TY  - JOUR
AU  - Merlani, M.
AU  - Barbakadze, V.
AU  - Amiranashvili, L.
AU  - Gogilashvili, L.
AU  - Petrou, A.
AU  - Geronikaki, A.
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2022
UR  - https://www.tandfonline.com/doi/full/10.1080/1062936X.2022.2066173
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4969
AB  - Herein we report the evaluation of the antimicrobial activity of some previously synthesized 3-(3,4-dihydroxyphenyl)glyceric acid in benzylated and in free 3,4 hydroxy groups in catechol moiety along with some caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid amides using the microdilution method. The evaluation revealed that compounds showed in general moderate to low activity with MIC in range of 0.36-4.5 mg/mL. Compounds were also studied against three resistant bacteria strains MRSA (Methicillin-resistant Staphylococcus aureus), E. coli and P. aeruginosa. Seven out of ten compounds were more potent than reference drugs ampicillin and streptomycin against MRSA, while against another two resistant strains seven compounds showed low activity and the rest were inactive. Antifungal activity of the tested compounds was much better than antibacterial, with MIC in the range of 0.019-3.0 mg/mL. Compounds #7 and 15 showed good activity against all fungi tested, being more potent than ketoconazole and in some case even better than bifonazole used as reference drugs. Docking studies revealed that the most active compound #7 binds to the haem group of the enzyme in the same way as ketoconazole.
T2  - SAR and QSAR in Environmental Research
T1  - Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.
IS  - 4
VL  - 33
DO  - 10.1080/1062936X.2022.2066173
SP  - 307
EP  - 321
ER  - 

@article{
author = "Merlani, M. and Barbakadze, V. and Amiranashvili, L. and Gogilashvili, L. and Petrou, A. and Geronikaki, A. and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2022",
abstract = "Herein we report the evaluation of the antimicrobial activity of some previously synthesized 3-(3,4-dihydroxyphenyl)glyceric acid in benzylated and in free 3,4 hydroxy groups in catechol moiety along with some caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid amides using the microdilution method. The evaluation revealed that compounds showed in general moderate to low activity with MIC in range of 0.36-4.5 mg/mL. Compounds were also studied against three resistant bacteria strains MRSA (Methicillin-resistant Staphylococcus aureus), E. coli and P. aeruginosa. Seven out of ten compounds were more potent than reference drugs ampicillin and streptomycin against MRSA, while against another two resistant strains seven compounds showed low activity and the rest were inactive. Antifungal activity of the tested compounds was much better than antibacterial, with MIC in the range of 0.019-3.0 mg/mL. Compounds #7 and 15 showed good activity against all fungi tested, being more potent than ketoconazole and in some case even better than bifonazole used as reference drugs. Docking studies revealed that the most active compound #7 binds to the haem group of the enzyme in the same way as ketoconazole.",
journal = "SAR and QSAR in Environmental Research",
title = "Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.",
number = "4",
volume = "33",
doi = "10.1080/1062936X.2022.2066173",
pages = "307-321"
}

Merlani, M., Barbakadze, V., Amiranashvili, L., Gogilashvili, L., Petrou, A., Geronikaki, A., Ćirić, A., Glamočlija, J.,& Soković, M.. (2022). Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.. in SAR and QSAR in Environmental Research, 33(4), 307-321.
https://doi.org/10.1080/1062936X.2022.2066173

Merlani M, Barbakadze V, Amiranashvili L, Gogilashvili L, Petrou A, Geronikaki A, Ćirić A, Glamočlija J, Soković M. Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.. in SAR and QSAR in Environmental Research. 2022;33(4):307-321.
doi:10.1080/1062936X.2022.2066173 .

Merlani, M., Barbakadze, V., Amiranashvili, L., Gogilashvili, L., Petrou, A., Geronikaki, A., Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies." in SAR and QSAR in Environmental Research, 33, no. 4 (2022):307-321,
https://doi.org/10.1080/1062936X.2022.2066173 . .

