TY  - JOUR
AU  - Dimkić, Ivica
AU  - Fira, Đorđe
AU  - Janakiev, Tamara
AU  - Kabić, Jovana
AU  - Stupar, Miloš
AU  - Nenadić, Marija
AU  - Unković, Nikola
AU  - Ljaljević Grbić, Milica
PY  - 2021
UR  - internal-pdf://Dimkić et al. - 2021 - The microbiome of bat guano for what is this knowledge important.pdf
UR  - https://doi.org/10.1007/s00253-021-11143-y
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4140
AB  - Abstract: Bats as flying mammals are potent vectors and natural reservoir hosts for many infectious viruses, bacteria, and fungi, also detected in their excreta such as guano. Accelerated deforestation, urbanization, and anthropization hastily lead to overpopulation of the bats in urban areas allowing easy interaction with other animals, expansion, and emergence of new zoonotic disease outbreaks potentially harmful to humans. Therefore, getting new insights in the microbiome of bat guano from different places represents an imperative for the future. Furthermore, the use of novel high-throughput sequencing technologies allows better insight in guano microbiome and potentially indicated that some species could be typical guano-dwelling members. Bats are well known as a natural reservoir of many zoonotic viruses such as Ebola, Nipah, Marburg, lyssaviruses, rabies, henipaviruses, and many coronaviruses which caused a high number of outbreaks including ongoing COVID-19 pandemic. Additionally, many bacterial and fungal pathogens were identified as common guano residents. Thus, the presence of multi-drug-resistant bacteria as environmental reservoirs of extended spectrum β-lactamases and carbapenemase-producing strains has been confirmed. Bat guano is the most suitable substrate for fungal reproduction and dissemination, including pathogenic yeasts and keratinophilic and dimorphic human pathogenic fungi known as notorious causative agents of severe endemic mycoses like histoplasmosis and fatal cryptococcosis, especially deadly in immunocompromised individuals. This review provides an overview of bat guano microbiota diversity and the significance of autochthonous and pathogenic taxa for humans and the environment, highlighting better understanding in preventing emerging diseases. Key points: Bat guano as reservoir and source for spreading of autochthonous and pathogenic microbiotaBat guano vs. novel zoonotic disease outbreaksDestruction of bat natural habitats urgently demands increased human awareness.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Applied Microbiology and Biotechnology
T1  - The microbiome of bat guano: for what is this knowledge important?
IS  - 4
VL  - 105
DO  - 10.1007/s00253-021-11143-y
SP  - 1407
EP  - 1419
ER  - 

@article{
author = "Dimkić, Ivica and Fira, Đorđe and Janakiev, Tamara and Kabić, Jovana and Stupar, Miloš and Nenadić, Marija and Unković, Nikola and Ljaljević Grbić, Milica",
year = "2021",
abstract = "Abstract: Bats as flying mammals are potent vectors and natural reservoir hosts for many infectious viruses, bacteria, and fungi, also detected in their excreta such as guano. Accelerated deforestation, urbanization, and anthropization hastily lead to overpopulation of the bats in urban areas allowing easy interaction with other animals, expansion, and emergence of new zoonotic disease outbreaks potentially harmful to humans. Therefore, getting new insights in the microbiome of bat guano from different places represents an imperative for the future. Furthermore, the use of novel high-throughput sequencing technologies allows better insight in guano microbiome and potentially indicated that some species could be typical guano-dwelling members. Bats are well known as a natural reservoir of many zoonotic viruses such as Ebola, Nipah, Marburg, lyssaviruses, rabies, henipaviruses, and many coronaviruses which caused a high number of outbreaks including ongoing COVID-19 pandemic. Additionally, many bacterial and fungal pathogens were identified as common guano residents. Thus, the presence of multi-drug-resistant bacteria as environmental reservoirs of extended spectrum β-lactamases and carbapenemase-producing strains has been confirmed. Bat guano is the most suitable substrate for fungal reproduction and dissemination, including pathogenic yeasts and keratinophilic and dimorphic human pathogenic fungi known as notorious causative agents of severe endemic mycoses like histoplasmosis and fatal cryptococcosis, especially deadly in immunocompromised individuals. This review provides an overview of bat guano microbiota diversity and the significance of autochthonous and pathogenic taxa for humans and the environment, highlighting better understanding in preventing emerging diseases. Key points: Bat guano as reservoir and source for spreading of autochthonous and pathogenic microbiotaBat guano vs. novel zoonotic disease outbreaksDestruction of bat natural habitats urgently demands increased human awareness.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Applied Microbiology and Biotechnology",
title = "The microbiome of bat guano: for what is this knowledge important?",
number = "4",
volume = "105",
doi = "10.1007/s00253-021-11143-y",
pages = "1407-1419"
}

