TY  - JOUR
AU  - Đuran, Boris
AU  - Tatić, Zoran
AU  - Perunović, Neda
AU  - Pejčić, Nataša
AU  - Vuković, Jovana
AU  - Petković-Ćurčin, Aleksandra
AU  - Vojvodić, Danilo
AU  - Rakić, Mia
PY  - 2023
UR  - https://www.mdpi.com/1660-4601/20/1/477
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9819861
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5403
AB  - Peri-implant diseases are an emerging public health problem, and it's considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies.
PB  - Basel: MDPI
T2  - International Journal of Environmental Research and Public Health
T1  - Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
IS  - 1
VL  - 20
DO  - 10.3390/ijerph20010477
SP  - 477
ER  - 

@article{
author = "Đuran, Boris and Tatić, Zoran and Perunović, Neda and Pejčić, Nataša and Vuković, Jovana and Petković-Ćurčin, Aleksandra and Vojvodić, Danilo and Rakić, Mia",
year = "2023",
abstract = "Peri-implant diseases are an emerging public health problem, and it's considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies.",
publisher = "Basel: MDPI",
journal = "International Journal of Environmental Research and Public Health",
title = "Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study",
number = "1",
volume = "20",
doi = "10.3390/ijerph20010477",
pages = "477"
}

Đuran, B., Tatić, Z., Perunović, N., Pejčić, N., Vuković, J., Petković-Ćurčin, A., Vojvodić, D.,& Rakić, M.. (2023). Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study. in International Journal of Environmental Research and Public Health
Basel: MDPI., 20(1), 477.
https://doi.org/10.3390/ijerph20010477

Đuran B, Tatić Z, Perunović N, Pejčić N, Vuković J, Petković-Ćurčin A, Vojvodić D, Rakić M. Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study. in International Journal of Environmental Research and Public Health. 2023;20(1):477.
doi:10.3390/ijerph20010477 .

Đuran, Boris, Tatić, Zoran, Perunović, Neda, Pejčić, Nataša, Vuković, Jovana, Petković-Ćurčin, Aleksandra, Vojvodić, Danilo, Rakić, Mia, "Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study" in International Journal of Environmental Research and Public Health, 20, no. 1 (2023):477,
https://doi.org/10.3390/ijerph20010477 . .