TY  - JOUR
AU  - Kulić, Milan
AU  - Drakul, Dragana
AU  - Sokolović, Dragana
AU  - Kordić-Bojinović, Jelena
AU  - Milovanović, Slobodan
AU  - Blagojević, Duško
PY  - 2023
UR  - http://www.acgpubs.org/journal/
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5387
UR  - http://www.acgpubs.org/article/records-of-natural-products/in-press/satureja-montana-l-from-herzegovina-assessment-of-composition-antispasmodic-and-antidiarrheal-effects
AB  - Satureja montana L. (SM) has a long traditional use as a spice and a medicine for various gastrointestinal disorders, including painful spasms and diarrhea. Contrary to conventional drugs, administration of SM and its extracts are considered safe. Previous studies have shown that the essential oils (EOs) of SM from different areas are rich in monoterpenes, sesquiterpenes, diterpens, and phenolic compounds, including flavonoids, tannins, and acids with great composition variability. Determination of composition of EO from Herzegovinian SM done by gas chromatography-flame ionization detection and gas chromatography mass spectrometry (GC-FID and GC/MS, respectively) revealed carvacrol as a primary substance followed by γ-terpinene, p-cymene, and β-caryophyllene. Ex vivo spasmolitic activity caused by EO was evident in different types of isolated rat ileum function with the most potent effect on spontaneous activity followed by electrical field stimulation and KCl-and CaCl2-induced activity. SMEO produced in vivo antidiarreal activity on castor oil-induced diarrhea in young rats and showed the potential to cause a decrese water content in the feces of adult Wistar rats.This study indicates that effects of SM on the intestinum could be mediated through combination of Kv channel activation and Ca channel blockade, but additional mechanisms might be involved. The results of this study corroborate the traditional use of SM as antispasmodic, antidiarrheal, and antisecretory agents.
T2  - Records of Natural Products
T1  - Essential Oil of Satureja montana L. from Herzegovina: Assessment of Composition, Antispasmodic, and Antidiarrheal Effects
IS  - 3
VL  - 17
DO  - 10.25135/rnp.358.2207.2522
SP  - 536
EP  - 548
ER  - 

@article{
author = "Kulić, Milan and Drakul, Dragana and Sokolović, Dragana and Kordić-Bojinović, Jelena and Milovanović, Slobodan and Blagojević, Duško",
year = "2023",
abstract = "Satureja montana L. (SM) has a long traditional use as a spice and a medicine for various gastrointestinal disorders, including painful spasms and diarrhea. Contrary to conventional drugs, administration of SM and its extracts are considered safe. Previous studies have shown that the essential oils (EOs) of SM from different areas are rich in monoterpenes, sesquiterpenes, diterpens, and phenolic compounds, including flavonoids, tannins, and acids with great composition variability. Determination of composition of EO from Herzegovinian SM done by gas chromatography-flame ionization detection and gas chromatography mass spectrometry (GC-FID and GC/MS, respectively) revealed carvacrol as a primary substance followed by γ-terpinene, p-cymene, and β-caryophyllene. Ex vivo spasmolitic activity caused by EO was evident in different types of isolated rat ileum function with the most potent effect on spontaneous activity followed by electrical field stimulation and KCl-and CaCl2-induced activity. SMEO produced in vivo antidiarreal activity on castor oil-induced diarrhea in young rats and showed the potential to cause a decrese water content in the feces of adult Wistar rats.This study indicates that effects of SM on the intestinum could be mediated through combination of Kv channel activation and Ca channel blockade, but additional mechanisms might be involved. The results of this study corroborate the traditional use of SM as antispasmodic, antidiarrheal, and antisecretory agents.",
journal = "Records of Natural Products",
title = "Essential Oil of Satureja montana L. from Herzegovina: Assessment of Composition, Antispasmodic, and Antidiarrheal Effects",
number = "3",
volume = "17",
doi = "10.25135/rnp.358.2207.2522",
pages = "536-548"
}

Kulić, M., Drakul, D., Sokolović, D., Kordić-Bojinović, J., Milovanović, S.,& Blagojević, D.. (2023). Essential Oil of Satureja montana L. from Herzegovina: Assessment of Composition, Antispasmodic, and Antidiarrheal Effects. in Records of Natural Products, 17(3), 536-548.
https://doi.org/10.25135/rnp.358.2207.2522

Kulić M, Drakul D, Sokolović D, Kordić-Bojinović J, Milovanović S, Blagojević D. Essential Oil of Satureja montana L. from Herzegovina: Assessment of Composition, Antispasmodic, and Antidiarrheal Effects. in Records of Natural Products. 2023;17(3):536-548.
doi:10.25135/rnp.358.2207.2522 .

Kulić, Milan, Drakul, Dragana, Sokolović, Dragana, Kordić-Bojinović, Jelena, Milovanović, Slobodan, Blagojević, Duško, "Essential Oil of Satureja montana L. from Herzegovina: Assessment of Composition, Antispasmodic, and Antidiarrheal Effects" in Records of Natural Products, 17, no. 3 (2023):536-548,
https://doi.org/10.25135/rnp.358.2207.2522 . .