TY  - JOUR
AU  - Taso, Ervin
AU  - Stefanović, Vladimir
AU  - Gaudin, Alexis
AU  - Grujić, Jovan
AU  - Maldonado, Estela
AU  - Petković-Curcin, Aleksandra
AU  - Vojvodić, Danilo
AU  - Sculean, Anton
AU  - Rakić, Mia
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0003996919309392?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3550
AB  - OBJECTIVE This controlled split-mouth study aimed to estimate the effect of caries and related treatment on concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-12, IL-17A, IL-13, IL-10, IL-6, IL-5, IL-4, IL-22, tumor necrosis factor (TNF)-α, and IL1-β in gingival crevicular fluid (GCF) of caries affected teeth before (B), 7 (7D) and 30 (30D) days post-treatment and to compare them with concentrations from healthy teeth. DESIGN Study population included 81 systemically and periodontally healthy non-smokers exhibiting at least one shallow occlusal/ inter-proximal caries and one healthy tooth from the same morphologic group at the contralateral position. Following clinical exam, the GCF samples were collected baseline as well as 7D and 30D, while the biomarker measurement was performed using multiplex flowcytometry. RESULTS Caries affected teeth exhibited significantly higher levels of IFN-γ, IL-1β, IL-2, IL-4 and IL-6 when compared to healthy teeth. Post-treatment cytokines levels showed general trend of increase when compared to baseline, that was significant for IL-22 and IL-17 at 7D, while IFN-γ was significantly increased at 7D compared to the healthy teeth. At 30D, IFN-γ, TNF-α, IL-17 and IL-4 levels were significantly increased when compared to healthy teeth, while IL-2 levels were significantly higher than baseline levels. CONCLUSION Considering significantly increased periodontal levels of inflammatory markers in caries affected teeth and in response to performed treatment, it seems that dental caries and related restorative treatment might contribute to periodontal inflammation via additive effects already in early-stage caries.
PB  - Pergamon
T2  - Archives of Oral Biology
T1  - Effect of dental caries on periodontal inflammatory status: A split-mouth study.
VL  - 110
DO  - 10.1016/j.archoralbio.2019.104620
SP  - 104620
ER  - 

@article{
author = "Taso, Ervin and Stefanović, Vladimir and Gaudin, Alexis and Grujić, Jovan and Maldonado, Estela and Petković-Curcin, Aleksandra and Vojvodić, Danilo and Sculean, Anton and Rakić, Mia",
year = "2019",
abstract = "OBJECTIVE This controlled split-mouth study aimed to estimate the effect of caries and related treatment on concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-12, IL-17A, IL-13, IL-10, IL-6, IL-5, IL-4, IL-22, tumor necrosis factor (TNF)-α, and IL1-β in gingival crevicular fluid (GCF) of caries affected teeth before (B), 7 (7D) and 30 (30D) days post-treatment and to compare them with concentrations from healthy teeth. DESIGN Study population included 81 systemically and periodontally healthy non-smokers exhibiting at least one shallow occlusal/ inter-proximal caries and one healthy tooth from the same morphologic group at the contralateral position. Following clinical exam, the GCF samples were collected baseline as well as 7D and 30D, while the biomarker measurement was performed using multiplex flowcytometry. RESULTS Caries affected teeth exhibited significantly higher levels of IFN-γ, IL-1β, IL-2, IL-4 and IL-6 when compared to healthy teeth. Post-treatment cytokines levels showed general trend of increase when compared to baseline, that was significant for IL-22 and IL-17 at 7D, while IFN-γ was significantly increased at 7D compared to the healthy teeth. At 30D, IFN-γ, TNF-α, IL-17 and IL-4 levels were significantly increased when compared to healthy teeth, while IL-2 levels were significantly higher than baseline levels. CONCLUSION Considering significantly increased periodontal levels of inflammatory markers in caries affected teeth and in response to performed treatment, it seems that dental caries and related restorative treatment might contribute to periodontal inflammation via additive effects already in early-stage caries.",
publisher = "Pergamon",
journal = "Archives of Oral Biology",
title = "Effect of dental caries on periodontal inflammatory status: A split-mouth study.",
volume = "110",
doi = "10.1016/j.archoralbio.2019.104620",
pages = "104620"
}

Taso, E., Stefanović, V., Gaudin, A., Grujić, J., Maldonado, E., Petković-Curcin, A., Vojvodić, D., Sculean, A.,& Rakić, M.. (2019). Effect of dental caries on periodontal inflammatory status: A split-mouth study.. in Archives of Oral Biology
Pergamon., 110, 104620.
https://doi.org/10.1016/j.archoralbio.2019.104620

Taso E, Stefanović V, Gaudin A, Grujić J, Maldonado E, Petković-Curcin A, Vojvodić D, Sculean A, Rakić M. Effect of dental caries on periodontal inflammatory status: A split-mouth study.. in Archives of Oral Biology. 2019;110:104620.
doi:10.1016/j.archoralbio.2019.104620 .