Dimkić, I., Fira, Đ., Janakiev, T., Kabić, J., Stupar, M., Nenadić, M., Unković, N.,& Ljaljević Grbić, M.. (2021). The microbiome of bat guano: for what is this knowledge important?. in Applied Microbiology and Biotechnology
Springer Science and Business Media Deutschland GmbH., 105(4), 1407-1419.
https://doi.org/10.1007/s00253-021-11143-y

Dimkić I, Fira Đ, Janakiev T, Kabić J, Stupar M, Nenadić M, Unković N, Ljaljević Grbić M. The microbiome of bat guano: for what is this knowledge important?. in Applied Microbiology and Biotechnology. 2021;105(4):1407-1419.
doi:10.1007/s00253-021-11143-y .

Dimkić, Ivica, Fira, Đorđe, Janakiev, Tamara, Kabić, Jovana, Stupar, Miloš, Nenadić, Marija, Unković, Nikola, Ljaljević Grbić, Milica, "The microbiome of bat guano: for what is this knowledge important?" in Applied Microbiology and Biotechnology, 105, no. 4 (2021):1407-1419,
https://doi.org/10.1007/s00253-021-11143-y . .

TY  - JOUR
AU  - Nenadić, Marija
AU  - Ljaljević-Grbić, Milica
AU  - Stupar, Miloš
AU  - Vukojević, Jelena
AU  - Ćirić, Ana
AU  - Tešević, Vele
AU  - Vujisić, Ljubodrag
AU  - Todosijević, Marina
AU  - Vesović, Nikola
AU  - Živković, Nemanja
AU  - Ćurčić, Srećko
PY  - 2017
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4296
AB  - The antifungal potential of the pygidial gland secretion of the troglophilic ground beetle Laemostenus
punctatus from a cave in Southeastern Serbia against cavedwelling micromycetes, isolated from the same habitat, has
been investigated. Eleven collected samples were analyzed
and 32 isolates of cave-dwelling fungi were documented. A
total of 14 fungal species were identified as members of the
genera Aspergillus, Penicillium, Alternaria, Cladosporium,
Rhizopus, Trichoderma, Arthrinium, Aureobasidium,
Epicoccum, Talaromyces, and Fusarium. Five isolates were
selected for testing the antifungal activity of the pygidial gland
se cr etio n: Talaromyces d uclauxi, Aspergillus
brunneouniseriatus, Penicillium sp., Rhizopus stolonifer, and
Trichoderma viride. The microdilution method has been applied to detect minimal inhibitory concentrations (MICs) and
minimal fungicidal concentrations (MFCs). The most sensitive isolate was Penicillium sp., while the other isolates demonstrated a high level of resistance to the tested agent.
L. punctatus has developed a special mechanism of producing
specific compounds that act synergistically within the
secretion mixture, which are responsible for the antifungal
action against pathogens from the cave. The results open opportunities for further research in the field of ground beetle
defense against pathogens, which could have an important
application in human medicine, in addition to the environmental impact, primarily.
PB  - Berlin, Heidelberg: Springer-Verlag
T2  - The Science of Nature
T1  - Antifungal activity of the pygidial gland secretion of Laemostenus punctatus (Coleoptera: Carabidae) against cave-dwelling micromycetes
IS  - 5-6
VL  - 104
DO  - 10.1007/s00114-017-1474-4
SP  - 52
ER  - 

