TY  - CONF
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5834
AB  - MK-801 can mimic the cognitive, negative, psychotic, and physiological features of
schizophrenia, including increased hyperlocomotion and altered behavioral flexibility.
As N-methyl-D-aspartate (NMDA) receptor antagonist, it is widely used to test the
“glutamate hypofunction hypothesis of schizophrenia”. An extremely low-frequency
magnetic field (ELF-MF) can stimulate NMDA receptor activity, but its effect on
dysregulated glutamine transmission is unknown. Therefore, this study addresses the
effect of continuous exposure to ELF-MF (50 Hz, 0.5 mT) for 7 days on rat
psychomotor behavior induced by acute administration of MK-801 (0.25 mg/kg, i.p.).
During the experiment, adult male Wistar rats were placed near the on/off generator of
ELF-MF, injected with MK-801/saline immediately after 7-day sham/ELF-MF
exposure, and subjected to the open field test for 2 hours. Their behavior was analyzed
using the ANY-maze software and expressed as travel distance, time in movement,
and average speed while in motion in 30-min intervals. The results show that (1) acute
administration of 0.25 mg/kg MK-801 significantly increased travel distance and time
in movement from 60 to 120 min and average speed while in motion from 60 to 90
min compared with saline-injected animals; (2) 7-day exposure to ELF-MF had no
significant effect on the behavior of saline- and MK-801-injected animals compared
with the corresponding controls. Therefore, it can be concluded that this regime of
ELF-MF exposure does not affect the psychomotor behavior of rats caused by the
pharmacological modification of glutamine transmission with the applied MK-801
dose.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801
SP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5834
ER  - 

@conference{
author = "Kesić, Srđan and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Petković, Branka",
year = "2023",
abstract = "MK-801 can mimic the cognitive, negative, psychotic, and physiological features of
schizophrenia, including increased hyperlocomotion and altered behavioral flexibility.
As N-methyl-D-aspartate (NMDA) receptor antagonist, it is widely used to test the
“glutamate hypofunction hypothesis of schizophrenia”. An extremely low-frequency
magnetic field (ELF-MF) can stimulate NMDA receptor activity, but its effect on
dysregulated glutamine transmission is unknown. Therefore, this study addresses the
effect of continuous exposure to ELF-MF (50 Hz, 0.5 mT) for 7 days on rat
psychomotor behavior induced by acute administration of MK-801 (0.25 mg/kg, i.p.).
During the experiment, adult male Wistar rats were placed near the on/off generator of
ELF-MF, injected with MK-801/saline immediately after 7-day sham/ELF-MF
exposure, and subjected to the open field test for 2 hours. Their behavior was analyzed
using the ANY-maze software and expressed as travel distance, time in movement,
and average speed while in motion in 30-min intervals. The results show that (1) acute
administration of 0.25 mg/kg MK-801 significantly increased travel distance and time
in movement from 60 to 120 min and average speed while in motion from 60 to 90
min compared with saline-injected animals; (2) 7-day exposure to ELF-MF had no
significant effect on the behavior of saline- and MK-801-injected animals compared
with the corresponding controls. Therefore, it can be concluded that this regime of
ELF-MF exposure does not affect the psychomotor behavior of rats caused by the
pharmacological modification of glutamine transmission with the applied MK-801
dose.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801",
pages = "50",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5834"
}

Kesić, S., Stojadinović, G., Martać, L., Sekulić, S.,& Petković, B.. (2023). Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801. in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 50.
https://hdl.handle.net/21.15107/rcub_ibiss_5834

Kesić S, Stojadinović G, Martać L, Sekulić S, Petković B. Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801. in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:50.
https://hdl.handle.net/21.15107/rcub_ibiss_5834 .

Kesić, Srđan, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Petković, Branka, "Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801" in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):50,
https://hdl.handle.net/21.15107/rcub_ibiss_5834 .

TY  - JOUR
AU  - Podgorac, Jelena
AU  - Sekulić, Slobodan
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Pešić, Vesna
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9557044
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5169
AB  - Clinical findings show that the use of valproic acid (VPA) during pregnancy increases the risk of birth defects and autism spectrum disorder in offspring. Although there is a consensus that monitoring of potential long-term outcomes of VPA exposure is needed, especially in undiagnosed individuals, preclinical studies addressing this issue are rare. The present study examined the effects of continuous intrauterine exposure to a wide dose range of VPA (50, 100, 200, and 400 mg/kg/day) on the physical and behavioral response in peripubertal mice as a rodent model of adolescence. Body weight and the hot plate test [on postnatal days (PND) 25 and 32], the elevated plus-maze test (on PND35), and the open field test (on PND40) served to examine physical growth, the supraspinal reflex response to a painful thermal stimulus and conditional learning, anxiety-like/risk-assessment behavior, as well as novelty-induced psychomotor activity, respectively. VPA exposure produced the following responses: (i) a negative effect on body weight, except for the dose of 100 mg/kg/day in both sexes; (ii) an increase in the percentage of animals that responded to the thermal stimulus above the defined cut-off time interval and the response latency in both sexes; (iii) dose-specific changes within sexes in behavior provoked by a novel anxiogenic environment, i.e., in females less anxiety-like/risk-assessment behavior in response to the lowest exposure dose, and in males more pronounced anxiety-like/risk-assessment behavior after exposure to the highest dose and 100 mg/kg/day; (iv) dose-specific changes within sexes in novelty-induced psychomotor activity, i.e., in females a decrease in stereotypy-like activity along with an increase in rearing, and in males a decrease in stereotypy-like activity only. These findings show that continuous intrauterine exposure to VPA produces maladaptive functioning in different behavioral domains in adolescence and that the consequences are delicate to assess as they are dose-related within sexes.
PB  - Lausanne: Frontiers Media S.A.
T2  - Frontiers in Behavioral Neuroscience
T1  - The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes
VL  - 16
DO  - 10.3389/fnbeh.2022.982811
SP  - 982811
ER  - 

@article{
author = "Podgorac, Jelena and Sekulić, Slobodan and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Pešić, Vesna",
year = "2022",
abstract = "Clinical findings show that the use of valproic acid (VPA) during pregnancy increases the risk of birth defects and autism spectrum disorder in offspring. Although there is a consensus that monitoring of potential long-term outcomes of VPA exposure is needed, especially in undiagnosed individuals, preclinical studies addressing this issue are rare. The present study examined the effects of continuous intrauterine exposure to a wide dose range of VPA (50, 100, 200, and 400 mg/kg/day) on the physical and behavioral response in peripubertal mice as a rodent model of adolescence. Body weight and the hot plate test [on postnatal days (PND) 25 and 32], the elevated plus-maze test (on PND35), and the open field test (on PND40) served to examine physical growth, the supraspinal reflex response to a painful thermal stimulus and conditional learning, anxiety-like/risk-assessment behavior, as well as novelty-induced psychomotor activity, respectively. VPA exposure produced the following responses: (i) a negative effect on body weight, except for the dose of 100 mg/kg/day in both sexes; (ii) an increase in the percentage of animals that responded to the thermal stimulus above the defined cut-off time interval and the response latency in both sexes; (iii) dose-specific changes within sexes in behavior provoked by a novel anxiogenic environment, i.e., in females less anxiety-like/risk-assessment behavior in response to the lowest exposure dose, and in males more pronounced anxiety-like/risk-assessment behavior after exposure to the highest dose and 100 mg/kg/day; (iv) dose-specific changes within sexes in novelty-induced psychomotor activity, i.e., in females a decrease in stereotypy-like activity along with an increase in rearing, and in males a decrease in stereotypy-like activity only. These findings show that continuous intrauterine exposure to VPA produces maladaptive functioning in different behavioral domains in adolescence and that the consequences are delicate to assess as they are dose-related within sexes.",
publisher = "Lausanne: Frontiers Media S.A.",
journal = "Frontiers in Behavioral Neuroscience",
title = "The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes",
volume = "16",
doi = "10.3389/fnbeh.2022.982811",
pages = "982811"
}

Podgorac, J., Sekulić, S., Petković, B., Stojadinović, G., Martać, L.,& Pešić, V.. (2022). The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes. in Frontiers in Behavioral Neuroscience
Lausanne: Frontiers Media S.A.., 16, 982811.
https://doi.org/10.3389/fnbeh.2022.982811

Podgorac J, Sekulić S, Petković B, Stojadinović G, Martać L, Pešić V. The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes. in Frontiers in Behavioral Neuroscience. 2022;16:982811.
doi:10.3389/fnbeh.2022.982811 .

Podgorac, Jelena, Sekulić, Slobodan, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Pešić, Vesna, "The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes" in Frontiers in Behavioral Neuroscience, 16 (2022):982811,
https://doi.org/10.3389/fnbeh.2022.982811 . .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Jakovljević, Branislava
AU  - Korovljev, Darinka
AU  - Simić, Svetlana
AU  - Čapo, Ivan
AU  - Podgorac, Jelena
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Rakić, Srđan
AU  - Petković, Branka
PY  - 2022
UR  - https://www.frontiersin.org/articles/10.3389/fphys.2021.810391/full
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4787
AB  - Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid
in the third trimester of pregnancy and it can be acute and chronic depending on
the duration. Published data suggest that during muscle development, in the stage
of late histochemical differentiation decreased mechanical loading cause decreased
expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the
case of chronic polyhydramnios, histochemical muscle differentiation could be affected
as a consequence of permanent decreased physical loading. Most affected would
be muscles which are the most active i.e., spine extensor muscles and muscles of
legs. Long-lasting decreased mechanical loading on muscle should cause decreased
expression of MHC type 1 leading to slow-to-fast transition, decreased number of
muscle fiber type I especially in extensor muscles of spine and legs. Additionally,
because MHC type 1 is present in all skeletal muscles it could lead to various degrees
of hypotrophy depending on constituting a percentage of MHC type 1 in affected
muscles. These changes in the case of preexisting muscle disorders have the potential
to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic
polyhydramnios is a rare opportunity to study the influence of reduced physical loading
on muscle development in the human fetus. Also, it could be a medical entity to examine
the influence of micro- and hypogravity conditions on the development of the fetal
muscular system during the last trimester of gestation.
PB  - Switzerland: Frontiers Media SA
T2  - Frontiers in Physiology
T1  - Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition
VL  - 12
DO  - 10.3389/fphys.2021.810391
SP  - 810391
ER  - 

