TY  - JOUR
AU  - Pogrebnoi, Serghei
AU  - Radul, Oleg
AU  - Stingaci, Eugenia
AU  - Lupascu, Lucian
AU  - Valica, Vladimir
AU  - Uncu, Livia
AU  - Smetanscaia, Anastasia
AU  - Petrou, Anthi
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Geronikaki, Athina
AU  - Macaev, Fliur Z.
PY  - 2022
UR  - https://www.mdpi.com/2079-6382/11/5/588
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4982
AB  - The control of fungal pathogens is increasingly difficult due to the limited number of effective drugs available for antifungal therapy. In addition, both humans and fungi are eukaryotic organisms; antifungal drugs may have significant toxicity due to the inhibition of related human targets. Furthermore, another problem is increased incidents of fungal resistance to azoles, such as fluconazole, ketoconazole, voriconazole, etc. Thus, the interest in developing new azoles with an extended spectrum of activity still attracts the interest of the scientific community. Herein, we report the synthesis of a series of triazolium salts, an evaluation of their antifungal activity, and docking studies. Ketoconazole and bifonazole were used as reference drugs. All compounds showed good antifungal activity with MIC/MFC in the range of 0.0003 to 0.2/0.0006-0.4 mg/mL. Compound 19 exhibited the best activity among all tested with MIC/MFC in the range of 0.009 to 0.037 mg/mL and 0.0125-0.05 mg/mL, respectively. All compounds appeared to be more potent than both reference drugs. The docking studies are in accordance with experimental results.
PB  - Basel: MDPI
T2  - Antibiotics (Basel, Switzerland)
T1  - The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation.
IS  - 5
VL  - 11
DO  - 10.3390/antibiotics11050588
SP  - 588
ER  - 

@article{
author = "Pogrebnoi, Serghei and Radul, Oleg and Stingaci, Eugenia and Lupascu, Lucian and Valica, Vladimir and Uncu, Livia and Smetanscaia, Anastasia and Petrou, Anthi and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina and Geronikaki, Athina and Macaev, Fliur Z.",
year = "2022",
abstract = "The control of fungal pathogens is increasingly difficult due to the limited number of effective drugs available for antifungal therapy. In addition, both humans and fungi are eukaryotic organisms; antifungal drugs may have significant toxicity due to the inhibition of related human targets. Furthermore, another problem is increased incidents of fungal resistance to azoles, such as fluconazole, ketoconazole, voriconazole, etc. Thus, the interest in developing new azoles with an extended spectrum of activity still attracts the interest of the scientific community. Herein, we report the synthesis of a series of triazolium salts, an evaluation of their antifungal activity, and docking studies. Ketoconazole and bifonazole were used as reference drugs. All compounds showed good antifungal activity with MIC/MFC in the range of 0.0003 to 0.2/0.0006-0.4 mg/mL. Compound 19 exhibited the best activity among all tested with MIC/MFC in the range of 0.009 to 0.037 mg/mL and 0.0125-0.05 mg/mL, respectively. All compounds appeared to be more potent than both reference drugs. The docking studies are in accordance with experimental results.",
publisher = "Basel: MDPI",
journal = "Antibiotics (Basel, Switzerland)",
title = "The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation.",
number = "5",
volume = "11",
doi = "10.3390/antibiotics11050588",
pages = "588"
}

Pogrebnoi, S., Radul, O., Stingaci, E., Lupascu, L., Valica, V., Uncu, L., Smetanscaia, A., Petrou, A., Ćirić, A., Glamočlija, J., Soković, M., Geronikaki, A.,& Macaev, F. Z.. (2022). The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation.. in Antibiotics (Basel, Switzerland)
Basel: MDPI., 11(5), 588.
https://doi.org/10.3390/antibiotics11050588

Pogrebnoi S, Radul O, Stingaci E, Lupascu L, Valica V, Uncu L, Smetanscaia A, Petrou A, Ćirić A, Glamočlija J, Soković M, Geronikaki A, Macaev FZ. The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation.. in Antibiotics (Basel, Switzerland). 2022;11(5):588.
doi:10.3390/antibiotics11050588 .

Pogrebnoi, Serghei, Radul, Oleg, Stingaci, Eugenia, Lupascu, Lucian, Valica, Vladimir, Uncu, Livia, Smetanscaia, Anastasia, Petrou, Anthi, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, Geronikaki, Athina, Macaev, Fliur Z., "The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation." in Antibiotics (Basel, Switzerland), 11, no. 5 (2022):588,
https://doi.org/10.3390/antibiotics11050588 . .