TY  - CONF
AU  - Živković, Suzana
AU  - Savić, Aleksandar
AU  - Jovanović, Katarina
AU  - Milenković, Ivana
AU  - Mišić, Danijela
AU  - Popović-Bijelić, Ana
AU  - Mojović, Miloš
PY  - 2013
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6803
AB  - Group of higher plants, known as desiccation tolerant or resurrection plants, possess uniquely effec­tive mechanism to withstand extreme dehydration and rapid rehydration of vegetative tissues without cell damage. Resurrection plants survive the loss of most of their tissue water content until a quiescent stage is achieved. Upon watering, the plants revive and are restored to their former state within 24 h. In order to cope with desiccation, resurrection plants have to overcome a number of stresses, among them the most critical being oxidative stress. In our previous investigations, we have shown that during the rehydration process in A. ceterach, OH radicals are produced. In vivo productions of free radicaIs remain unexplained and difficult for examination. By application of specif­ic fluorescence probe for detection of hydroxyl radical APF (3'-(p-aminophenyl) fluorescein) it is possible to get insight into processes occurring in fronds during the dehydration process. In reaction of hydroxyl radical with APF, fluorescent product emerges. Examination under fluorescence microscope and image capturing in time intervals provides determination of hydroxyl radical production in different plant tissues. Through image analysis based on multivariate techniques, it is possible to simultaneously distinguish plant tissues according to its morphological and physiological properties.
PB  - Belgrade: Serbian Plant Physiology Society
C3  - Programme and Abstracts: 1st International Conference on Plant Biology and 20th Symposium of the Serbian Plant Physiology Society; 2013 Jun 4-7; Subotica, Belgrade
T1  - Comparative analysis of hydroxyl radical production in fresh and desiccated fronds of Asplenium ceterach L. examined by fluorescence  microscopy
SP  - 134
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6803
ER  - 

@conference{
author = "Živković, Suzana and Savić, Aleksandar and Jovanović, Katarina and Milenković, Ivana and Mišić, Danijela and Popović-Bijelić, Ana and Mojović, Miloš",
year = "2013",
abstract = "Group of higher plants, known as desiccation tolerant or resurrection plants, possess uniquely effec­tive mechanism to withstand extreme dehydration and rapid rehydration of vegetative tissues without cell damage. Resurrection plants survive the loss of most of their tissue water content until a quiescent stage is achieved. Upon watering, the plants revive and are restored to their former state within 24 h. In order to cope with desiccation, resurrection plants have to overcome a number of stresses, among them the most critical being oxidative stress. In our previous investigations, we have shown that during the rehydration process in A. ceterach, OH radicals are produced. In vivo productions of free radicaIs remain unexplained and difficult for examination. By application of specif­ic fluorescence probe for detection of hydroxyl radical APF (3'-(p-aminophenyl) fluorescein) it is possible to get insight into processes occurring in fronds during the dehydration process. In reaction of hydroxyl radical with APF, fluorescent product emerges. Examination under fluorescence microscope and image capturing in time intervals provides determination of hydroxyl radical production in different plant tissues. Through image analysis based on multivariate techniques, it is possible to simultaneously distinguish plant tissues according to its morphological and physiological properties.",
publisher = "Belgrade: Serbian Plant Physiology Society",
journal = "Programme and Abstracts: 1st International Conference on Plant Biology and 20th Symposium of the Serbian Plant Physiology Society; 2013 Jun 4-7; Subotica, Belgrade",
title = "Comparative analysis of hydroxyl radical production in fresh and desiccated fronds of Asplenium ceterach L. examined by fluorescence  microscopy",
pages = "134",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6803"
}

Živković, S., Savić, A., Jovanović, K., Milenković, I., Mišić, D., Popović-Bijelić, A.,& Mojović, M.. (2013). Comparative analysis of hydroxyl radical production in fresh and desiccated fronds of Asplenium ceterach L. examined by fluorescence  microscopy. in Programme and Abstracts: 1st International Conference on Plant Biology and 20th Symposium of the Serbian Plant Physiology Society; 2013 Jun 4-7; Subotica, Belgrade
Belgrade: Serbian Plant Physiology Society., 134.
https://hdl.handle.net/21.15107/rcub_ibiss_6803

Živković S, Savić A, Jovanović K, Milenković I, Mišić D, Popović-Bijelić A, Mojović M. Comparative analysis of hydroxyl radical production in fresh and desiccated fronds of Asplenium ceterach L. examined by fluorescence  microscopy. in Programme and Abstracts: 1st International Conference on Plant Biology and 20th Symposium of the Serbian Plant Physiology Society; 2013 Jun 4-7; Subotica, Belgrade. 2013;:134.
https://hdl.handle.net/21.15107/rcub_ibiss_6803 .

Živković, Suzana, Savić, Aleksandar, Jovanović, Katarina, Milenković, Ivana, Mišić, Danijela, Popović-Bijelić, Ana, Mojović, Miloš, "Comparative analysis of hydroxyl radical production in fresh and desiccated fronds of Asplenium ceterach L. examined by fluorescence  microscopy" in Programme and Abstracts: 1st International Conference on Plant Biology and 20th Symposium of the Serbian Plant Physiology Society; 2013 Jun 4-7; Subotica, Belgrade (2013):134,
https://hdl.handle.net/21.15107/rcub_ibiss_6803 .

TY  - JOUR
AU  - Mihajlović, Ljiljana E
AU  - Savić, Aleksandar R
AU  - Poljarević, Jelena M
AU  - Vucković, Ivan M
AU  - Mojić, Marija
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Grgurić-Sipka, Sanja R
AU  - Sabo, Tibor J
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1195
AB  - This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
IS  - null
VL  - 109
EP  - 48
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1195
ER  - 

@article{
author = "Mihajlović, Ljiljana E and Savić, Aleksandar R and Poljarević, Jelena M and Vucković, Ivan M and Mojić, Marija and Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Grgurić-Sipka, Sanja R and Sabo, Tibor J",
year = "2012",
abstract = "This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity",
number = "null",
volume = "109",
pages = "48",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1195"
}

Mihajlović, L. E., Savić, A. R., Poljarević, J. M., Vucković, I. M., Mojić, M., Bulatović, M. Z., Maksimović-Ivanić, D., Mijatović, S., Kaluđerović, G. N., Stošić-Grujičić, S., Miljković, Đ., Grgurić-Sipka, S. R.,& Sabo, T. J.. (2012). Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry, 109(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1195

Mihajlović LE, Savić AR, Poljarević JM, Vucković IM, Mojić M, Bulatović MZ, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN, Stošić-Grujičić S, Miljković Đ, Grgurić-Sipka SR, Sabo TJ. Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry. 2012;109(null):null-48.
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .

Mihajlović, Ljiljana E, Savić, Aleksandar R, Poljarević, Jelena M, Vucković, Ivan M, Mojić, Marija, Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., Stošić-Grujičić, Stanislava, Miljković, Đorđe, Grgurić-Sipka, Sanja R, Sabo, Tibor J, "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity" in Journal of Inorganic Biochemistry, 109, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .