TY  - JOUR
AU  - Đurović, Dijana
AU  - Đorđević, Zorica
AU  - Mugoša, Boban
AU  - Bajić, Borko
AU  - Nikolić-Kokić, Aleksandra
AU  - Miletić, Srđan
AU  - Spasić, Snežana
PY  - 2022
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ijgo.14370
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5104
AB  - OBJECTIVE In this study, iodine level in pregnant women of Montenegro and their needs for supplementation were investigated. METHODS A urinary iodine concentration (UIC) study of 326 pregnant women between September and December 2017 in three regions of Montenegro was performed. UIC was related to creatinine (UI/Cr ratio). RESULTS The median UIC (133 ± 5 μg/L) was indicative of iodine deficiency, as the WHO recommended UIC is 150-249 μg/L. The UI/Cr ratio (160 ± 6 μg/g creatinine) was just above the WHO/UNICEF/IGN recommendation. Approximately 50% of the surveyed women had a lower UIC than that recommended. CONCLUSION Iodine deficiency is present in pregnant women in Montenegro. Monitoring the UIC during routine analyses in pregnant women in Montenegro is recommended, along with iodine supplementation for individuals that need it.
PB  - Hoboken: Wiley
T2  - International Journal of Gynecology and Obstetrics
T1  - Half of expectant women in Montenegro show iodine deficiency, indicating that supplementation during pregnancy is necessary.
IS  - 2
VL  - 160
DO  - 10.1002/ijgo.14370
SP  - 691
EP  - 697
ER  - 

@article{
author = "Đurović, Dijana and Đorđević, Zorica and Mugoša, Boban and Bajić, Borko and Nikolić-Kokić, Aleksandra and Miletić, Srđan and Spasić, Snežana",
year = "2022",
abstract = "OBJECTIVE In this study, iodine level in pregnant women of Montenegro and their needs for supplementation were investigated. METHODS A urinary iodine concentration (UIC) study of 326 pregnant women between September and December 2017 in three regions of Montenegro was performed. UIC was related to creatinine (UI/Cr ratio). RESULTS The median UIC (133 ± 5 μg/L) was indicative of iodine deficiency, as the WHO recommended UIC is 150-249 μg/L. The UI/Cr ratio (160 ± 6 μg/g creatinine) was just above the WHO/UNICEF/IGN recommendation. Approximately 50% of the surveyed women had a lower UIC than that recommended. CONCLUSION Iodine deficiency is present in pregnant women in Montenegro. Monitoring the UIC during routine analyses in pregnant women in Montenegro is recommended, along with iodine supplementation for individuals that need it.",
publisher = "Hoboken: Wiley",
journal = "International Journal of Gynecology and Obstetrics",
title = "Half of expectant women in Montenegro show iodine deficiency, indicating that supplementation during pregnancy is necessary.",
number = "2",
volume = "160",
doi = "10.1002/ijgo.14370",
pages = "691-697"
}

Đurović, D., Đorđević, Z., Mugoša, B., Bajić, B., Nikolić-Kokić, A., Miletić, S.,& Spasić, S.. (2022). Half of expectant women in Montenegro show iodine deficiency, indicating that supplementation during pregnancy is necessary.. in International Journal of Gynecology and Obstetrics
Hoboken: Wiley., 160(2), 691-697.
https://doi.org/10.1002/ijgo.14370

Đurović D, Đorđević Z, Mugoša B, Bajić B, Nikolić-Kokić A, Miletić S, Spasić S. Half of expectant women in Montenegro show iodine deficiency, indicating that supplementation during pregnancy is necessary.. in International Journal of Gynecology and Obstetrics. 2022;160(2):691-697.
doi:10.1002/ijgo.14370 .

Đurović, Dijana, Đorđević, Zorica, Mugoša, Boban, Bajić, Borko, Nikolić-Kokić, Aleksandra, Miletić, Srđan, Spasić, Snežana, "Half of expectant women in Montenegro show iodine deficiency, indicating that supplementation during pregnancy is necessary." in International Journal of Gynecology and Obstetrics, 160, no. 2 (2022):691-697,
https://doi.org/10.1002/ijgo.14370 . .

