TY  - JOUR
AU  - Stevanović, Ivana
AU  - Čolić, Miodrag
AU  - Jovanović, Marina
AU  - Jelenković, Ankica V.
AU  - Ninković, Milica I.
PY  - 2009
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/558
AB  - The present study was aimed at determining the effectiveness of nitric oxide synthase (NOS) inhibitors: N-nitro-L-arginine methyl ester, 7-nitroindazole and aminoguanidine in modulating the toxicity of AlCl3 on superoxide production and the malondialdehyde concentration of Wistar rats. The animals were sacrificed 10 min and 3 days after the treatment and the forebrain cortex was removed. The results show that AlCl3 exposure promotes oxidative stress in different neural areas. The biochemical changes observed in the neuronal tissues show that aluminum acts as pro-oxidant, while NOS inhibitors exert an anti-oxidant action in AlCl3-treated animals.
AB  - U eksperimentu je određivana efikasnost inhibitora azot-oksid-sintaze (NOS): metil-estra N-nitro-L-arginina, 7-nitroindazola i aminogvanidina u modulaciji toksičnosti AlCl3 na stvaranje superoksidnog anjona i koncentraciju malondialdehida kod Wistar pacova. Životinje su žrtvovane 10 min i 3 dana nakon tretmana i izolovana je kora velikog mozga. Rezultati pokazuju da izlaganje AlCl3 pokreće oksidativni stres u različitim moždanim regionima. Biohemijske promene opisane u neuronskom tkivu pokazuju da aluminijum deluje kao pro-oksidant, dok inhibitori NOS imaju antioksidativno dejstvo kod životinja tretiranih AlCl3.
T2  - Journal of the Serbian Chemical Society
T1  - Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3
T1  - Effects of various nitric oxide synthase inhibitors on AlCl3-induced neuronal injury in rats
IS  - 5
VL  - 74
SP  - 503
EP  - 511
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_558
ER  - 

@article{
author = "Stevanović, Ivana and Čolić, Miodrag and Jovanović, Marina and Jelenković, Ankica V. and Ninković, Milica I.",
year = "2009, 2009",
abstract = "The present study was aimed at determining the effectiveness of nitric oxide synthase (NOS) inhibitors: N-nitro-L-arginine methyl ester, 7-nitroindazole and aminoguanidine in modulating the toxicity of AlCl3 on superoxide production and the malondialdehyde concentration of Wistar rats. The animals were sacrificed 10 min and 3 days after the treatment and the forebrain cortex was removed. The results show that AlCl3 exposure promotes oxidative stress in different neural areas. The biochemical changes observed in the neuronal tissues show that aluminum acts as pro-oxidant, while NOS inhibitors exert an anti-oxidant action in AlCl3-treated animals., U eksperimentu je određivana efikasnost inhibitora azot-oksid-sintaze (NOS): metil-estra N-nitro-L-arginina, 7-nitroindazola i aminogvanidina u modulaciji toksičnosti AlCl3 na stvaranje superoksidnog anjona i koncentraciju malondialdehida kod Wistar pacova. Životinje su žrtvovane 10 min i 3 dana nakon tretmana i izolovana je kora velikog mozga. Rezultati pokazuju da izlaganje AlCl3 pokreće oksidativni stres u različitim moždanim regionima. Biohemijske promene opisane u neuronskom tkivu pokazuju da aluminijum deluje kao pro-oksidant, dok inhibitori NOS imaju antioksidativno dejstvo kod životinja tretiranih AlCl3.",
journal = "Journal of the Serbian Chemical Society",
title = "Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3, Effects of various nitric oxide synthase inhibitors on AlCl3-induced neuronal injury in rats",
number = "5",
volume = "74",
pages = "503-511",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_558"
}

Stevanović, I., Čolić, M., Jovanović, M., Jelenković, A. V.,& Ninković, M. I.. (2009). Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3. in Journal of the Serbian Chemical Society, 74(5), 503-511.
https://hdl.handle.net/21.15107/rcub_ibiss_558

Stevanović I, Čolić M, Jovanović M, Jelenković AV, Ninković MI. Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3. in Journal of the Serbian Chemical Society. 2009;74(5):503-511.
https://hdl.handle.net/21.15107/rcub_ibiss_558 .

Stevanović, Ivana, Čolić, Miodrag, Jovanović, Marina, Jelenković, Ankica V., Ninković, Milica I., "Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3" in Journal of the Serbian Chemical Society, 74, no. 5 (2009):503-511,
https://hdl.handle.net/21.15107/rcub_ibiss_558 .