TY  - CONF
AU  - Brkić, Predrag D
AU  - Jovanović, Tomislav S
AU  - Krstić, Danijela Z
AU  - Stojiljković, Mirjana B
AU  - Colović, Mirjana B
AU  - Dačić, Sanja
AU  - Mitrović, Ana
AU  - Bjelobaba, Ivana
AU  - Savić, Danijela
AU  - Parbucki, Ana
AU  - Lavrnja, Irena
AU  - Rakić, Ljubisav
AU  - Peković, Sanja
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1188
C3  - Brain Injury
T1  - Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury
IS  - 4-5
VL  - 26
EP  - 487
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1188
ER  - 

@conference{
author = "Brkić, Predrag D and Jovanović, Tomislav S and Krstić, Danijela Z and Stojiljković, Mirjana B and Colović, Mirjana B and Dačić, Sanja and Mitrović, Ana and Bjelobaba, Ivana and Savić, Danijela and Parbucki, Ana and Lavrnja, Irena and Rakić, Ljubisav and Peković, Sanja",
year = "2012",
journal = "Brain Injury",
title = "Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury",
number = "4-5",
volume = "26",
pages = "487",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1188"
}

Brkić, P. D., Jovanović, T. S., Krstić, D. Z., Stojiljković, M. B., Colović, M. B., Dačić, S., Mitrović, A., Bjelobaba, I., Savić, D., Parbucki, A., Lavrnja, I., Rakić, L.,& Peković, S.. (2012). Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury. in Brain Injury, 26(4-5).
https://hdl.handle.net/21.15107/rcub_ibiss_1188

Brkić PD, Jovanović TS, Krstić DZ, Stojiljković MB, Colović MB, Dačić S, Mitrović A, Bjelobaba I, Savić D, Parbucki A, Lavrnja I, Rakić L, Peković S. Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury. in Brain Injury. 2012;26(4-5):null-487.
https://hdl.handle.net/21.15107/rcub_ibiss_1188 .

Brkić, Predrag D, Jovanović, Tomislav S, Krstić, Danijela Z, Stojiljković, Mirjana B, Colović, Mirjana B, Dačić, Sanja, Mitrović, Ana, Bjelobaba, Ivana, Savić, Danijela, Parbucki, Ana, Lavrnja, Irena, Rakić, Ljubisav, Peković, Sanja, "Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury" in Brain Injury, 26, no. 4-5 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1188 .

TY  - JOUR
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Bjelobaba, Ivana
AU  - Dačić, Sanja
AU  - Božić, Iva D.
AU  - Parabučki, Ana B.
AU  - Nedeljković, Nadezda N
AU  - Peković, Sanja
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana B
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1167
AB  - Experimental autoimmune encephalomyelitis (EAE) is an animal model of CNS inflammatory and demyelinating disease multiple sclerosis. Microglia and astrocytes represent two related cell types involved in the brain pathology in EAE. Accumulations of hypertrophic reactive astrocytes, intensely stained with glial fibrillary acidic protein (GFAP), which also expressed vimentin, are prominent features of EAE lesions. Recent studies from our laboratory reported that ribavirin attenuated the disease process in EAE by reducing clinical and histological manifestations. EAE was induced in genetically susceptible Dark Agouti rats with syngeneic spinal cord homogenate in complete Freund's adjuvant. Real time PCR and immunohistochemistry were used for determination of GFAP and vimentin gene and tissue expression. We have observed the increased gene and tissue expression of GFAP and vimentin in EAE rats. Ribavirin treatment significantly decreased the number of reactive astrocytes at the peak of disease. At the end of the disease, we have observed reactive GFAP(+) and vimentin(+) astrocytes in both immunized and ribavirin-treated groups, accompanied by increased level of GFAP mRNA. The present study indicates that ribavirin may have the ability to attenuate astrocyte proliferation and glial scaring at the peak of the disease and modulate the astroglial response to EAE during the time-course of the disease.
T2  - Journal of Pharmacological Sciences
T1  - The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis
IS  - 3
VL  - 119
EP  - 232
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1167
ER  - 

@article{
author = "Lavrnja, Irena and Savić, Danijela and Bjelobaba, Ivana and Dačić, Sanja and Božić, Iva D. and Parabučki, Ana B. and Nedeljković, Nadezda N and Peković, Sanja and Rakić, Ljubisav and Stojiljković, Mirjana B",
year = "2012",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is an animal model of CNS inflammatory and demyelinating disease multiple sclerosis. Microglia and astrocytes represent two related cell types involved in the brain pathology in EAE. Accumulations of hypertrophic reactive astrocytes, intensely stained with glial fibrillary acidic protein (GFAP), which also expressed vimentin, are prominent features of EAE lesions. Recent studies from our laboratory reported that ribavirin attenuated the disease process in EAE by reducing clinical and histological manifestations. EAE was induced in genetically susceptible Dark Agouti rats with syngeneic spinal cord homogenate in complete Freund's adjuvant. Real time PCR and immunohistochemistry were used for determination of GFAP and vimentin gene and tissue expression. We have observed the increased gene and tissue expression of GFAP and vimentin in EAE rats. Ribavirin treatment significantly decreased the number of reactive astrocytes at the peak of disease. At the end of the disease, we have observed reactive GFAP(+) and vimentin(+) astrocytes in both immunized and ribavirin-treated groups, accompanied by increased level of GFAP mRNA. The present study indicates that ribavirin may have the ability to attenuate astrocyte proliferation and glial scaring at the peak of the disease and modulate the astroglial response to EAE during the time-course of the disease.",
journal = "Journal of Pharmacological Sciences",
title = "The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis",
number = "3",
volume = "119",
pages = "232",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1167"
}

