TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Zmejkovski, Bojana B
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojić, Marija
AU  - Steinborn, Dirk
AU  - Miljković, Đorđe
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava
AU  - Sabo, Tibor J
AU  - Maksimović-Ivanić, Danijela
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1223
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
IS  - 9
VL  - 4
EP  - 987
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1223
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatović, Sanja and Zmejkovski, Bojana B and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojić, Marija and Steinborn, Dirk and Miljković, Đorđe and Schmidt, Harry and Stošić-Grujičić, Stanislava and Sabo, Tibor J and Maksimović-Ivanić, Danijela",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
number = "9",
volume = "4",
pages = "987",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1223"
}

Kaluđerović, G. N., Mijatović, S., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojić, M., Steinborn, D., Miljković, Đ., Schmidt, H., Stošić-Grujičić, S., Sabo, T. J.,& Maksimović-Ivanić, D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics, 4(9).
https://hdl.handle.net/21.15107/rcub_ibiss_1223

Kaluđerović GN, Mijatović S, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojić M, Steinborn D, Miljković Đ, Schmidt H, Stošić-Grujičić S, Sabo TJ, Maksimović-Ivanić D. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):null-987.
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

Kaluđerović, Goran N., Mijatović, Sanja, Zmejkovski, Bojana B, Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojić, Marija, Steinborn, Dirk, Miljković, Đorđe, Schmidt, Harry, Stošić-Grujičić, Stanislava, Sabo, Tibor J, Maksimović-Ivanić, Danijela, "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .