TY  - JOUR
AU  - Joseph, Blessy
AU  - John, Amrit Jose
AU  - Glamočlija, Jasmina
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Lazović, Saša
AU  - Kochupurackal, Jayachandran
AU  - Kalarikkal, Nandakumar
AU  - Thomas, Sabu
PY  - 2023
UR  - https://linkinghub.elsevier.com/retrieve/pii/S2352492822018025
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5348
AB  - Electrospun fibers with large surface area are of particular importance in the tissue engineering field as their highly porous structure favours cell adhesion, proliferation, and migration. Herein, we report a facile approach for the development of polycaprolactone (PCL) scaffolds incorporated with zirconium dioxide (ZrO2) nanoparticles. Zirconium dioxide nanoparticles were incorporated into the fibers at five different concentrations (0.5, 1, 3, 5 and 7 wt%), based on the amount of polymer. The morphology of the scaffolds was evaluated by scanning electron microscopy which showed interconnected pore structure. The incorporation of nanoparticles was confirmed from EDX studies. The functional groups were analysed using FTIR and crystallinity was analysed by XRD. Mechanical studies demonstrated that the scaffolds containing 1 wt% Zirconium dioxide nanoparticles exhibited the highest tensile strength. The scaffolds showed antibacterial activity against Gram positive bacterium Staphylococcus lugdunensis and were not active against Gram-negative bacterium Proteus vulgaris, at all time-points. ZrO2 loaded PCL scaffolds with good mechanical and biological properties will open avenues for the potential applications of the electrospun membranes for tissue engineering.
PB  - Elsevier Ltd
T2  - Materials Today Communications
T1  - Processing and evaluation of the structure-properties of electrospun PCL/ zirconium nanoparticle scaffolds
VL  - 34
DO  - 10.1016/j.mtcomm.2022.104961
SP  - 104961
ER  - 

@article{
author = "Joseph, Blessy and John, Amrit Jose and Glamočlija, Jasmina and Stojković, Dejan and Soković, Marina and Lazović, Saša and Kochupurackal, Jayachandran and Kalarikkal, Nandakumar and Thomas, Sabu",
year = "2023",
abstract = "Electrospun fibers with large surface area are of particular importance in the tissue engineering field as their highly porous structure favours cell adhesion, proliferation, and migration. Herein, we report a facile approach for the development of polycaprolactone (PCL) scaffolds incorporated with zirconium dioxide (ZrO2) nanoparticles. Zirconium dioxide nanoparticles were incorporated into the fibers at five different concentrations (0.5, 1, 3, 5 and 7 wt%), based on the amount of polymer. The morphology of the scaffolds was evaluated by scanning electron microscopy which showed interconnected pore structure. The incorporation of nanoparticles was confirmed from EDX studies. The functional groups were analysed using FTIR and crystallinity was analysed by XRD. Mechanical studies demonstrated that the scaffolds containing 1 wt% Zirconium dioxide nanoparticles exhibited the highest tensile strength. The scaffolds showed antibacterial activity against Gram positive bacterium Staphylococcus lugdunensis and were not active against Gram-negative bacterium Proteus vulgaris, at all time-points. ZrO2 loaded PCL scaffolds with good mechanical and biological properties will open avenues for the potential applications of the electrospun membranes for tissue engineering.",
publisher = "Elsevier Ltd",
journal = "Materials Today Communications",
title = "Processing and evaluation of the structure-properties of electrospun PCL/ zirconium nanoparticle scaffolds",
volume = "34",
doi = "10.1016/j.mtcomm.2022.104961",
pages = "104961"
}

Joseph, B., John, A. J., Glamočlija, J., Stojković, D., Soković, M., Lazović, S., Kochupurackal, J., Kalarikkal, N.,& Thomas, S.. (2023). Processing and evaluation of the structure-properties of electrospun PCL/ zirconium nanoparticle scaffolds. in Materials Today Communications
Elsevier Ltd., 34, 104961.
https://doi.org/10.1016/j.mtcomm.2022.104961

Joseph B, John AJ, Glamočlija J, Stojković D, Soković M, Lazović S, Kochupurackal J, Kalarikkal N, Thomas S. Processing and evaluation of the structure-properties of electrospun PCL/ zirconium nanoparticle scaffolds. in Materials Today Communications. 2023;34:104961.
doi:10.1016/j.mtcomm.2022.104961 .

Joseph, Blessy, John, Amrit Jose, Glamočlija, Jasmina, Stojković, Dejan, Soković, Marina, Lazović, Saša, Kochupurackal, Jayachandran, Kalarikkal, Nandakumar, Thomas, Sabu, "Processing and evaluation of the structure-properties of electrospun PCL/ zirconium nanoparticle scaffolds" in Materials Today Communications, 34 (2023):104961,
https://doi.org/10.1016/j.mtcomm.2022.104961 . .