@article{
author = "Sekulić, Slobodan and Jakovljević, Branislava and Korovljev, Darinka and Simić, Svetlana and Čapo, Ivan and Podgorac, Jelena and Martać, Ljiljana and Kesić, Srđan and Rakić, Srđan and Petković, Branka",
year = "2022",
abstract = "Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid
in the third trimester of pregnancy and it can be acute and chronic depending on
the duration. Published data suggest that during muscle development, in the stage
of late histochemical differentiation decreased mechanical loading cause decreased
expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the
case of chronic polyhydramnios, histochemical muscle differentiation could be affected
as a consequence of permanent decreased physical loading. Most affected would
be muscles which are the most active i.e., spine extensor muscles and muscles of
legs. Long-lasting decreased mechanical loading on muscle should cause decreased
expression of MHC type 1 leading to slow-to-fast transition, decreased number of
muscle fiber type I especially in extensor muscles of spine and legs. Additionally,
because MHC type 1 is present in all skeletal muscles it could lead to various degrees
of hypotrophy depending on constituting a percentage of MHC type 1 in affected
muscles. These changes in the case of preexisting muscle disorders have the potential
to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic
polyhydramnios is a rare opportunity to study the influence of reduced physical loading
on muscle development in the human fetus. Also, it could be a medical entity to examine
the influence of micro- and hypogravity conditions on the development of the fetal
muscular system during the last trimester of gestation.",
publisher = "Switzerland: Frontiers Media SA",
journal = "Frontiers in Physiology",
title = "Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition",
volume = "12",
doi = "10.3389/fphys.2021.810391",
pages = "810391"
}

Sekulić, S., Jakovljević, B., Korovljev, D., Simić, S., Čapo, I., Podgorac, J., Martać, L., Kesić, S., Rakić, S.,& Petković, B.. (2022). Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition. in Frontiers in Physiology
Switzerland: Frontiers Media SA., 12, 810391.
https://doi.org/10.3389/fphys.2021.810391

Sekulić S, Jakovljević B, Korovljev D, Simić S, Čapo I, Podgorac J, Martać L, Kesić S, Rakić S, Petković B. Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition. in Frontiers in Physiology. 2022;12:810391.
doi:10.3389/fphys.2021.810391 .

Sekulić, Slobodan, Jakovljević, Branislava, Korovljev, Darinka, Simić, Svetlana, Čapo, Ivan, Podgorac, Jelena, Martać, Ljiljana, Kesić, Srđan, Rakić, Srđan, Petković, Branka, "Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition" in Frontiers in Physiology, 12 (2022):810391,
https://doi.org/10.3389/fphys.2021.810391 . .

TY  - CONF
AU  - Nikolić, Ljiljana
AU  - Vidović, Marija
AU  - Todorović, Nataša
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Bogdanović Pristov, Jelena
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5508
AB  - Investigating membrane properties of plants is a challenging task, considering that success of
experiments is highly dependent on the possibility to isolate metabolically active protoplasts that
can withstand membrane current recordings. The aim of the present work is to obtain viable
protoplasts derived from root cells of Pisum sativum that can be used for the whole-cell patchclamp. We designed the procedure of the pea protoplasts isolation that delivers stable protoplasts
with preserved membrane integrity suitable for electrophysiological experiments. We applied a
custom approach for patch-clamping protoplasts using a microscope with a movable microscope
stage. We recorded prominent inward and prominent outward types of membrane current profiles of
protoplasts. Obtained data indicate that optimized isolation protocol and custom system for patchclamping, can be applied to study membrane properties of root protoplasts.
PB  - Belgrade: Society of Physical Chemists of Serbia
C3  - Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
T1  - Protoplast patch-clamping using an upright microscope with a movable stage
SP  - 271
EP  - 274
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5508
ER  - 

@conference{
editor = "Čupić, Željko, Anić, Slobodan",
author = "Nikolić, Ljiljana and Vidović, Marija and Todorović, Nataša and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Bogdanović Pristov, Jelena",
year = "2022",
abstract = "Investigating membrane properties of plants is a challenging task, considering that success of
experiments is highly dependent on the possibility to isolate metabolically active protoplasts that
can withstand membrane current recordings. The aim of the present work is to obtain viable
protoplasts derived from root cells of Pisum sativum that can be used for the whole-cell patchclamp. We designed the procedure of the pea protoplasts isolation that delivers stable protoplasts
with preserved membrane integrity suitable for electrophysiological experiments. We applied a
custom approach for patch-clamping protoplasts using a microscope with a movable microscope
stage. We recorded prominent inward and prominent outward types of membrane current profiles of
protoplasts. Obtained data indicate that optimized isolation protocol and custom system for patchclamping, can be applied to study membrane properties of root protoplasts.",
publisher = "Belgrade: Society of Physical Chemists of Serbia",
journal = "Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia",
title = "Protoplast patch-clamping using an upright microscope with a movable stage",
pages = "271-274",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5508"
}

Čupić, Ž., Anić, S., Nikolić, L., Vidović, M., Todorović, N., Petković, B., Stojadinović, G., Martać, L.,& Bogdanović Pristov, J.. (2022). Protoplast patch-clamping using an upright microscope with a movable stage. in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
Belgrade: Society of Physical Chemists of Serbia., 271-274.
https://hdl.handle.net/21.15107/rcub_ibiss_5508

Čupić Ž, Anić S, Nikolić L, Vidović M, Todorović N, Petković B, Stojadinović G, Martać L, Bogdanović Pristov J. Protoplast patch-clamping using an upright microscope with a movable stage. in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia. 2022;:271-274.
https://hdl.handle.net/21.15107/rcub_ibiss_5508 .

Čupić, Željko, Anić, Slobodan, Nikolić, Ljiljana, Vidović, Marija, Todorović, Nataša, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Bogdanović Pristov, Jelena, "Protoplast patch-clamping using an upright microscope with a movable stage" in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia (2022):271-274,
https://hdl.handle.net/21.15107/rcub_ibiss_5508 .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
AU  - Sekulić, Slobodan
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5745
AB  - Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu.
AB  - Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa
T1  - Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева
SP  - 369
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5745
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Martać, Ljiljana and Stojadinović, Gordana and Pešić, Vesna and Sekulić, Slobodan",
year = "2022",
abstract = "Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu., Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa, Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева",
pages = "369",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5745"
}

Podgorac, J., Petković, B., Martać, L., Stojadinović, G., Pešić, V.,& Sekulić, S.. (2022). Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745

Podgorac J, Petković B, Martać L, Stojadinović G, Pešić V, Sekulić S. Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

Podgorac, Jelena, Petković, Branka, Martać, Ljiljana, Stojadinović, Gordana, Pešić, Vesna, Sekulić, Slobodan, "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):369,
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

TY  - CONF
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5746
AB  - Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije.
AB  - Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina
T1  - Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина
SP  - 388
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5746
ER  - 

@conference{
author = "Kesić, Srđan and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Petković, Branka",
year = "2022",
abstract = "Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije., Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina, Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина",
pages = "388",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5746"
}

Kesić, S., Stojadinović, G., Martać, L., Sekulić, S.,& Petković, B.. (2022). Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746

Kesić S, Stojadinović G, Martać L, Sekulić S, Petković B. Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

Kesić, Srđan, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Petković, Branka, "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):388,
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Pešić, Vesna
PY  - 2022
UR  - https://kenesvm.azureedge.net/public/general/FENS2022.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5734
AB  - Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.
PB  - Federation of European Neuroscience Societies
C3  - E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
T1  - Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam
SP  - S02-173
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5734
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Pešić, Vesna",
year = "2022",
abstract = "Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.",
publisher = "Federation of European Neuroscience Societies",
journal = "E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France",
title = "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam",
pages = "S02-173",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5734"
}

Podgorac, J., Petković, B., Stojadinović, G., Martać, L., Sekulić, S.,& Pešić, V.. (2022). Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
Federation of European Neuroscience Societies., S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734

Podgorac J, Petković B, Stojadinović G, Martać L, Sekulić S, Pešić V. Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France. 2022;:S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

Podgorac, Jelena, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Pešić, Vesna, "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam" in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France (2022):S02-173,
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
PY  - 2022
UR  - https://www.primescholars.com/articles/aluminium-neurotoxicity-and-neuroprotection.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5736
AB  - Aluminium is considered to be the most widely distributed metal in nature and industry and is extensively used in products and processes associated with human activity. Contamination may occur by air, water, food, additives, medicaments, vaccines, cosmetics, agrochemicals, etc. Aluminium is recognized as a highly neurotoxic element in animals and humans connected with several diseases such as Alzheimer’s and Parkinson’s disease, neurodegenerative motor disorders, encephalopathy, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and autism. There are many animal models in rats developed to investigate aluminium neurotoxicity. Nevertheless, molecular mechanisms of its action are not yet resolved, and mechanisms of damage and safety concentrations are still much discussed. The brain is the most susceptible system to damages provoked by aluminium exposure, such as oxidative stress, iron dyshomeostasis, changes in neurotransmission, immunologic alteration and pro-inflammation, genotoxicity, transformation and peptide denaturation, changes in enzyme activity, membrane perturbation, apoptosis, necrosis, and dysplasia. A novel investigation of aluminium neurotoxicity includes the assessment of neuroprotection and the identification of new substances as potential drugs.
PB  - London: Prime Scholars
T2  - Journal of Heavy Metal Toxicity and Diseases
T1  - Aluminium neurotoxicity and neuroprotection
IS  - 4
VL  - 7
DO  - 10.21767/2473-6457.22.7.4.11
SP  - 11
ER  - 

@article{
author = "Martać, Ljiljana and Podgorac, Jelena and Petković, Branka and Stojadinović, Gordana",
year = "2022",
abstract = "Aluminium is considered to be the most widely distributed metal in nature and industry and is extensively used in products and processes associated with human activity. Contamination may occur by air, water, food, additives, medicaments, vaccines, cosmetics, agrochemicals, etc. Aluminium is recognized as a highly neurotoxic element in animals and humans connected with several diseases such as Alzheimer’s and Parkinson’s disease, neurodegenerative motor disorders, encephalopathy, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and autism. There are many animal models in rats developed to investigate aluminium neurotoxicity. Nevertheless, molecular mechanisms of its action are not yet resolved, and mechanisms of damage and safety concentrations are still much discussed. The brain is the most susceptible system to damages provoked by aluminium exposure, such as oxidative stress, iron dyshomeostasis, changes in neurotransmission, immunologic alteration and pro-inflammation, genotoxicity, transformation and peptide denaturation, changes in enzyme activity, membrane perturbation, apoptosis, necrosis, and dysplasia. A novel investigation of aluminium neurotoxicity includes the assessment of neuroprotection and the identification of new substances as potential drugs.",
publisher = "London: Prime Scholars",
journal = "Journal of Heavy Metal Toxicity and Diseases",
title = "Aluminium neurotoxicity and neuroprotection",
number = "4",
volume = "7",
doi = "10.21767/2473-6457.22.7.4.11",
pages = "11"
}

Martać, L., Podgorac, J., Petković, B.,& Stojadinović, G.. (2022). Aluminium neurotoxicity and neuroprotection. in Journal of Heavy Metal Toxicity and Diseases
London: Prime Scholars., 7(4), 11.
https://doi.org/10.21767/2473-6457.22.7.4.11

Martać L, Podgorac J, Petković B, Stojadinović G. Aluminium neurotoxicity and neuroprotection. in Journal of Heavy Metal Toxicity and Diseases. 2022;7(4):11.
doi:10.21767/2473-6457.22.7.4.11 .