Lavrnja, I., Savić, D., Bjelobaba, I., Dačić, S., Božić, I. D., Parabučki, A. B., Nedeljković, N. N., Peković, S., Rakić, L.,& Stojiljković, M. B.. (2012). The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis. in Journal of Pharmacological Sciences, 119(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1167

Lavrnja I, Savić D, Bjelobaba I, Dačić S, Božić ID, Parabučki AB, Nedeljković NN, Peković S, Rakić L, Stojiljković MB. The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis. in Journal of Pharmacological Sciences. 2012;119(3):null-232.
https://hdl.handle.net/21.15107/rcub_ibiss_1167 .

Lavrnja, Irena, Savić, Danijela, Bjelobaba, Ivana, Dačić, Sanja, Božić, Iva D., Parabučki, Ana B., Nedeljković, Nadezda N, Peković, Sanja, Rakić, Ljubisav, Stojiljković, Mirjana B, "The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis" in Journal of Pharmacological Sciences, 119, no. 3 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1167 .

TY  - JOUR
AU  - Brkić, Predrag D
AU  - Stojiljković, Mirjana B
AU  - Jovanović, Tomislav S
AU  - Dačić, Sanja
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Parabučki, Ana B.
AU  - Bjelobaba, Ivana
AU  - Rakić, Ljubisav
AU  - Peković, Sanja
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1146
AB  - Objective: To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex. Methods: The experimental paradigm implies the following groups: Control animals (C), Control+HBO (CHBO), Sham controls (S), Sham control+HBO (SHBO), Lesion group (L), right sensorimotor cortex was removed by suction, Lesion+HBO (LHBO). Hyperbaric protocol: pressure applied 2.5 atmospheres absolute, for 60 minutes, once a day for 10 days. A beam walking test and grip strength meter were used to evaluate the recovery of motor functions. Expression profiles of growth-associated protein 43 (GAP43) and synaptophysin (SYP) were detected using immunohistochemistry. Results: The LHBO group achieved statistically superior scores in the beam walking test compared to the L group. Additionally, the recovery of muscle strength of the affected hindpaw was significantly enhanced after HBO treatment. Hyperbaric oxygenation induced over-expression of GAP43 and SYP in the neurons surrounding the lesion site. Conclusions: Data presented suggest that hyperbaric oxygen therapy can intensify neuroplastic responses by promoting axonal sprouting and synapse remodelling, which contributes to the recovery of locomotor performances in rats. This provides the perspective for implementation of HBO in clinical strategies for treating traumatic brain injuries.
T2  - Brain Injury
T1  - Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats
IS  - 10
VL  - 26
SP  - 961
EP  - 1284
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1146
ER  - 

@article{
author = "Brkić, Predrag D and Stojiljković, Mirjana B and Jovanović, Tomislav S and Dačić, Sanja and Lavrnja, Irena and Savić, Danijela and Parabučki, Ana B. and Bjelobaba, Ivana and Rakić, Ljubisav and Peković, Sanja",
year = "2012",
abstract = "Objective: To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex. Methods: The experimental paradigm implies the following groups: Control animals (C), Control+HBO (CHBO), Sham controls (S), Sham control+HBO (SHBO), Lesion group (L), right sensorimotor cortex was removed by suction, Lesion+HBO (LHBO). Hyperbaric protocol: pressure applied 2.5 atmospheres absolute, for 60 minutes, once a day for 10 days. A beam walking test and grip strength meter were used to evaluate the recovery of motor functions. Expression profiles of growth-associated protein 43 (GAP43) and synaptophysin (SYP) were detected using immunohistochemistry. Results: The LHBO group achieved statistically superior scores in the beam walking test compared to the L group. Additionally, the recovery of muscle strength of the affected hindpaw was significantly enhanced after HBO treatment. Hyperbaric oxygenation induced over-expression of GAP43 and SYP in the neurons surrounding the lesion site. Conclusions: Data presented suggest that hyperbaric oxygen therapy can intensify neuroplastic responses by promoting axonal sprouting and synapse remodelling, which contributes to the recovery of locomotor performances in rats. This provides the perspective for implementation of HBO in clinical strategies for treating traumatic brain injuries.",
journal = "Brain Injury",
title = "Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats",
number = "10",
volume = "26",
pages = "961-1284",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1146"
}

Brkić, P. D., Stojiljković, M. B., Jovanović, T. S., Dačić, S., Lavrnja, I., Savić, D., Parabučki, A. B., Bjelobaba, I., Rakić, L.,& Peković, S.. (2012). Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats. in Brain Injury, 26(10), 961-1284.
https://hdl.handle.net/21.15107/rcub_ibiss_1146

Brkić PD, Stojiljković MB, Jovanović TS, Dačić S, Lavrnja I, Savić D, Parabučki AB, Bjelobaba I, Rakić L, Peković S. Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats. in Brain Injury. 2012;26(10):961-1284.
https://hdl.handle.net/21.15107/rcub_ibiss_1146 .

