TY  - JOUR
AU  - Golbidi, Saeid
AU  - Daiber, Andreas
AU  - Korać, Bato
AU  - Li, Huige
AU  - Essop, M. Faadiel
AU  - Laher, Ismail
PY  - 2017
UR  - http://link.springer.com/10.1007/s11892-017-0951-7
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2891
AB  - Purpose of Review: Obesity and obesity-related diseases, largely resulting from urbanization and behavioral changes, are now of global importance. Energy restriction, though, is associated with health improvements and increased longevity. We review some important mechanisms related to calorie limitation aimed at controlling of metabolic diseases, particularly diabetes. Recent Findings: Calorie restriction triggers a complex series of intricate events, including activation of cellular stress response elements, improved autophagy, modification of apoptosis, and alteration in hormonal balance. Intermittent fasting is not only more acceptable to patients, but it also prevents some of the adverse effects of chronic calorie restriction, especially malnutrition. Summary: There are many somatic and potentially psychologic benefits of fasting or intermittent calorie restriction. However, some behavioral modifications related to abstinence of binge eating following a fasting period are crucial in maintaining the desired favorable outcomes.
T2  - Current Diabetes Reports
T1  - Health Benefits of Fasting and Caloric Restriction
IS  - 12
VL  - 17
DO  - 10.1007/s11892-017-0951-7
SP  - 123
EP  - 123
ER  - 

@article{
author = "Golbidi, Saeid and Daiber, Andreas and Korać, Bato and Li, Huige and Essop, M. Faadiel and Laher, Ismail",
year = "2017",
abstract = "Purpose of Review: Obesity and obesity-related diseases, largely resulting from urbanization and behavioral changes, are now of global importance. Energy restriction, though, is associated with health improvements and increased longevity. We review some important mechanisms related to calorie limitation aimed at controlling of metabolic diseases, particularly diabetes. Recent Findings: Calorie restriction triggers a complex series of intricate events, including activation of cellular stress response elements, improved autophagy, modification of apoptosis, and alteration in hormonal balance. Intermittent fasting is not only more acceptable to patients, but it also prevents some of the adverse effects of chronic calorie restriction, especially malnutrition. Summary: There are many somatic and potentially psychologic benefits of fasting or intermittent calorie restriction. However, some behavioral modifications related to abstinence of binge eating following a fasting period are crucial in maintaining the desired favorable outcomes.",
journal = "Current Diabetes Reports",
title = "Health Benefits of Fasting and Caloric Restriction",
number = "12",
volume = "17",
doi = "10.1007/s11892-017-0951-7",
pages = "123-123"
}

Golbidi, S., Daiber, A., Korać, B., Li, H., Essop, M. F.,& Laher, I.. (2017). Health Benefits of Fasting and Caloric Restriction. in Current Diabetes Reports, 17(12), 123-123.
https://doi.org/10.1007/s11892-017-0951-7

Golbidi S, Daiber A, Korać B, Li H, Essop MF, Laher I. Health Benefits of Fasting and Caloric Restriction. in Current Diabetes Reports. 2017;17(12):123-123.
doi:10.1007/s11892-017-0951-7 .

Golbidi, Saeid, Daiber, Andreas, Korać, Bato, Li, Huige, Essop, M. Faadiel, Laher, Ismail, "Health Benefits of Fasting and Caloric Restriction" in Current Diabetes Reports, 17, no. 12 (2017):123-123,
https://doi.org/10.1007/s11892-017-0951-7 . .