Martać, Ljiljana, Podgorac, Jelena, Petković, Branka, Stojadinović, Gordana, "Aluminium neurotoxicity and neuroprotection" in Journal of Heavy Metal Toxicity and Diseases, 7, no. 4 (2022):11,
https://doi.org/10.21767/2473-6457.22.7.4.11 . .

TY  - CONF
AU  - Nikolić, Ljiljana
AU  - Savić, Danijela
AU  - Korać Jačić, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Bogdanović Pristov, Jelena
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5509
AB  - Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target
for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine
effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically
evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not
affect inward currents. Our results thus provide fine resolution and time frame for targeting ion
channel activity that is crucial in pharmacological investigations.
PB  - Belgrade: Society of Physical Chemists of Serbia
C3  - Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
T1  - Membrane currents of C6 cells in pharmacological investigation
SP  - 589
EP  - 592
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5509
ER  - 

@conference{
author = "Nikolić, Ljiljana and Savić, Danijela and Korać Jačić, Jelena and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Bogdanović Pristov, Jelena",
year = "2022",
abstract = "Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target
for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine
effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically
evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not
affect inward currents. Our results thus provide fine resolution and time frame for targeting ion
channel activity that is crucial in pharmacological investigations.",
publisher = "Belgrade: Society of Physical Chemists of Serbia",
journal = "Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia",
title = "Membrane currents of C6 cells in pharmacological investigation",
pages = "589-592",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5509"
}

Nikolić, L., Savić, D., Korać Jačić, J., Petković, B., Stojadinović, G., Martać, L.,& Bogdanović Pristov, J.. (2022). Membrane currents of C6 cells in pharmacological investigation. in Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
Belgrade: Society of Physical Chemists of Serbia., 589-592.
https://hdl.handle.net/21.15107/rcub_ibiss_5509

Nikolić L, Savić D, Korać Jačić J, Petković B, Stojadinović G, Martać L, Bogdanović Pristov J. Membrane currents of C6 cells in pharmacological investigation. in Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia. 2022;:589-592.
https://hdl.handle.net/21.15107/rcub_ibiss_5509 .

Nikolić, Ljiljana, Savić, Danijela, Korać Jačić, Jelena, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Bogdanović Pristov, Jelena, "Membrane currents of C6 cells in pharmacological investigation" in Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia (2022):589-592,
https://hdl.handle.net/21.15107/rcub_ibiss_5509 .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Lemajić-Komazec, Slobodanka
AU  - Sokolovac, Ivana
AU  - Topalidou, Anastasia
AU  - Gouni, Olga
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Keković, Goran
AU  - Redžek-Mudrinić, Tatjana
AU  - Čapo, Ivan
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32159401
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3635
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4772
AB  - Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.
PB  - Taylor and Francis Ltd
T2  - Fetal and Pediatric Pathology
T1  - Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation
IS  - 6
VL  - 40
DO  - 10.1080/15513815.2020.1737993
SP  - 674
EP  - 684
ER  - 

@article{
author = "Sekulić, Slobodan and Lemajić-Komazec, Slobodanka and Sokolovac, Ivana and Topalidou, Anastasia and Gouni, Olga and Petković, Branka and Martać, Ljiljana and Keković, Goran and Redžek-Mudrinić, Tatjana and Čapo, Ivan",
year = "2021",
abstract = "Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.",
publisher = "Taylor and Francis Ltd",
journal = "Fetal and Pediatric Pathology",
title = "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation",
number = "6",
volume = "40",
doi = "10.1080/15513815.2020.1737993",
pages = "674-684"
}

Sekulić, S., Lemajić-Komazec, S., Sokolovac, I., Topalidou, A., Gouni, O., Petković, B., Martać, L., Keković, G., Redžek-Mudrinić, T.,& Čapo, I.. (2021). Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology
Taylor and Francis Ltd., 40(6), 674-684.
https://doi.org/10.1080/15513815.2020.1737993

Sekulić S, Lemajić-Komazec S, Sokolovac I, Topalidou A, Gouni O, Petković B, Martać L, Keković G, Redžek-Mudrinić T, Čapo I. Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology. 2021;40(6):674-684.
doi:10.1080/15513815.2020.1737993 .

Sekulić, Slobodan, Lemajić-Komazec, Slobodanka, Sokolovac, Ivana, Topalidou, Anastasia, Gouni, Olga, Petković, Branka, Martać, Ljiljana, Keković, Goran, Redžek-Mudrinić, Tatjana, Čapo, Ivan, "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation" in Fetal and Pediatric Pathology, 40, no. 6 (2021):674-684,
https://doi.org/10.1080/15513815.2020.1737993 . .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Lemajić-Komazec, Slobodanka
AU  - Sokolovac, Ivana
AU  - Topalidou, Anastasia
AU  - Gouni, Olga
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Keković, Goran
AU  - Redžek-Mudrinić, Tatjana
AU  - Čapo, Ivan
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32159401
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3635
AB  - Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.
PB  - Taylor and Francis Ltd
T2  - Fetal and Pediatric Pathology
T1  - Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation
IS  - 6
VL  - 40
DO  - 10.1080/15513815.2020.1737993
SP  - 674
EP  - 684
ER  - 

@article{
author = "Sekulić, Slobodan and Lemajić-Komazec, Slobodanka and Sokolovac, Ivana and Topalidou, Anastasia and Gouni, Olga and Petković, Branka and Martać, Ljiljana and Keković, Goran and Redžek-Mudrinić, Tatjana and Čapo, Ivan",
year = "2021",
abstract = "Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.",
publisher = "Taylor and Francis Ltd",
journal = "Fetal and Pediatric Pathology",
title = "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation",
number = "6",
volume = "40",
doi = "10.1080/15513815.2020.1737993",
pages = "674-684"
}

Sekulić, S., Lemajić-Komazec, S., Sokolovac, I., Topalidou, A., Gouni, O., Petković, B., Martać, L., Keković, G., Redžek-Mudrinić, T.,& Čapo, I.. (2021). Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology
Taylor and Francis Ltd., 40(6), 674-684.
https://doi.org/10.1080/15513815.2020.1737993

Sekulić S, Lemajić-Komazec S, Sokolovac I, Topalidou A, Gouni O, Petković B, Martać L, Keković G, Redžek-Mudrinić T, Čapo I. Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology. 2021;40(6):674-684.
doi:10.1080/15513815.2020.1737993 .

Sekulić, Slobodan, Lemajić-Komazec, Slobodanka, Sokolovac, Ivana, Topalidou, Anastasia, Gouni, Olga, Petković, Branka, Martać, Ljiljana, Keković, Goran, Redžek-Mudrinić, Tatjana, Čapo, Ivan, "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation" in Fetal and Pediatric Pathology, 40, no. 6 (2021):674-684,
https://doi.org/10.1080/15513815.2020.1737993 . .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Spasić, Slađana Z.
AU  - Petković, Branka
AU  - Sekulić, Slobodan
AU  - Kesić, Srđan
PY  - 2020
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/5405
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4005
AB  - A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi’s fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis
IS  - 3
VL  - 72
DO  - 10.2298/ABS200524036S
SP  - 425
EP  - 432
ER  - 

@article{
author = "Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Spasić, Slađana Z. and Petković, Branka and Sekulić, Slobodan and Kesić, Srđan",
year = "2020",
abstract = "A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi’s fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis",
number = "3",
volume = "72",
doi = "10.2298/ABS200524036S",
pages = "425-432"
}

Stojadinović, G., Martać, L., Podgorac, J., Spasić, S. Z., Petković, B., Sekulić, S.,& Kesić, S.. (2020). The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences
Serbian Biological Society., 72(3), 425-432.
https://doi.org/10.2298/ABS200524036S

Stojadinović G, Martać L, Podgorac J, Spasić SZ, Petković B, Sekulić S, Kesić S. The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences. 2020;72(3):425-432.
doi:10.2298/ABS200524036S .

Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Spasić, Slađana Z., Petković, Branka, Sekulić, Slobodan, Kesić, Srđan, "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis" in Archives of Biological Sciences, 72, no. 3 (2020):425-432,
https://doi.org/10.2298/ABS200524036S . .

TY  - JOUR
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Pešić, Vesna
PY  - 2019
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641900018P
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/3970
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3400
AB  - Clinically-related basic studies on the behavioral effects of ribavirin treatment are still lacking despite its wide use as an antiviral medication. This paper considers the effects of low ribavirin doses (10, 20 and 30 mg/kg/day) on psychomotor activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced motor activity), and body weight gain in socially undisturbed adult male Wistar rats 24 h after the first, seventh and fourteenth once-a-day injection. Low doses of ribavirin were tested in an attempt to avoid the recognized systemic side effects related to high-dose usage. None of the singly applied ribavirin doses affected exploratory/spontaneous and AMPH-induced motor behavior (locomotion, stereotypy-like and vertical activity), however, body weight gain was significantly lower after treatment with 30 mg/kg of ribavirin. The 7- and 14-day treatments with 10 and 30 mg/kg/day of ribavirin significantly suppressed novelty-induced locomotion and body weight gain; the 14-day treatment with ribavirin at a dose of 30 mg/kg/ day decreased AMPH-induced stereotypy. These findings indicate that repeated application (up to 14 days) of low ribavirin doses results in low novelty-induced locomotion along with reduced weight gain, accentuating the existence of a U-shaped dose-response relationship with a prolonged duration of ribavirin treatment.
T2  - Archives of Biological Sciences
T1  - Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration
IS  - 2
VL  - 71
DO  - 10.2298/ABS190205018P
SP  - 357
EP  - 368
ER  - 

@article{
author = "Petković, Branka and Stojadinović, Gordana and Kesić, Srđan and Ristić, Slavica and Martać, Ljiljana and Podgorac, Jelena and Pešić, Vesna",
year = "2019",
abstract = "Clinically-related basic studies on the behavioral effects of ribavirin treatment are still lacking despite its wide use as an antiviral medication. This paper considers the effects of low ribavirin doses (10, 20 and 30 mg/kg/day) on psychomotor activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced motor activity), and body weight gain in socially undisturbed adult male Wistar rats 24 h after the first, seventh and fourteenth once-a-day injection. Low doses of ribavirin were tested in an attempt to avoid the recognized systemic side effects related to high-dose usage. None of the singly applied ribavirin doses affected exploratory/spontaneous and AMPH-induced motor behavior (locomotion, stereotypy-like and vertical activity), however, body weight gain was significantly lower after treatment with 30 mg/kg of ribavirin. The 7- and 14-day treatments with 10 and 30 mg/kg/day of ribavirin significantly suppressed novelty-induced locomotion and body weight gain; the 14-day treatment with ribavirin at a dose of 30 mg/kg/ day decreased AMPH-induced stereotypy. These findings indicate that repeated application (up to 14 days) of low ribavirin doses results in low novelty-induced locomotion along with reduced weight gain, accentuating the existence of a U-shaped dose-response relationship with a prolonged duration of ribavirin treatment.",
journal = "Archives of Biological Sciences",
title = "Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration",
number = "2",
volume = "71",
doi = "10.2298/ABS190205018P",
pages = "357-368"
}

Petković, B., Stojadinović, G., Kesić, S., Ristić, S., Martać, L., Podgorac, J.,& Pešić, V.. (2019). Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration. in Archives of Biological Sciences, 71(2), 357-368.
https://doi.org/10.2298/ABS190205018P

Petković B, Stojadinović G, Kesić S, Ristić S, Martać L, Podgorac J, Pešić V. Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration. in Archives of Biological Sciences. 2019;71(2):357-368.
doi:10.2298/ABS190205018P .

