@conference{
author = "Petrović, Jovana and Glamočlija, Jasmina and Ilić-Tomić, Tatjana and Soković, Marina and Robajac, Dragana and Nedić, Olgica and Pavić, Aleksandar",
year = "2020",
abstract = "Laetiporus sulphureus, an edible mushroom, for centuries has been used in traditional
European and Asian ethno-medicine. Its therapeutic properties have been attributed to different
types of biologically active compounds, such as terpenes, polysaccharides, steroids, proteins
and lectins. Recently, mushroom lectins emerged as very potent macromolecules with
antiproliferative, cytotoxic, antiviral and immunostimulatory activities. Therefore, we isolated
lectin from L. sulphureus (LSL) and evaluated its anti-angiogenic and anticancer activity in
vivo, using the zebrafish model. We found that LSL is not toxic at high doses up to 400-
500 μg/mL, while it effectively inhibited angiogenesis and cancer development at much lower
doses. Compared to sunitinib-malate, cardiotoxic and myelosupressive anti-angiogenic drug of
clinical relevance, therapeutic potential of LSL was 378-fold higher. Wound healing and MTT
assays were employed to examine antimigratory effect and endothelial cytotoxicity.
Surprisingly, LSL affected human colorectal carcinoma and mouse melanoma cell lines, by
almost completely diminishing their growth, neovascularization and metastasis. Moreover, in
comparison to the used control (cisplatin), LSL showed markedly greater activity, while its
potency turned out to be 8-fold higher towards colorectal carcinoma than melanoma. These
encouraging data strongly imply that LSL can be considered for the application as supporting
agent in chemotherapy against colorectal carcinoma and melanoma or used in pharmaceutical
industry.",
publisher = "Belgrade: NutRedox, COST Action CA16112",
journal = "WGs Meeting of the NutRedOx COST Action CA16112: Nutraceuticals in balancing redox status in ageing and age-related diseases; 2020 Mar 2-3; Belgrade, Serbia",
title = "Laetiporus sulphureus lectin inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.",
pages = "43",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6535"
}