TY  - JOUR
AU  - Sveljo, O.
AU  - Ćulić, Milka
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1917
AB  - The cerebellum is involved in the control of motor and nonmotor
   functions. Refined and innovative experimental and clinical approaches,
   starting from anatomy and including functional magnetic resonance
   imaging (fMRI), have allowed researchers to store extensive information
   on the cerebellar contributions to motor control and also helped them to
   understanding cerebellar nonmotor functions. Does the cerebellum process
   exclusively cerebral information related to certain specificactions, or
   does it also process some forms of information independent of such
   relation? At present, researchers are close to evaluating how the
   cerebellum is active during resolution of cognitive tasks. Various
   therapy lines in perspective, from cerebellar stimulation to cerbellar
   grafts and artificial cerebellum, are of particular significance, as
   they can restore lost brain functions in animal models and repair in
   sufficient brain processes in patients.
T2  - Neurophysiology
T1  - Cerebellar Nonmotor Functions - Approaches and Significance
IS  - 4
VL  - 47
DO  - 10.1007/s11062-015-9541-y
SP  - 337
EP  - 347
ER  - 

@article{
author = "Sveljo, O. and Ćulić, Milka",
year = "2015",
abstract = "The cerebellum is involved in the control of motor and nonmotor
   functions. Refined and innovative experimental and clinical approaches,
   starting from anatomy and including functional magnetic resonance
   imaging (fMRI), have allowed researchers to store extensive information
   on the cerebellar contributions to motor control and also helped them to
   understanding cerebellar nonmotor functions. Does the cerebellum process
   exclusively cerebral information related to certain specificactions, or
   does it also process some forms of information independent of such
   relation? At present, researchers are close to evaluating how the
   cerebellum is active during resolution of cognitive tasks. Various
   therapy lines in perspective, from cerebellar stimulation to cerbellar
   grafts and artificial cerebellum, are of particular significance, as
   they can restore lost brain functions in animal models and repair in
   sufficient brain processes in patients.",
journal = "Neurophysiology",
title = "Cerebellar Nonmotor Functions - Approaches and Significance",
number = "4",
volume = "47",
doi = "10.1007/s11062-015-9541-y",
pages = "337-347"
}

Sveljo, O.,& Ćulić, M.. (2015). Cerebellar Nonmotor Functions - Approaches and Significance. in Neurophysiology, 47(4), 337-347.
https://doi.org/10.1007/s11062-015-9541-y

Sveljo O, Ćulić M. Cerebellar Nonmotor Functions - Approaches and Significance. in Neurophysiology. 2015;47(4):337-347.
doi:10.1007/s11062-015-9541-y .

Sveljo, O., Ćulić, Milka, "Cerebellar Nonmotor Functions - Approaches and Significance" in Neurophysiology, 47, no. 4 (2015):337-347,
https://doi.org/10.1007/s11062-015-9541-y . .

TY  - JOUR
AU  - Sveljo, Olivera
AU  - Ćulić, Milka
AU  - Koprivsek, Katarina
AU  - Lucic, Milos
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2110
AB  - Cerebellar involvement in cognitive functions has been revealed in
   numerous anatomical, clinical and neuroimaging studies and several
   hypotheses about potential the role of the cerebellum in higher level
   brain function have been established. The aim of this study was to show
   involvement of the cerebellum in simple cognitive tasks. For this
   matter, we contrasted two tasks from the same semantic domain with
   specific cognitive content and level of practice: counting forward and
   counting backward. Twelve volunteers participated in this fMRI study and
   they were asked to perform both tasks within the same number range (1 to
   30 and vice versa). Results showed greater activation in the right
   cerebellum for the task of counting forward than for counting backward,
   while for counting backward greater activation was found in prefrontal
   cortex, supplementary motor area, and anterior cingulate of both
   hemispheres. Our results correlate with already established hypotheses
   about cerebellar role in precise and smooth control, not only in
   well-trained motor but in well trained cognitive tasks as well.
T2  - Brain Imaging and Behavior
T1  - The functional neuroimaging evidence of cerebellar involvement in the
 simple cognitive task
IS  - 4
VL  - 8
DO  - 10.1007/s11682-014-9290-3
SP  - 480
EP  - 486
ER  - 

