TY  - JOUR
AU  - Kartsev, Victor
AU  - Geronikaki, Athina
AU  - Lichitsky, Boris
AU  - Komogortsev, Andrey
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2022
UR  - https://onlinelibrary.wiley.com/doi/10.1002/jhet.4491
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4962
AB  - Herein we report the design and synthesis of thiazolo[4,5-b]pyridin-5-ones and evaluation of their antimicrobial activity. The design was based on a molecular hybridization approach. Evaluation of their antibacterial activity revealed that these compounds generally showed moderate antibacterial activity. The best activity was achieved for compound 4p with MIC/MBC in the range of 0.12-0.47 and 0.23-0.94 mg mL(-1) respectively. Three compounds (4g, 4n, and 4p) were tested against three resistant strains, namely MRSA, p.aeruginosa, and E.coli, showing higher inhibition potential than the reference drug ampicillin. These three compounds also were tested for their ability to inhibit biofilm formation, with two of them showing better activity than streptomycin in a concentration of MIC (4p) and ampicillin in both concentrations (MIC and 0.5 MIC). As far as antifungal activity is concerned, the best activity was observed for compound 4i with MIC at 0.12-0.47 mg mL(-1) and MFC at 0.23-0.94 mg m(-1). According to docking studies, the predicted inhibition of E.coli MurB enzyme is probably a putative mechanism of the antibacterial activity of these compounds, while inhibition of 14a-lanosterol demethylase is probably the mechanism of their antifungal activity.
T2  - Journal of Heterocyclic Chemistry
T1  - Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents
IS  - 9
VL  - 59
DO  - 10.1002/jhet.4491
SP  - 1573
EP  - 1590
ER  - 

@article{
author = "Kartsev, Victor and Geronikaki, Athina and Lichitsky, Boris and Komogortsev, Andrey and Petrou, Anthi and Ivanov, Marija and Glamočlija, Jasmina and Soković, Marina",
year = "2022",
abstract = "Herein we report the design and synthesis of thiazolo[4,5-b]pyridin-5-ones and evaluation of their antimicrobial activity. The design was based on a molecular hybridization approach. Evaluation of their antibacterial activity revealed that these compounds generally showed moderate antibacterial activity. The best activity was achieved for compound 4p with MIC/MBC in the range of 0.12-0.47 and 0.23-0.94 mg mL(-1) respectively. Three compounds (4g, 4n, and 4p) were tested against three resistant strains, namely MRSA, p.aeruginosa, and E.coli, showing higher inhibition potential than the reference drug ampicillin. These three compounds also were tested for their ability to inhibit biofilm formation, with two of them showing better activity than streptomycin in a concentration of MIC (4p) and ampicillin in both concentrations (MIC and 0.5 MIC). As far as antifungal activity is concerned, the best activity was observed for compound 4i with MIC at 0.12-0.47 mg mL(-1) and MFC at 0.23-0.94 mg m(-1). According to docking studies, the predicted inhibition of E.coli MurB enzyme is probably a putative mechanism of the antibacterial activity of these compounds, while inhibition of 14a-lanosterol demethylase is probably the mechanism of their antifungal activity.",
journal = "Journal of Heterocyclic Chemistry",
title = "Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents",
number = "9",
volume = "59",
doi = "10.1002/jhet.4491",
pages = "1573-1590"
}

Kartsev, V., Geronikaki, A., Lichitsky, B., Komogortsev, A., Petrou, A., Ivanov, M., Glamočlija, J.,& Soković, M.. (2022). Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents. in Journal of Heterocyclic Chemistry, 59(9), 1573-1590.
https://doi.org/10.1002/jhet.4491

Kartsev V, Geronikaki A, Lichitsky B, Komogortsev A, Petrou A, Ivanov M, Glamočlija J, Soković M. Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents. in Journal of Heterocyclic Chemistry. 2022;59(9):1573-1590.
doi:10.1002/jhet.4491 .

Kartsev, Victor, Geronikaki, Athina, Lichitsky, Boris, Komogortsev, Andrey, Petrou, Anthi, Ivanov, Marija, Glamočlija, Jasmina, Soković, Marina, "Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents" in Journal of Heterocyclic Chemistry, 59, no. 9 (2022):1573-1590,
https://doi.org/10.1002/jhet.4491 . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Lichitsky, Boris
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Radanović, Oliver
AU  - Soković, Marina
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C8MD90056F
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3252
AB  - The authors regret that the author names were not displayed correctly on the original manuscript. The corrected list of authors for this paper is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
T2  - MedChemComm
T2  - MedChemComm
T1  - Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)
IS  - 1
VL  - 10
DO  - 10.1039/C8MD90056F
SP  - 180
ER  - 

@article{
author = "Kartsev, Victor and Lichitsky, Boris and Geronikaki, Athina and Petrou, Anthi and Ivanov, Marija and Kostić, Marina and Radanović, Oliver and Soković, Marina",
year = "2019",
abstract = "The authors regret that the author names were not displayed correctly on the original manuscript. The corrected list of authors for this paper is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.",
journal = "MedChemComm, MedChemComm",
title = "Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)",
number = "1",
volume = "10",
doi = "10.1039/C8MD90056F",
pages = "180"
}

Kartsev, V., Lichitsky, B., Geronikaki, A., Petrou, A., Ivanov, M., Kostić, M., Radanović, O.,& Soković, M.. (2019). Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J). in MedChemComm, 10(1), 180.
https://doi.org/10.1039/C8MD90056F

Kartsev V, Lichitsky B, Geronikaki A, Petrou A, Ivanov M, Kostić M, Radanović O, Soković M. Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J). in MedChemComm. 2019;10(1):180.
doi:10.1039/C8MD90056F .

