TY  - JOUR
AU  - Vlaisavljević, Sanja
AU  - Jelača, Sanja
AU  - Zengin, Gökhan
AU  - Mimica-Dukić, Neda
AU  - Berežni, Sanja
AU  - Miljić, Milorad
AU  - Dajić Stevanović, Zora
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C9RA08231J
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3547
AB  - The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.
T2  - RSC Advances
T1  - Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties
IS  - 64
VL  - 9
DO  - 10.1039/C9RA08231J
SP  - 37474
EP  - 37483
ER  - 

@article{
author = "Vlaisavljević, Sanja and Jelača, Sanja and Zengin, Gökhan and Mimica-Dukić, Neda and Berežni, Sanja and Miljić, Milorad and Dajić Stevanović, Zora",
year = "2019",
abstract = "The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.",
journal = "RSC Advances",
title = "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties",
number = "64",
volume = "9",
doi = "10.1039/C9RA08231J",
pages = "37474-37483"
}

Vlaisavljević, S., Jelača, S., Zengin, G., Mimica-Dukić, N., Berežni, S., Miljić, M.,& Dajić Stevanović, Z.. (2019). Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances, 9(64), 37474-37483.
https://doi.org/10.1039/C9RA08231J

Vlaisavljević S, Jelača S, Zengin G, Mimica-Dukić N, Berežni S, Miljić M, Dajić Stevanović Z. Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances. 2019;9(64):37474-37483.
doi:10.1039/C9RA08231J .

Vlaisavljević, Sanja, Jelača, Sanja, Zengin, Gökhan, Mimica-Dukić, Neda, Berežni, Sanja, Miljić, Milorad, Dajić Stevanović, Zora, "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties" in RSC Advances, 9, no. 64 (2019):37474-37483,
https://doi.org/10.1039/C9RA08231J . .

TY  - JOUR
AU  - Couladis, M
AU  - Tzakou, Olga
AU  - Kujundžić, S
AU  - Soković, Marina
AU  - Mimica-Dukić, Neda M
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1758
AB  - The essential oil composition from Thymus striatus collected from Mountain Orjen (Montenegro) has been investigated by gas chromatography-mass spectrometry. Thymol, gamma-terpinene and p-cymene were found to be the major components. Furthermore, the oil and its major component, thymol, were analysed for potential antifungal activity against plant, animal and human pathogenic fungi from different genera by a macrodilution test. The oil exhibited a strong inhibitory effect against all fungi investigated. Copyright (C) 2004 John Wiley Sons, Ltd.
T2  - Phytotherapy Research
T1  - Chemical analysis and antifungal activity of Thymus striatus
IS  - 1
VL  - 18
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1758
ER  - 

@article{
author = "Couladis, M and Tzakou, Olga and Kujundžić, S and Soković, Marina and Mimica-Dukić, Neda M",
year = "2004",
abstract = "The essential oil composition from Thymus striatus collected from Mountain Orjen (Montenegro) has been investigated by gas chromatography-mass spectrometry. Thymol, gamma-terpinene and p-cymene were found to be the major components. Furthermore, the oil and its major component, thymol, were analysed for potential antifungal activity against plant, animal and human pathogenic fungi from different genera by a macrodilution test. The oil exhibited a strong inhibitory effect against all fungi investigated. Copyright (C) 2004 John Wiley Sons, Ltd.",
journal = "Phytotherapy Research",
title = "Chemical analysis and antifungal activity of Thymus striatus",
number = "1",
volume = "18",
pages = "42",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1758"
}

Couladis, M., Tzakou, O., Kujundžić, S., Soković, M.,& Mimica-Dukić, N. M.. (2004). Chemical analysis and antifungal activity of Thymus striatus. in Phytotherapy Research, 18(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1758

Couladis M, Tzakou O, Kujundžić S, Soković M, Mimica-Dukić NM. Chemical analysis and antifungal activity of Thymus striatus. in Phytotherapy Research. 2004;18(1):null-42.
https://hdl.handle.net/21.15107/rcub_ibiss_1758 .