@article{
author = "Sveljo, Olivera and Ćulić, Milka and Koprivsek, Katarina and Lucic, Milos",
year = "2014",
abstract = "Cerebellar involvement in cognitive functions has been revealed in
   numerous anatomical, clinical and neuroimaging studies and several
   hypotheses about potential the role of the cerebellum in higher level
   brain function have been established. The aim of this study was to show
   involvement of the cerebellum in simple cognitive tasks. For this
   matter, we contrasted two tasks from the same semantic domain with
   specific cognitive content and level of practice: counting forward and
   counting backward. Twelve volunteers participated in this fMRI study and
   they were asked to perform both tasks within the same number range (1 to
   30 and vice versa). Results showed greater activation in the right
   cerebellum for the task of counting forward than for counting backward,
   while for counting backward greater activation was found in prefrontal
   cortex, supplementary motor area, and anterior cingulate of both
   hemispheres. Our results correlate with already established hypotheses
   about cerebellar role in precise and smooth control, not only in
   well-trained motor but in well trained cognitive tasks as well.",
journal = "Brain Imaging and Behavior",
title = "The functional neuroimaging evidence of cerebellar involvement in the
 simple cognitive task",
number = "4",
volume = "8",
doi = "10.1007/s11682-014-9290-3",
pages = "480-486"
}

Sveljo, O., Ćulić, M., Koprivsek, K.,& Lucic, M.. (2014). The functional neuroimaging evidence of cerebellar involvement in the
 simple cognitive task. in Brain Imaging and Behavior, 8(4), 480-486.
https://doi.org/10.1007/s11682-014-9290-3

Sveljo O, Ćulić M, Koprivsek K, Lucic M. The functional neuroimaging evidence of cerebellar involvement in the
 simple cognitive task. in Brain Imaging and Behavior. 2014;8(4):480-486.
doi:10.1007/s11682-014-9290-3 .

Sveljo, Olivera, Ćulić, Milka, Koprivsek, Katarina, Lucic, Milos, "The functional neuroimaging evidence of cerebellar involvement in the
 simple cognitive task" in Brain Imaging and Behavior, 8, no. 4 (2014):480-486,
https://doi.org/10.1007/s11682-014-9290-3 . .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Soković, Marina
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1364
AB  - In this study, we investigated the presence of long-range correlation effects in the electrocortical activity of rats using the Hurst exponent (H) calculated by dispersion analysis (DA) and an aggregated variance method (AGV). A slow decline of the autocorrelation function during time expansion and the existence of a correlation between distant time points of electrocorticograms (ECoGs) were shown to be typical of various pathophysiological states. In these cases, the H values were within a 0.5 < H < 1 range. A particularly slow decay of the autocorrelation function is typical of a long-range dependence (LRD). We found that ECoGs after i.p. administrations of camphor essential oil or its main constituent, 1,8-cineole, included attacks of uncontrolled electrical discharges and showed the presence of long-range correlation effects. Such findings are in agreement with recent data obtained by other authors and suggest that initiation of seizures can be predicted by certain ECoG indices. We estimated the critical period where the H values for ECoGs containing uncontrolled electrical discharges continuously increased within a few minutes before the attack. We believe that the AGV demonstrates certain advantages over DA in calculations of the H.
T2  - Neurophysiology
T1  - Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole
IS  - 1
VL  - 42
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1364
ER  - 