@article{
author = "Nenadić, Marija and Ljaljević-Grbić, Milica and Stupar, Miloš and Vukojević, Jelena and Ćirić, Ana and Tešević, Vele and Vujisić, Ljubodrag and Todosijević, Marina and Vesović, Nikola and Živković, Nemanja and Ćurčić, Srećko",
year = "2017",
abstract = "The antifungal potential of the pygidial gland secretion of the troglophilic ground beetle Laemostenus
punctatus from a cave in Southeastern Serbia against cavedwelling micromycetes, isolated from the same habitat, has
been investigated. Eleven collected samples were analyzed
and 32 isolates of cave-dwelling fungi were documented. A
total of 14 fungal species were identified as members of the
genera Aspergillus, Penicillium, Alternaria, Cladosporium,
Rhizopus, Trichoderma, Arthrinium, Aureobasidium,
Epicoccum, Talaromyces, and Fusarium. Five isolates were
selected for testing the antifungal activity of the pygidial gland
se cr etio n: Talaromyces d uclauxi, Aspergillus
brunneouniseriatus, Penicillium sp., Rhizopus stolonifer, and
Trichoderma viride. The microdilution method has been applied to detect minimal inhibitory concentrations (MICs) and
minimal fungicidal concentrations (MFCs). The most sensitive isolate was Penicillium sp., while the other isolates demonstrated a high level of resistance to the tested agent.
L. punctatus has developed a special mechanism of producing
specific compounds that act synergistically within the
secretion mixture, which are responsible for the antifungal
action against pathogens from the cave. The results open opportunities for further research in the field of ground beetle
defense against pathogens, which could have an important
application in human medicine, in addition to the environmental impact, primarily.",
publisher = "Berlin, Heidelberg: Springer-Verlag",
journal = "The Science of Nature",
title = "Antifungal activity of the pygidial gland secretion of Laemostenus punctatus (Coleoptera: Carabidae) against cave-dwelling micromycetes",
number = "5-6",
volume = "104",
doi = "10.1007/s00114-017-1474-4",
pages = "52"
}

Nenadić, M., Ljaljević-Grbić, M., Stupar, M., Vukojević, J., Ćirić, A., Tešević, V., Vujisić, L., Todosijević, M., Vesović, N., Živković, N.,& Ćurčić, S.. (2017). Antifungal activity of the pygidial gland secretion of Laemostenus punctatus (Coleoptera: Carabidae) against cave-dwelling micromycetes. in The Science of Nature
Berlin, Heidelberg: Springer-Verlag., 104(5-6), 52.
https://doi.org/10.1007/s00114-017-1474-4

Nenadić M, Ljaljević-Grbić M, Stupar M, Vukojević J, Ćirić A, Tešević V, Vujisić L, Todosijević M, Vesović N, Živković N, Ćurčić S. Antifungal activity of the pygidial gland secretion of Laemostenus punctatus (Coleoptera: Carabidae) against cave-dwelling micromycetes. in The Science of Nature. 2017;104(5-6):52.
doi:10.1007/s00114-017-1474-4 .

Nenadić, Marija, Ljaljević-Grbić, Milica, Stupar, Miloš, Vukojević, Jelena, Ćirić, Ana, Tešević, Vele, Vujisić, Ljubodrag, Todosijević, Marina, Vesović, Nikola, Živković, Nemanja, Ćurčić, Srećko, "Antifungal activity of the pygidial gland secretion of Laemostenus punctatus (Coleoptera: Carabidae) against cave-dwelling micromycetes" in The Science of Nature, 104, no. 5-6 (2017):52,
https://doi.org/10.1007/s00114-017-1474-4 . .

TY  - JOUR
AU  - Grbić-Ljaljević, Milica
AU  - Soković, Marina
AU  - Stupar, Miloš
AU  - Mišić, Danijela
AU  - Vukojević, Jelena
AU  - Grubišić, Dragoljub
AU  - Ristić, Mihailo
PY  - 2008
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/556
AB  - The chemical composition and antifungal activity of the essential oil of an endemic Serbian plant Nepeta rtanjensis Diklić & Milojević was studied. The essential oil was isolated from cultivated plants. Inhibition of mycelia growth of five micromycetes, two Alternaria species originally isolated from N. rtanjensis, Cladosporium cladosporoides, Trichoderma viride and Bipolaris spicifera, were tested using the agar dilution method. The essential oil of N. rtanjensis, the main component of which was 4aα,7α,7αβ-nepetalactone, showed strong antifungal activity against all the tested micromycetes. The minimum inhibitory concentration of N. rtanjensis essential oil ranged from 0.6 to 1.4 μg mL-1. The fungi most sensitive to the tested oil were Alternaria species, while Trichoderma viride was the most resistant.
AB  - U ovom radu prezentovan je hemijski sastav i antifungalna aktivnost etarskog ulja endemične biljke Nepeta rtanjensis Diklić & Milojević. Etarsko ulje je izolovano iz kultivisanih biljaka. Inhibicija micelijalnog rasta pet mikromiceta, dve vrste roda Alternaria, izolovane sa N. rtanjensis, Cladosporium cladosporioides, Trichoderma viride i Bipolaris spicifera, testirana je makrodilucionom metodom. Etarsko ulje N. rtanjensis, čija je glavna komponenta 4aα,7α,7aβ-nepetalakton pokazuje jaku antifungalnu aktivnost u odnosu na sve testirane mikromicete. Minimalna inhibitorna koncentracija (MIC) etaskog ulja bila je u rasponu od 0,6 μg mL-1 do 1,4 μg mL-1. Najveću osetljivost na testirano ulje pokazale su vrste roda Alternaria dok je Trichoderma viride bila najotpornija.
T2  - Journal of the Serbian Chemical Society
T1  - Antifungalna aktivnost etarskog ulja
T1  - Antifungal activity of Nepeta rtanjensis essential oil
IS  - 10
VL  - 73
SP  - 961
EP  - 965
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_556
ER  - 