TY  - JOUR
AU  - Spasić, Snežana
AU  - Nikolić-Kokić, Aleksandra
AU  - Miletić, Srđan
AU  - Oreščanin Dušić, Zorana
AU  - Spasić, Mihajlo
AU  - Blagojević, Duško
AU  - Stević, Zorica
PY  - 2020
UR  - https://www.eurekaselect.com/179582/article
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32077821
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3757
AB  - Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting with lipid radicals in the cell. In ALS disease the multiple cell types are involved in devastating loss of motor neurons. Mutations and biochemical changes in various cell types jointly contribute to motor neuron death, disease onset, and disease progression. The overall mechanism of neurodegeneration in ALS is still not completely understood. Dying motor neurons have been reported to exhibit features of apoptosis. However, non-apoptotic features of dying motor neurons have also been reported such as ferroptosis. The role of Edaravone in the prevention of ferroptosis in parallel with other therapeutic approaches to ALS therapy is discussed.
PB  - Bentham Science Publishers Ltd.
T2  - Current Drug Targets
T1  - Edaravone May Prevent Ferroptosis in ALS.
IS  - 8
VL  - 21
DO  - 10.2174/1389450121666200220123305
SP  - 776
EP  - 780
ER  - 

@article{
author = "Spasić, Snežana and Nikolić-Kokić, Aleksandra and Miletić, Srđan and Oreščanin Dušić, Zorana and Spasić, Mihajlo and Blagojević, Duško and Stević, Zorica",
year = "2020",
abstract = "Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting with lipid radicals in the cell. In ALS disease the multiple cell types are involved in devastating loss of motor neurons. Mutations and biochemical changes in various cell types jointly contribute to motor neuron death, disease onset, and disease progression. The overall mechanism of neurodegeneration in ALS is still not completely understood. Dying motor neurons have been reported to exhibit features of apoptosis. However, non-apoptotic features of dying motor neurons have also been reported such as ferroptosis. The role of Edaravone in the prevention of ferroptosis in parallel with other therapeutic approaches to ALS therapy is discussed.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Drug Targets",
title = "Edaravone May Prevent Ferroptosis in ALS.",
number = "8",
volume = "21",
doi = "10.2174/1389450121666200220123305",
pages = "776-780"
}

Spasić, S., Nikolić-Kokić, A., Miletić, S., Oreščanin Dušić, Z., Spasić, M., Blagojević, D.,& Stević, Z.. (2020). Edaravone May Prevent Ferroptosis in ALS.. in Current Drug Targets
Bentham Science Publishers Ltd.., 21(8), 776-780.
https://doi.org/10.2174/1389450121666200220123305

Spasić S, Nikolić-Kokić A, Miletić S, Oreščanin Dušić Z, Spasić M, Blagojević D, Stević Z. Edaravone May Prevent Ferroptosis in ALS.. in Current Drug Targets. 2020;21(8):776-780.
doi:10.2174/1389450121666200220123305 .

Spasić, Snežana, Nikolić-Kokić, Aleksandra, Miletić, Srđan, Oreščanin Dušić, Zorana, Spasić, Mihajlo, Blagojević, Duško, Stević, Zorica, "Edaravone May Prevent Ferroptosis in ALS." in Current Drug Targets, 21, no. 8 (2020):776-780,
https://doi.org/10.2174/1389450121666200220123305 . .