Petković, Branka, Stojadinović, Gordana, Kesić, Srđan, Ristić, Slavica, Martać, Ljiljana, Podgorac, Jelena, Pešić, Vesna, "Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration" in Archives of Biological Sciences, 71, no. 2 (2019):357-368,
https://doi.org/10.2298/ABS190205018P . .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Petković, Branka
PY  - 2017
UR  - http://www.doiserbia.nb.rs/issue.aspx?issueid=3008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3773
AB  - Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2–3 months old rats weighing 200 – 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity.
AB  - Uvod. U eksperimentima je uporedo registrovana elektrokortikalna aktivnost parijetalne kore velikog mozga, kao i aktivnost kore malog mozga. Cilj je da se uporedi njihova spontana aktivnost jer se registrovanje vrši u anesteziji. Materijal i metode. U istraživanju smo koristili pacove starosti 2 - 3 meseca, telesne mase 200 - 350 g. Formirane su dve grupe pacova sa istim karakteristikama. Kod prve grupe, koju cinilo je 15 pacova (kontrolna grupa) ispitivanje je rađeno u anesteziji, zabeležene su promene spektralne snage u skladu sa obimom frekvencije. Druga grupa od 30 pacova je ispitivana pod istim eksperimentalnim uslovima, ali su pacovi tretirani rastvorom aluminijum hlorid heksahidrata, ili 1.5 % rastvorom aluminijum hlorid heksahidrata per os. Diskusija. Promena spontane aktivnosti malog mozga u uslovima intoksikacije aluminijumom je poređena sa kontrolnim vrednostima. Pokazano je da lezija i neurotoksičnost u uslovima stabilne anestezije dovode do desinhronizacije aktivnosti malog mozga. Ovo je opisano promenom fraktalne dimenzije elektrokortikalne aktivnosti. Pretpostavka je da se inhibicija izazvana anestetikom kompenzuje u uslovima intoksikacije aluminijumom. Zaključak. Mali mozak ima ulogu u kompenzaciji putem promene spontane aktivnosti. Ovakav odgovor podrazumeva povećanje vrednosti fraktalne dimenzije elektrokortikalne aktivnosti malog mozga koja je u uslovima neurotoksičnosti smanjena.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva
T2  - Medical Review
T1  - Spontaneous cerebellar activity and its role in neurotoxicity
T1  - Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti
IS  - 9-10
VL  - 70
DO  - 10.2298/MPNS1710283M
SP  - 283
EP  - 289
ER  - 

@article{
author = "Martać, Ljiljana and Stojadinović, Gordana and Petković, Branka",
year = "2017",
abstract = "Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2–3 months old rats weighing 200 – 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity., Uvod. U eksperimentima je uporedo registrovana elektrokortikalna aktivnost parijetalne kore velikog mozga, kao i aktivnost kore malog mozga. Cilj je da se uporedi njihova spontana aktivnost jer se registrovanje vrši u anesteziji. Materijal i metode. U istraživanju smo koristili pacove starosti 2 - 3 meseca, telesne mase 200 - 350 g. Formirane su dve grupe pacova sa istim karakteristikama. Kod prve grupe, koju cinilo je 15 pacova (kontrolna grupa) ispitivanje je rađeno u anesteziji, zabeležene su promene spektralne snage u skladu sa obimom frekvencije. Druga grupa od 30 pacova je ispitivana pod istim eksperimentalnim uslovima, ali su pacovi tretirani rastvorom aluminijum hlorid heksahidrata, ili 1.5 % rastvorom aluminijum hlorid heksahidrata per os. Diskusija. Promena spontane aktivnosti malog mozga u uslovima intoksikacije aluminijumom je poređena sa kontrolnim vrednostima. Pokazano je da lezija i neurotoksičnost u uslovima stabilne anestezije dovode do desinhronizacije aktivnosti malog mozga. Ovo je opisano promenom fraktalne dimenzije elektrokortikalne aktivnosti. Pretpostavka je da se inhibicija izazvana anestetikom kompenzuje u uslovima intoksikacije aluminijumom. Zaključak. Mali mozak ima ulogu u kompenzaciji putem promene spontane aktivnosti. Ovakav odgovor podrazumeva povećanje vrednosti fraktalne dimenzije elektrokortikalne aktivnosti malog mozga koja je u uslovima neurotoksičnosti smanjena.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva",
journal = "Medical Review",
title = "Spontaneous cerebellar activity and its role in neurotoxicity, Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti",
number = "9-10",
volume = "70",
doi = "10.2298/MPNS1710283M",
pages = "283-289"
}

Martać, L., Stojadinović, G.,& Petković, B.. (2017). Spontaneous cerebellar activity and its role in neurotoxicity. in Medical Review
Društvo lekara Vojvodine Srpskog lekarskog društva., 70(9-10), 283-289.
https://doi.org/10.2298/MPNS1710283M

Martać L, Stojadinović G, Petković B. Spontaneous cerebellar activity and its role in neurotoxicity. in Medical Review. 2017;70(9-10):283-289.
doi:10.2298/MPNS1710283M .

Martać, Ljiljana, Stojadinović, Gordana, Petković, Branka, "Spontaneous cerebellar activity and its role in neurotoxicity" in Medical Review, 70, no. 9-10 (2017):283-289,
https://doi.org/10.2298/MPNS1710283M . .

TY  - JOUR
AU  - Podgorac, Jelena
AU  - Pešić, Vesna
AU  - Pavković, Željko
AU  - Martać, Ljiljana
AU  - Kanazir, Selma
AU  - Filipović, Ljupka
AU  - Sekulić, Slobodan
PY  - 2016
UR  - http://www.journals.elsevier.com/behavioural-brain-research/
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5456
AB  - Clinical research has identified developmental delay and physical malformations in children prenatally exposed to the antiepileptic drug (AED) valproic acid (VPA). However, the early signs of neurodevelopmental deficits, their evolution during postnatal development and growth, and the dose effects of VPA are not well understood. The present study aimed to examine the influence of maternal exposure to a wide dose range (50, 100, 200 and 400 mg/kg/day) of VPA during breeding and gestation on early physical and neuromotor development in mice offspring. Body weight gain, eye opening, the surface righting reflex (SRR) and tail suspension test (TST) were examined in the offspring at postnatal days 5, 10 and 15. We observed that: (1) all tested doses of VPA reduced the body weight of the offspring and the timing of eye opening; (2) offspring exposed to VPA displayed immature forms of righting and required more time to complete the SRR; (3) latency for the first immobilization in the TST is shorter in offspring exposed to higher doses of VPA; however, mice in all groups exposed to VPA exhibited atypical changes in this parameter during the examined period of maturation; (4) irregularities in swinging and curling activities were observed in animals exposed to higher doses of VPA. This study points to delayed somatic development and postponed maturation of the motor system in all of the offspring prenatally exposed to VPA, with stronger effects observed at higher doses. The results implicate that the strategy of continuous monitoring of general health and achievements in motor milestones during the early postnatal development in prenatally VPA-exposed offspring, irrespectively of the dose applied, could help to recognize early developmental irregularities.
PB  - Amsterdam : Elsevier
T2  - Behavioural Brain Research
T1  - Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development
VL  - 311
DO  - 10.1016/j.bbr.2016.05.023
SP  - 99
EP  - 109
ER  - 

@article{
author = "Podgorac, Jelena and Pešić, Vesna and Pavković, Željko and Martać, Ljiljana and Kanazir, Selma and Filipović, Ljupka and Sekulić, Slobodan",
year = "2016",
abstract = "Clinical research has identified developmental delay and physical malformations in children prenatally exposed to the antiepileptic drug (AED) valproic acid (VPA). However, the early signs of neurodevelopmental deficits, their evolution during postnatal development and growth, and the dose effects of VPA are not well understood. The present study aimed to examine the influence of maternal exposure to a wide dose range (50, 100, 200 and 400 mg/kg/day) of VPA during breeding and gestation on early physical and neuromotor development in mice offspring. Body weight gain, eye opening, the surface righting reflex (SRR) and tail suspension test (TST) were examined in the offspring at postnatal days 5, 10 and 15. We observed that: (1) all tested doses of VPA reduced the body weight of the offspring and the timing of eye opening; (2) offspring exposed to VPA displayed immature forms of righting and required more time to complete the SRR; (3) latency for the first immobilization in the TST is shorter in offspring exposed to higher doses of VPA; however, mice in all groups exposed to VPA exhibited atypical changes in this parameter during the examined period of maturation; (4) irregularities in swinging and curling activities were observed in animals exposed to higher doses of VPA. This study points to delayed somatic development and postponed maturation of the motor system in all of the offspring prenatally exposed to VPA, with stronger effects observed at higher doses. The results implicate that the strategy of continuous monitoring of general health and achievements in motor milestones during the early postnatal development in prenatally VPA-exposed offspring, irrespectively of the dose applied, could help to recognize early developmental irregularities.",
publisher = "Amsterdam : Elsevier",
journal = "Behavioural Brain Research",
title = "Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development",
volume = "311",
doi = "10.1016/j.bbr.2016.05.023",
pages = "99-109"
}

Podgorac, J., Pešić, V., Pavković, Ž., Martać, L., Kanazir, S., Filipović, L.,& Sekulić, S.. (2016). Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development. in Behavioural Brain Research
Amsterdam : Elsevier., 311, 99-109.
https://doi.org/10.1016/j.bbr.2016.05.023

Podgorac J, Pešić V, Pavković Ž, Martać L, Kanazir S, Filipović L, Sekulić S. Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development. in Behavioural Brain Research. 2016;311:99-109.
doi:10.1016/j.bbr.2016.05.023 .