@article{
author = "Grbić-Ljaljević, Milica and Soković, Marina and Stupar, Miloš and Mišić, Danijela and Vukojević, Jelena and Grubišić, Dragoljub and Ristić, Mihailo",
year = "2008, 2008",
abstract = "The chemical composition and antifungal activity of the essential oil of an endemic Serbian plant Nepeta rtanjensis Diklić & Milojević was studied. The essential oil was isolated from cultivated plants. Inhibition of mycelia growth of five micromycetes, two Alternaria species originally isolated from N. rtanjensis, Cladosporium cladosporoides, Trichoderma viride and Bipolaris spicifera, were tested using the agar dilution method. The essential oil of N. rtanjensis, the main component of which was 4aα,7α,7αβ-nepetalactone, showed strong antifungal activity against all the tested micromycetes. The minimum inhibitory concentration of N. rtanjensis essential oil ranged from 0.6 to 1.4 μg mL-1. The fungi most sensitive to the tested oil were Alternaria species, while Trichoderma viride was the most resistant., U ovom radu prezentovan je hemijski sastav i antifungalna aktivnost etarskog ulja endemične biljke Nepeta rtanjensis Diklić & Milojević. Etarsko ulje je izolovano iz kultivisanih biljaka. Inhibicija micelijalnog rasta pet mikromiceta, dve vrste roda Alternaria, izolovane sa N. rtanjensis, Cladosporium cladosporioides, Trichoderma viride i Bipolaris spicifera, testirana je makrodilucionom metodom. Etarsko ulje N. rtanjensis, čija je glavna komponenta 4aα,7α,7aβ-nepetalakton pokazuje jaku antifungalnu aktivnost u odnosu na sve testirane mikromicete. Minimalna inhibitorna koncentracija (MIC) etaskog ulja bila je u rasponu od 0,6 μg mL-1 do 1,4 μg mL-1. Najveću osetljivost na testirano ulje pokazale su vrste roda Alternaria dok je Trichoderma viride bila najotpornija.",
journal = "Journal of the Serbian Chemical Society",
title = "Antifungalna aktivnost etarskog ulja, Antifungal activity of Nepeta rtanjensis essential oil",
number = "10",
volume = "73",
pages = "961-965",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_556"
}

Grbić-Ljaljević, M., Soković, M., Stupar, M., Mišić, D., Vukojević, J., Grubišić, D.,& Ristić, M.. (2008). Antifungalna aktivnost etarskog ulja. in Journal of the Serbian Chemical Society, 73(10), 961-965.
https://hdl.handle.net/21.15107/rcub_ibiss_556

Grbić-Ljaljević M, Soković M, Stupar M, Mišić D, Vukojević J, Grubišić D, Ristić M. Antifungalna aktivnost etarskog ulja. in Journal of the Serbian Chemical Society. 2008;73(10):961-965.
https://hdl.handle.net/21.15107/rcub_ibiss_556 .

Grbić-Ljaljević, Milica, Soković, Marina, Stupar, Miloš, Mišić, Danijela, Vukojević, Jelena, Grubišić, Dragoljub, Ristić, Mihailo, "Antifungalna aktivnost etarskog ulja" in Journal of the Serbian Chemical Society, 73, no. 10 (2008):961-965,
https://hdl.handle.net/21.15107/rcub_ibiss_556 .