@article{
author = "Ćulić, Milka and Stojadinović, Gordana and Martać, Ljiljana and Soković, Marina",
year = "2010",
abstract = "In this study, we investigated the presence of long-range correlation effects in the electrocortical activity of rats using the Hurst exponent (H) calculated by dispersion analysis (DA) and an aggregated variance method (AGV). A slow decline of the autocorrelation function during time expansion and the existence of a correlation between distant time points of electrocorticograms (ECoGs) were shown to be typical of various pathophysiological states. In these cases, the H values were within a 0.5 < H < 1 range. A particularly slow decay of the autocorrelation function is typical of a long-range dependence (LRD). We found that ECoGs after i.p. administrations of camphor essential oil or its main constituent, 1,8-cineole, included attacks of uncontrolled electrical discharges and showed the presence of long-range correlation effects. Such findings are in agreement with recent data obtained by other authors and suggest that initiation of seizures can be predicted by certain ECoG indices. We estimated the critical period where the H values for ECoGs containing uncontrolled electrical discharges continuously increased within a few minutes before the attack. We believe that the AGV demonstrates certain advantages over DA in calculations of the H.",
journal = "Neurophysiology",
title = "Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole",
number = "1",
volume = "42",
pages = "62",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1364"
}

Ćulić, M., Stojadinović, G., Martać, L.,& Soković, M.. (2010). Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole. in Neurophysiology, 42(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1364

Ćulić M, Stojadinović G, Martać L, Soković M. Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole. in Neurophysiology. 2010;42(1):null-62.
https://hdl.handle.net/21.15107/rcub_ibiss_1364 .

Ćulić, Milka, Stojadinović, Gordana, Martać, Ljiljana, Soković, Marina, "Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole" in Neurophysiology, 42, no. 1 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1364 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Keković, G.
AU  - Podgorac, Jelena
AU  - Ćulić, Milka
AU  - Sekulić, S.
AU  - Lalošević, D.
AU  - Čapo, I.
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/243
AB  - Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls.
AB  - Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.
T2  - Archives of Biological Sciences
T1  - Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije
T1  - Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation
IS  - 1
VL  - 62
SP  - 9
EP  - 13
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_243
ER  - 

@article{
author = "Martać, Ljiljana and Stojadinović, Gordana and Keković, G. and Podgorac, Jelena and Ćulić, Milka and Sekulić, S. and Lalošević, D. and Čapo, I.",
year = "2010, 2010",
abstract = "Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls., Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.",
journal = "Archives of Biological Sciences",
title = "Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije, Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation",
number = "1",
volume = "62",
pages = "9-13",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_243"
}

Martać, L., Stojadinović, G., Keković, G., Podgorac, J., Ćulić, M., Sekulić, S., Lalošević, D.,& Čapo, I.. (2010). Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije. in Archives of Biological Sciences, 62(1), 9-13.
https://hdl.handle.net/21.15107/rcub_ibiss_243

Martać L, Stojadinović G, Keković G, Podgorac J, Ćulić M, Sekulić S, Lalošević D, Čapo I. Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije. in Archives of Biological Sciences. 2010;62(1):9-13.
https://hdl.handle.net/21.15107/rcub_ibiss_243 .

Martać, Ljiljana, Stojadinović, Gordana, Keković, G., Podgorac, Jelena, Ćulić, Milka, Sekulić, S., Lalošević, D., Čapo, I., "Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije" in Archives of Biological Sciences, 62, no. 1 (2010):9-13,
https://hdl.handle.net/21.15107/rcub_ibiss_243 .

TY  - JOUR
AU  - Keković, Goran
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Sekulić, Slobodan R
AU  - Ćulić, Milka
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1127
AB  - The features of rat cerebral and cerebellar electrocortical activity (ECoG) under different types of anaesthesia (nembutal. ketamine or zoletil) were examined by the distribution of spectral entropy across frequency bands of ECoG and by calculation of fractal dimension determined on the basis of Higuchi's algorithm. Spectral entropy, as a measure of activity, in the case of cerebrum had greater values than the spectral entropy of cerebellum in low frequency ranges, regardless of the type or applied anesthetic. Various anesthetics evoked different effects on spectral entropy of electrocortical activity: spectral entropy of delta range greatly dominated under nembutal anesthesia, while ketamine or zoletil appeared to affect the spectral entropy of higher frequency ranges. The pronounced effect of ketamine or zoletil anesthesia on spectral entropy of higher frequency was confirmed by the higher values of Higucihi's fractal dimension (ED) of ECoGs, with a tendency of higher ED values in cerebellar activity than cerebral activity.
T2  - Acta Neurobiologiae Experimentalis
T1  - Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia
IS  - 1
VL  - 70
SP  - 173
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1127
ER  - 

