TY  - JOUR
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Sanković Babić, Snežana
AU  - Tepavčević, Zvezdana
AU  - Radanović, Oliver
AU  - Soković, Marina
AU  - Ćirić, Ana
PY  - 2022
UR  - https://www.mdpi.com/2079-6382/11/12/1747
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5353
AB  - Chronic tonsillitis (CT) is a global health issue which can impair patient’s quality of life and has an important socioeconomic impact due to the nonrational use of antibiotics, increased antimicrobial resistance and frequent need for surgical treatment. In order to isolate and identify the causing agents of CT, a total of 79 postoperative palatine and adenoid tissue samples were obtained from the ENT Clinic, KBC Zvezdara, Belgrade, Serbia. Culture identification was performed by MALDI-TOF MS and the Staphylococcus aureus isolates were tested for biofilm forming capability and antibiotic susceptibility. Additionally, a histological examination of palatine and adenoid tissue was performed in order to detect the presence of CT-causing bacteria. The slight majority of participants were females with median age of 28 years for adult patients (group I) and 6 years for children (group II). Analysis of the incidence of bacteria isolated from tissue samples in both groups showed the highest prevalence of S. aureus, Streptococcus oralis and Streptococcus parasanquinis. In addition to interfollicular hyperplasia, colonies of species S. aureus were detected in histological material. The presence of biofilm might be the reason for the recurrence of infection. Therefore, searching for a new treatment of CT is of great importance.
PB  - Basel: MDPI
T2  - Antibiotics
T1  - Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis—Microbiological Profile, Biofilm-Forming Capacity and Histology
IS  - 12
VL  - 11
DO  - 10.3390/antibiotics11121747
SP  - 1747
ER  - 

@article{
author = "Kostić, Marina and Ivanov, Marija and Sanković Babić, Snežana and Tepavčević, Zvezdana and Radanović, Oliver and Soković, Marina and Ćirić, Ana",
year = "2022",
abstract = "Chronic tonsillitis (CT) is a global health issue which can impair patient’s quality of life and has an important socioeconomic impact due to the nonrational use of antibiotics, increased antimicrobial resistance and frequent need for surgical treatment. In order to isolate and identify the causing agents of CT, a total of 79 postoperative palatine and adenoid tissue samples were obtained from the ENT Clinic, KBC Zvezdara, Belgrade, Serbia. Culture identification was performed by MALDI-TOF MS and the Staphylococcus aureus isolates were tested for biofilm forming capability and antibiotic susceptibility. Additionally, a histological examination of palatine and adenoid tissue was performed in order to detect the presence of CT-causing bacteria. The slight majority of participants were females with median age of 28 years for adult patients (group I) and 6 years for children (group II). Analysis of the incidence of bacteria isolated from tissue samples in both groups showed the highest prevalence of S. aureus, Streptococcus oralis and Streptococcus parasanquinis. In addition to interfollicular hyperplasia, colonies of species S. aureus were detected in histological material. The presence of biofilm might be the reason for the recurrence of infection. Therefore, searching for a new treatment of CT is of great importance.",
publisher = "Basel: MDPI",
journal = "Antibiotics",
title = "Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis—Microbiological Profile, Biofilm-Forming Capacity and Histology",
number = "12",
volume = "11",
doi = "10.3390/antibiotics11121747",
pages = "1747"
}

Kostić, M., Ivanov, M., Sanković Babić, S., Tepavčević, Z., Radanović, O., Soković, M.,& Ćirić, A.. (2022). Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis—Microbiological Profile, Biofilm-Forming Capacity and Histology. in Antibiotics
Basel: MDPI., 11(12), 1747.
https://doi.org/10.3390/antibiotics11121747

Kostić M, Ivanov M, Sanković Babić S, Tepavčević Z, Radanović O, Soković M, Ćirić A. Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis—Microbiological Profile, Biofilm-Forming Capacity and Histology. in Antibiotics. 2022;11(12):1747.
doi:10.3390/antibiotics11121747 .