Kartsev, Victor, Lichitsky, Boris, Geronikaki, Athina, Petrou, Anthi, Ivanov, Marija, Kostić, Marina, Radanović, Oliver, Soković, Marina, "Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)" in MedChemComm, 10, no. 1 (2019):180,
https://doi.org/10.1039/C8MD90056F . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Lichitsky, Boris
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Soković, Marina
AU  - Sirakanyan, Samvel
PY  - 2019
UR  - http://www.eurekaselect.com/172243/article
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3469
AB  - BACKGROUND Griseofulvin - a mold metabolite produced by Penisilium griseofulvum is known as an antifungal drug. OBJECTIVE Thus, the goal of this paper is the design and synthesis of new griseofulvin derivatives and evaluation of their antifungal activity. METHODS Forty-two new compounds were synthesized using classical methods of organic synthesis and evaluated for their antimicrobial activity by microdilution method. RESULTS All forty-two new compounds exhibited very good activity against eight tested micromycetes with MIC ranging from 0.0075-0.055 mg/ml and MFC from 0.02-024 mg/ml. All compounds exhibited better activity than reference drugs ketoconazole (7-42 times) and bifonazole (3-16 fold). The most promising was compound 15. The most sensitive fungal was found to be T. viride, while the most resistant, as was expected, was A. fumigatus. It should be mentioned that most of compounds exhibited better activity than griseofulvin. The molecular docking studies revealed that the most active compound have the same hydrophobic and H-bonding interactions with Thr276 residue observed for griseofulvin forming 3 hydrogen bonds while griseofulvin only one. In general, the molecular docking results coincide with experimental. CONCLUSION Forty-two giseofulvin derivatives were designed, synthesized and evaluated for antimicrobial activity. These derivatives revealed good antifungal activity, better than reference drugs ketoconazole, bifonazole, and griseofulvin as well.
T2  - Current Topics in Medicinal Chemistry
T1  - Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation.
IS  - 13
VL  - 19
DO  - 10.2174/1568026619666190523080136
SP  - 1145
EP  - 1161
ER  - 

@article{
author = "Kartsev, Victor and Geronikaki, Athina and Petrou, Anthi and Lichitsky, Boris and Kostić, Marina and Ivanov, Marija and Soković, Marina and Sirakanyan, Samvel",
year = "2019",
abstract = "BACKGROUND Griseofulvin - a mold metabolite produced by Penisilium griseofulvum is known as an antifungal drug. OBJECTIVE Thus, the goal of this paper is the design and synthesis of new griseofulvin derivatives and evaluation of their antifungal activity. METHODS Forty-two new compounds were synthesized using classical methods of organic synthesis and evaluated for their antimicrobial activity by microdilution method. RESULTS All forty-two new compounds exhibited very good activity against eight tested micromycetes with MIC ranging from 0.0075-0.055 mg/ml and MFC from 0.02-024 mg/ml. All compounds exhibited better activity than reference drugs ketoconazole (7-42 times) and bifonazole (3-16 fold). The most promising was compound 15. The most sensitive fungal was found to be T. viride, while the most resistant, as was expected, was A. fumigatus. It should be mentioned that most of compounds exhibited better activity than griseofulvin. The molecular docking studies revealed that the most active compound have the same hydrophobic and H-bonding interactions with Thr276 residue observed for griseofulvin forming 3 hydrogen bonds while griseofulvin only one. In general, the molecular docking results coincide with experimental. CONCLUSION Forty-two giseofulvin derivatives were designed, synthesized and evaluated for antimicrobial activity. These derivatives revealed good antifungal activity, better than reference drugs ketoconazole, bifonazole, and griseofulvin as well.",
journal = "Current Topics in Medicinal Chemistry",
title = "Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation.",
number = "13",
volume = "19",
doi = "10.2174/1568026619666190523080136",
pages = "1145-1161"
}

Kartsev, V., Geronikaki, A., Petrou, A., Lichitsky, B., Kostić, M., Ivanov, M., Soković, M.,& Sirakanyan, S.. (2019). Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation.. in Current Topics in Medicinal Chemistry, 19(13), 1145-1161.
https://doi.org/10.2174/1568026619666190523080136

Kartsev V, Geronikaki A, Petrou A, Lichitsky B, Kostić M, Ivanov M, Soković M, Sirakanyan S. Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation.. in Current Topics in Medicinal Chemistry. 2019;19(13):1145-1161.
doi:10.2174/1568026619666190523080136 .