TY  - JOUR
AU  - Geronikaki, A.
AU  - Kartsev, V.
AU  - Petrou, A.
AU  - Akrivou, M. G.
AU  - Vizirianakis, I. S.
AU  - Chatzopoulou, F. M.
AU  - Lichitsky, B.
AU  - Sirakanyan, S.
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Soković, Marina
AU  - Druzhilovskiy, D.
AU  - Poroikov, V.
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3621
AB  - Griseofulvin is a well-known antifungal drug that was launched in 1962 by Merck & Co. for the treatment of dermatophyte infections. However, according to predictions using the Way2Drug computational drug repurposing platform, it may also have antibacterial activity. As no confirmation of this prediction was found in the published literature, this study estimated in-silico antibacterial activity for 42 griseofulvin derivatives. Antibacterial activity was predicted for 33 of the 42 compounds, which led to the conclusion that this activity might be considered as typical for this chemical series. Therefore, experimental testing of antibacterial activity was performed on a panel of Gram-positive and Gram-negative micro-organisms. Antibacterial activity was evaluated using the microdilution method detecting the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC). The tested compounds exhibited potent antibacterial activity against all the studied bacteria, with MIC and MBC values ranging from 0.0037 to 0.04 mg/mL and from 0.01 to 0.16 mg/mL, respectively. Activity was 2.5–12 times greater than that of ampicillin and 2–8 times greater than that of streptomycin, which were used as the reference drugs. Similarity analysis for all 42 compounds with the (approximately) 470,000 drug-like compounds indexed in the Clarivate Analytics Integrity database confirmed the significant novelty of the antibacterial activity for the compounds from this chemical class. Therefore, this study demonstrated that by using computer-aided prediction of biological activity spectra for a particular chemical series, it is possible to identify typical biological activities which may be used for discovery of new applications (e.g. drug repurposing).
PB  - Elsevier B.V.
T2  - International Journal of Antimicrobial Agents
T1  - Antibacterial activity of griseofulvin analogues as an example of drug repurposing
IS  - 3
VL  - 55
DO  - 10.1016/j.ijantimicag.2020.105884
SP  - 105884
ER  - 

@article{
author = "Geronikaki, A. and Kartsev, V. and Petrou, A. and Akrivou, M. G. and Vizirianakis, I. S. and Chatzopoulou, F. M. and Lichitsky, B. and Sirakanyan, S. and Kostić, Marina and Ivanov, Marija and Soković, Marina and Druzhilovskiy, D. and Poroikov, V.",
year = "2020",
abstract = "Griseofulvin is a well-known antifungal drug that was launched in 1962 by Merck & Co. for the treatment of dermatophyte infections. However, according to predictions using the Way2Drug computational drug repurposing platform, it may also have antibacterial activity. As no confirmation of this prediction was found in the published literature, this study estimated in-silico antibacterial activity for 42 griseofulvin derivatives. Antibacterial activity was predicted for 33 of the 42 compounds, which led to the conclusion that this activity might be considered as typical for this chemical series. Therefore, experimental testing of antibacterial activity was performed on a panel of Gram-positive and Gram-negative micro-organisms. Antibacterial activity was evaluated using the microdilution method detecting the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC). The tested compounds exhibited potent antibacterial activity against all the studied bacteria, with MIC and MBC values ranging from 0.0037 to 0.04 mg/mL and from 0.01 to 0.16 mg/mL, respectively. Activity was 2.5–12 times greater than that of ampicillin and 2–8 times greater than that of streptomycin, which were used as the reference drugs. Similarity analysis for all 42 compounds with the (approximately) 470,000 drug-like compounds indexed in the Clarivate Analytics Integrity database confirmed the significant novelty of the antibacterial activity for the compounds from this chemical class. Therefore, this study demonstrated that by using computer-aided prediction of biological activity spectra for a particular chemical series, it is possible to identify typical biological activities which may be used for discovery of new applications (e.g. drug repurposing).",
publisher = "Elsevier B.V.",
journal = "International Journal of Antimicrobial Agents",
title = "Antibacterial activity of griseofulvin analogues as an example of drug repurposing",
number = "3",
volume = "55",
doi = "10.1016/j.ijantimicag.2020.105884",
pages = "105884"
}

Geronikaki, A., Kartsev, V., Petrou, A., Akrivou, M. G., Vizirianakis, I. S., Chatzopoulou, F. M., Lichitsky, B., Sirakanyan, S., Kostić, M., Ivanov, M., Soković, M., Druzhilovskiy, D.,& Poroikov, V.. (2020). Antibacterial activity of griseofulvin analogues as an example of drug repurposing. in International Journal of Antimicrobial Agents
Elsevier B.V.., 55(3), 105884.
https://doi.org/10.1016/j.ijantimicag.2020.105884

Geronikaki A, Kartsev V, Petrou A, Akrivou MG, Vizirianakis IS, Chatzopoulou FM, Lichitsky B, Sirakanyan S, Kostić M, Ivanov M, Soković M, Druzhilovskiy D, Poroikov V. Antibacterial activity of griseofulvin analogues as an example of drug repurposing. in International Journal of Antimicrobial Agents. 2020;55(3):105884.
doi:10.1016/j.ijantimicag.2020.105884 .

Geronikaki, A., Kartsev, V., Petrou, A., Akrivou, M. G., Vizirianakis, I. S., Chatzopoulou, F. M., Lichitsky, B., Sirakanyan, S., Kostić, Marina, Ivanov, Marija, Soković, Marina, Druzhilovskiy, D., Poroikov, V., "Antibacterial activity of griseofulvin analogues as an example of drug repurposing" in International Journal of Antimicrobial Agents, 55, no. 3 (2020):105884,
https://doi.org/10.1016/j.ijantimicag.2020.105884 . .