Brkić, Predrag D, Stojiljković, Mirjana B, Jovanović, Tomislav S, Dačić, Sanja, Lavrnja, Irena, Savić, Danijela, Parabučki, Ana B., Bjelobaba, Ivana, Rakić, Ljubisav, Peković, Sanja, "Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats" in Brain Injury, 26, no. 10 (2012):961-1284,
https://hdl.handle.net/21.15107/rcub_ibiss_1146 .

TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Parabučki, Ana B.
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Dačić, Sanja
AU  - Peković, Sanja
AU  - Rakić, Ljubisa M
AU  - Stojiljković, Mirjana B
AU  - Nedeljković, Nadezda N
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1289
AB  - Traumatic injury induces massive release of ATP in the extracellular space, where it influences numerous aspects of neuronal, astrocytic, and microglial responses to injury by activating P2X and P2Y receptors. The extracellular ATP actions are controlled by the ectonucleotidase enzyme pathway, which hydrolyses ATP to adenosine at all neuronal and nonneuronal cell types. Adenosine activates its P1 receptors, which have important neuroprotective roles. The rate-limiting enzyme in the ectonucleotidase pathway is ecto-5 '-nucleotidase (e-5NT), which catalyzes the final step of dephosphorylation of AMP to adenosine. The aim of the present study was to characterize the expression pattern and cellular distribution of e-5NT in the perilesioned cortex at 4 hr and 1, 2, 7, and 15 days after unilateral cortical stab injury (CSI). Immunoblot and immunohistochemical studies showed that overall e-5NT expression was lower 4 hr and 1 day postinjury and then gradually increased above the control levels. Double-immunofluorescence studies further showed in control tissue the presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes. CSI caused a rapid (after 4 hr) and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression. This was accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for up-regulation of the enzyme levels in the injured area. Thus, CSI induced dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after CSI. (C) 2011 Wiley-Liss, Inc.
T2  - Journal of Neuroscience Research
T1  - Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury
IS  - 6
VL  - 89
EP  - 873
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1289
ER  - 

@article{
author = "Bjelobaba, Ivana and Parabučki, Ana B. and Lavrnja, Irena and Savić, Danijela and Dačić, Sanja and Peković, Sanja and Rakić, Ljubisa M and Stojiljković, Mirjana B and Nedeljković, Nadezda N",
year = "2011",
abstract = "Traumatic injury induces massive release of ATP in the extracellular space, where it influences numerous aspects of neuronal, astrocytic, and microglial responses to injury by activating P2X and P2Y receptors. The extracellular ATP actions are controlled by the ectonucleotidase enzyme pathway, which hydrolyses ATP to adenosine at all neuronal and nonneuronal cell types. Adenosine activates its P1 receptors, which have important neuroprotective roles. The rate-limiting enzyme in the ectonucleotidase pathway is ecto-5 '-nucleotidase (e-5NT), which catalyzes the final step of dephosphorylation of AMP to adenosine. The aim of the present study was to characterize the expression pattern and cellular distribution of e-5NT in the perilesioned cortex at 4 hr and 1, 2, 7, and 15 days after unilateral cortical stab injury (CSI). Immunoblot and immunohistochemical studies showed that overall e-5NT expression was lower 4 hr and 1 day postinjury and then gradually increased above the control levels. Double-immunofluorescence studies further showed in control tissue the presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes. CSI caused a rapid (after 4 hr) and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression. This was accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for up-regulation of the enzyme levels in the injured area. Thus, CSI induced dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after CSI. (C) 2011 Wiley-Liss, Inc.",
journal = "Journal of Neuroscience Research",
title = "Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury",
number = "6",
volume = "89",
pages = "873",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1289"
}

Bjelobaba, I., Parabučki, A. B., Lavrnja, I., Savić, D., Dačić, S., Peković, S., Rakić, L. M., Stojiljković, M. B.,& Nedeljković, N. N.. (2011). Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury. in Journal of Neuroscience Research, 89(6).
https://hdl.handle.net/21.15107/rcub_ibiss_1289

Bjelobaba I, Parabučki AB, Lavrnja I, Savić D, Dačić S, Peković S, Rakić LM, Stojiljković MB, Nedeljković NN. Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury. in Journal of Neuroscience Research. 2011;89(6):null-873.
https://hdl.handle.net/21.15107/rcub_ibiss_1289 .

Bjelobaba, Ivana, Parabučki, Ana B., Lavrnja, Irena, Savić, Danijela, Dačić, Sanja, Peković, Sanja, Rakić, Ljubisa M, Stojiljković, Mirjana B, Nedeljković, Nadezda N, "Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury" in Journal of Neuroscience Research, 89, no. 6 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1289 .

TY  - CONF
AU  - Dačić, Sanja
AU  - Stojiljković, Mirjana B
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Parabučki, Ana B.
AU  - Božić, Iva D.
AU  - Bjelobaba, Ivana
AU  - Laketa, Danijela
AU  - Nedeljković, Nadezda N
AU  - Rakić, Ljubisa M
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1262
C3  - Glia
T1  - Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation
IS  - null
VL  - 59
EP  - S52
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1262
ER  - 

@conference{
author = "Dačić, Sanja and Stojiljković, Mirjana B and Lavrnja, Irena and Savić, Danijela and Parabučki, Ana B. and Božić, Iva D. and Bjelobaba, Ivana and Laketa, Danijela and Nedeljković, Nadezda N and Rakić, Ljubisa M and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation",
number = "null",
volume = "59",
pages = "S52",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1262"
}

Dačić, S., Stojiljković, M. B., Lavrnja, I., Savić, D., Parabučki, A. B., Božić, I. D., Bjelobaba, I., Laketa, D., Nedeljković, N. N., Rakić, L. M.,& Peković, S.. (2011). Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1262

Dačić S, Stojiljković MB, Lavrnja I, Savić D, Parabučki AB, Božić ID, Bjelobaba I, Laketa D, Nedeljković NN, Rakić LM, Peković S. Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation. in Glia. 2011;59(null):null-S52.
https://hdl.handle.net/21.15107/rcub_ibiss_1262 .