Kartsev, Victor, Geronikaki, Athina, Petrou, Anthi, Lichitsky, Boris, Kostić, Marina, Ivanov, Marija, Soković, Marina, Sirakanyan, Samvel, "Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation." in Current Topics in Medicinal Chemistry, 19, no. 13 (2019):1145-1161,
https://doi.org/10.2174/1568026619666190523080136 . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Lichitsky, Boris
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Radanović, Oliver
AU  - Soković, Marina
PY  - 2018
UR  - http://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00076J#!divAbstract
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3080
AB  - Usnic acid, a dibenzofuran, was originally isolated from lichens producing secondary metabolites, and is well known as an antibiotic, but is also endowed with several other interesting properties. Thus, the goal of this paper is the design of new usnic acid derivatives and evaluation of their antimicrobial activity. All newly synthesized compounds possess good antibacterial activity with MIC ranging from 1.02-50.93 × 10-2 mmol mL-1 and MBC from 2.05-70.57 × 10-2 mmol mL-1. The most sensitive bacterial species was Staphylococcus aureus, while Pseudomonas aeruginosa and Escherichia coli were the most resistant among the ATCC strains, and MRSA was the most resistant among all tested bacteria (ATCC and clinical isolates). Their antifungal activity was very strong (MIC = 0.35-7.53 × 10-2 mmol mL-1 and MFC = 0.70-15.05 × 10-2 mmol mL-1)-better than those of reference compounds and usnic acid itself. The most sensitive fungal species was Trichoderma viride, while Penicillium versicolor var. cyclopium appeared to be the most resistant. It should be mentioned that in general most of the compounds showed weaker antibacterial activity, but better antifungal properties than usnic acid itself. The results allow us to conclude that the title compounds are good lead compounds for novel more active antibacterial drugs. On the other hand, these compounds are very promising as antifungals.
T2  - MedChemComm
T2  - MedChemComm
T1  - Design, synthesis and antimicrobial activity of usnic acid derivatives
IS  - 5
VL  - 9
DO  - 10.1039/C8MD00076J
SP  - 870
EP  - 882
ER  - 

@article{
author = "Kartsev, Victor and Lichitsky, Boris and Geronikaki, Athina and Petrou, Anthi and Ivanov, Marija and Kostić, Marina and Radanović, Oliver and Soković, Marina",
year = "2018",
abstract = "Usnic acid, a dibenzofuran, was originally isolated from lichens producing secondary metabolites, and is well known as an antibiotic, but is also endowed with several other interesting properties. Thus, the goal of this paper is the design of new usnic acid derivatives and evaluation of their antimicrobial activity. All newly synthesized compounds possess good antibacterial activity with MIC ranging from 1.02-50.93 × 10-2 mmol mL-1 and MBC from 2.05-70.57 × 10-2 mmol mL-1. The most sensitive bacterial species was Staphylococcus aureus, while Pseudomonas aeruginosa and Escherichia coli were the most resistant among the ATCC strains, and MRSA was the most resistant among all tested bacteria (ATCC and clinical isolates). Their antifungal activity was very strong (MIC = 0.35-7.53 × 10-2 mmol mL-1 and MFC = 0.70-15.05 × 10-2 mmol mL-1)-better than those of reference compounds and usnic acid itself. The most sensitive fungal species was Trichoderma viride, while Penicillium versicolor var. cyclopium appeared to be the most resistant. It should be mentioned that in general most of the compounds showed weaker antibacterial activity, but better antifungal properties than usnic acid itself. The results allow us to conclude that the title compounds are good lead compounds for novel more active antibacterial drugs. On the other hand, these compounds are very promising as antifungals.",
journal = "MedChemComm, MedChemComm",
title = "Design, synthesis and antimicrobial activity of usnic acid derivatives",
number = "5",
volume = "9",
doi = "10.1039/C8MD00076J",
pages = "870-882"
}

Kartsev, V., Lichitsky, B., Geronikaki, A., Petrou, A., Ivanov, M., Kostić, M., Radanović, O.,& Soković, M.. (2018). Design, synthesis and antimicrobial activity of usnic acid derivatives. in MedChemComm, 9(5), 870-882.
https://doi.org/10.1039/C8MD00076J

Kartsev V, Lichitsky B, Geronikaki A, Petrou A, Ivanov M, Kostić M, Radanović O, Soković M. Design, synthesis and antimicrobial activity of usnic acid derivatives. in MedChemComm. 2018;9(5):870-882.
doi:10.1039/C8MD00076J .

Kartsev, Victor, Lichitsky, Boris, Geronikaki, Athina, Petrou, Anthi, Ivanov, Marija, Kostić, Marina, Radanović, Oliver, Soković, Marina, "Design, synthesis and antimicrobial activity of usnic acid derivatives" in MedChemComm, 9, no. 5 (2018):870-882,
https://doi.org/10.1039/C8MD00076J . .