TY  - JOUR
AU  - Milovanović, Slobodan R.
AU  - Oreščanin Dušić, Zorana
AU  - Spasić, Snežana D.
AU  - Miletić, Srđan
AU  - Prostran, Milica Š.
AU  - Spasić, Mihajlo
PY  - 2004
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/548
AB  - In this study themolecular foundation of nitric oxide induced relaxation of arteries, with or without endothelium, of normotensive and spontanously hypertensive ratswas re-examined. With this purpose in mind, the effects of the nitric oxide donor sodium nitroprusside (NaNP), with and without manganese containing superoxide dismutase (MnSOD E.C. 1.15.1.1), on rat renal artery relaxation was strudied. The results show that the relaxation effect of NaNP is two times higher in normotensive, compared to spontaneously hypertensive rats. Similar differences exist in the relaxation effects of NaNP on isolated renal arteries without endothelium, indicating that besides the difference in the function of an endothelium, concerning basal NO production in normotensive and hypertensive rats, there is a differencewith respect to NO relaxation in the smoothmuscle that is induced by hypertension. MnSOD decreased the relaxation effect of NaNP in all the examined renal arteries, more in normotensive than in hypertensive ones regardless of the presence of an endothelium. These results show that MnSOD, by modifying the chemical versatility of NO into redox active forms - nitrosonium (NO+) and nitroxyl (NO-), produces different relaxation effects in normotensive and hypertensive arteries of rats, with or without an endothelium, potentiating the role of nitroxyl induced relaxation in sponteneously hypertensive rats. The results prove the need for the synthesis of complex NO donors, as the mechanisms of artery relaxation are different due to an endothel and smooth mouscle changes in hypertensive, as compared to normotensive rats.
AB  - U ovom radu smo pokušali da detaljnije ispitamo molekulsku osnovu azotoksid indukovane relaksacije arterija, sa i bez endotela, normotenzivnih i spontano hipertenzivnih pacova. U tu svrhu ispitivan je efekat azot-oksid (NO) donora natrijum- nitroprusida (NaNP), bez i u prisustvu superoksid-dismutaze koja sadrži mangan (MnSOD, EC 1.15.1.1) na relaksaciju renalne arterije. Rezulati pokazuju dvostruko veći relaksantni efekat NaNP kod normotenzivnih, u odnosu na spontano hipertenzivne pacove. Slična razlika postoji i u relaksantnom efektu NaNP na izolovane renalne arterije normotenzivnog i hipertenzivnog pacova kada je odstranjen endotel što ukazuje da, pored razlike u funciji endotela u odnosu na bazalnu NO produkciju kod normotenzivnih i spontano hipertenzivnih pacova, postoje i promene u glatkim mišićima indukovane hipertenzijom, u odnosu na NO relaksaciju. MnSOD kod svih grupa smanjuje relaksantni efekat SNP i to više kod normotenzivnih nego kod hipertenzivnih nezavisno od prisustva endotela. Ovi rezultati pokazuju da MnSOD menjajući hemijsku prirodu iz NaNP oslobođenog NO u redoks aktivne forme – nitrozonijum (NO+) i nitroksil (NO–) – ostvaruje različit relaksantni efekat kod normotenzivnih i kod hiperetenzivnih pacova sa i bez endotela potencirajući značaj nitroksilom indukovane relaksacije kod spontano-hipertenzivnih pacova. Dobijeni rezultati potvrđuju potrebu sinteze NO donora koji daju različite redoks-aktivne forme NO budući da se primarni mehanismi relaksacije razlikuju u zavisnosti od karakteristika endotela i glatkih mišića, kod hipertenzije u odnosu na normotenzivno stanje.
T2  - Journal of the Serbian Chemical Society
T1  - Efekat MnSOD (E. coli) Na relaksaciju izolovane renalne arterije pacova izazvanu natrijum-nitro-prusidom
T1  - Effect of MnSOD (E. coli) on the relaxation caused by sodium nitroprusside on isolated rat renal artery
IS  - 11
VL  - 69
SP  - 973
EP  - 980
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_548
ER  - 