Dačić, Sanja, Stojiljković, Mirjana B, Lavrnja, Irena, Savić, Danijela, Parabučki, Ana B., Božić, Iva D., Bjelobaba, Ivana, Laketa, Danijela, Nedeljković, Nadezda N, Rakić, Ljubisa M, Peković, Sanja, "Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1262 .

TY  - CONF
AU  - Božić, Iva D.
AU  - Gađanski, Ivana
AU  - Lavrnja, Irena
AU  - Parabučki, Ana B.
AU  - Dačić, Sanja
AU  - Bjelobaba, Ivana
AU  - Savić, Danijela
AU  - Rakić, Ljubisa M
AU  - Stojiljković, Mirjana B
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1261
C3  - Glia
T1  - Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury
IS  - null
VL  - 59
EP  - S101
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1261
ER  - 

@conference{
author = "Božić, Iva D. and Gađanski, Ivana and Lavrnja, Irena and Parabučki, Ana B. and Dačić, Sanja and Bjelobaba, Ivana and Savić, Danijela and Rakić, Ljubisa M and Stojiljković, Mirjana B and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury",
number = "null",
volume = "59",
pages = "S101",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1261"
}

Božić, I. D., Gađanski, I., Lavrnja, I., Parabučki, A. B., Dačić, S., Bjelobaba, I., Savić, D., Rakić, L. M., Stojiljković, M. B.,& Peković, S.. (2011). Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1261

Božić ID, Gađanski I, Lavrnja I, Parabučki AB, Dačić S, Bjelobaba I, Savić D, Rakić LM, Stojiljković MB, Peković S. Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury. in Glia. 2011;59(null):null-S101.
https://hdl.handle.net/21.15107/rcub_ibiss_1261 .

Božić, Iva D., Gađanski, Ivana, Lavrnja, Irena, Parabučki, Ana B., Dačić, Sanja, Bjelobaba, Ivana, Savić, Danijela, Rakić, Ljubisa M, Stojiljković, Mirjana B, Peković, Sanja, "Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1261 .

TY  - CONF
AU  - Savić, Danijela
AU  - Stojiljković, Mirjana B
AU  - Lavrnja, Irena
AU  - Parabučki, Ana B.
AU  - Dačić, Sanja
AU  - Bjelobaba, Ivana
AU  - Nedeljković, Nadezda N
AU  - Herdegen, T
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1264
C3  - Glia
T1  - In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation
IS  - null
VL  - 59
EP  - S149
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1264
ER  - 

@conference{
author = "Savić, Danijela and Stojiljković, Mirjana B and Lavrnja, Irena and Parabučki, Ana B. and Dačić, Sanja and Bjelobaba, Ivana and Nedeljković, Nadezda N and Herdegen, T and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation",
number = "null",
volume = "59",
pages = "S149",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1264"
}

Savić, D., Stojiljković, M. B., Lavrnja, I., Parabučki, A. B., Dačić, S., Bjelobaba, I., Nedeljković, N. N., Herdegen, T.,& Peković, S.. (2011). In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1264

Savić D, Stojiljković MB, Lavrnja I, Parabučki AB, Dačić S, Bjelobaba I, Nedeljković NN, Herdegen T, Peković S. In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation. in Glia. 2011;59(null):null-S149.
https://hdl.handle.net/21.15107/rcub_ibiss_1264 .

Savić, Danijela, Stojiljković, Mirjana B, Lavrnja, Irena, Parabučki, Ana B., Dačić, Sanja, Bjelobaba, Ivana, Nedeljković, Nadezda N, Herdegen, T, Peković, Sanja, "In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1264 .

TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Stojiljković, Mirjana B
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Peković, Sanja
AU  - Dačić, Sanja
AU  - Laketa, Danijela
AU  - Rakić, Ljubisav
AU  - Nedeljković, Nadezda N
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1473
AB  - During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering local cellular and biochemical responses to injury. Different models of brain injury reveal that the local increase in adenine nucleotides levels is followed by a compensatory up-regulation of ectonucleotidase enzymes that catalyze sequential hydrolysis of ATP to ADP, AMP and adenosine. However, recent studies imply that changes in adenine nucleotides release may also occur in the areas distant from the site of direct damage. Therefore, in the present study we have used the model of cortical stab injury to analyze extracellular ATP, ADP and AMP hydrolysis in the membrane preparations obtained from the brain regions that were not subjected to direct tissue damage. The brain regions analyzed were contralateral cortex, hippocampus, caudate nucleus, thalamus and hypothalamus. It was evidenced that cortical stab injury induced early widespread decrease in AMP hydrolysis in all brain areas tested, except in the hypothalamus, without changes in ATP hydrolysis. These findings imply that brain injury affects global extracellular adenine nucleotide and nucleoside levels, consequently affecting neuronal function in the regions distant to the primary damage.
T2  - General Physiology and Biophysics
T1  - Regional changes in ectonucleotidase activity after cortical stab injury in rat
IS  - null
VL  - 28
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1473
ER  - 

