TY  - CONF
AU  - Guševac Stojanović, Ivana
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Tatalović, Nikola
AU  - Blagojević, Duško
AU  - Martinović, Jelena
AU  - Grković, Ivana
AU  - Mitrović, Nataša
AU  - Zarić, Marina
AU  - Drakulić, Dunja
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5247
AB  - Numerous natural compounds, like progesterone (P4), a sex steroid hormone, are highlighted as promising agents for treatment of different disorders including prolonged disturbance of blood flow. However, its action on several oxidative stress markers (pro/antioxidant balance, products of lipid peroxidation and phosphatidylcholine to lysophosphatidylcholine intensity ratio) and one of the major components of antioxidant system, superoxide dismutase in rat prefrontal cortex (PFC) following permanent bilateral occlusion of common carotid arteries (2VO) is not completely investigated. According to the obtained results, levels of investigated oxidative stress markers and SOD activity were altered in 2VO animals treated with vehicle, while P4 treatment returned them to control values. Overall, presented data indicate that P4 might manifest antioxidative features in PFC of 2VO rats.
PB  - Belgrade: Society of Physical Chemists of Serbia
C3  - Proceeding: 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2021: the Conference is dedicated to the 30th Anniversary of the founding of the Society of Physical Chemists of Serbia and 100th Anniversary of Bray-Liebhafsky reaction. Vol. 1; 2021 Sep 20-24; Belgrade, Serbia
T1  - Cerebral hypoperfusion and progesterone treatment alter parameters of oxidative stress and antioxidant defence in male rats
VL  - 1
SP  - 25
EP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5247
ER  - 

@conference{
author = "Guševac Stojanović, Ivana and Todorović, Ana and Pejić, Snežana and Tatalović, Nikola and Blagojević, Duško and Martinović, Jelena and Grković, Ivana and Mitrović, Nataša and Zarić, Marina and Drakulić, Dunja",
year = "2021",
abstract = "Numerous natural compounds, like progesterone (P4), a sex steroid hormone, are highlighted as promising agents for treatment of different disorders including prolonged disturbance of blood flow. However, its action on several oxidative stress markers (pro/antioxidant balance, products of lipid peroxidation and phosphatidylcholine to lysophosphatidylcholine intensity ratio) and one of the major components of antioxidant system, superoxide dismutase in rat prefrontal cortex (PFC) following permanent bilateral occlusion of common carotid arteries (2VO) is not completely investigated. According to the obtained results, levels of investigated oxidative stress markers and SOD activity were altered in 2VO animals treated with vehicle, while P4 treatment returned them to control values. Overall, presented data indicate that P4 might manifest antioxidative features in PFC of 2VO rats.",
publisher = "Belgrade: Society of Physical Chemists of Serbia",
journal = "Proceeding: 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2021: the Conference is dedicated to the 30th Anniversary of the founding of the Society of Physical Chemists of Serbia and 100th Anniversary of Bray-Liebhafsky reaction. Vol. 1; 2021 Sep 20-24; Belgrade, Serbia",
title = "Cerebral hypoperfusion and progesterone treatment alter parameters of oxidative stress and antioxidant defence in male rats",
volume = "1",
pages = "25-32",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5247"
}

Guševac Stojanović, I., Todorović, A., Pejić, S., Tatalović, N., Blagojević, D., Martinović, J., Grković, I., Mitrović, N., Zarić, M.,& Drakulić, D.. (2021). Cerebral hypoperfusion and progesterone treatment alter parameters of oxidative stress and antioxidant defence in male rats. in Proceeding: 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2021: the Conference is dedicated to the 30th Anniversary of the founding of the Society of Physical Chemists of Serbia and 100th Anniversary of Bray-Liebhafsky reaction. Vol. 1; 2021 Sep 20-24; Belgrade, Serbia
Belgrade: Society of Physical Chemists of Serbia., 1, 25-32.
https://hdl.handle.net/21.15107/rcub_ibiss_5247

Guševac Stojanović I, Todorović A, Pejić S, Tatalović N, Blagojević D, Martinović J, Grković I, Mitrović N, Zarić M, Drakulić D. Cerebral hypoperfusion and progesterone treatment alter parameters of oxidative stress and antioxidant defence in male rats. in Proceeding: 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2021: the Conference is dedicated to the 30th Anniversary of the founding of the Society of Physical Chemists of Serbia and 100th Anniversary of Bray-Liebhafsky reaction. Vol. 1; 2021 Sep 20-24; Belgrade, Serbia. 2021;1:25-32.
https://hdl.handle.net/21.15107/rcub_ibiss_5247 .

Guševac Stojanović, Ivana, Todorović, Ana, Pejić, Snežana, Tatalović, Nikola, Blagojević, Duško, Martinović, Jelena, Grković, Ivana, Mitrović, Nataša, Zarić, Marina, Drakulić, Dunja, "Cerebral hypoperfusion and progesterone treatment alter parameters of oxidative stress and antioxidant defence in male rats" in Proceeding: 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2021: the Conference is dedicated to the 30th Anniversary of the founding of the Society of Physical Chemists of Serbia and 100th Anniversary of Bray-Liebhafsky reaction. Vol. 1; 2021 Sep 20-24; Belgrade, Serbia, 1 (2021):25-32,
https://hdl.handle.net/21.15107/rcub_ibiss_5247 .