Podgorac, Jelena, Pešić, Vesna, Pavković, Željko, Martać, Ljiljana, Kanazir, Selma, Filipović, Ljupka, Sekulić, Slobodan, "Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development" in Behavioural Brain Research, 311 (2016):99-109,
https://doi.org/10.1016/j.bbr.2016.05.023 . .

TY  - JOUR
AU  - Podgorac, Jelena
AU  - Pešić, Vesna
AU  - Pavković, Željko
AU  - Martać, Ljiljana
AU  - Kanazir, Selma
AU  - Filipović, Ljupka
AU  - Sekulić, Slobodan
PY  - 2016
UR  - http://www.journals.elsevier.com/behavioural-brain-research/
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5455
AB  - Clinical research has identified developmental delay and physical malformations in children prenatally exposed to the antiepileptic drug (AED) valproic acid (VPA). However, the early signs of neurodevelopmental deficits, their evolution during postnatal development and growth, and the dose effects of VPA are not well understood. The present study aimed to examine the influence of maternal exposure to a wide dose range (50, 100, 200 and 400 mg/kg/day) of VPA during breeding and gestation on early physical and neuromotor development in mice offspring. Body weight gain, eye opening, the surface righting reflex (SRR) and tail suspension test (TST) were examined in the offspring at postnatal days 5, 10 and 15. We observed that: (1) all tested doses of VPA reduced the body weight of the offspring and the timing of eye opening; (2) offspring exposed to VPA displayed immature forms of righting and required more time to complete the SRR; (3) latency for the first immobilization in the TST is shorter in offspring exposed to higher doses of VPA; however, mice in all groups exposed to VPA exhibited atypical changes in this parameter during the examined period of maturation; (4) irregularities in swinging and curling activities were observed in animals exposed to higher doses of VPA. This study points to delayed somatic development and postponed maturation of the motor system in all of the offspring prenatally exposed to VPA, with stronger effects observed at higher doses. The results implicate that the strategy of continuous monitoring of general health and achievements in motor milestones during the early postnatal development in prenatally VPA-exposed offspring, irrespectively of the dose applied, could help to recognize early developmental irregularities.
PB  - Amsterdam : Elsevier
T2  - Behavioural Brain Research
T1  - Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development
VL  - 311
DO  - 10.1016/j.bbr.2016.05.023
SP  - 99
EP  - 109
ER  - 

@article{
author = "Podgorac, Jelena and Pešić, Vesna and Pavković, Željko and Martać, Ljiljana and Kanazir, Selma and Filipović, Ljupka and Sekulić, Slobodan",
year = "2016",
abstract = "Clinical research has identified developmental delay and physical malformations in children prenatally exposed to the antiepileptic drug (AED) valproic acid (VPA). However, the early signs of neurodevelopmental deficits, their evolution during postnatal development and growth, and the dose effects of VPA are not well understood. The present study aimed to examine the influence of maternal exposure to a wide dose range (50, 100, 200 and 400 mg/kg/day) of VPA during breeding and gestation on early physical and neuromotor development in mice offspring. Body weight gain, eye opening, the surface righting reflex (SRR) and tail suspension test (TST) were examined in the offspring at postnatal days 5, 10 and 15. We observed that: (1) all tested doses of VPA reduced the body weight of the offspring and the timing of eye opening; (2) offspring exposed to VPA displayed immature forms of righting and required more time to complete the SRR; (3) latency for the first immobilization in the TST is shorter in offspring exposed to higher doses of VPA; however, mice in all groups exposed to VPA exhibited atypical changes in this parameter during the examined period of maturation; (4) irregularities in swinging and curling activities were observed in animals exposed to higher doses of VPA. This study points to delayed somatic development and postponed maturation of the motor system in all of the offspring prenatally exposed to VPA, with stronger effects observed at higher doses. The results implicate that the strategy of continuous monitoring of general health and achievements in motor milestones during the early postnatal development in prenatally VPA-exposed offspring, irrespectively of the dose applied, could help to recognize early developmental irregularities.",
publisher = "Amsterdam : Elsevier",
journal = "Behavioural Brain Research",
title = "Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development",
volume = "311",
doi = "10.1016/j.bbr.2016.05.023",
pages = "99-109"
}

Podgorac, J., Pešić, V., Pavković, Ž., Martać, L., Kanazir, S., Filipović, L.,& Sekulić, S.. (2016). Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development. in Behavioural Brain Research
Amsterdam : Elsevier., 311, 99-109.
https://doi.org/10.1016/j.bbr.2016.05.023

Podgorac J, Pešić V, Pavković Ž, Martać L, Kanazir S, Filipović L, Sekulić S. Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development. in Behavioural Brain Research. 2016;311:99-109.
doi:10.1016/j.bbr.2016.05.023 .

Podgorac, Jelena, Pešić, Vesna, Pavković, Željko, Martać, Ljiljana, Kanazir, Selma, Filipović, Ljupka, Sekulić, Slobodan, "Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development" in Behavioural Brain Research, 311 (2016):99-109,
https://doi.org/10.1016/j.bbr.2016.05.023 . .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Cvijanović, Milan
PY  - 2016
UR  - http://www.architalbiol.org/aib/article/view/154118
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2755
AB  - We used electrocortical spectral analysis and fractal methods for assessing the effects of unilateral, single brain injury on cerebellum. Cerebellar electrocortical activity was recorded in control state (before the injury) and after a single brain injury of the cerebellar cortex in anesthetized rats. We noticed that the mean power in gamma high-frequency domain (32-128 Hz) of the cerebellum, was increased after the first brain injury, while after a two-week recovery, it was larger than before the injury. The unilateral brain injury induced a permanent increase of the mild gamma activity in both the left and the right side of cerebellum cortex, but there was no further increase after the lesion was repeated. Our recent electrophysiological study on the cerebellum (Culic et al., 2005) suggested that the mean power spectra of the cerebellar cortical activity in the gamma frequency range might be the indicator of acute single focal brain injury. However, there is insufficient information on the effects of the repeated brain injury on the cerebellar electrocortical activity and morphology. There was no significant difference between the absolute and the relative mean power of the left and the right paravermal cortical activity (before, as well as, after the injury), in each of the animals tested afterwards, but there were differences between the left and the right side of cerebellum in experimental animals. Repeated injury of the cerebellar cortical areas, is strengthened by morphological changes in the cerebellar hemisphere, and shows a decrease in delta and an increase in gamma range.
T2  - Archives Italiennes de Biologie
T1  - Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum
IS  - 4
VL  - 154
DO  - 10.12871/00039829201441
SP  - 118
EP  - 124
ER  - 

@article{
author = "Martać, Ljiljana and Sekulić, Slobodan and Cvijanović, Milan",
year = "2016",
abstract = "We used electrocortical spectral analysis and fractal methods for assessing the effects of unilateral, single brain injury on cerebellum. Cerebellar electrocortical activity was recorded in control state (before the injury) and after a single brain injury of the cerebellar cortex in anesthetized rats. We noticed that the mean power in gamma high-frequency domain (32-128 Hz) of the cerebellum, was increased after the first brain injury, while after a two-week recovery, it was larger than before the injury. The unilateral brain injury induced a permanent increase of the mild gamma activity in both the left and the right side of cerebellum cortex, but there was no further increase after the lesion was repeated. Our recent electrophysiological study on the cerebellum (Culic et al., 2005) suggested that the mean power spectra of the cerebellar cortical activity in the gamma frequency range might be the indicator of acute single focal brain injury. However, there is insufficient information on the effects of the repeated brain injury on the cerebellar electrocortical activity and morphology. There was no significant difference between the absolute and the relative mean power of the left and the right paravermal cortical activity (before, as well as, after the injury), in each of the animals tested afterwards, but there were differences between the left and the right side of cerebellum in experimental animals. Repeated injury of the cerebellar cortical areas, is strengthened by morphological changes in the cerebellar hemisphere, and shows a decrease in delta and an increase in gamma range.",
journal = "Archives Italiennes de Biologie",
title = "Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum",
number = "4",
volume = "154",
doi = "10.12871/00039829201441",
pages = "118-124"
}

Martać, L., Sekulić, S.,& Cvijanović, M.. (2016). Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum. in Archives Italiennes de Biologie, 154(4), 118-124.
https://doi.org/10.12871/00039829201441

Martać L, Sekulić S, Cvijanović M. Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum. in Archives Italiennes de Biologie. 2016;154(4):118-124.
doi:10.12871/00039829201441 .

Martać, Ljiljana, Sekulić, Slobodan, Cvijanović, Milan, "Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum" in Archives Italiennes de Biologie, 154, no. 4 (2016):118-124,
https://doi.org/10.12871/00039829201441 . .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Sekulić, Slobodan
AU  - Čapo, Ivan
PY  - 2015
UR  - http://arpgweb.com/?ic=journal&journal=16&info=aims
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3777
AB  - This paper presents an overview of rat animal model of Alzheimer’s disease. Model is based on the
toxicity, oxidative stress and neurodegeneration. The model is obtained by treatment of rats with intraperitoneal aluminum. Electrocortical group neuron activity describes changes in neurotransmission caused by different factors. Such changes could be qualitatively described by spectral and fractal analysis of electrocortical activity as a variation of the relative spectral power. Both animals and patients with Alzheimers demention have increased relative spectral power in delta range. By fractal analysis we described changes in electrocortical activity of aluminum intoxication animals compare to physiological control. We used change in delta range to calculate fractal dimension. Also we used fractal dimension to compare treated animals with control ones to quantitatively describe the degree of pathophysiological state. All changes are correlated with an increase in the relative spectral power in the delta range and can be quantitatively described by fractal dimension. Results are presented as the effect and can also be applied to the human model of neurotoxicity and neurodegeneration like Alzheimer’s dementia. The model itself may be used for diagnostic and prognostic purposes since it describes the parameters underlying Alzheimer’s disease. However in definition of disease should be consider a state of dementia and menthal activity.
PB  - Academic Research Publishing Group
T2  - Journal of Biotechnology Research
T1  - Spectral and Fractal Analysis of ECoG in Animal Model of Aluminium Intoxication
IS  - 5
VL  - 1
SP  - 21
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3777
ER  - 