Taso, Ervin, Stefanović, Vladimir, Gaudin, Alexis, Grujić, Jovan, Maldonado, Estela, Petković-Curcin, Aleksandra, Vojvodić, Danilo, Sculean, Anton, Rakić, Mia, "Effect of dental caries on periodontal inflammatory status: A split-mouth study." in Archives of Oral Biology, 110 (2019):104620,
https://doi.org/10.1016/j.archoralbio.2019.104620 . .

TY  - JOUR
AU  - Rakić, Mia
AU  - Galindo-Moreno, Pablo
AU  - Monje, Alberto
AU  - Radovanović, Sandro
AU  - Wang, Hom-Lay
AU  - Cochran, David
AU  - Sculean, Anton
AU  - Canullo, Luigi
PY  - 2017
UR  - http://link.springer.com/10.1007/s00784-017-2276-y
UR  - http://www.ncbi.nlm.nih.gov/pubmed/29218422
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2941
AB  - OBJECTIVES The objective of this study is to estimate the overall prevalence of peri-implantitis (PI) and the effect of different study designs, function times, and implant surfaces on prevalence rate reported by the studies adhering to the case definition of Sanz & Chapple 2012. MATERIAL AND METHODS Following electronic and manual searches of the literature published up to February 2016, data were extracted from the studies fitting the study criteria. Meta-analysis was performed for estimation of overall prevalence of PI while the effects of the study design, function time, and implant surface type on prevalence rate were investigated using meta-regression method. RESULTS Twenty-nine articles were included in this study. The prevalence rate in all subset meta-analyses was always higher at patient level when compared to the prevalence rate at the implant level. Prevalence of PI was 18.5% at the patient level and 12.8% at the implant level. Meta-regression analysis did not identify any association for different study designs and function times while it was demonstrated the significant association between moderately rough surfaces with lower prevalence rate of PI (p = 0.011). CONCLUSIONS The prevalence rate of PI remains highly variable even following restriction to the clinical case definition and it seems to be affected by local factors such as implant surface characteristics. The identification of adjuvant diagnostic markers seems necessary for more accurate disease classification. CLINICAL RELEVANCE The occurrence of PI is affected by local factors such as implant surface characteristics hence the careful assessment of the local factors should be performed within treatment planning.
T2  - Clinical Oral Investigations
T2  - Clinical Oral Investigations
T1  - How frequent does peri-implantitis occur? A systematic review and meta-analysis.
DO  - 10.1007/s00784-017-2276-y
ER  - 

@article{
author = "Rakić, Mia and Galindo-Moreno, Pablo and Monje, Alberto and Radovanović, Sandro and Wang, Hom-Lay and Cochran, David and Sculean, Anton and Canullo, Luigi",
year = "2017",
abstract = "OBJECTIVES The objective of this study is to estimate the overall prevalence of peri-implantitis (PI) and the effect of different study designs, function times, and implant surfaces on prevalence rate reported by the studies adhering to the case definition of Sanz & Chapple 2012. MATERIAL AND METHODS Following electronic and manual searches of the literature published up to February 2016, data were extracted from the studies fitting the study criteria. Meta-analysis was performed for estimation of overall prevalence of PI while the effects of the study design, function time, and implant surface type on prevalence rate were investigated using meta-regression method. RESULTS Twenty-nine articles were included in this study. The prevalence rate in all subset meta-analyses was always higher at patient level when compared to the prevalence rate at the implant level. Prevalence of PI was 18.5% at the patient level and 12.8% at the implant level. Meta-regression analysis did not identify any association for different study designs and function times while it was demonstrated the significant association between moderately rough surfaces with lower prevalence rate of PI (p = 0.011). CONCLUSIONS The prevalence rate of PI remains highly variable even following restriction to the clinical case definition and it seems to be affected by local factors such as implant surface characteristics. The identification of adjuvant diagnostic markers seems necessary for more accurate disease classification. CLINICAL RELEVANCE The occurrence of PI is affected by local factors such as implant surface characteristics hence the careful assessment of the local factors should be performed within treatment planning.",
journal = "Clinical Oral Investigations, Clinical Oral Investigations",
title = "How frequent does peri-implantitis occur? A systematic review and meta-analysis.",
doi = "10.1007/s00784-017-2276-y"
}

Rakić, M., Galindo-Moreno, P., Monje, A., Radovanović, S., Wang, H., Cochran, D., Sculean, A.,& Canullo, L.. (2017). How frequent does peri-implantitis occur? A systematic review and meta-analysis.. in Clinical Oral Investigations.
https://doi.org/10.1007/s00784-017-2276-y

Rakić M, Galindo-Moreno P, Monje A, Radovanović S, Wang H, Cochran D, Sculean A, Canullo L. How frequent does peri-implantitis occur? A systematic review and meta-analysis.. in Clinical Oral Investigations. 2017;.
doi:10.1007/s00784-017-2276-y .

Rakić, Mia, Galindo-Moreno, Pablo, Monje, Alberto, Radovanović, Sandro, Wang, Hom-Lay, Cochran, David, Sculean, Anton, Canullo, Luigi, "How frequent does peri-implantitis occur? A systematic review and meta-analysis." in Clinical Oral Investigations (2017),
https://doi.org/10.1007/s00784-017-2276-y . .