TY  - JOUR
AU  - Ak, Gunes
AU  - Zengin, Gokhan
AU  - Dall’Acqua, Stefano
AU  - Ferrarese, Irene
AU  - Sut, Stefania
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Nenadić, Marija
AU  - Chiavaroli, Annalisa
AU  - Recinella, Lucia
AU  - Leone, Sheila
AU  - Orlando, Giustino
AU  - Menghini, Luigi
AU  - Ferrante, Claudio
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5069
AB  - The genus Scorzonera is one of the most important genera in the Asteraceae family, and members of the genus have great potential in traditional medicine systems. In this article we aimed to determine skin protective and antimicrobial effects of different extracts from the roots and aerial parts of three Scorzonera species (S. hieraciifolia, S. hispanica, S. tomentosa). Antimicrobial properties were evaluated against different pathogen bacterial and fungal strains, whereas protective effects were studied in isolated mouse skin specimens exposed to hydrogen peroxide. In this biological model, the levels of l-dopa and prostaglandin E2 (PGE2) were evaluated, as markers of tyrosinase activity and inflammation, respectively. All extracts were effective in blunting the increased hydrogen peroxide-induced l-dopa turnover and PGE2 level; thus, suggesting skin protection that could be partly related to the content of flavonoids, among which rutin, in the tested extracts. Additionally, all extracts were effective as antibacterial and antifungal agents; intriguing results were observed against Trichoderma viride, which was particularly sensitive to S. tomentosa root extracts. Therefore, the present study strengthens the importance of investigating herbal preparations obtained from plants belonging to the genus Scorzonera, for the management and prevention of inflammatory and infectious skin conditions.
PB  - Taylor and Francis Ltd.
T2  - Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
T1  - A new step on the chemical profiles and pharmacological effects of three Scorzonera species ( S. hieraciifolia , S. hispanica and S. tomentosa )
IS  - 1
VL  - 157
DO  - 10.1080/11263504.2022.2089766
SP  - 119
EP  - 128
ER  - 

@article{
author = "Ak, Gunes and Zengin, Gokhan and Dall’Acqua, Stefano and Ferrarese, Irene and Sut, Stefania and Glamočlija, Jasmina and Soković, Marina and Nenadić, Marija and Chiavaroli, Annalisa and Recinella, Lucia and Leone, Sheila and Orlando, Giustino and Menghini, Luigi and Ferrante, Claudio",
year = "2023",
abstract = "The genus Scorzonera is one of the most important genera in the Asteraceae family, and members of the genus have great potential in traditional medicine systems. In this article we aimed to determine skin protective and antimicrobial effects of different extracts from the roots and aerial parts of three Scorzonera species (S. hieraciifolia, S. hispanica, S. tomentosa). Antimicrobial properties were evaluated against different pathogen bacterial and fungal strains, whereas protective effects were studied in isolated mouse skin specimens exposed to hydrogen peroxide. In this biological model, the levels of l-dopa and prostaglandin E2 (PGE2) were evaluated, as markers of tyrosinase activity and inflammation, respectively. All extracts were effective in blunting the increased hydrogen peroxide-induced l-dopa turnover and PGE2 level; thus, suggesting skin protection that could be partly related to the content of flavonoids, among which rutin, in the tested extracts. Additionally, all extracts were effective as antibacterial and antifungal agents; intriguing results were observed against Trichoderma viride, which was particularly sensitive to S. tomentosa root extracts. Therefore, the present study strengthens the importance of investigating herbal preparations obtained from plants belonging to the genus Scorzonera, for the management and prevention of inflammatory and infectious skin conditions.",
publisher = "Taylor and Francis Ltd.",
journal = "Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology",
title = "A new step on the chemical profiles and pharmacological effects of three Scorzonera species ( S. hieraciifolia , S. hispanica and S. tomentosa )",
number = "1",
volume = "157",
doi = "10.1080/11263504.2022.2089766",
pages = "119-128"
}

Ak, G., Zengin, G., Dall’Acqua, S., Ferrarese, I., Sut, S., Glamočlija, J., Soković, M., Nenadić, M., Chiavaroli, A., Recinella, L., Leone, S., Orlando, G., Menghini, L.,& Ferrante, C.. (2023). A new step on the chemical profiles and pharmacological effects of three Scorzonera species ( S. hieraciifolia , S. hispanica and S. tomentosa ). in Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
Taylor and Francis Ltd.., 157(1), 119-128.
https://doi.org/10.1080/11263504.2022.2089766

Ak G, Zengin G, Dall’Acqua S, Ferrarese I, Sut S, Glamočlija J, Soković M, Nenadić M, Chiavaroli A, Recinella L, Leone S, Orlando G, Menghini L, Ferrante C. A new step on the chemical profiles and pharmacological effects of three Scorzonera species ( S. hieraciifolia , S. hispanica and S. tomentosa ). in Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology. 2023;157(1):119-128.
doi:10.1080/11263504.2022.2089766 .

Ak, Gunes, Zengin, Gokhan, Dall’Acqua, Stefano, Ferrarese, Irene, Sut, Stefania, Glamočlija, Jasmina, Soković, Marina, Nenadić, Marija, Chiavaroli, Annalisa, Recinella, Lucia, Leone, Sheila, Orlando, Giustino, Menghini, Luigi, Ferrante, Claudio, "A new step on the chemical profiles and pharmacological effects of three Scorzonera species ( S. hieraciifolia , S. hispanica and S. tomentosa )" in Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 157, no. 1 (2023):119-128,
https://doi.org/10.1080/11263504.2022.2089766 . .