@article{
author = "Bjelobaba, Ivana and Stojiljković, Mirjana B and Lavrnja, Irena and Savić, Danijela and Peković, Sanja and Dačić, Sanja and Laketa, Danijela and Rakić, Ljubisav and Nedeljković, Nadezda N",
year = "2009",
abstract = "During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering local cellular and biochemical responses to injury. Different models of brain injury reveal that the local increase in adenine nucleotides levels is followed by a compensatory up-regulation of ectonucleotidase enzymes that catalyze sequential hydrolysis of ATP to ADP, AMP and adenosine. However, recent studies imply that changes in adenine nucleotides release may also occur in the areas distant from the site of direct damage. Therefore, in the present study we have used the model of cortical stab injury to analyze extracellular ATP, ADP and AMP hydrolysis in the membrane preparations obtained from the brain regions that were not subjected to direct tissue damage. The brain regions analyzed were contralateral cortex, hippocampus, caudate nucleus, thalamus and hypothalamus. It was evidenced that cortical stab injury induced early widespread decrease in AMP hydrolysis in all brain areas tested, except in the hypothalamus, without changes in ATP hydrolysis. These findings imply that brain injury affects global extracellular adenine nucleotide and nucleoside levels, consequently affecting neuronal function in the regions distant to the primary damage.",
journal = "General Physiology and Biophysics",
title = "Regional changes in ectonucleotidase activity after cortical stab injury in rat",
number = "null",
volume = "28",
pages = "68",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1473"
}

Bjelobaba, I., Stojiljković, M. B., Lavrnja, I., Savić, D., Peković, S., Dačić, S., Laketa, D., Rakić, L.,& Nedeljković, N. N.. (2009). Regional changes in ectonucleotidase activity after cortical stab injury in rat. in General Physiology and Biophysics, 28(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1473

Bjelobaba I, Stojiljković MB, Lavrnja I, Savić D, Peković S, Dačić S, Laketa D, Rakić L, Nedeljković NN. Regional changes in ectonucleotidase activity after cortical stab injury in rat. in General Physiology and Biophysics. 2009;28(null):null-68.
https://hdl.handle.net/21.15107/rcub_ibiss_1473 .

Bjelobaba, Ivana, Stojiljković, Mirjana B, Lavrnja, Irena, Savić, Danijela, Peković, Sanja, Dačić, Sanja, Laketa, Danijela, Rakić, Ljubisav, Nedeljković, Nadezda N, "Regional changes in ectonucleotidase activity after cortical stab injury in rat" in General Physiology and Biophysics, 28, no. null (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1473 .

TY  - JOUR
AU  - Lavrnja, Irena
AU  - Nedeljković, Nadezda N
AU  - Bjelobaba, Ivana
AU  - Savić, Danijela
AU  - Dačić, Sanja
AU  - Peković, Sanja
AU  - Rakić, Ljubisav
AU  - Mostarica-Stojković, Marija B
AU  - Stošić-Grujičić, Stanislava
AU  - Stojiljković, Mirjana B
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1474
AB  - The role of extracellular purines and purinoreceptors in the pathophysiology of different neurological disorders is the focus of rapidly expanding area of research. Ectonucleotidases are the enzymes with multiple roles in extracellular nucleotides metabolism and regulation of nucleotide-based intercellular signaling. The aim of present study was to investigate the changes in the ATP, ADP and AMP hydrolyzing activities after ribavirin treatment in spinal cord during experimental autoimmune encephalomyelitis (EAE). Our results demonstrate that ribavirin itself had no significant effect on ectoenzyme activities, when tested in vitro and in vivo on spinal cord crude membrane preparation of intact animals. We observed significant increase in ATP, ADP and AMP hydrolyzing activity in the spinal cord crude membrane preparation in EAE animals at 15 days post immunization compared to control animals. The increase was registered at 28 days post immunization, as well. At same time points, ribavirin treatment decreased ATP, ADP and AMP hydrolyzing activity compared to EAE animals. In addition, no significant changes 8 days post immunization was observed between EAE-induced and ribavirin- treated EAE animals and these levels were similar to control level. Thus, we suppose that ribavirin-induced alteration in ectonucleotidase activities is rather due to its suppression of inflammation, than to its direct action on ATP, ADP and AMP hydrolysis.
T2  - General Physiology and Biophysics
T1  - Ribavirin administration alters ectonudeotidase activities in experimental autoimmune encephalomyelitis
IS  - null
VL  - 28
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1474
ER  - 