Kostić, Marina, Ivanov, Marija, Sanković Babić, Snežana, Tepavčević, Zvezdana, Radanović, Oliver, Soković, Marina, Ćirić, Ana, "Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis—Microbiological Profile, Biofilm-Forming Capacity and Histology" in Antibiotics, 11, no. 12 (2022):1747,
https://doi.org/10.3390/antibiotics11121747 . .

TY  - CONF
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Sanković Babić, Snežana
AU  - Tapavčević, Zvezdana
AU  - Radanović, Oliver
AU  - Ćirić, Ana
AU  - Soković, Marina
PY  - 2022
UR  - https://www.femsbelgrade2022.org/abstract-book
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5155
AB  - If chronic tonsillitis (CT) is treated surgically, the long-term risks of infections and respiratory diseases are
higher, making of high importance to find an alternative for tonsillectomy. In order to isolate and identify
the causing agents of CT, a total of 79 postoperative palatine and adenoid tissue samples were obtained
from the ENT Clinic, KBC Zvezdara. A total of 82 bacterial species were isolated and identified by MALDI-TOF.
They belong to the genera Streptococcus, Staphylococcus, Micrococcus, Rothia, Enterobacter and Stenotrophomonas.
Analysis of the incidence of bacteria isolated from tissue samples showed the highest prevalence of Streptococcus
oralis (27/33%), followed by S. aureus (17/21%) and Streptococcus parasanquinis (16/20%). Histological analysis
of tissue samples was conducted in order to detect the presence of CT-causing bacteria. In addition to interfollicular
hyperplasia, colonies of species S. aureus and Stenotrophomonas maltophilia were detected in histological material.
The presented results confirm that the colonizers of tonsils tissues can be both G (+) and G (-) bacteria. The
presence of S. aureus in the tonsillar tissue even after the antibiotic therapy may be related to its ability to
form biofilm. Our study demonstrated that among 17 S. aureus isolates, 13 displays more pronounced biofilm
forming ability than the reference strain S. aureus ATCC 11632, and only 4 isolates display lower biofilm forming ability.
The presence of biofilm might be the reason for the recurrence of infection. Therefore, a searching for new
antibiofilm therapeutics in CT therapy is of great importance.
PB  - Belgrade: Serbian Society of Microbiology
C3  - Electronic abstract book: FEMS Conference on Microbiology in association with Serbian Society of Microbiology; 2022 Jun 30 - Jul 2; Belgrade, Serbia
T1  - Microbiological and histological analysis of tonsil tissue from patients diagnosed with chronic tonsilitis
SP  - 853
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5155
ER  - 

@conference{
author = "Kostić, Marina and Ivanov, Marija and Sanković Babić, Snežana and Tapavčević, Zvezdana and Radanović, Oliver and Ćirić, Ana and Soković, Marina",
year = "2022",
abstract = "If chronic tonsillitis (CT) is treated surgically, the long-term risks of infections and respiratory diseases are
higher, making of high importance to find an alternative for tonsillectomy. In order to isolate and identify
the causing agents of CT, a total of 79 postoperative palatine and adenoid tissue samples were obtained
from the ENT Clinic, KBC Zvezdara. A total of 82 bacterial species were isolated and identified by MALDI-TOF.
They belong to the genera Streptococcus, Staphylococcus, Micrococcus, Rothia, Enterobacter and Stenotrophomonas.
Analysis of the incidence of bacteria isolated from tissue samples showed the highest prevalence of Streptococcus
oralis (27/33%), followed by S. aureus (17/21%) and Streptococcus parasanquinis (16/20%). Histological analysis
of tissue samples was conducted in order to detect the presence of CT-causing bacteria. In addition to interfollicular
hyperplasia, colonies of species S. aureus and Stenotrophomonas maltophilia were detected in histological material.
The presented results confirm that the colonizers of tonsils tissues can be both G (+) and G (-) bacteria. The
presence of S. aureus in the tonsillar tissue even after the antibiotic therapy may be related to its ability to
form biofilm. Our study demonstrated that among 17 S. aureus isolates, 13 displays more pronounced biofilm
forming ability than the reference strain S. aureus ATCC 11632, and only 4 isolates display lower biofilm forming ability.
The presence of biofilm might be the reason for the recurrence of infection. Therefore, a searching for new
antibiofilm therapeutics in CT therapy is of great importance.",
publisher = "Belgrade: Serbian Society of Microbiology",
journal = "Electronic abstract book: FEMS Conference on Microbiology in association with Serbian Society of Microbiology; 2022 Jun 30 - Jul 2; Belgrade, Serbia",
title = "Microbiological and histological analysis of tonsil tissue from patients diagnosed with chronic tonsilitis",
pages = "853",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5155"
}