Couladis, M, Tzakou, Olga, Kujundžić, S, Soković, Marina, Mimica-Dukić, Neda M, "Chemical analysis and antifungal activity of Thymus striatus" in Phytotherapy Research, 18, no. 1 (2004),
https://hdl.handle.net/21.15107/rcub_ibiss_1758 .

TY  - JOUR
AU  - Mimica-Dukić, Neda M
AU  - Bozin, Biljana N
AU  - Soković, Marina
AU  - Simin, Natasa D
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1734
AB  - The present study describes antimicrobial and free radical scavenging capacity (RSC) together with the effects on lipid peroxidation (LP) of Melissa officinalis essential oil. The chemical profile of essential oil was evaluated by the means of gas chromatography-mass spectrometry (GC-MS) and thin-layer chromatography (TLC). RSC was assessed measuring the scavenging activity of essential oil on the 2,2-diphenyl-1-picrylhydrazyl (DPPH.) and OH. radicals. The effect on LP was evaluated following the activities on Fe2+/ascorbate and Fe2+/H2O2 systems of induction, The antimicrobial activity was tested against 13 bacterial strains and six fungi. The examined essential oil exhibited very strong RSC, reducing the DPPH radical formation (IC50 = 7.58 mug/mL) and OH radical generation (IC50 = 1.74 mug/mL) in a dose-dependent manner. According to the GC-MS and TLC (dot-blot techniques), the most powerful scavenging compounds were monoterpene aldehydes and ketones (neral/geranial, citronellal, isomenthone, and menthone) and mono- and sesquiterpene hydrocarbons (E-caryophyllene). Very strong inhibition of LP, particularly in the Fe2+/H2O2 system of induction (94.59% for 2.13 mug/mL), was observed in both cases, also in a dose-dependent manner. The most effective antibacterial activity was expressed on a multiresistant strain of Shigella sonei. A significant rate of antifungal activity was exhibited on Trichophyton species.
T2  - Journal of Agricultural and Food Chemistry
T1  - Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil
IS  - 9
VL  - 52
EP  - 2489
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1734
ER  - 

@article{
author = "Mimica-Dukić, Neda M and Bozin, Biljana N and Soković, Marina and Simin, Natasa D",
year = "2004",
abstract = "The present study describes antimicrobial and free radical scavenging capacity (RSC) together with the effects on lipid peroxidation (LP) of Melissa officinalis essential oil. The chemical profile of essential oil was evaluated by the means of gas chromatography-mass spectrometry (GC-MS) and thin-layer chromatography (TLC). RSC was assessed measuring the scavenging activity of essential oil on the 2,2-diphenyl-1-picrylhydrazyl (DPPH.) and OH. radicals. The effect on LP was evaluated following the activities on Fe2+/ascorbate and Fe2+/H2O2 systems of induction, The antimicrobial activity was tested against 13 bacterial strains and six fungi. The examined essential oil exhibited very strong RSC, reducing the DPPH radical formation (IC50 = 7.58 mug/mL) and OH radical generation (IC50 = 1.74 mug/mL) in a dose-dependent manner. According to the GC-MS and TLC (dot-blot techniques), the most powerful scavenging compounds were monoterpene aldehydes and ketones (neral/geranial, citronellal, isomenthone, and menthone) and mono- and sesquiterpene hydrocarbons (E-caryophyllene). Very strong inhibition of LP, particularly in the Fe2+/H2O2 system of induction (94.59% for 2.13 mug/mL), was observed in both cases, also in a dose-dependent manner. The most effective antibacterial activity was expressed on a multiresistant strain of Shigella sonei. A significant rate of antifungal activity was exhibited on Trichophyton species.",
journal = "Journal of Agricultural and Food Chemistry",
title = "Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil",
number = "9",
volume = "52",
pages = "2489",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1734"
}

Mimica-Dukić, N. M., Bozin, B. N., Soković, M.,& Simin, N. D.. (2004). Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. in Journal of Agricultural and Food Chemistry, 52(9).
https://hdl.handle.net/21.15107/rcub_ibiss_1734

Mimica-Dukić NM, Bozin BN, Soković M, Simin ND. Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. in Journal of Agricultural and Food Chemistry. 2004;52(9):null-2489.
https://hdl.handle.net/21.15107/rcub_ibiss_1734 .