TY  - CONF
AU  - Guševac, Ivana
AU  - Tatalović, Nikola
AU  - Zarić, Marina
AU  - Martinović, Jelena
AU  - Mitrović, Nataša
AU  - Blagojević, Duško
AU  - Grković, Ivana
AU  - Drakulić, Dunja
PY  - 2018
UR  - https://forum2018.fens.org/
UR  - https://radar.ibiss.bg.ac.rs/123456789/3897
AB  - Potent neurosteroid progesterone (P4) strongly influences functional recovery in
various models of neurological diseases. However, its protective antioxidative
potential is not well established in stance of chronic cerebral hypoperfusion (CCH)
that induces ischemic milieu in the brain. CCH results in a cascade of events
leading to uncontrolled generation of 4-hydroxynonenal (HNE), a hallmark of
oxidative stress that can be abolished by mitochondrial antioxidant enzyme
manganese superoxide dismutase (MnSOD). Post-ischemic brain regeneration
requires preservation of cerebral blood flow that could be achieved by production of
vasodilatator nitric oxide (NO), synthesized by endothelial NO synthase (eNOS)
whose actions are regulated by phosphorylation at various sites. Decreased
phosphorylation of eNOS at Thr495 during antioxidative response, promotes its
activity and NO production, contributing to neuroprotection. Given the scarcity of
data about P4 antioxidative actions in prefrontal cortex during CCH, current study
assessed the level of HNE and NO, as well as MnSOD activity and the extent of
eNOS phosphorylation at Thr495 in rats subjected to sham operation and injected
with vehicle (commercial flax oil) or animals with permanent occlusion of common
carotid arteries and treated either with vehicle or P4 (1.7 mg/kg/day) for 7 days.
Results indicate that P4 decreases CCH-induced HNE generation and MnSOD
activity, diminishes inactivation of eNOS and increases production of protective NO.
In conclusion, P4 might downscale oxidative stress and boost antioxidant defense
capacity in CCH model, pointing investigated parameters as potential targets of P4
neuroprotective actions. Financially supported by MNTPR RS, grants 173044 and
41014.
PB  - Brussels, Belgium : Federation of European Neurocience Societies
C3  - 11th FENS Forum of Neuroscience
T1  - Progesterone downscales oxidative stress and boosts antioxidant defense capacity in rat model of permanent common carotid artery occlusion
SP  - 1971
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3897
ER  - 

@conference{
author = "Guševac, Ivana and Tatalović, Nikola and Zarić, Marina and Martinović, Jelena and Mitrović, Nataša and Blagojević, Duško and Grković, Ivana and Drakulić, Dunja",
year = "2018",
abstract = "Potent neurosteroid progesterone (P4) strongly influences functional recovery in
various models of neurological diseases. However, its protective antioxidative
potential is not well established in stance of chronic cerebral hypoperfusion (CCH)
that induces ischemic milieu in the brain. CCH results in a cascade of events
leading to uncontrolled generation of 4-hydroxynonenal (HNE), a hallmark of
oxidative stress that can be abolished by mitochondrial antioxidant enzyme
manganese superoxide dismutase (MnSOD). Post-ischemic brain regeneration
requires preservation of cerebral blood flow that could be achieved by production of
vasodilatator nitric oxide (NO), synthesized by endothelial NO synthase (eNOS)
whose actions are regulated by phosphorylation at various sites. Decreased
phosphorylation of eNOS at Thr495 during antioxidative response, promotes its
activity and NO production, contributing to neuroprotection. Given the scarcity of
data about P4 antioxidative actions in prefrontal cortex during CCH, current study
assessed the level of HNE and NO, as well as MnSOD activity and the extent of
eNOS phosphorylation at Thr495 in rats subjected to sham operation and injected
with vehicle (commercial flax oil) or animals with permanent occlusion of common
carotid arteries and treated either with vehicle or P4 (1.7 mg/kg/day) for 7 days.
Results indicate that P4 decreases CCH-induced HNE generation and MnSOD
activity, diminishes inactivation of eNOS and increases production of protective NO.
In conclusion, P4 might downscale oxidative stress and boost antioxidant defense
capacity in CCH model, pointing investigated parameters as potential targets of P4
neuroprotective actions. Financially supported by MNTPR RS, grants 173044 and
41014.",
publisher = "Brussels, Belgium : Federation of European Neurocience Societies",
journal = "11th FENS Forum of Neuroscience",
title = "Progesterone downscales oxidative stress and boosts antioxidant defense capacity in rat model of permanent common carotid artery occlusion",
pages = "1971",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3897"
}

Guševac, I., Tatalović, N., Zarić, M., Martinović, J., Mitrović, N., Blagojević, D., Grković, I.,& Drakulić, D.. (2018). Progesterone downscales oxidative stress and boosts antioxidant defense capacity in rat model of permanent common carotid artery occlusion. in 11th FENS Forum of Neuroscience
Brussels, Belgium : Federation of European Neurocience Societies., 1971.
https://hdl.handle.net/21.15107/rcub_ibiss_3897

Guševac I, Tatalović N, Zarić M, Martinović J, Mitrović N, Blagojević D, Grković I, Drakulić D. Progesterone downscales oxidative stress and boosts antioxidant defense capacity in rat model of permanent common carotid artery occlusion. in 11th FENS Forum of Neuroscience. 2018;:1971.
https://hdl.handle.net/21.15107/rcub_ibiss_3897 .

Guševac, Ivana, Tatalović, Nikola, Zarić, Marina, Martinović, Jelena, Mitrović, Nataša, Blagojević, Duško, Grković, Ivana, Drakulić, Dunja, "Progesterone downscales oxidative stress and boosts antioxidant defense capacity in rat model of permanent common carotid artery occlusion" in 11th FENS Forum of Neuroscience (2018):1971,
https://hdl.handle.net/21.15107/rcub_ibiss_3897 .