TY  - JOUR
AU  - Mihailović, Vladimir
AU  - Mišić, Danijela
AU  - Matić, Sanja
AU  - Mihailović, Mirjana
AU  - Stanić, Snežana
AU  - Vrvić, Miroslav M.
AU  - Katanić, Jelena
AU  - Mladenović, Milan
AU  - Stanković, Nevena
AU  - Boroja, Tatjana
AU  - Stanković, Milan S.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2350
AB  - The purpose of this study was to evaluate the antioxidant potential of
   methanol extracts of Gentiana crudata L. aerial parts and roots, as well
   as the stability of the phenolic compounds and antioxidant capacity of
   extracts during heating, at different pHs and after an in vitro
   digestion procedure. Also, their genotoxicity and antigenotoxicity
   against carbon tetrachloride in the liver of albino Wistar rats using
   the comet assay were evaluated. Three secoiridoid glycosides
   (swertiamarin, gentiopicrin, and sweroside) and four phenolic compounds
   (orientin, vitexin and two isovitexin-glucosides) were identified as the
   major constituents in aerial parts and roots of G. cruciata, using
   UHPLC-DAD/+/- HESI-MS/MS analysis. The results of antioxidant assays
   showed that aerial parts displayed higher antioxidant activity compared
   to the roots, which could be related to higher phenolics content,
   especially flavonoids. In general, extracts showed pH and thermal
   stability, while duodenal condition had more influence on total phenolic
   condition and antioxidant activity of extracts. Both extracts showed a
   protective effect against CCl4 in comet assays. The roots extract showed
   no genotoxic activity, while aerial parts extract showed slight
   genotoxicity at concentrations of 400 mg/kg b.w. (C) 2015 Elsevier B.V.
   All rights reserved.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Comparative phytochemical analysis of Gentiana cruciata L. roots and
 aerial parts, and their biological activities
VL  - 73
DO  - 10.1016/j.indcrop.2015.04.013
SP  - 49
EP  - 62
ER  - 

@article{
author = "Mihailović, Vladimir and Mišić, Danijela and Matić, Sanja and Mihailović, Mirjana and Stanić, Snežana and Vrvić, Miroslav M. and Katanić, Jelena and Mladenović, Milan and Stanković, Nevena and Boroja, Tatjana and Stanković, Milan S.",
year = "2015",
abstract = "The purpose of this study was to evaluate the antioxidant potential of
   methanol extracts of Gentiana crudata L. aerial parts and roots, as well
   as the stability of the phenolic compounds and antioxidant capacity of
   extracts during heating, at different pHs and after an in vitro
   digestion procedure. Also, their genotoxicity and antigenotoxicity
   against carbon tetrachloride in the liver of albino Wistar rats using
   the comet assay were evaluated. Three secoiridoid glycosides
   (swertiamarin, gentiopicrin, and sweroside) and four phenolic compounds
   (orientin, vitexin and two isovitexin-glucosides) were identified as the
   major constituents in aerial parts and roots of G. cruciata, using
   UHPLC-DAD/+/- HESI-MS/MS analysis. The results of antioxidant assays
   showed that aerial parts displayed higher antioxidant activity compared
   to the roots, which could be related to higher phenolics content,
   especially flavonoids. In general, extracts showed pH and thermal
   stability, while duodenal condition had more influence on total phenolic
   condition and antioxidant activity of extracts. Both extracts showed a
   protective effect against CCl4 in comet assays. The roots extract showed
   no genotoxic activity, while aerial parts extract showed slight
   genotoxicity at concentrations of 400 mg/kg b.w. (C) 2015 Elsevier B.V.
   All rights reserved.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Comparative phytochemical analysis of Gentiana cruciata L. roots and
 aerial parts, and their biological activities",
volume = "73",
doi = "10.1016/j.indcrop.2015.04.013",
pages = "49-62"
}

Mihailović, V., Mišić, D., Matić, S., Mihailović, M., Stanić, S., Vrvić, M. M., Katanić, J., Mladenović, M., Stanković, N., Boroja, T.,& Stanković, M. S.. (2015). Comparative phytochemical analysis of Gentiana cruciata L. roots and
 aerial parts, and their biological activities. in Industrial Crops and Products
Elsevier., 73, 49-62.
https://doi.org/10.1016/j.indcrop.2015.04.013

Mihailović V, Mišić D, Matić S, Mihailović M, Stanić S, Vrvić MM, Katanić J, Mladenović M, Stanković N, Boroja T, Stanković MS. Comparative phytochemical analysis of Gentiana cruciata L. roots and
 aerial parts, and their biological activities. in Industrial Crops and Products. 2015;73:49-62.
doi:10.1016/j.indcrop.2015.04.013 .

Mihailović, Vladimir, Mišić, Danijela, Matić, Sanja, Mihailović, Mirjana, Stanić, Snežana, Vrvić, Miroslav M., Katanić, Jelena, Mladenović, Milan, Stanković, Nevena, Boroja, Tatjana, Stanković, Milan S., "Comparative phytochemical analysis of Gentiana cruciata L. roots and
 aerial parts, and their biological activities" in Industrial Crops and Products, 73 (2015):49-62,
https://doi.org/10.1016/j.indcrop.2015.04.013 . .