TY  - CONF
AU  - Kirschner, Alexander K.T.
AU  - Kittinger, Clemens
AU  - Schachner, Iris
AU  - Jakwerth, Stefan
AU  - Koller, Michael
AU  - Kolarević, Stoimir
AU  - Kračun-Kolarević, Margareta
AU  - Toumi, Marwene
AU  - Farkas, Rosza
AU  - Tóth, Erika
AU  - Kandler, W
AU  - Sulyok, M
AU  - Savio, Domenico
AU  - Farnleitner, Andreas H.
AU  - Zarfel, Gernot
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4731
AB  - The problem of human-induced antimicrobial resistance (acquired due to human activities) is an
emerging concern in aquatic environments. The isolation of (facultative) pathogenic organisms with
acquired antibiotic resistance, even concerning last-line antibiotics, from rivers and lakes, is well
documented throughout the world. In the last few years, there has been a rapid increase in the number
of studies addressing these topics and their possible implications for human health. However, most
studies concentrate on a relatively limited methodology, e.g. applying non-quantitative and either
cultivation-based or direct-detection based molecular biological methods. In addition, often only small
geographic areas and short periods of time are covered. This is one of the reasons why many relevant
questions concerning the occurrence and spread of antimicrobial resistance in aquatic ecosystems still
remain unanswered.
The largest European river water survey (Joint Danube Survey 4) offered a unique opportunity to study
the occurrence and spread of human-induced antimicrobial resistance along the whole Danube River.
Within the research project, isolates from samples from the entire course of the Danube and their
main tributaries, including high frequency sampling at selected locations, have been collected and
analysed. Samples from the water compartment but also from submerged biofilms have been
considered. State-of-the-art quantitative molecular biological techniques and culture-based analyses
targeting different bacterial organisms have been combined with a large set of physical, chemical and
biological parameters to obtain a robust and comprehensive picture of the occurrence and spread of
human-induced antimicrobial resistance in the Danube River.
Based on the findings of this quantitative, integrative study approach, it seems likely to significantly
improve the current understanding on the importance on the spread and stabilization of human -
induced antibiotic resistance in large rivers. The results of this study will also be useful to guide future
monitoring and management strategies.
PB  - Neuburg:  Aueninstitut Neuburg
C3  - 43rd IAD Conference: Rivers and Floodplains in the Antropocene: Upcoming Challenges in the Danube River Basin
T1  - Occurrence and spread of human- induced antimicrobial resistance in a large river water system: developing a holistic picture based on the Joint Danube Survey 4 activities
SP  - 20
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4731
ER  - 

@conference{
author = "Kirschner, Alexander K.T. and Kittinger, Clemens and Schachner, Iris and Jakwerth, Stefan and Koller, Michael and Kolarević, Stoimir and Kračun-Kolarević, Margareta and Toumi, Marwene and Farkas, Rosza and Tóth, Erika and Kandler, W and Sulyok, M and Savio, Domenico and Farnleitner, Andreas H. and Zarfel, Gernot",
year = "2021",
abstract = "The problem of human-induced antimicrobial resistance (acquired due to human activities) is an
emerging concern in aquatic environments. The isolation of (facultative) pathogenic organisms with
acquired antibiotic resistance, even concerning last-line antibiotics, from rivers and lakes, is well
documented throughout the world. In the last few years, there has been a rapid increase in the number
of studies addressing these topics and their possible implications for human health. However, most
studies concentrate on a relatively limited methodology, e.g. applying non-quantitative and either
cultivation-based or direct-detection based molecular biological methods. In addition, often only small
geographic areas and short periods of time are covered. This is one of the reasons why many relevant
questions concerning the occurrence and spread of antimicrobial resistance in aquatic ecosystems still
remain unanswered.
The largest European river water survey (Joint Danube Survey 4) offered a unique opportunity to study
the occurrence and spread of human-induced antimicrobial resistance along the whole Danube River.
Within the research project, isolates from samples from the entire course of the Danube and their
main tributaries, including high frequency sampling at selected locations, have been collected and
analysed. Samples from the water compartment but also from submerged biofilms have been
considered. State-of-the-art quantitative molecular biological techniques and culture-based analyses
targeting different bacterial organisms have been combined with a large set of physical, chemical and
biological parameters to obtain a robust and comprehensive picture of the occurrence and spread of
human-induced antimicrobial resistance in the Danube River.
Based on the findings of this quantitative, integrative study approach, it seems likely to significantly
improve the current understanding on the importance on the spread and stabilization of human -
induced antibiotic resistance in large rivers. The results of this study will also be useful to guide future
monitoring and management strategies.",
publisher = "Neuburg:  Aueninstitut Neuburg",
journal = "43rd IAD Conference: Rivers and Floodplains in the Antropocene: Upcoming Challenges in the Danube River Basin",
title = "Occurrence and spread of human- induced antimicrobial resistance in a large river water system: developing a holistic picture based on the Joint Danube Survey 4 activities",
pages = "20",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4731"
}

Kirschner, A. K.T., Kittinger, C., Schachner, I., Jakwerth, S., Koller, M., Kolarević, S., Kračun-Kolarević, M., Toumi, M., Farkas, R., Tóth, E., Kandler, W., Sulyok, M., Savio, D., Farnleitner, A. H.,& Zarfel, G.. (2021). Occurrence and spread of human- induced antimicrobial resistance in a large river water system: developing a holistic picture based on the Joint Danube Survey 4 activities. in 43rd IAD Conference: Rivers and Floodplains in the Antropocene: Upcoming Challenges in the Danube River Basin
Neuburg:  Aueninstitut Neuburg., 20.
https://hdl.handle.net/21.15107/rcub_ibiss_4731

Kirschner AK, Kittinger C, Schachner I, Jakwerth S, Koller M, Kolarević S, Kračun-Kolarević M, Toumi M, Farkas R, Tóth E, Kandler W, Sulyok M, Savio D, Farnleitner AH, Zarfel G. Occurrence and spread of human- induced antimicrobial resistance in a large river water system: developing a holistic picture based on the Joint Danube Survey 4 activities. in 43rd IAD Conference: Rivers and Floodplains in the Antropocene: Upcoming Challenges in the Danube River Basin. 2021;:20.
https://hdl.handle.net/21.15107/rcub_ibiss_4731 .

Kirschner, Alexander K.T., Kittinger, Clemens, Schachner, Iris, Jakwerth, Stefan, Koller, Michael, Kolarević, Stoimir, Kračun-Kolarević, Margareta, Toumi, Marwene, Farkas, Rosza, Tóth, Erika, Kandler, W, Sulyok, M, Savio, Domenico, Farnleitner, Andreas H., Zarfel, Gernot, "Occurrence and spread of human- induced antimicrobial resistance in a large river water system: developing a holistic picture based on the Joint Danube Survey 4 activities" in 43rd IAD Conference: Rivers and Floodplains in the Antropocene: Upcoming Challenges in the Danube River Basin (2021):20,
https://hdl.handle.net/21.15107/rcub_ibiss_4731 .