@article{
author = "Keković, Goran and Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Sekulić, Slobodan R and Ćulić, Milka",
year = "2010",
abstract = "The features of rat cerebral and cerebellar electrocortical activity (ECoG) under different types of anaesthesia (nembutal. ketamine or zoletil) were examined by the distribution of spectral entropy across frequency bands of ECoG and by calculation of fractal dimension determined on the basis of Higuchi's algorithm. Spectral entropy, as a measure of activity, in the case of cerebrum had greater values than the spectral entropy of cerebellum in low frequency ranges, regardless of the type or applied anesthetic. Various anesthetics evoked different effects on spectral entropy of electrocortical activity: spectral entropy of delta range greatly dominated under nembutal anesthesia, while ketamine or zoletil appeared to affect the spectral entropy of higher frequency ranges. The pronounced effect of ketamine or zoletil anesthesia on spectral entropy of higher frequency was confirmed by the higher values of Higucihi's fractal dimension (ED) of ECoGs, with a tendency of higher ED values in cerebellar activity than cerebral activity.",
journal = "Acta Neurobiologiae Experimentalis",
title = "Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia",
number = "1",
volume = "70",
pages = "173-75",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1127"
}

Keković, G., Stojadinović, G., Martać, L., Podgorac, J., Sekulić, S. R.,& Ćulić, M.. (2010). Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia. in Acta Neurobiologiae Experimentalis, 70(1), 173-75.
https://hdl.handle.net/21.15107/rcub_ibiss_1127

Keković G, Stojadinović G, Martać L, Podgorac J, Sekulić SR, Ćulić M. Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia. in Acta Neurobiologiae Experimentalis. 2010;70(1):173-75.
https://hdl.handle.net/21.15107/rcub_ibiss_1127 .

Keković, Goran, Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Sekulić, Slobodan R, Ćulić, Milka, "Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia" in Acta Neurobiologiae Experimentalis, 70, no. 1 (2010):173-75,
https://hdl.handle.net/21.15107/rcub_ibiss_1127 .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Keković, Goran
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Soković, Marina
AU  - Podgorac, Jelena
AU  - Sekulić, Slobodan R
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1133
AB  - We investigated the rat brain activity in acute seizures evoked by camphor essential oil or its main constituent 1,8-cineole by wavelet (primarily) and fractal analysis. Experiments were performed on anesthetized animals before and after intraperitoneal camphor oil or cineole administration. The properties of frequency bands in pre-ictal, ictal and inter-ictal stages have been determined by wavelet analysis. The domination of 6 frequency band was confirmed in obtained brain activities, which participate with approximate to 45% of mean relative wavelet energy (MRWE) in control signals and arise up to approximate to 76% MRWE in energy spectrum during the ictal stage (after drug administration). Other frequency bands decreased during ictal stage and arised in inter-ictal stage. There was a dose-dependent response of cineole effect: increase in cineole concentration leaded to the higher values of relative wavelet energy (RWE) of delta frequency band while there were slight changes of the mean fractal dimension (FD) values as a measure of system complexity.
T2  - General Physiology and Biophysics
T1  - Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole
IS  - null
VL  - 28
SP  - 289
EP  - 40
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1133
ER  - 