@article{
author = "Martać, Ljiljana and Podgorac, Jelena and Petković, Branka and Sekulić, Slobodan and Čapo, Ivan",
year = "2015",
abstract = "This paper presents an overview of rat animal model of Alzheimer’s disease. Model is based on the
toxicity, oxidative stress and neurodegeneration. The model is obtained by treatment of rats with intraperitoneal aluminum. Electrocortical group neuron activity describes changes in neurotransmission caused by different factors. Such changes could be qualitatively described by spectral and fractal analysis of electrocortical activity as a variation of the relative spectral power. Both animals and patients with Alzheimers demention have increased relative spectral power in delta range. By fractal analysis we described changes in electrocortical activity of aluminum intoxication animals compare to physiological control. We used change in delta range to calculate fractal dimension. Also we used fractal dimension to compare treated animals with control ones to quantitatively describe the degree of pathophysiological state. All changes are correlated with an increase in the relative spectral power in the delta range and can be quantitatively described by fractal dimension. Results are presented as the effect and can also be applied to the human model of neurotoxicity and neurodegeneration like Alzheimer’s dementia. The model itself may be used for diagnostic and prognostic purposes since it describes the parameters underlying Alzheimer’s disease. However in definition of disease should be consider a state of dementia and menthal activity.",
publisher = "Academic Research Publishing Group",
journal = "Journal of Biotechnology Research",
title = "Spectral and Fractal Analysis of ECoG in Animal Model of Aluminium Intoxication",
number = "5",
volume = "1",
pages = "21-25",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3777"
}

Martać, L., Podgorac, J., Petković, B., Sekulić, S.,& Čapo, I.. (2015). Spectral and Fractal Analysis of ECoG in Animal Model of Aluminium Intoxication. in Journal of Biotechnology Research
Academic Research Publishing Group., 1(5), 21-25.
https://hdl.handle.net/21.15107/rcub_ibiss_3777

Martać L, Podgorac J, Petković B, Sekulić S, Čapo I. Spectral and Fractal Analysis of ECoG in Animal Model of Aluminium Intoxication. in Journal of Biotechnology Research. 2015;1(5):21-25.
https://hdl.handle.net/21.15107/rcub_ibiss_3777 .

Martać, Ljiljana, Podgorac, Jelena, Petković, Branka, Sekulić, Slobodan, Čapo, Ivan, "Spectral and Fractal Analysis of ECoG in Animal Model of Aluminium Intoxication" in Journal of Biotechnology Research, 1, no. 5 (2015):21-25,
https://hdl.handle.net/21.15107/rcub_ibiss_3777 .

TY  - JOUR
AU  - Sekulić, S.
AU  - Keković, G.
AU  - Filipović, Danka
AU  - Drapšin, M.
AU  - Podgorac, Jelena
AU  - Martać, Ljiljana
AU  - Novakov-Mikić, Aleksandra
PY  - 2013
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/350
AB  - The aim of this work was to determine the changes in the duration of spontaneous movements in the guinea pig fetus after the appearance of its first movements. Every day from the 25th to the 35th gestation day, one fetus from each of twenty pregnant animals was examined by ultrasound. Fetal movements were observed for 5 min. The episode with the longest period of movement was taken into consideration and was recorded as: <1 s, 1-3 s, and >3 s. Days 25 and 26 were characterized by episodes lasting <1 s; days 29 to 31 were dominated by episodes lasting 1-3 s, and days 34 and 35 by episodes lasting >3 s (χ2 = 140.51 p <0.05). Tracking the dynamics of progressive increases in the longest episode of spontaneous movement could be a useful factor in estimating the maturity and condition of a fetus.
T2  - Archives of Biological Sciences
T1  - Monitoring the progressive increase of the longest episode of spontaneous movements in Guinea pig fetus
IS  - 4
VL  - 65
SP  - 1459
EP  - 1462
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_350
ER  - 

@article{
author = "Sekulić, S. and Keković, G. and Filipović, Danka and Drapšin, M. and Podgorac, Jelena and Martać, Ljiljana and Novakov-Mikić, Aleksandra",
year = "2013, 2013",
abstract = "The aim of this work was to determine the changes in the duration of spontaneous movements in the guinea pig fetus after the appearance of its first movements. Every day from the 25th to the 35th gestation day, one fetus from each of twenty pregnant animals was examined by ultrasound. Fetal movements were observed for 5 min. The episode with the longest period of movement was taken into consideration and was recorded as: <1 s, 1-3 s, and >3 s. Days 25 and 26 were characterized by episodes lasting <1 s; days 29 to 31 were dominated by episodes lasting 1-3 s, and days 34 and 35 by episodes lasting >3 s (χ2 = 140.51 p <0.05). Tracking the dynamics of progressive increases in the longest episode of spontaneous movement could be a useful factor in estimating the maturity and condition of a fetus.",
journal = "Archives of Biological Sciences",
title = "Monitoring the progressive increase of the longest episode of spontaneous movements in Guinea pig fetus",
number = "4",
volume = "65",
pages = "1459-1462",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_350"
}

Sekulić, S., Keković, G., Filipović, D., Drapšin, M., Podgorac, J., Martać, L.,& Novakov-Mikić, A.. (2013). Monitoring the progressive increase of the longest episode of spontaneous movements in Guinea pig fetus. in Archives of Biological Sciences, 65(4), 1459-1462.
https://hdl.handle.net/21.15107/rcub_ibiss_350

Sekulić S, Keković G, Filipović D, Drapšin M, Podgorac J, Martać L, Novakov-Mikić A. Monitoring the progressive increase of the longest episode of spontaneous movements in Guinea pig fetus. in Archives of Biological Sciences. 2013;65(4):1459-1462.
https://hdl.handle.net/21.15107/rcub_ibiss_350 .

Sekulić, S., Keković, G., Filipović, Danka, Drapšin, M., Podgorac, Jelena, Martać, Ljiljana, Novakov-Mikić, Aleksandra, "Monitoring the progressive increase of the longest episode of spontaneous movements in Guinea pig fetus" in Archives of Biological Sciences, 65, no. 4 (2013):1459-1462,
https://hdl.handle.net/21.15107/rcub_ibiss_350 .

TY  - THES
AU  - Martać, Ljiljana
PY  - 2013
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=1145
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:7927/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024589746
UR  - http://nardus.mpn.gov.rs/123456789/2148
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2394
AB  - Cilj ove teze je prikaz metoda za kvalitativnu i kvantitativnu analizu moždaneaktivnosti. Ujedno je matematički urađena biomedicinska aproksimacija rezultata.Animalni model intoksikacije aluminijumom je korišćen zbog rasprostranjenostialuminijuma u prirodi i okruženju. Aluminijum ima selektivno neurotoksično dejstvo napojedine delove mozga. Ujedno neurotoksičnost aluminijuma ima za posledicu izmenjenuaktivnost celog mozga, ali i specifično dejstvo na pojedine moždane funkcije. Animalnimodel nudi mogućnost više parametara i može se koristiti za izučavanje neurotoksičnostialuminijuma pod različitim okolnostima. Procesi koji prate neurotoksičnost mogu seporediti sa promenama koje se javljaju u akutnim i hroničnim stanjima bolesti.Spektralna analiza zasnovana na Furijerovoj transformaciji daje opis promenaelektrokortikalne aktivnosti po frekventnim oblastima. Poređenje spektara snage i njihovastatistička analiza omogućavaju kvantifikaciju promena. Praćena je elektrokortikalnaaktivnost parijetalnog korteksa i malog mozga kako bi se obuhvatila sva tri parametraintoksikacije: akumulacija u tkivu, lokalno izmenjena aktivnost neurona i promenaregulatorne funkcije - plastičnost i adaptabilnost mozga. Eksperimentalni dizajnpodrazumeva variranje parametara intoksikacije (aplikacija aluminijuma, moždanastruktura, doza, starost, soj, fiziološko stanje). Na osnovu dobijenih podataka definisani suefekti neurotoksičnosti aluminijuma. Varijabilnost parametara fizioloških promena i efekataneurotoksičnosti su matematički analizirani. Rezultati ukazuju da promena moždaneaktivnosti može biti graduisana tako da može poslužiti kao dijagnostičko-prognostičkiparametar patofiziološkog stanja.Ova studija ima multidisciplinarni značaj jer obrađuje različite aspekte - biološki,fiziološki i medicinski.
AB  - The aim of the study was quantitative and qualitative analysis of electrocortical brainactivity in rat model of aluminium intoxication. We used animal model of aluminiumintoxication becouse aluminium toxicity is widespread in nature. Aluminium has selectiveeffects on different brain regiones. Animal model included different variables, so it can beused to study neurotoxicity in different conditiones. Also, processes due to neurotoxicitycan be compared with state of some acute or chronic diseases.Spectral analysis was based on Fast Fourie Transform and changes of electrocorticalactivity was obsreved in relation to frequency ranges. Comparation of power spectra andstatistic analyses was used for quantification of changes in brain activity. We recordedelectrocortical activity of parietal cortex and cerebellum to include all parameters ofintoxication: acumulation in tissue, changes of neuronal local group activity and changes inregulatory function - plasticity and adaptability of brain. Experimental procedure includeddifferent parametars of intoxication - aplication of aluminium, brain structure, doses, age,straint and physiological state of animals. Based on obtained data we define effects ofneurotoxicity. Biological parameters, such as neurotoxical effects, physiological changeand intoxication are matematicaly analyzed. Results suggest that the change of brainactivity can be used in diagnoses and prognoses of pathophisiological state.This study presents synthesis of biological, physiological and medical aspect.
PB  - Belgrade: University of Belgrade, Faculty of Biology
T2  - University of Belgrade, Faculty of Biology
T1  - Spektralna analiza elektrokortikalne aktivnosti mozga pacova u modelu intoksikacije aluminijumom
T1  - Spectral analysis of electrocortical brain activity in rat model of aluminium intoxication
SP  - [1]
EP  - [77]
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2148
ER  - 