Kostić, M., Ivanov, M., Sanković Babić, S., Tapavčević, Z., Radanović, O., Ćirić, A.,& Soković, M.. (2022). Microbiological and histological analysis of tonsil tissue from patients diagnosed with chronic tonsilitis. in Electronic abstract book: FEMS Conference on Microbiology in association with Serbian Society of Microbiology; 2022 Jun 30 - Jul 2; Belgrade, Serbia
Belgrade: Serbian Society of Microbiology., 853.
https://hdl.handle.net/21.15107/rcub_ibiss_5155

Kostić M, Ivanov M, Sanković Babić S, Tapavčević Z, Radanović O, Ćirić A, Soković M. Microbiological and histological analysis of tonsil tissue from patients diagnosed with chronic tonsilitis. in Electronic abstract book: FEMS Conference on Microbiology in association with Serbian Society of Microbiology; 2022 Jun 30 - Jul 2; Belgrade, Serbia. 2022;:853.
https://hdl.handle.net/21.15107/rcub_ibiss_5155 .

Kostić, Marina, Ivanov, Marija, Sanković Babić, Snežana, Tapavčević, Zvezdana, Radanović, Oliver, Ćirić, Ana, Soković, Marina, "Microbiological and histological analysis of tonsil tissue from patients diagnosed with chronic tonsilitis" in Electronic abstract book: FEMS Conference on Microbiology in association with Serbian Society of Microbiology; 2022 Jun 30 - Jul 2; Belgrade, Serbia (2022):853,
https://hdl.handle.net/21.15107/rcub_ibiss_5155 .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Lichitsky, Boris
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Radanović, Oliver
AU  - Soković, Marina
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C8MD90056F
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3252
AB  - The authors regret that the author names were not displayed correctly on the original manuscript. The corrected list of authors for this paper is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
T2  - MedChemComm
T2  - MedChemComm
T1  - Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)
IS  - 1
VL  - 10
DO  - 10.1039/C8MD90056F
SP  - 180
ER  - 

@article{
author = "Kartsev, Victor and Lichitsky, Boris and Geronikaki, Athina and Petrou, Anthi and Ivanov, Marija and Kostić, Marina and Radanović, Oliver and Soković, Marina",
year = "2019",
abstract = "The authors regret that the author names were not displayed correctly on the original manuscript. The corrected list of authors for this paper is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.",
journal = "MedChemComm, MedChemComm",
title = "Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)",
number = "1",
volume = "10",
doi = "10.1039/C8MD90056F",
pages = "180"
}

Kartsev, V., Lichitsky, B., Geronikaki, A., Petrou, A., Ivanov, M., Kostić, M., Radanović, O.,& Soković, M.. (2019). Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J). in MedChemComm, 10(1), 180.
https://doi.org/10.1039/C8MD90056F

Kartsev V, Lichitsky B, Geronikaki A, Petrou A, Ivanov M, Kostić M, Radanović O, Soković M. Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J). in MedChemComm. 2019;10(1):180.
doi:10.1039/C8MD90056F .

