@article{
author = "Katanić, Jelena and Mihailović, Vladimir and Matić, Sanja and Stanković, Vesna and Stanković, Nevena and Boroja, Tatjana and Mladenović, Milan and Stanić, Snezana and Kreft, Samo and Mihailović, Mirjana",
year = "2015",
abstract = "The effects of the methanolic extracts of Filipendula hexapetala Gilib.
aerial parts (FHA) and roots (FHR) against cisplatin induced kidney and
liver injuries in rats were investigated as well as determination of
genotoxicity and antigenotoxicity of the extracts. Treatment with FHA
and FHR significantly decreased levels of urea, uric acid, serum
transaminases, alkaline phosphatase and gamma-glutamyl transferase, and
increased the content of total protein. In addition, treatment with the
extracts significantly attenuated the cisplatin-induced oxidative stress
in kidney and liver tissues by increasing catalase and superoxide
dismutase activities and the content of reduced glutathione and
decreasing the content of thiobarbituric acid reactive substances
(TSARS). The histopathological studies confirmed the protective effects
of the extracts against cisplatin-induced kidney and liver injuries. The
extracts ameliorated cisplatin-induced genotoxicity. These results
suggest that F. hexapetala extracts are effective nephro- and
hepatoprotective agents, with potential to reduce oxidative stress and
ameliorate cisplatin-induced nephro- and hepatotoxicity.",
journal = "Journal of Functional Foods",
title = "The ameliorating effect of Filipendula hexapetala extracts on
hepatorenal toxicity of cisplatin",
number = "Part A",
volume = "18",
doi = "10.1016/j.jff.2015.07.004",
pages = "198-212"
}