@article{
author = "Lavrnja, Irena and Nedeljković, Nadezda N and Bjelobaba, Ivana and Savić, Danijela and Dačić, Sanja and Peković, Sanja and Rakić, Ljubisav and Mostarica-Stojković, Marija B and Stošić-Grujičić, Stanislava and Stojiljković, Mirjana B",
year = "2009",
abstract = "The role of extracellular purines and purinoreceptors in the pathophysiology of different neurological disorders is the focus of rapidly expanding area of research. Ectonucleotidases are the enzymes with multiple roles in extracellular nucleotides metabolism and regulation of nucleotide-based intercellular signaling. The aim of present study was to investigate the changes in the ATP, ADP and AMP hydrolyzing activities after ribavirin treatment in spinal cord during experimental autoimmune encephalomyelitis (EAE). Our results demonstrate that ribavirin itself had no significant effect on ectoenzyme activities, when tested in vitro and in vivo on spinal cord crude membrane preparation of intact animals. We observed significant increase in ATP, ADP and AMP hydrolyzing activity in the spinal cord crude membrane preparation in EAE animals at 15 days post immunization compared to control animals. The increase was registered at 28 days post immunization, as well. At same time points, ribavirin treatment decreased ATP, ADP and AMP hydrolyzing activity compared to EAE animals. In addition, no significant changes 8 days post immunization was observed between EAE-induced and ribavirin- treated EAE animals and these levels were similar to control level. Thus, we suppose that ribavirin-induced alteration in ectonucleotidase activities is rather due to its suppression of inflammation, than to its direct action on ATP, ADP and AMP hydrolysis.",
journal = "General Physiology and Biophysics",
title = "Ribavirin administration alters ectonudeotidase activities in experimental autoimmune encephalomyelitis",
number = "null",
volume = "28",
pages = "76",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1474"
}

Lavrnja, I., Nedeljković, N. N., Bjelobaba, I., Savić, D., Dačić, S., Peković, S., Rakić, L., Mostarica-Stojković, M. B., Stošić-Grujičić, S.,& Stojiljković, M. B.. (2009). Ribavirin administration alters ectonudeotidase activities in experimental autoimmune encephalomyelitis. in General Physiology and Biophysics, 28(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1474

Lavrnja I, Nedeljković NN, Bjelobaba I, Savić D, Dačić S, Peković S, Rakić L, Mostarica-Stojković MB, Stošić-Grujičić S, Stojiljković MB. Ribavirin administration alters ectonudeotidase activities in experimental autoimmune encephalomyelitis. in General Physiology and Biophysics. 2009;28(null):null-76.
https://hdl.handle.net/21.15107/rcub_ibiss_1474 .

Lavrnja, Irena, Nedeljković, Nadezda N, Bjelobaba, Ivana, Savić, Danijela, Dačić, Sanja, Peković, Sanja, Rakić, Ljubisav, Mostarica-Stojković, Marija B, Stošić-Grujičić, Stanislava, Stojiljković, Mirjana B, "Ribavirin administration alters ectonudeotidase activities in experimental autoimmune encephalomyelitis" in General Physiology and Biophysics, 28, no. null (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1474 .

TY  - JOUR
AU  - Savić, Danijela
AU  - Lavrnja, Irena
AU  - Peković, Sanja
AU  - Dacić, Sanja
AU  - Bjelobaba, Ivana
AU  - Mostarica-Stojković, Marija B
AU  - Stošić-Grujičić, Stanislava
AU  - Jovanović, Saša
AU  - Nedeljković, Nadežda N.
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana B.
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1534
AB  - Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) and the helpful tool in preclinical testing of various substances considered for treatment of this human CNS disease. Ribavirin (R) and tiazofurin (T) are purine nucleoside analogues, with the broad spectrum of anti-viral, anti-tumoral and anti-inflammatory properties. We proposed that combined treatment with RT, administrated during the effector phase of EAE, would attenuate disease severity, both clinically and pathologically. Ribavirin was given daily at a dosage of 30 mg/kg and tiazofurin was given at a dosage of 10 mg/kg every other day for 15 days. We detected amelioration of clinical signs and faster recovery in the RT group compared to the control group. Immunohistochemical analyses revealed that RT treatment decrease the number of T cells, macrophages and microglia. In the controls, we detected reactive type of microglia, while in the RT group we noticed ramified/resting form. Demyelination areas and axonal damage were not recorded in the RT group, in contrast to the control group where multiple areas of demyelination zones and axonal loss were found. RT combination treatment suppresses ongoing EAE, prevents demyelination and axonal loss, and therefore may well be the potential therapy for the treatment of MS. (C) 2007 Elsevier B.V. All rights reserved.
PB  - New York, USA: Springer - Plenum publishers
T2  - Journal of the Neurological Sciences
T1  - Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation
IS  - 1-2
VL  - 267
DO  - 10.1016/j.jns.2007.10.010
SP  - 76
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1534
ER  - 

@article{
author = "Savić, Danijela and Lavrnja, Irena and Peković, Sanja and Dacić, Sanja and Bjelobaba, Ivana and Mostarica-Stojković, Marija B and Stošić-Grujičić, Stanislava and Jovanović, Saša and Nedeljković, Nadežda N. and Rakić, Ljubisav and Stojiljković, Mirjana B.",
year = "2008",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) and the helpful tool in preclinical testing of various substances considered for treatment of this human CNS disease. Ribavirin (R) and tiazofurin (T) are purine nucleoside analogues, with the broad spectrum of anti-viral, anti-tumoral and anti-inflammatory properties. We proposed that combined treatment with RT, administrated during the effector phase of EAE, would attenuate disease severity, both clinically and pathologically. Ribavirin was given daily at a dosage of 30 mg/kg and tiazofurin was given at a dosage of 10 mg/kg every other day for 15 days. We detected amelioration of clinical signs and faster recovery in the RT group compared to the control group. Immunohistochemical analyses revealed that RT treatment decrease the number of T cells, macrophages and microglia. In the controls, we detected reactive type of microglia, while in the RT group we noticed ramified/resting form. Demyelination areas and axonal damage were not recorded in the RT group, in contrast to the control group where multiple areas of demyelination zones and axonal loss were found. RT combination treatment suppresses ongoing EAE, prevents demyelination and axonal loss, and therefore may well be the potential therapy for the treatment of MS. (C) 2007 Elsevier B.V. All rights reserved.",
publisher = "New York, USA: Springer - Plenum publishers",
journal = "Journal of the Neurological Sciences",
title = "Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation",
number = "1-2",
volume = "267",
doi = "10.1016/j.jns.2007.10.010",
pages = "76-85",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1534"
}