@article{
author = "Milovanović, Slobodan R. and Oreščanin Dušić, Zorana and Spasić, Snežana D. and Miletić, Srđan and Prostran, Milica Š. and Spasić, Mihajlo",
year = "2004, 2004",
abstract = "In this study themolecular foundation of nitric oxide induced relaxation of arteries, with or without endothelium, of normotensive and spontanously hypertensive ratswas re-examined. With this purpose in mind, the effects of the nitric oxide donor sodium nitroprusside (NaNP), with and without manganese containing superoxide dismutase (MnSOD E.C. 1.15.1.1), on rat renal artery relaxation was strudied. The results show that the relaxation effect of NaNP is two times higher in normotensive, compared to spontaneously hypertensive rats. Similar differences exist in the relaxation effects of NaNP on isolated renal arteries without endothelium, indicating that besides the difference in the function of an endothelium, concerning basal NO production in normotensive and hypertensive rats, there is a differencewith respect to NO relaxation in the smoothmuscle that is induced by hypertension. MnSOD decreased the relaxation effect of NaNP in all the examined renal arteries, more in normotensive than in hypertensive ones regardless of the presence of an endothelium. These results show that MnSOD, by modifying the chemical versatility of NO into redox active forms - nitrosonium (NO+) and nitroxyl (NO-), produces different relaxation effects in normotensive and hypertensive arteries of rats, with or without an endothelium, potentiating the role of nitroxyl induced relaxation in sponteneously hypertensive rats. The results prove the need for the synthesis of complex NO donors, as the mechanisms of artery relaxation are different due to an endothel and smooth mouscle changes in hypertensive, as compared to normotensive rats., U ovom radu smo pokušali da detaljnije ispitamo molekulsku osnovu azotoksid indukovane relaksacije arterija, sa i bez endotela, normotenzivnih i spontano hipertenzivnih pacova. U tu svrhu ispitivan je efekat azot-oksid (NO) donora natrijum- nitroprusida (NaNP), bez i u prisustvu superoksid-dismutaze koja sadrži mangan (MnSOD, EC 1.15.1.1) na relaksaciju renalne arterije. Rezulati pokazuju dvostruko veći relaksantni efekat NaNP kod normotenzivnih, u odnosu na spontano hipertenzivne pacove. Slična razlika postoji i u relaksantnom efektu NaNP na izolovane renalne arterije normotenzivnog i hipertenzivnog pacova kada je odstranjen endotel što ukazuje da, pored razlike u funciji endotela u odnosu na bazalnu NO produkciju kod normotenzivnih i spontano hipertenzivnih pacova, postoje i promene u glatkim mišićima indukovane hipertenzijom, u odnosu na NO relaksaciju. MnSOD kod svih grupa smanjuje relaksantni efekat SNP i to više kod normotenzivnih nego kod hipertenzivnih nezavisno od prisustva endotela. Ovi rezultati pokazuju da MnSOD menjajući hemijsku prirodu iz NaNP oslobođenog NO u redoks aktivne forme – nitrozonijum (NO+) i nitroksil (NO–) – ostvaruje različit relaksantni efekat kod normotenzivnih i kod hiperetenzivnih pacova sa i bez endotela potencirajući značaj nitroksilom indukovane relaksacije kod spontano-hipertenzivnih pacova. Dobijeni rezultati potvrđuju potrebu sinteze NO donora koji daju različite redoks-aktivne forme NO budući da se primarni mehanismi relaksacije razlikuju u zavisnosti od karakteristika endotela i glatkih mišića, kod hipertenzije u odnosu na normotenzivno stanje.",
journal = "Journal of the Serbian Chemical Society",
title = "Efekat MnSOD (E. coli) Na relaksaciju izolovane renalne arterije pacova izazvanu natrijum-nitro-prusidom, Effect of MnSOD (E. coli) on the relaxation caused by sodium nitroprusside on isolated rat renal artery",
number = "11",
volume = "69",
pages = "973-980",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_548"
}

Milovanović, S. R., Oreščanin Dušić, Z., Spasić, S. D., Miletić, S., Prostran, M. Š.,& Spasić, M.. (2004). Efekat MnSOD (E. coli) Na relaksaciju izolovane renalne arterije pacova izazvanu natrijum-nitro-prusidom. in Journal of the Serbian Chemical Society, 69(11), 973-980.
https://hdl.handle.net/21.15107/rcub_ibiss_548

Milovanović SR, Oreščanin Dušić Z, Spasić SD, Miletić S, Prostran MŠ, Spasić M. Efekat MnSOD (E. coli) Na relaksaciju izolovane renalne arterije pacova izazvanu natrijum-nitro-prusidom. in Journal of the Serbian Chemical Society. 2004;69(11):973-980.
https://hdl.handle.net/21.15107/rcub_ibiss_548 .

Milovanović, Slobodan R., Oreščanin Dušić, Zorana, Spasić, Snežana D., Miletić, Srđan, Prostran, Milica Š., Spasić, Mihajlo, "Efekat MnSOD (E. coli) Na relaksaciju izolovane renalne arterije pacova izazvanu natrijum-nitro-prusidom" in Journal of the Serbian Chemical Society, 69, no. 11 (2004):973-980,
https://hdl.handle.net/21.15107/rcub_ibiss_548 .