TY  - JOUR
AU  - Milošević, Verica
AU  - Severs, Walter B
AU  - Ristić, Nataša
AU  - Manojlović-Stojanoski, Milica
AU  - Popovska-Perčinić, Florina V
AU  - Šošić-Jurjević, Branka 
AU  - Pendovski, Lazo B
AU  - Trifunović, Svetlana
AU  - Miler, Marko
AU  - Ajdžanović, Vladimir
PY  - 2018
UR  - http://www.hh.um.es/Abstracts/Vol_/_/__11984.htm
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3103
AB  - Genistein (G) and related soy phytoestrogens have been studied for potential usefulness in different chronic diseases, and may ameliorate signs of aging. They have a profound influence on the hypothalamo-pituitary-adrenal (HPA) axis. The present study utilized the rat model of mild andropause to thoroughly evaluate the effects of G and soy extract on the adrenal gland and related blood hormones. Adult male rats were orchidectomized (Orx) or sham operated (SO). Orx rats received daily subcutaneous injections for 3 weeks of solvent, or G (Orx+G, 30 mg/kg), or commercial soy extract (Orx+Soy, 30 mg/kg). Adrenal glands and blood were harvested at the end of the treatment for hormone analyses, histology and design-based stereology. Compared to SO rats Orx evoked significant (P<0.05) changes including: the replicating cell number in the 3 adrenocortical zones; vascularity and cortical volume and blood levels of adrenocorticotropic hormone (ACTH), aldosterone and dehydroepiandrosterone (DHEA). When comparing Orx vs. Orx+G groups the following significant (P<0.05) changes were observed: a further increase in number of replicating cells in zonas glomerulosa and reticularis, vasculature network presence, cortical and zona reticularis volumes, ACTH and corticosterone concentrations, and lower DHEA levels. Comparing Orx vs. Orx+Soy resulted in elevated (P<0.05) ACTH and corticosterone levels. Structural integrity of the adrenal gland was unchanged vs. SO rats. Overall, G and soy extract treatments resulted in proliferative activity and/or vasculature support in the adrenal cortex. The data and current literature support the impression of a beneficial effect of soy components on the homeostatic response to stress.
T2  - Histology and Histopathology
T1  - Soy isoflavone effects on the adrenal glands of orchidectomized adult male rats: a comprehensive histological and hormonal study.
IS  - 8
VL  - 33
DO  - 10.14670/HH-11-984
SP  - 843
EP  - 857
ER  - 

@article{
author = "Milošević, Verica and Severs, Walter B and Ristić, Nataša and Manojlović-Stojanoski, Milica and Popovska-Perčinić, Florina V and Šošić-Jurjević, Branka  and Pendovski, Lazo B and Trifunović, Svetlana and Miler, Marko and Ajdžanović, Vladimir",
year = "2018",
abstract = "Genistein (G) and related soy phytoestrogens have been studied for potential usefulness in different chronic diseases, and may ameliorate signs of aging. They have a profound influence on the hypothalamo-pituitary-adrenal (HPA) axis. The present study utilized the rat model of mild andropause to thoroughly evaluate the effects of G and soy extract on the adrenal gland and related blood hormones. Adult male rats were orchidectomized (Orx) or sham operated (SO). Orx rats received daily subcutaneous injections for 3 weeks of solvent, or G (Orx+G, 30 mg/kg), or commercial soy extract (Orx+Soy, 30 mg/kg). Adrenal glands and blood were harvested at the end of the treatment for hormone analyses, histology and design-based stereology. Compared to SO rats Orx evoked significant (P<0.05) changes including: the replicating cell number in the 3 adrenocortical zones; vascularity and cortical volume and blood levels of adrenocorticotropic hormone (ACTH), aldosterone and dehydroepiandrosterone (DHEA). When comparing Orx vs. Orx+G groups the following significant (P<0.05) changes were observed: a further increase in number of replicating cells in zonas glomerulosa and reticularis, vasculature network presence, cortical and zona reticularis volumes, ACTH and corticosterone concentrations, and lower DHEA levels. Comparing Orx vs. Orx+Soy resulted in elevated (P<0.05) ACTH and corticosterone levels. Structural integrity of the adrenal gland was unchanged vs. SO rats. Overall, G and soy extract treatments resulted in proliferative activity and/or vasculature support in the adrenal cortex. The data and current literature support the impression of a beneficial effect of soy components on the homeostatic response to stress.",
journal = "Histology and Histopathology",
title = "Soy isoflavone effects on the adrenal glands of orchidectomized adult male rats: a comprehensive histological and hormonal study.",
number = "8",
volume = "33",
doi = "10.14670/HH-11-984",
pages = "843-857"
}

Milošević, V., Severs, W. B., Ristić, N., Manojlović-Stojanoski, M., Popovska-Perčinić, F. V., Šošić-Jurjević, B., Pendovski, L. B., Trifunović, S., Miler, M.,& Ajdžanović, V.. (2018). Soy isoflavone effects on the adrenal glands of orchidectomized adult male rats: a comprehensive histological and hormonal study.. in Histology and Histopathology, 33(8), 843-857.
https://doi.org/10.14670/HH-11-984

Milošević V, Severs WB, Ristić N, Manojlović-Stojanoski M, Popovska-Perčinić FV, Šošić-Jurjević B, Pendovski LB, Trifunović S, Miler M, Ajdžanović V. Soy isoflavone effects on the adrenal glands of orchidectomized adult male rats: a comprehensive histological and hormonal study.. in Histology and Histopathology. 2018;33(8):843-857.
doi:10.14670/HH-11-984 .

Milošević, Verica, Severs, Walter B, Ristić, Nataša, Manojlović-Stojanoski, Milica, Popovska-Perčinić, Florina V, Šošić-Jurjević, Branka , Pendovski, Lazo B, Trifunović, Svetlana, Miler, Marko, Ajdžanović, Vladimir, "Soy isoflavone effects on the adrenal glands of orchidectomized adult male rats: a comprehensive histological and hormonal study." in Histology and Histopathology, 33, no. 8 (2018):843-857,
https://doi.org/10.14670/HH-11-984 . .