Savić, D., Lavrnja, I., Peković, S., Dacić, S., Bjelobaba, I., Mostarica-Stojković, M. B., Stošić-Grujičić, S., Jovanović, S., Nedeljković, N. N., Rakić, L.,& Stojiljković, M. B.. (2008). Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation. in Journal of the Neurological Sciences
New York, USA: Springer - Plenum publishers., 267(1-2), 76-85.
https://doi.org/10.1016/j.jns.2007.10.010
https://hdl.handle.net/21.15107/rcub_ibiss_1534

Savić D, Lavrnja I, Peković S, Dacić S, Bjelobaba I, Mostarica-Stojković MB, Stošić-Grujičić S, Jovanović S, Nedeljković NN, Rakić L, Stojiljković MB. Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation. in Journal of the Neurological Sciences. 2008;267(1-2):76-85.
doi:10.1016/j.jns.2007.10.010
https://hdl.handle.net/21.15107/rcub_ibiss_1534 .

Savić, Danijela, Lavrnja, Irena, Peković, Sanja, Dacić, Sanja, Bjelobaba, Ivana, Mostarica-Stojković, Marija B, Stošić-Grujičić, Stanislava, Jovanović, Saša, Nedeljković, Nadežda N., Rakić, Ljubisav, Stojiljković, Mirjana B., "Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation" in Journal of the Neurological Sciences, 267, no. 1-2 (2008):76-85,
https://doi.org/10.1016/j.jns.2007.10.010 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1534 .

TY  - JOUR
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Bjelobaba, Ivana
AU  - Peković, Sanja
AU  - Dacić, Sanja
AU  - Nedeljković, Nadežda N.
AU  - Mostarica-Stojković, Marija B.
AU  - Stošić-Grujičić, Stanislava
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana B.
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1141
AB  - To determine the mechanism underlying ribavirin induced amelioration of experimental autoimmune encephalomyelitis (EAE), cytokine profiles were evaluated in draining lymph node (DLN) cell culture supernatants and spinal cord obtained from EAE and/or ribavirin-treated EAE Dark Agouti rats. Administration of ribavirin to EAE rats markedly affected the production of pro-inflammatory cytokines IFN-gamma, IL-1 beta and TNF-alpha in DLN and spinal cord, thus shifting the balance towards the anti-inflammatory cytokines IL-10 and TGF-beta. These findings suggest that ribavirin attenuates EAE by limiting cytokine-mediated immunoinflammatory events leading to CNS destruction. The conducted experiments provide rationale for ribavirin to be considered as a candidate drug in the development of new therapeutic strategies for the treatment of autoimmune diseases in humans, such as multiple sclerosis. (c) 2008 Elsevier B.V. All rights reserved.
PB  - Amsterdam, Netherlands: Elsevier
T2  - International Immunopharmacology
T1  - Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production
IS  - 9
VL  - 8
DO  - 10.1016/j.intimp.2008.05.008
SP  - 1282
EP  - 1290
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1141
ER  - 

@article{
author = "Lavrnja, Irena and Savić, Danijela and Bjelobaba, Ivana and Peković, Sanja and Dacić, Sanja and Nedeljković, Nadežda N. and Mostarica-Stojković, Marija B. and Stošić-Grujičić, Stanislava and Rakić, Ljubisav and Stojiljković, Mirjana B.",
year = "2008",
abstract = "To determine the mechanism underlying ribavirin induced amelioration of experimental autoimmune encephalomyelitis (EAE), cytokine profiles were evaluated in draining lymph node (DLN) cell culture supernatants and spinal cord obtained from EAE and/or ribavirin-treated EAE Dark Agouti rats. Administration of ribavirin to EAE rats markedly affected the production of pro-inflammatory cytokines IFN-gamma, IL-1 beta and TNF-alpha in DLN and spinal cord, thus shifting the balance towards the anti-inflammatory cytokines IL-10 and TGF-beta. These findings suggest that ribavirin attenuates EAE by limiting cytokine-mediated immunoinflammatory events leading to CNS destruction. The conducted experiments provide rationale for ribavirin to be considered as a candidate drug in the development of new therapeutic strategies for the treatment of autoimmune diseases in humans, such as multiple sclerosis. (c) 2008 Elsevier B.V. All rights reserved.",
publisher = "Amsterdam, Netherlands: Elsevier",
journal = "International Immunopharmacology",
title = "Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production",
number = "9",
volume = "8",
doi = "10.1016/j.intimp.2008.05.008",
pages = "1282-1290",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1141"
}

Lavrnja, I., Savić, D., Bjelobaba, I., Peković, S., Dacić, S., Nedeljković, N. N., Mostarica-Stojković, M. B., Stošić-Grujičić, S., Rakić, L.,& Stojiljković, M. B.. (2008). Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production. in International Immunopharmacology
Amsterdam, Netherlands: Elsevier., 8(9), 1282-1290.
https://doi.org/10.1016/j.intimp.2008.05.008
https://hdl.handle.net/21.15107/rcub_ibiss_1141

Lavrnja I, Savić D, Bjelobaba I, Peković S, Dacić S, Nedeljković NN, Mostarica-Stojković MB, Stošić-Grujičić S, Rakić L, Stojiljković MB. Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production. in International Immunopharmacology. 2008;8(9):1282-1290.
doi:10.1016/j.intimp.2008.05.008
https://hdl.handle.net/21.15107/rcub_ibiss_1141 .