@phdthesis{
author = "Martać, Ljiljana",
year = "2013",
abstract = "Cilj ove teze je prikaz metoda za kvalitativnu i kvantitativnu analizu moždaneaktivnosti. Ujedno je matematički urađena biomedicinska aproksimacija rezultata.Animalni model intoksikacije aluminijumom je korišćen zbog rasprostranjenostialuminijuma u prirodi i okruženju. Aluminijum ima selektivno neurotoksično dejstvo napojedine delove mozga. Ujedno neurotoksičnost aluminijuma ima za posledicu izmenjenuaktivnost celog mozga, ali i specifično dejstvo na pojedine moždane funkcije. Animalnimodel nudi mogućnost više parametara i može se koristiti za izučavanje neurotoksičnostialuminijuma pod različitim okolnostima. Procesi koji prate neurotoksičnost mogu seporediti sa promenama koje se javljaju u akutnim i hroničnim stanjima bolesti.Spektralna analiza zasnovana na Furijerovoj transformaciji daje opis promenaelektrokortikalne aktivnosti po frekventnim oblastima. Poređenje spektara snage i njihovastatistička analiza omogućavaju kvantifikaciju promena. Praćena je elektrokortikalnaaktivnost parijetalnog korteksa i malog mozga kako bi se obuhvatila sva tri parametraintoksikacije: akumulacija u tkivu, lokalno izmenjena aktivnost neurona i promenaregulatorne funkcije - plastičnost i adaptabilnost mozga. Eksperimentalni dizajnpodrazumeva variranje parametara intoksikacije (aplikacija aluminijuma, moždanastruktura, doza, starost, soj, fiziološko stanje). Na osnovu dobijenih podataka definisani suefekti neurotoksičnosti aluminijuma. Varijabilnost parametara fizioloških promena i efekataneurotoksičnosti su matematički analizirani. Rezultati ukazuju da promena moždaneaktivnosti može biti graduisana tako da može poslužiti kao dijagnostičko-prognostičkiparametar patofiziološkog stanja.Ova studija ima multidisciplinarni značaj jer obrađuje različite aspekte - biološki,fiziološki i medicinski., The aim of the study was quantitative and qualitative analysis of electrocortical brainactivity in rat model of aluminium intoxication. We used animal model of aluminiumintoxication becouse aluminium toxicity is widespread in nature. Aluminium has selectiveeffects on different brain regiones. Animal model included different variables, so it can beused to study neurotoxicity in different conditiones. Also, processes due to neurotoxicitycan be compared with state of some acute or chronic diseases.Spectral analysis was based on Fast Fourie Transform and changes of electrocorticalactivity was obsreved in relation to frequency ranges. Comparation of power spectra andstatistic analyses was used for quantification of changes in brain activity. We recordedelectrocortical activity of parietal cortex and cerebellum to include all parameters ofintoxication: acumulation in tissue, changes of neuronal local group activity and changes inregulatory function - plasticity and adaptability of brain. Experimental procedure includeddifferent parametars of intoxication - aplication of aluminium, brain structure, doses, age,straint and physiological state of animals. Based on obtained data we define effects ofneurotoxicity. Biological parameters, such as neurotoxical effects, physiological changeand intoxication are matematicaly analyzed. Results suggest that the change of brainactivity can be used in diagnoses and prognoses of pathophisiological state.This study presents synthesis of biological, physiological and medical aspect.",
publisher = "Belgrade: University of Belgrade, Faculty of Biology",
journal = "University of Belgrade, Faculty of Biology",
title = "Spektralna analiza elektrokortikalne aktivnosti mozga pacova u modelu intoksikacije aluminijumom, Spectral analysis of electrocortical brain activity in rat model of aluminium intoxication",
pages = "[1]-[77]",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2148"
}

Martać, L.. (2013). Spektralna analiza elektrokortikalne aktivnosti mozga pacova u modelu intoksikacije aluminijumom. in University of Belgrade, Faculty of Biology
Belgrade: University of Belgrade, Faculty of Biology., [1]-[77].
https://hdl.handle.net/21.15107/rcub_nardus_2148

Martać L. Spektralna analiza elektrokortikalne aktivnosti mozga pacova u modelu intoksikacije aluminijumom. in University of Belgrade, Faculty of Biology. 2013;:[1]-[77].
https://hdl.handle.net/21.15107/rcub_nardus_2148 .

Martać, Ljiljana, "Spektralna analiza elektrokortikalne aktivnosti mozga pacova u modelu intoksikacije aluminijumom" in University of Belgrade, Faculty of Biology (2013):[1]-[77],
https://hdl.handle.net/21.15107/rcub_nardus_2148 .

TY  - JOUR
AU  - Podgorac, Jelena
AU  - Čapo, Ivan
AU  - Sekulić, Slobodan
AU  - Pepelčević, Nenad
AU  - Martać, Ljiljana
AU  - Keković, Goran
PY  - 2012
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/516
AB  - Serotonin is, evolutionary, the oldest neurotransmitter. Ubiquitous distribution of serotonin in central nervous system, also implication in many physiological functions indicates significance of serotonergic system. Expression of the serotonin function is the most conditioned by the interaction with postsynaptic receptors. In this article, the classification of the serotonergic receptors and its role is reviewed. The expectations of future research are detection of new subpopulations of receptors, their functions and summation of knowledge in order to find new therapy and new manner in treatment of central nervous system disturbances, which imply serotonergic dysfunction.
AB  - Serotonin predstavlja jedan od evolutivno najstarijih neurotransmitrera. Njegova široka distribucija u centralnom nervnom sistemu i povezanost sa mnogobrojnim fiziološkim funkcijama ukazuje na značaj serotoninskog sistema. Karakter ispoljavanja serotonina u najvećoj meri određuje postsinaptički receptor sa kojim stupa u kontakt. U radu su prikazani do sada klasifikovani receptori i njihova uloga. Od budućih istraživanja očekuje se otkrivanje novih subpopulacija receptora, njihove uloge i sumacija saznanja u cilju pronalaženja novih lekova i načina lečenja uzrokovanih poremećajima serotinskog sistema CNS-a.
T2  - MD - Medical data
T1  - Funkcija serotoninskih receptora i njihov uticaj na ponašanje
T1  - Function of serotonin receptors and its role in the behavior
IS  - 2
VL  - 4
SP  - 167
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_516
ER  - 

@article{
author = "Podgorac, Jelena and Čapo, Ivan and Sekulić, Slobodan and Pepelčević, Nenad and Martać, Ljiljana and Keković, Goran",
year = "2012, 2012",
abstract = "Serotonin is, evolutionary, the oldest neurotransmitter. Ubiquitous distribution of serotonin in central nervous system, also implication in many physiological functions indicates significance of serotonergic system. Expression of the serotonin function is the most conditioned by the interaction with postsynaptic receptors. In this article, the classification of the serotonergic receptors and its role is reviewed. The expectations of future research are detection of new subpopulations of receptors, their functions and summation of knowledge in order to find new therapy and new manner in treatment of central nervous system disturbances, which imply serotonergic dysfunction., Serotonin predstavlja jedan od evolutivno najstarijih neurotransmitrera. Njegova široka distribucija u centralnom nervnom sistemu i povezanost sa mnogobrojnim fiziološkim funkcijama ukazuje na značaj serotoninskog sistema. Karakter ispoljavanja serotonina u najvećoj meri određuje postsinaptički receptor sa kojim stupa u kontakt. U radu su prikazani do sada klasifikovani receptori i njihova uloga. Od budućih istraživanja očekuje se otkrivanje novih subpopulacija receptora, njihove uloge i sumacija saznanja u cilju pronalaženja novih lekova i načina lečenja uzrokovanih poremećajima serotinskog sistema CNS-a.",
journal = "MD - Medical data",
title = "Funkcija serotoninskih receptora i njihov uticaj na ponašanje, Function of serotonin receptors and its role in the behavior",
number = "2",
volume = "4",
pages = "167-170",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_516"
}

Podgorac, J., Čapo, I., Sekulić, S., Pepelčević, N., Martać, L.,& Keković, G.. (2012). Funkcija serotoninskih receptora i njihov uticaj na ponašanje. in MD - Medical data, 4(2), 167-170.
https://hdl.handle.net/21.15107/rcub_ibiss_516

Podgorac J, Čapo I, Sekulić S, Pepelčević N, Martać L, Keković G. Funkcija serotoninskih receptora i njihov uticaj na ponašanje. in MD - Medical data. 2012;4(2):167-170.
https://hdl.handle.net/21.15107/rcub_ibiss_516 .

Podgorac, Jelena, Čapo, Ivan, Sekulić, Slobodan, Pepelčević, Nenad, Martać, Ljiljana, Keković, Goran, "Funkcija serotoninskih receptora i njihov uticaj na ponašanje" in MD - Medical data, 4, no. 2 (2012):167-170,
https://hdl.handle.net/21.15107/rcub_ibiss_516 .

TY  - JOUR
AU  - Sekulić, Slobodan R
AU  - Bozić, Aleksandar K
AU  - Zarkov, Marija G
AU  - Keković, Goran
AU  - Podgorac, Jelena
AU  - Novakov-Mikić, Aleksandra S
AU  - Martać, Ljiljana
AU  - Barna, Tomislav
AU  - Milovanović, Aleksandar
AU  - Pusić, Ivan
AU  - Stojanović, Dragica
AU  - Pepelcević, Nenad
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1217
AB  - The hypothesis tested was that fetal postural development causes anterior presentation of the sheep fetus during a period of exclusive increase in anterior presentation. Exposing fetuses to a ventro-sacral position during a period of equal incidence of anterior and posterior presentations [50th-90th gestation day (GD)] should not cause changes in fetal presentation. During a period of an exclusive increase in anterior presentation (90th-140th GD) a ventro-sacral position should cause a 1800 turn of the fetus. Singleton gestations with fetus in anterior presentation were included. Ultrasound examinations consisted of three consecutive two minute scans to determine fetal presentation, and were conducted with the ewe in the following three positions: the upright quadrupedal position, sitting position in which the ewe's trunk is vertical to the ground; and again the upright quadrupedal position. The Mann-Whitney nonparametric U-test was used. On the 83rd GD (14 fetuses), there were no changes in fetal presentation, whereas on the 86th GD (10 fetuses) (p=0.035 p<0.05) and on the 116th GD (12 fetuses) (p=0.000 p<0.05) fetuses frequently assumed a transverse presentation at the second examination position. Further experiments would require the fetuses to be artificially maintained in a ventro-sacral position for a prolonged period.
T2  - Philippine Journal of Veterinary Medicine
T1  - Changes in the Anterior Presentation in Sheep Fetuses Due to Their Ventro-Sacral Position in the Second Half of Gestation
IS  - 1
VL  - 49
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1217
ER  - 

@article{
author = "Sekulić, Slobodan R and Bozić, Aleksandar K and Zarkov, Marija G and Keković, Goran and Podgorac, Jelena and Novakov-Mikić, Aleksandra S and Martać, Ljiljana and Barna, Tomislav and Milovanović, Aleksandar and Pusić, Ivan and Stojanović, Dragica and Pepelcević, Nenad",
year = "2012",
abstract = "The hypothesis tested was that fetal postural development causes anterior presentation of the sheep fetus during a period of exclusive increase in anterior presentation. Exposing fetuses to a ventro-sacral position during a period of equal incidence of anterior and posterior presentations [50th-90th gestation day (GD)] should not cause changes in fetal presentation. During a period of an exclusive increase in anterior presentation (90th-140th GD) a ventro-sacral position should cause a 1800 turn of the fetus. Singleton gestations with fetus in anterior presentation were included. Ultrasound examinations consisted of three consecutive two minute scans to determine fetal presentation, and were conducted with the ewe in the following three positions: the upright quadrupedal position, sitting position in which the ewe's trunk is vertical to the ground; and again the upright quadrupedal position. The Mann-Whitney nonparametric U-test was used. On the 83rd GD (14 fetuses), there were no changes in fetal presentation, whereas on the 86th GD (10 fetuses) (p=0.035 p<0.05) and on the 116th GD (12 fetuses) (p=0.000 p<0.05) fetuses frequently assumed a transverse presentation at the second examination position. Further experiments would require the fetuses to be artificially maintained in a ventro-sacral position for a prolonged period.",
journal = "Philippine Journal of Veterinary Medicine",
title = "Changes in the Anterior Presentation in Sheep Fetuses Due to Their Ventro-Sacral Position in the Second Half of Gestation",
number = "1",
volume = "49",
pages = "56",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1217"
}