Mimica-Dukić, Neda M, Bozin, Biljana N, Soković, Marina, Simin, Natasa D, "Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil" in Journal of Agricultural and Food Chemistry, 52, no. 9 (2004),
https://hdl.handle.net/21.15107/rcub_ibiss_1734 .

TY  - JOUR
AU  - Mimica-Dukić, Neda M
AU  - Bozin, Biljana N
AU  - Soković, Marina
AU  - Mihajlović, B
AU  - Matavulj, Milan N
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1767
AB  - The present study describes the antimicrobial activity and free radical scavenging capacity (RSC) of essential oils from Mentha aquatica L., Mentha longifolia L., and Mentha piperita L. The chemical profile of each essential oil was determined by GC-MS and TLC. All essential oils exhibited very strong antibacterial activity, in particularly against Esherichia coli strains. The most powerful was M. piperita essential oil, especially towards multiresistant strain of Shigella sonei and Micrococcus flavus ATTC 10240. All tested oils showed significant fungistatic and fungicidal activity [expressed as minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values, respectively], that were considerably higher than those of the commercial fungicide bifonazole. The essential oils of M. piperita and M. longifolia were found to be more active than the essential oil of M. aquatica. Especially low MIC (4 muL/mL) and MFC (4 muL/mL) were found with M. piperita oil against Trichophyton tonsurans and Candida albicans (both 8 muL/mL). The RSC was evaluated by measuring the scavenging activity of the essential oils on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals. All examined essential oils were able to reduce DPPH radicals into the neutral DPPH-H form, and this activity was dose-dependent. However, only the M. piperita oil reduced DPPH to 50% (IC50 = 2.53 mug/mL). The M. piperita essential oil also exhibited the highest OH radical scavenging activity, reducing OH radical generation in the Fenton reaction by 24% (pure oil). According to GC-MS and TLC (dot-blot techniques), the most powerful scavenging compounds were monoterpene ketones (menthone and isomenthone) in the essential oils of M. longifolia and M. piperita and 1,8-cineole in the oil of M. aquatica.
T2  - Planta Medica
T1  - Antimicrobial and antioxidant activities of three Mentha species essential oils
IS  - 5
VL  - 69
DO  - 10.1055/s-2003-39704
EP  - 419
ER  - 

@article{
author = "Mimica-Dukić, Neda M and Bozin, Biljana N and Soković, Marina and Mihajlović, B and Matavulj, Milan N",
year = "2003",
abstract = "The present study describes the antimicrobial activity and free radical scavenging capacity (RSC) of essential oils from Mentha aquatica L., Mentha longifolia L., and Mentha piperita L. The chemical profile of each essential oil was determined by GC-MS and TLC. All essential oils exhibited very strong antibacterial activity, in particularly against Esherichia coli strains. The most powerful was M. piperita essential oil, especially towards multiresistant strain of Shigella sonei and Micrococcus flavus ATTC 10240. All tested oils showed significant fungistatic and fungicidal activity [expressed as minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values, respectively], that were considerably higher than those of the commercial fungicide bifonazole. The essential oils of M. piperita and M. longifolia were found to be more active than the essential oil of M. aquatica. Especially low MIC (4 muL/mL) and MFC (4 muL/mL) were found with M. piperita oil against Trichophyton tonsurans and Candida albicans (both 8 muL/mL). The RSC was evaluated by measuring the scavenging activity of the essential oils on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals. All examined essential oils were able to reduce DPPH radicals into the neutral DPPH-H form, and this activity was dose-dependent. However, only the M. piperita oil reduced DPPH to 50% (IC50 = 2.53 mug/mL). The M. piperita essential oil also exhibited the highest OH radical scavenging activity, reducing OH radical generation in the Fenton reaction by 24% (pure oil). According to GC-MS and TLC (dot-blot techniques), the most powerful scavenging compounds were monoterpene ketones (menthone and isomenthone) in the essential oils of M. longifolia and M. piperita and 1,8-cineole in the oil of M. aquatica.",
journal = "Planta Medica",
title = "Antimicrobial and antioxidant activities of three Mentha species essential oils",
number = "5",
volume = "69",
doi = "10.1055/s-2003-39704",
pages = "419"
}