Kartsev, Victor, Lichitsky, Boris, Geronikaki, Athina, Petrou, Anthi, Ivanov, Marija, Kostić, Marina, Radanović, Oliver, Soković, Marina, "Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)" in MedChemComm, 10, no. 1 (2019):180,
https://doi.org/10.1039/C8MD90056F . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Lichitsky, Boris
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Radanović, Oliver
AU  - Soković, Marina
PY  - 2018
UR  - http://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00076J#!divAbstract
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3080
AB  - Usnic acid, a dibenzofuran, was originally isolated from lichens producing secondary metabolites, and is well known as an antibiotic, but is also endowed with several other interesting properties. Thus, the goal of this paper is the design of new usnic acid derivatives and evaluation of their antimicrobial activity. All newly synthesized compounds possess good antibacterial activity with MIC ranging from 1.02-50.93 × 10-2 mmol mL-1 and MBC from 2.05-70.57 × 10-2 mmol mL-1. The most sensitive bacterial species was Staphylococcus aureus, while Pseudomonas aeruginosa and Escherichia coli were the most resistant among the ATCC strains, and MRSA was the most resistant among all tested bacteria (ATCC and clinical isolates). Their antifungal activity was very strong (MIC = 0.35-7.53 × 10-2 mmol mL-1 and MFC = 0.70-15.05 × 10-2 mmol mL-1)-better than those of reference compounds and usnic acid itself. The most sensitive fungal species was Trichoderma viride, while Penicillium versicolor var. cyclopium appeared to be the most resistant. It should be mentioned that in general most of the compounds showed weaker antibacterial activity, but better antifungal properties than usnic acid itself. The results allow us to conclude that the title compounds are good lead compounds for novel more active antibacterial drugs. On the other hand, these compounds are very promising as antifungals.
T2  - MedChemComm
T2  - MedChemComm
T1  - Design, synthesis and antimicrobial activity of usnic acid derivatives
IS  - 5
VL  - 9
DO  - 10.1039/C8MD00076J
SP  - 870
EP  - 882
ER  - 

@article{
author = "Kartsev, Victor and Lichitsky, Boris and Geronikaki, Athina and Petrou, Anthi and Ivanov, Marija and Kostić, Marina and Radanović, Oliver and Soković, Marina",
year = "2018",
abstract = "Usnic acid, a dibenzofuran, was originally isolated from lichens producing secondary metabolites, and is well known as an antibiotic, but is also endowed with several other interesting properties. Thus, the goal of this paper is the design of new usnic acid derivatives and evaluation of their antimicrobial activity. All newly synthesized compounds possess good antibacterial activity with MIC ranging from 1.02-50.93 × 10-2 mmol mL-1 and MBC from 2.05-70.57 × 10-2 mmol mL-1. The most sensitive bacterial species was Staphylococcus aureus, while Pseudomonas aeruginosa and Escherichia coli were the most resistant among the ATCC strains, and MRSA was the most resistant among all tested bacteria (ATCC and clinical isolates). Their antifungal activity was very strong (MIC = 0.35-7.53 × 10-2 mmol mL-1 and MFC = 0.70-15.05 × 10-2 mmol mL-1)-better than those of reference compounds and usnic acid itself. The most sensitive fungal species was Trichoderma viride, while Penicillium versicolor var. cyclopium appeared to be the most resistant. It should be mentioned that in general most of the compounds showed weaker antibacterial activity, but better antifungal properties than usnic acid itself. The results allow us to conclude that the title compounds are good lead compounds for novel more active antibacterial drugs. On the other hand, these compounds are very promising as antifungals.",
journal = "MedChemComm, MedChemComm",
title = "Design, synthesis and antimicrobial activity of usnic acid derivatives",
number = "5",
volume = "9",
doi = "10.1039/C8MD00076J",
pages = "870-882"
}

Kartsev, V., Lichitsky, B., Geronikaki, A., Petrou, A., Ivanov, M., Kostić, M., Radanović, O.,& Soković, M.. (2018). Design, synthesis and antimicrobial activity of usnic acid derivatives. in MedChemComm, 9(5), 870-882.
https://doi.org/10.1039/C8MD00076J

Kartsev V, Lichitsky B, Geronikaki A, Petrou A, Ivanov M, Kostić M, Radanović O, Soković M. Design, synthesis and antimicrobial activity of usnic acid derivatives. in MedChemComm. 2018;9(5):870-882.
doi:10.1039/C8MD00076J .

Kartsev, Victor, Lichitsky, Boris, Geronikaki, Athina, Petrou, Anthi, Ivanov, Marija, Kostić, Marina, Radanović, Oliver, Soković, Marina, "Design, synthesis and antimicrobial activity of usnic acid derivatives" in MedChemComm, 9, no. 5 (2018):870-882,
https://doi.org/10.1039/C8MD00076J . .