Sekulić, S. R., Bozić, A. K., Zarkov, M. G., Keković, G., Podgorac, J., Novakov-Mikić, A. S., Martać, L., Barna, T., Milovanović, A., Pusić, I., Stojanović, D.,& Pepelcević, N.. (2012). Changes in the Anterior Presentation in Sheep Fetuses Due to Their Ventro-Sacral Position in the Second Half of Gestation. in Philippine Journal of Veterinary Medicine, 49(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1217

Sekulić SR, Bozić AK, Zarkov MG, Keković G, Podgorac J, Novakov-Mikić AS, Martać L, Barna T, Milovanović A, Pusić I, Stojanović D, Pepelcević N. Changes in the Anterior Presentation in Sheep Fetuses Due to Their Ventro-Sacral Position in the Second Half of Gestation. in Philippine Journal of Veterinary Medicine. 2012;49(1):null-56.
https://hdl.handle.net/21.15107/rcub_ibiss_1217 .

Sekulić, Slobodan R, Bozić, Aleksandar K, Zarkov, Marija G, Keković, Goran, Podgorac, Jelena, Novakov-Mikić, Aleksandra S, Martać, Ljiljana, Barna, Tomislav, Milovanović, Aleksandar, Pusić, Ivan, Stojanović, Dragica, Pepelcević, Nenad, "Changes in the Anterior Presentation in Sheep Fetuses Due to Their Ventro-Sacral Position in the Second Half of Gestation" in Philippine Journal of Veterinary Medicine, 49, no. 1 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1217 .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Soković, Marina
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1364
AB  - In this study, we investigated the presence of long-range correlation effects in the electrocortical activity of rats using the Hurst exponent (H) calculated by dispersion analysis (DA) and an aggregated variance method (AGV). A slow decline of the autocorrelation function during time expansion and the existence of a correlation between distant time points of electrocorticograms (ECoGs) were shown to be typical of various pathophysiological states. In these cases, the H values were within a 0.5 < H < 1 range. A particularly slow decay of the autocorrelation function is typical of a long-range dependence (LRD). We found that ECoGs after i.p. administrations of camphor essential oil or its main constituent, 1,8-cineole, included attacks of uncontrolled electrical discharges and showed the presence of long-range correlation effects. Such findings are in agreement with recent data obtained by other authors and suggest that initiation of seizures can be predicted by certain ECoG indices. We estimated the critical period where the H values for ECoGs containing uncontrolled electrical discharges continuously increased within a few minutes before the attack. We believe that the AGV demonstrates certain advantages over DA in calculations of the H.
T2  - Neurophysiology
T1  - Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole
IS  - 1
VL  - 42
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1364
ER  - 

@article{
author = "Ćulić, Milka and Stojadinović, Gordana and Martać, Ljiljana and Soković, Marina",
year = "2010",
abstract = "In this study, we investigated the presence of long-range correlation effects in the electrocortical activity of rats using the Hurst exponent (H) calculated by dispersion analysis (DA) and an aggregated variance method (AGV). A slow decline of the autocorrelation function during time expansion and the existence of a correlation between distant time points of electrocorticograms (ECoGs) were shown to be typical of various pathophysiological states. In these cases, the H values were within a 0.5 < H < 1 range. A particularly slow decay of the autocorrelation function is typical of a long-range dependence (LRD). We found that ECoGs after i.p. administrations of camphor essential oil or its main constituent, 1,8-cineole, included attacks of uncontrolled electrical discharges and showed the presence of long-range correlation effects. Such findings are in agreement with recent data obtained by other authors and suggest that initiation of seizures can be predicted by certain ECoG indices. We estimated the critical period where the H values for ECoGs containing uncontrolled electrical discharges continuously increased within a few minutes before the attack. We believe that the AGV demonstrates certain advantages over DA in calculations of the H.",
journal = "Neurophysiology",
title = "Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole",
number = "1",
volume = "42",
pages = "62",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1364"
}

Ćulić, M., Stojadinović, G., Martać, L.,& Soković, M.. (2010). Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole. in Neurophysiology, 42(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1364

Ćulić M, Stojadinović G, Martać L, Soković M. Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole. in Neurophysiology. 2010;42(1):null-62.
https://hdl.handle.net/21.15107/rcub_ibiss_1364 .

Ćulić, Milka, Stojadinović, Gordana, Martać, Ljiljana, Soković, Marina, "Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole" in Neurophysiology, 42, no. 1 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1364 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Sekulić, S.
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/261
AB  - Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer's dementia and Parkinson's disease.
AB  - Prethodna istraživanja na animalnom modelu neurotoksičnosti aluminijuma pokazuju da povećanje spektralne snage u delta opsegu je indikator neurotoksičnosti. U ovoj studiji smo koristili nekoliko životinja koje su pogodne za procenu neurotoksičnog efekta aluminijuma u poređenju sa kontrolom. Za kvalitativni opis neurotoksičnosti koristili smo odnos delta i teta opsega i t test za opis promene između tretiranih i kontrolnih pacova. Korišćen je animalni model u uslovima anestezije je opis moždane aktivnosti sa suprimiranim funkcionalnim vezama između moždanih struktura. Koristili smo i fraktalnu dimenziju za kvantitativni opis neurotoksičnog efekta u različitim patofiziološkim stanjima. Smanjenje fraktalne dimenzije je izraz neurodegeneracije u uslovima stresa. Ovaj model je komparabilan sa neurodegenerativnim i neurotransmiterskim promenama u Alchejmerovoj bolesti i Parkinsonovoj bolesti.
T2  - Archives of Biological Sciences
T1  - Procena neurotoksičnog efekta aluminijuma u animalnom modelu Wistar pacova
T1  - Evaluation of the neurotoxical effect of aluminum on the Wistar rat
IS  - 3
VL  - 62
SP  - 585
EP  - 588
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_261
ER  - 

@article{
author = "Martać, Ljiljana and Podgorac, Jelena and Sekulić, S.",
year = "2010, 2010",
abstract = "Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer's dementia and Parkinson's disease., Prethodna istraživanja na animalnom modelu neurotoksičnosti aluminijuma pokazuju da povećanje spektralne snage u delta opsegu je indikator neurotoksičnosti. U ovoj studiji smo koristili nekoliko životinja koje su pogodne za procenu neurotoksičnog efekta aluminijuma u poređenju sa kontrolom. Za kvalitativni opis neurotoksičnosti koristili smo odnos delta i teta opsega i t test za opis promene između tretiranih i kontrolnih pacova. Korišćen je animalni model u uslovima anestezije je opis moždane aktivnosti sa suprimiranim funkcionalnim vezama između moždanih struktura. Koristili smo i fraktalnu dimenziju za kvantitativni opis neurotoksičnog efekta u različitim patofiziološkim stanjima. Smanjenje fraktalne dimenzije je izraz neurodegeneracije u uslovima stresa. Ovaj model je komparabilan sa neurodegenerativnim i neurotransmiterskim promenama u Alchejmerovoj bolesti i Parkinsonovoj bolesti.",
journal = "Archives of Biological Sciences",
title = "Procena neurotoksičnog efekta aluminijuma u animalnom modelu Wistar pacova, Evaluation of the neurotoxical effect of aluminum on the Wistar rat",
number = "3",
volume = "62",
pages = "585-588",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_261"
}

Martać, L., Podgorac, J.,& Sekulić, S.. (2010). Procena neurotoksičnog efekta aluminijuma u animalnom modelu Wistar pacova. in Archives of Biological Sciences, 62(3), 585-588.
https://hdl.handle.net/21.15107/rcub_ibiss_261

Martać L, Podgorac J, Sekulić S. Procena neurotoksičnog efekta aluminijuma u animalnom modelu Wistar pacova. in Archives of Biological Sciences. 2010;62(3):585-588.
https://hdl.handle.net/21.15107/rcub_ibiss_261 .

Martać, Ljiljana, Podgorac, Jelena, Sekulić, S., "Procena neurotoksičnog efekta aluminijuma u animalnom modelu Wistar pacova" in Archives of Biological Sciences, 62, no. 3 (2010):585-588,
https://hdl.handle.net/21.15107/rcub_ibiss_261 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Keković, G.
AU  - Podgorac, Jelena
AU  - Ćulić, Milka
AU  - Sekulić, S.
AU  - Lalošević, D.
AU  - Čapo, I.
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/243
AB  - Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls.
AB  - Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.
T2  - Archives of Biological Sciences
T1  - Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije
T1  - Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation
IS  - 1
VL  - 62
SP  - 9
EP  - 13
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_243
ER  - 

@article{
author = "Martać, Ljiljana and Stojadinović, Gordana and Keković, G. and Podgorac, Jelena and Ćulić, Milka and Sekulić, S. and Lalošević, D. and Čapo, I.",
year = "2010, 2010",
abstract = "Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls., Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.",
journal = "Archives of Biological Sciences",
title = "Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije, Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation",
number = "1",
volume = "62",
pages = "9-13",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_243"
}

Martać, L., Stojadinović, G., Keković, G., Podgorac, J., Ćulić, M., Sekulić, S., Lalošević, D.,& Čapo, I.. (2010). Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije. in Archives of Biological Sciences, 62(1), 9-13.
https://hdl.handle.net/21.15107/rcub_ibiss_243

Martać L, Stojadinović G, Keković G, Podgorac J, Ćulić M, Sekulić S, Lalošević D, Čapo I. Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije. in Archives of Biological Sciences. 2010;62(1):9-13.
https://hdl.handle.net/21.15107/rcub_ibiss_243 .

Martać, Ljiljana, Stojadinović, Gordana, Keković, G., Podgorac, Jelena, Ćulić, Milka, Sekulić, S., Lalošević, D., Čapo, I., "Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije" in Archives of Biological Sciences, 62, no. 1 (2010):9-13,
https://hdl.handle.net/21.15107/rcub_ibiss_243 .