TY  - CHAP
AU  - Blagojević, Duško
PY  - 2014
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84949175330&partnerID=tZOtx3y1
UR  - http://link.springer.com/10.1007/978-3-642-30018-9
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2892
AB  - In accidental hypothermia, elevated levels of ROS induce oxidative stress that leads to different degrees of cellular and tissue injury. In controlled hypothermia, a new thermal balance that is instated is regulated by the establishment of the hypothermic steady state characterized by altered ROS generation and an altered free radical balance. During cold periods, ectotherms decrease their metabolic rate, slow down their respiration, and cease physical activity by intrinsic physiological mechanisms. ROS production is decreased but regulated by rearrangements of metabolic redox processes and a restructuring of the cellular antioxidant defense system (ADS). The increased baseline activity of key ADS enzymes, as well as secondary enzymatic defenses and/or increased glutathione levels in preparation for an oxidative stressful situation arising from tissue reoxygenation, seem to be the preferred evolutionary adaptations in ecto- and heterotherms. Hypothermia is also manifested as a behavioral hypothermia response in which ectotherms react to hypoxic stress by opting for cooler environments. The hypometabolic state is the most effective of the available hypoxia defense mechanisms. The molecular mechanisms that regulate the transitions to and from hypometabolic states are highly conserved across phylogenic lines. A number of synergistic adaptations in hibernation might have therapeutic potential for human disease states, such as ischemia-reperfusion injury, traumatic CNS injury, and neurodegenerative diseases. The protective effects of hypothermia on ROS-mediated processes have been shown in several experimental models; however, hypothermia induces autonomous biological changes and acts at different cellular levels that may extend the therapeutic window by reducing free radical production, a key component of hypoxia-ischemia/reperfusion (I/R) injury. Hypothermia has to be combined with a multicomponent supplementary therapy which is dosed and timed to suit the specific cell type and tissue as well as the severity of the injury, but it must not interfere with the obvious benefit of hypothermia on overall ROS-mediated processes.
PB  - Springer Berlin Heidelberg, Berlin, Heidelberg
T2  - Systems Biology of Free Radicals and Antioxidants
T1  - Free radical biology in hypothermia
DO  - 10.1007/978-3-642-30018-9
SP  - 375
EP  - 391
ER  - 

@inbook{
editor = "Laher, Ismail",
author = "Blagojević, Duško",
year = "2014",
abstract = "In accidental hypothermia, elevated levels of ROS induce oxidative stress that leads to different degrees of cellular and tissue injury. In controlled hypothermia, a new thermal balance that is instated is regulated by the establishment of the hypothermic steady state characterized by altered ROS generation and an altered free radical balance. During cold periods, ectotherms decrease their metabolic rate, slow down their respiration, and cease physical activity by intrinsic physiological mechanisms. ROS production is decreased but regulated by rearrangements of metabolic redox processes and a restructuring of the cellular antioxidant defense system (ADS). The increased baseline activity of key ADS enzymes, as well as secondary enzymatic defenses and/or increased glutathione levels in preparation for an oxidative stressful situation arising from tissue reoxygenation, seem to be the preferred evolutionary adaptations in ecto- and heterotherms. Hypothermia is also manifested as a behavioral hypothermia response in which ectotherms react to hypoxic stress by opting for cooler environments. The hypometabolic state is the most effective of the available hypoxia defense mechanisms. The molecular mechanisms that regulate the transitions to and from hypometabolic states are highly conserved across phylogenic lines. A number of synergistic adaptations in hibernation might have therapeutic potential for human disease states, such as ischemia-reperfusion injury, traumatic CNS injury, and neurodegenerative diseases. The protective effects of hypothermia on ROS-mediated processes have been shown in several experimental models; however, hypothermia induces autonomous biological changes and acts at different cellular levels that may extend the therapeutic window by reducing free radical production, a key component of hypoxia-ischemia/reperfusion (I/R) injury. Hypothermia has to be combined with a multicomponent supplementary therapy which is dosed and timed to suit the specific cell type and tissue as well as the severity of the injury, but it must not interfere with the obvious benefit of hypothermia on overall ROS-mediated processes.",
publisher = "Springer Berlin Heidelberg, Berlin, Heidelberg",
journal = "Systems Biology of Free Radicals and Antioxidants",
booktitle = "Free radical biology in hypothermia",
doi = "10.1007/978-3-642-30018-9",
pages = "375-391"
}

Laher, I.,& Blagojević, D.. (2014). Free radical biology in hypothermia. in Systems Biology of Free Radicals and Antioxidants
Springer Berlin Heidelberg, Berlin, Heidelberg., 375-391.
https://doi.org/10.1007/978-3-642-30018-9

Laher I, Blagojević D. Free radical biology in hypothermia. in Systems Biology of Free Radicals and Antioxidants. 2014;:375-391.
doi:10.1007/978-3-642-30018-9 .

Laher, Ismail, Blagojević, Duško, "Free radical biology in hypothermia" in Systems Biology of Free Radicals and Antioxidants (2014):375-391,
https://doi.org/10.1007/978-3-642-30018-9 . .