TY  - JOUR
AU  - Merlani, M.
AU  - Barbakadze, V.
AU  - Amiranashvili, L.
AU  - Gogilashvili, L.
AU  - Petrou, A.
AU  - Geronikaki, A.
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2022
UR  - https://www.tandfonline.com/doi/full/10.1080/1062936X.2022.2066173
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4969
AB  - Herein we report the evaluation of the antimicrobial activity of some previously synthesized 3-(3,4-dihydroxyphenyl)glyceric acid in benzylated and in free 3,4 hydroxy groups in catechol moiety along with some caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid amides using the microdilution method. The evaluation revealed that compounds showed in general moderate to low activity with MIC in range of 0.36-4.5 mg/mL. Compounds were also studied against three resistant bacteria strains MRSA (Methicillin-resistant Staphylococcus aureus), E. coli and P. aeruginosa. Seven out of ten compounds were more potent than reference drugs ampicillin and streptomycin against MRSA, while against another two resistant strains seven compounds showed low activity and the rest were inactive. Antifungal activity of the tested compounds was much better than antibacterial, with MIC in the range of 0.019-3.0 mg/mL. Compounds #7 and 15 showed good activity against all fungi tested, being more potent than ketoconazole and in some case even better than bifonazole used as reference drugs. Docking studies revealed that the most active compound #7 binds to the haem group of the enzyme in the same way as ketoconazole.
T2  - SAR and QSAR in Environmental Research
T1  - Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.
IS  - 4
VL  - 33
DO  - 10.1080/1062936X.2022.2066173
SP  - 307
EP  - 321
ER  - 

@article{
author = "Merlani, M. and Barbakadze, V. and Amiranashvili, L. and Gogilashvili, L. and Petrou, A. and Geronikaki, A. and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2022",
abstract = "Herein we report the evaluation of the antimicrobial activity of some previously synthesized 3-(3,4-dihydroxyphenyl)glyceric acid in benzylated and in free 3,4 hydroxy groups in catechol moiety along with some caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid amides using the microdilution method. The evaluation revealed that compounds showed in general moderate to low activity with MIC in range of 0.36-4.5 mg/mL. Compounds were also studied against three resistant bacteria strains MRSA (Methicillin-resistant Staphylococcus aureus), E. coli and P. aeruginosa. Seven out of ten compounds were more potent than reference drugs ampicillin and streptomycin against MRSA, while against another two resistant strains seven compounds showed low activity and the rest were inactive. Antifungal activity of the tested compounds was much better than antibacterial, with MIC in the range of 0.019-3.0 mg/mL. Compounds #7 and 15 showed good activity against all fungi tested, being more potent than ketoconazole and in some case even better than bifonazole used as reference drugs. Docking studies revealed that the most active compound #7 binds to the haem group of the enzyme in the same way as ketoconazole.",
journal = "SAR and QSAR in Environmental Research",
title = "Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.",
number = "4",
volume = "33",
doi = "10.1080/1062936X.2022.2066173",
pages = "307-321"
}

Merlani, M., Barbakadze, V., Amiranashvili, L., Gogilashvili, L., Petrou, A., Geronikaki, A., Ćirić, A., Glamočlija, J.,& Soković, M.. (2022). Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.. in SAR and QSAR in Environmental Research, 33(4), 307-321.
https://doi.org/10.1080/1062936X.2022.2066173

Merlani M, Barbakadze V, Amiranashvili L, Gogilashvili L, Petrou A, Geronikaki A, Ćirić A, Glamočlija J, Soković M. Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.. in SAR and QSAR in Environmental Research. 2022;33(4):307-321.
doi:10.1080/1062936X.2022.2066173 .

Merlani, M., Barbakadze, V., Amiranashvili, L., Gogilashvili, L., Petrou, A., Geronikaki, A., Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies." in SAR and QSAR in Environmental Research, 33, no. 4 (2022):307-321,
https://doi.org/10.1080/1062936X.2022.2066173 . .