TY  - JOUR
AU  - Taso, Ervin
AU  - Stefanović, Vladimir
AU  - Gaudin, Alexis
AU  - Grujić, Jovan
AU  - Maldonado, Estela
AU  - Petković-Curcin, Aleksandra
AU  - Vojvodić, Danilo
AU  - Sculean, Anton
AU  - Rakić, Mia
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0003996919309392?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3550
AB  - OBJECTIVE This controlled split-mouth study aimed to estimate the effect of caries and related treatment on concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-12, IL-17A, IL-13, IL-10, IL-6, IL-5, IL-4, IL-22, tumor necrosis factor (TNF)-α, and IL1-β in gingival crevicular fluid (GCF) of caries affected teeth before (B), 7 (7D) and 30 (30D) days post-treatment and to compare them with concentrations from healthy teeth. DESIGN Study population included 81 systemically and periodontally healthy non-smokers exhibiting at least one shallow occlusal/ inter-proximal caries and one healthy tooth from the same morphologic group at the contralateral position. Following clinical exam, the GCF samples were collected baseline as well as 7D and 30D, while the biomarker measurement was performed using multiplex flowcytometry. RESULTS Caries affected teeth exhibited significantly higher levels of IFN-γ, IL-1β, IL-2, IL-4 and IL-6 when compared to healthy teeth. Post-treatment cytokines levels showed general trend of increase when compared to baseline, that was significant for IL-22 and IL-17 at 7D, while IFN-γ was significantly increased at 7D compared to the healthy teeth. At 30D, IFN-γ, TNF-α, IL-17 and IL-4 levels were significantly increased when compared to healthy teeth, while IL-2 levels were significantly higher than baseline levels. CONCLUSION Considering significantly increased periodontal levels of inflammatory markers in caries affected teeth and in response to performed treatment, it seems that dental caries and related restorative treatment might contribute to periodontal inflammation via additive effects already in early-stage caries.
PB  - Pergamon
T2  - Archives of Oral Biology
T1  - Effect of dental caries on periodontal inflammatory status: A split-mouth study.
VL  - 110
DO  - 10.1016/j.archoralbio.2019.104620
SP  - 104620
ER  - 

@article{
author = "Taso, Ervin and Stefanović, Vladimir and Gaudin, Alexis and Grujić, Jovan and Maldonado, Estela and Petković-Curcin, Aleksandra and Vojvodić, Danilo and Sculean, Anton and Rakić, Mia",
year = "2019",
abstract = "OBJECTIVE This controlled split-mouth study aimed to estimate the effect of caries and related treatment on concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-12, IL-17A, IL-13, IL-10, IL-6, IL-5, IL-4, IL-22, tumor necrosis factor (TNF)-α, and IL1-β in gingival crevicular fluid (GCF) of caries affected teeth before (B), 7 (7D) and 30 (30D) days post-treatment and to compare them with concentrations from healthy teeth. DESIGN Study population included 81 systemically and periodontally healthy non-smokers exhibiting at least one shallow occlusal/ inter-proximal caries and one healthy tooth from the same morphologic group at the contralateral position. Following clinical exam, the GCF samples were collected baseline as well as 7D and 30D, while the biomarker measurement was performed using multiplex flowcytometry. RESULTS Caries affected teeth exhibited significantly higher levels of IFN-γ, IL-1β, IL-2, IL-4 and IL-6 when compared to healthy teeth. Post-treatment cytokines levels showed general trend of increase when compared to baseline, that was significant for IL-22 and IL-17 at 7D, while IFN-γ was significantly increased at 7D compared to the healthy teeth. At 30D, IFN-γ, TNF-α, IL-17 and IL-4 levels were significantly increased when compared to healthy teeth, while IL-2 levels were significantly higher than baseline levels. CONCLUSION Considering significantly increased periodontal levels of inflammatory markers in caries affected teeth and in response to performed treatment, it seems that dental caries and related restorative treatment might contribute to periodontal inflammation via additive effects already in early-stage caries.",
publisher = "Pergamon",
journal = "Archives of Oral Biology",
title = "Effect of dental caries on periodontal inflammatory status: A split-mouth study.",
volume = "110",
doi = "10.1016/j.archoralbio.2019.104620",
pages = "104620"
}

Taso, E., Stefanović, V., Gaudin, A., Grujić, J., Maldonado, E., Petković-Curcin, A., Vojvodić, D., Sculean, A.,& Rakić, M.. (2019). Effect of dental caries on periodontal inflammatory status: A split-mouth study.. in Archives of Oral Biology
Pergamon., 110, 104620.
https://doi.org/10.1016/j.archoralbio.2019.104620

Taso E, Stefanović V, Gaudin A, Grujić J, Maldonado E, Petković-Curcin A, Vojvodić D, Sculean A, Rakić M. Effect of dental caries on periodontal inflammatory status: A split-mouth study.. in Archives of Oral Biology. 2019;110:104620.
doi:10.1016/j.archoralbio.2019.104620 .

Taso, Ervin, Stefanović, Vladimir, Gaudin, Alexis, Grujić, Jovan, Maldonado, Estela, Petković-Curcin, Aleksandra, Vojvodić, Danilo, Sculean, Anton, Rakić, Mia, "Effect of dental caries on periodontal inflammatory status: A split-mouth study." in Archives of Oral Biology, 110 (2019):104620,
https://doi.org/10.1016/j.archoralbio.2019.104620 . .