TY  - JOUR
AU  - Edeler, David
AU  - Drača, Dijana
AU  - Petković, Vladana
AU  - Natalio, Filipe
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Schmidt, Harry
AU  - Kaluđerović, Goran N.
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0928493118329175?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3302
AB  - Herein appropriateness of nonfunctionalized mesoporous silica nanoparticles SBA-15 and functionalized with (3-chloropropyl)triethoxysilane (→ SBA-15~Cl) and (3-aminopropyl)triethoxysilane (→ SBA-15~NH2) on delivery of physically adsorbed Ph3Sn(CH2)6OH (Sn6) is evaluated. Fluorescent nanomaterial, bearing isatoic moiety, loaded with Sn6 (→ SBA-15~NF|Sn6) was used for cellular uptake study. The fluorescent nanomaterial is efficiently acquired and distributed into the cytoplasm of the cells even after 2 h of cultivation. According to the attained data, all SBA-15 materials loaded with Sn6 diminished cellular viability in dose dependent manner while carriers alone (SBA-15, SBA-15~Cl, SBA-15~NH2) did not show cytotoxicity against B16 cells. According to the MC50 values structural modification of SBA-15 did not improve the efficacy of tested drug. While progressive apoptosis was detected upon the treatment with SBA-15|Sn6, exposure of cells to SBA-15~NH2|Sn6 revealed extinguished apoptosis in time, accompanied with lower caspase activity. This effect is probably due to triggered autophagic process under the treatment with the SBA-15~NH2|Sn6, thus opposed to apoptosis. Presented results suggested that functionalization of SBA-15 was not beneficial for the efficacy of loaded drug, thus, all of them are almost equally efficient considering loaded Sn6 content. Importantly, functionalization of SBA-15 does have an influence on the mode of action and differentiation inducing properties.
T2  - Materials Science and Engineering: C
T1  - Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH
VL  - 100
DO  - 10.1016/J.MSEC.2019.03.010
SP  - 315
EP  - 322
ER  - 

@article{
author = "Edeler, David and Drača, Dijana and Petković, Vladana and Natalio, Filipe and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Schmidt, Harry and Kaluđerović, Goran N.",
year = "2019",
abstract = "Herein appropriateness of nonfunctionalized mesoporous silica nanoparticles SBA-15 and functionalized with (3-chloropropyl)triethoxysilane (→ SBA-15~Cl) and (3-aminopropyl)triethoxysilane (→ SBA-15~NH2) on delivery of physically adsorbed Ph3Sn(CH2)6OH (Sn6) is evaluated. Fluorescent nanomaterial, bearing isatoic moiety, loaded with Sn6 (→ SBA-15~NF|Sn6) was used for cellular uptake study. The fluorescent nanomaterial is efficiently acquired and distributed into the cytoplasm of the cells even after 2 h of cultivation. According to the attained data, all SBA-15 materials loaded with Sn6 diminished cellular viability in dose dependent manner while carriers alone (SBA-15, SBA-15~Cl, SBA-15~NH2) did not show cytotoxicity against B16 cells. According to the MC50 values structural modification of SBA-15 did not improve the efficacy of tested drug. While progressive apoptosis was detected upon the treatment with SBA-15|Sn6, exposure of cells to SBA-15~NH2|Sn6 revealed extinguished apoptosis in time, accompanied with lower caspase activity. This effect is probably due to triggered autophagic process under the treatment with the SBA-15~NH2|Sn6, thus opposed to apoptosis. Presented results suggested that functionalization of SBA-15 was not beneficial for the efficacy of loaded drug, thus, all of them are almost equally efficient considering loaded Sn6 content. Importantly, functionalization of SBA-15 does have an influence on the mode of action and differentiation inducing properties.",
journal = "Materials Science and Engineering: C",
title = "Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH",
volume = "100",
doi = "10.1016/J.MSEC.2019.03.010",
pages = "315-322"
}

Edeler, D., Drača, D., Petković, V., Natalio, F., Maksimović-Ivanić, D., Mijatović, S., Schmidt, H.,& Kaluđerović, G. N.. (2019). Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH. in Materials Science and Engineering: C, 100, 315-322.
https://doi.org/10.1016/J.MSEC.2019.03.010

Edeler D, Drača D, Petković V, Natalio F, Maksimović-Ivanić D, Mijatović S, Schmidt H, Kaluđerović GN. Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH. in Materials Science and Engineering: C. 2019;100:315-322.
doi:10.1016/J.MSEC.2019.03.010 .

Edeler, David, Drača, Dijana, Petković, Vladana, Natalio, Filipe, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Schmidt, Harry, Kaluđerović, Goran N., "Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH" in Materials Science and Engineering: C, 100 (2019):315-322,
https://doi.org/10.1016/J.MSEC.2019.03.010 . .