Mimica-Dukić, N. M., Bozin, B. N., Soković, M., Mihajlović, B.,& Matavulj, M. N.. (2003). Antimicrobial and antioxidant activities of three Mentha species essential oils. in Planta Medica, 69(5).
https://doi.org/10.1055/s-2003-39704

Mimica-Dukić NM, Bozin BN, Soković M, Mihajlović B, Matavulj MN. Antimicrobial and antioxidant activities of three Mentha species essential oils. in Planta Medica. 2003;69(5):null-419.
doi:10.1055/s-2003-39704 .

Mimica-Dukić, Neda M, Bozin, Biljana N, Soković, Marina, Mihajlović, B, Matavulj, Milan N, "Antimicrobial and antioxidant activities of three Mentha species essential oils" in Planta Medica, 69, no. 5 (2003),
https://doi.org/10.1055/s-2003-39704 . .

TY  - JOUR
AU  - Mimica-Dukić, Neda M
AU  - Kujundžić, S
AU  - Soković, Marina
AU  - Couladis, M
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1771
AB  - The influence of different hydrodistillation conditions was evaluated from the standpoint of essential oil yield, chemical composition and antifungal activity from seeds of Foeniculum vulgare Mill. Three hydrodistillation conditions were considered. The main constituents of the oils were: (E)-anethole (72.27%-74.18%), fenchone (11.32%-16.35%) and methyl chavicol (3.78%-5.29%). The method of distillation significantly effected the essential oil yield and quantitative composition, although the antifungal activity of the oils against some fungi was only slightly altered. Copyright (C) 2003 John Wiley Sons, Ltd.
T2  - Phytotherapy Research
T1  - Essential oil composition and antifungal activity of Foeniculum vulgare Mill. obtained by different distillation conditions
IS  - 4
VL  - 17
EP  - 371
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1771
ER  - 

@article{
author = "Mimica-Dukić, Neda M and Kujundžić, S and Soković, Marina and Couladis, M",
year = "2003",
abstract = "The influence of different hydrodistillation conditions was evaluated from the standpoint of essential oil yield, chemical composition and antifungal activity from seeds of Foeniculum vulgare Mill. Three hydrodistillation conditions were considered. The main constituents of the oils were: (E)-anethole (72.27%-74.18%), fenchone (11.32%-16.35%) and methyl chavicol (3.78%-5.29%). The method of distillation significantly effected the essential oil yield and quantitative composition, although the antifungal activity of the oils against some fungi was only slightly altered. Copyright (C) 2003 John Wiley Sons, Ltd.",
journal = "Phytotherapy Research",
title = "Essential oil composition and antifungal activity of Foeniculum vulgare Mill. obtained by different distillation conditions",
number = "4",
volume = "17",
pages = "371",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1771"
}

Mimica-Dukić, N. M., Kujundžić, S., Soković, M.,& Couladis, M.. (2003). Essential oil composition and antifungal activity of Foeniculum vulgare Mill. obtained by different distillation conditions. in Phytotherapy Research, 17(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1771

Mimica-Dukić NM, Kujundžić S, Soković M, Couladis M. Essential oil composition and antifungal activity of Foeniculum vulgare Mill. obtained by different distillation conditions. in Phytotherapy Research. 2003;17(4):null-371.
https://hdl.handle.net/21.15107/rcub_ibiss_1771 .

Mimica-Dukić, Neda M, Kujundžić, S, Soković, Marina, Couladis, M, "Essential oil composition and antifungal activity of Foeniculum vulgare Mill. obtained by different distillation conditions" in Phytotherapy Research, 17, no. 4 (2003),
https://hdl.handle.net/21.15107/rcub_ibiss_1771 .