TY  - JOUR
AU  - Katanić, Jelena
AU  - Mihailović, Vladimir
AU  - Matić, Sanja
AU  - Stanković, Vesna
AU  - Stanković, Nevena
AU  - Boroja, Tatjana
AU  - Mladenović, Milan
AU  - Stanić, Snezana
AU  - Kreft, Samo
AU  - Mihailović, Mirjana
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2352
UR  - http://www.sciencedirect.com/science/article/pii/S175646461500362X
AB  - The effects of the methanolic extracts of Filipendula hexapetala Gilib.
   aerial parts (FHA) and roots (FHR) against cisplatin induced kidney and
   liver injuries in rats were investigated as well as determination of
   genotoxicity and antigenotoxicity of the extracts. Treatment with FHA
   and FHR significantly decreased levels of urea, uric acid, serum
   transaminases, alkaline phosphatase and gamma-glutamyl transferase, and
   increased the content of total protein. In addition, treatment with the
   extracts significantly attenuated the cisplatin-induced oxidative stress
   in kidney and liver tissues by increasing catalase and superoxide
   dismutase activities and the content of reduced glutathione and
   decreasing the content of thiobarbituric acid reactive substances
   (TSARS). The histopathological studies confirmed the protective effects
   of the extracts against cisplatin-induced kidney and liver injuries. The
   extracts ameliorated cisplatin-induced genotoxicity. These results
   suggest that F. hexapetala extracts are effective nephro- and
   hepatoprotective agents, with potential to reduce oxidative stress and
   ameliorate cisplatin-induced nephro- and hepatotoxicity.
T2  - Journal of Functional Foods
T1  - The ameliorating effect of Filipendula hexapetala extracts on
 hepatorenal toxicity of cisplatin
IS  - Part A
VL  - 18
DO  - 10.1016/j.jff.2015.07.004
SP  - 198
EP  - 212
ER  - 

@article{
author = "Katanić, Jelena and Mihailović, Vladimir and Matić, Sanja and Stanković, Vesna and Stanković, Nevena and Boroja, Tatjana and Mladenović, Milan and Stanić, Snezana and Kreft, Samo and Mihailović, Mirjana",
year = "2015",
abstract = "The effects of the methanolic extracts of Filipendula hexapetala Gilib.
   aerial parts (FHA) and roots (FHR) against cisplatin induced kidney and
   liver injuries in rats were investigated as well as determination of
   genotoxicity and antigenotoxicity of the extracts. Treatment with FHA
   and FHR significantly decreased levels of urea, uric acid, serum
   transaminases, alkaline phosphatase and gamma-glutamyl transferase, and
   increased the content of total protein. In addition, treatment with the
   extracts significantly attenuated the cisplatin-induced oxidative stress
   in kidney and liver tissues by increasing catalase and superoxide
   dismutase activities and the content of reduced glutathione and
   decreasing the content of thiobarbituric acid reactive substances
   (TSARS). The histopathological studies confirmed the protective effects
   of the extracts against cisplatin-induced kidney and liver injuries. The
   extracts ameliorated cisplatin-induced genotoxicity. These results
   suggest that F. hexapetala extracts are effective nephro- and
   hepatoprotective agents, with potential to reduce oxidative stress and
   ameliorate cisplatin-induced nephro- and hepatotoxicity.",
journal = "Journal of Functional Foods",
title = "The ameliorating effect of Filipendula hexapetala extracts on
 hepatorenal toxicity of cisplatin",
number = "Part A",
volume = "18",
doi = "10.1016/j.jff.2015.07.004",
pages = "198-212"
}

Katanić, J., Mihailović, V., Matić, S., Stanković, V., Stanković, N., Boroja, T., Mladenović, M., Stanić, S., Kreft, S.,& Mihailović, M.. (2015). The ameliorating effect of Filipendula hexapetala extracts on
 hepatorenal toxicity of cisplatin. in Journal of Functional Foods, 18(Part A), 198-212.
https://doi.org/10.1016/j.jff.2015.07.004

Katanić J, Mihailović V, Matić S, Stanković V, Stanković N, Boroja T, Mladenović M, Stanić S, Kreft S, Mihailović M. The ameliorating effect of Filipendula hexapetala extracts on
 hepatorenal toxicity of cisplatin. in Journal of Functional Foods. 2015;18(Part A):198-212.
doi:10.1016/j.jff.2015.07.004 .

Katanić, Jelena, Mihailović, Vladimir, Matić, Sanja, Stanković, Vesna, Stanković, Nevena, Boroja, Tatjana, Mladenović, Milan, Stanić, Snezana, Kreft, Samo, Mihailović, Mirjana, "The ameliorating effect of Filipendula hexapetala extracts on
 hepatorenal toxicity of cisplatin" in Journal of Functional Foods, 18, no. Part A (2015):198-212,
https://doi.org/10.1016/j.jff.2015.07.004 . .