_1537 .

Gruden-Movsesijan, Alisa, Radulović, Nataša, Mostarica-Stojković, Marija B, Stošić-Grujičić, Stanislava, Milić, M, Sofronić-Milosavljević, Ljiljana, "Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats" in Experimental Parasitology, 118, no. 4 (2008),
https://hdl.handle.net/21.15107/rcub_ibiss_1537 .