Lavrnja, Irena, Savić, Danijela, Bjelobaba, Ivana, Peković, Sanja, Dacić, Sanja, Nedeljković, Nadežda N., Mostarica-Stojković, Marija B., Stošić-Grujičić, Stanislava, Rakić, Ljubisav, Stojiljković, Mirjana B., "Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production" in International Immunopharmacology, 8, no. 9 (2008):1282-1290,
https://doi.org/10.1016/j.intimp.2008.05.008 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1141 .

TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Stojiljković, Mirjana B
AU  - Peković, Sanja
AU  - Dacić, Sanja
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Rakić, Ljubisav
AU  - Nedeljković, Nadežda N.
PY  - 2007
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1579
AB  - Distribution of two enzymes involved in the ectonucleotidase enzyme chain, ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and ecto-5'-nucleotidase, was assessed by immunohistochemistry in the rat hippocampus. Obtained results have shown co-expression of the enzymes in the hippocampal region, as well as wide and strikingly similar cellular distribution. Both enzymes were expressed at the surface of pyramidal neurons in the CA1 and CA2 sections, while cells in the CA3 section were faintly stained. The granule cell layer of the dentate gyrus was moderately stained for NTPDase1, as well as for ecto-5'-nucleotidase. Glial association for ecto-5'-nucleotidase was also observed, and fiber tracts were intensively stained for both enzymes. This is the first comparative study of NTPDase1 and ecto-5'-nucleotidase distribution in the rat hippocampus. Obtained results suggest that the broad overlapping distribution of these enzymes in neurons and glial cells reflects the functional importance of ectonucleotidase actions in the nervous system.
PB  - New York, NY: Springer
T2  - Cellular and Molecular Neurobiology
T1  - Immunohistological determination of ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and 5'-nucleotidase in rat hippocampus reveals overlapping distribution
IS  - 6
VL  - 27
DO  - 10.1007/s10571-007-9159-8
SP  - 731
EP  - 743
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1579
ER  - 

@article{
author = "Bjelobaba, Ivana and Stojiljković, Mirjana B and Peković, Sanja and Dacić, Sanja and Lavrnja, Irena and Savić, Danijela and Rakić, Ljubisav and Nedeljković, Nadežda N.",
year = "2007",
abstract = "Distribution of two enzymes involved in the ectonucleotidase enzyme chain, ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and ecto-5'-nucleotidase, was assessed by immunohistochemistry in the rat hippocampus. Obtained results have shown co-expression of the enzymes in the hippocampal region, as well as wide and strikingly similar cellular distribution. Both enzymes were expressed at the surface of pyramidal neurons in the CA1 and CA2 sections, while cells in the CA3 section were faintly stained. The granule cell layer of the dentate gyrus was moderately stained for NTPDase1, as well as for ecto-5'-nucleotidase. Glial association for ecto-5'-nucleotidase was also observed, and fiber tracts were intensively stained for both enzymes. This is the first comparative study of NTPDase1 and ecto-5'-nucleotidase distribution in the rat hippocampus. Obtained results suggest that the broad overlapping distribution of these enzymes in neurons and glial cells reflects the functional importance of ectonucleotidase actions in the nervous system.",
publisher = "New York, NY: Springer",
journal = "Cellular and Molecular Neurobiology",
title = "Immunohistological determination of ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and 5'-nucleotidase in rat hippocampus reveals overlapping distribution",
number = "6",
volume = "27",
doi = "10.1007/s10571-007-9159-8",
pages = "731-743",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1579"
}

Bjelobaba, I., Stojiljković, M. B., Peković, S., Dacić, S., Lavrnja, I., Savić, D., Rakić, L.,& Nedeljković, N. N.. (2007). Immunohistological determination of ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and 5'-nucleotidase in rat hippocampus reveals overlapping distribution. in Cellular and Molecular Neurobiology
New York, NY: Springer., 27(6), 731-743.
https://doi.org/10.1007/s10571-007-9159-8
https://hdl.handle.net/21.15107/rcub_ibiss_1579

Bjelobaba I, Stojiljković MB, Peković S, Dacić S, Lavrnja I, Savić D, Rakić L, Nedeljković NN. Immunohistological determination of ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and 5'-nucleotidase in rat hippocampus reveals overlapping distribution. in Cellular and Molecular Neurobiology. 2007;27(6):731-743.
doi:10.1007/s10571-007-9159-8
https://hdl.handle.net/21.15107/rcub_ibiss_1579 .

Bjelobaba, Ivana, Stojiljković, Mirjana B, Peković, Sanja, Dacić, Sanja, Lavrnja, Irena, Savić, Danijela, Rakić, Ljubisav, Nedeljković, Nadežda N., "Immunohistological determination of ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and 5'-nucleotidase in rat hippocampus reveals overlapping distribution" in Cellular and Molecular Neurobiology, 27, no. 6 (2007):731-743,
https://doi.org/10.1007/s10571-007-9159-8 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1579 .