@article{
author = "Ćulić, Milka and Keković, Goran and Stojadinović, Gordana and Martać, Ljiljana and Soković, Marina and Podgorac, Jelena and Sekulić, Slobodan R",
year = "2009",
abstract = "We investigated the rat brain activity in acute seizures evoked by camphor essential oil or its main constituent 1,8-cineole by wavelet (primarily) and fractal analysis. Experiments were performed on anesthetized animals before and after intraperitoneal camphor oil or cineole administration. The properties of frequency bands in pre-ictal, ictal and inter-ictal stages have been determined by wavelet analysis. The domination of 6 frequency band was confirmed in obtained brain activities, which participate with approximate to 45% of mean relative wavelet energy (MRWE) in control signals and arise up to approximate to 76% MRWE in energy spectrum during the ictal stage (after drug administration). Other frequency bands decreased during ictal stage and arised in inter-ictal stage. There was a dose-dependent response of cineole effect: increase in cineole concentration leaded to the higher values of relative wavelet energy (RWE) of delta frequency band while there were slight changes of the mean fractal dimension (FD) values as a measure of system complexity.",
journal = "General Physiology and Biophysics",
title = "Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole",
number = "null",
volume = "28",
pages = "289-40",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1133"
}

Ćulić, M., Keković, G., Stojadinović, G., Martać, L., Soković, M., Podgorac, J.,& Sekulić, S. R.. (2009). Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole. in General Physiology and Biophysics, 28(null), 289-40.
https://hdl.handle.net/21.15107/rcub_ibiss_1133

Ćulić M, Keković G, Stojadinović G, Martać L, Soković M, Podgorac J, Sekulić SR. Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole. in General Physiology and Biophysics. 2009;28(null):289-40.
https://hdl.handle.net/21.15107/rcub_ibiss_1133 .

Ćulić, Milka, Keković, Goran, Stojadinović, Gordana, Martać, Ljiljana, Soković, Marina, Podgorac, Jelena, Sekulić, Slobodan R, "Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole" in General Physiology and Biophysics, 28, no. null (2009):289-40,
https://hdl.handle.net/21.15107/rcub_ibiss_1133 .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Ćulić, Milka
AU  - Martać, Ljiljana
AU  - Soković, M.
AU  - Spasić, S.
AU  - Đoković, D.
PY  - 2008
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/205
AB  - The aim of our study was to investigate the effect of camphor essential oil on rat cerebral cortex activity by fractal analysis. Fractal dimension (FD) values of the parietal electrocortical activity were calculated before and after intra-peritoneal administration of camphor essential oil (450-675 μl/kg) in anesthetized rats. Camphor oil induced seizure-like activity with single and multiple spiking of high amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions. The FD values of cortical activity after camphor oil administration increased on the average. Only FD values of cortical ECoG sequences were lower than those before camphor oil administration.
AB  - Cilj naše studije je bilo istraživanje efekta kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova pomoću fraktalne analize. Vrednosti fraktalne dimenzije parijetalne elektrokortikalne aktivnosti su izračunate pre i posle davanja kamforovog esencijalnog ulja (450-675 μl/kg,i.p.) anesteziranim pacovima. Kamforovo esencijalno ulje izazvalo je moždanu aktivnost nalik na napad sa pojedinačnim i višestrukim šiljak-talasima velike amplitude u parijetalnom elektrokortikogramu kao i povremene klonične konvulzije ekstremiteta. Posle davanja kamforovog ulja, srednje vrednosti fraktalne dimenzije kortikalne aktivnosti suse povećale u proseku. Jedino vrednosti fraktalne dimenzije iktalnih sekvenci elektrokortikograma su bile niže nego one pre davanja kamforovog ulja.
T2  - Archives of Biological Sciences
T1  - Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije
T1  - Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes
IS  - 4
VL  - 60
SP  - 547
EP  - 553
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_205
ER  - 

@article{
author = "Stojadinović, Gordana and Ćulić, Milka and Martać, Ljiljana and Soković, M. and Spasić, S. and Đoković, D.",
year = "2008, 2008",
abstract = "The aim of our study was to investigate the effect of camphor essential oil on rat cerebral cortex activity by fractal analysis. Fractal dimension (FD) values of the parietal electrocortical activity were calculated before and after intra-peritoneal administration of camphor essential oil (450-675 μl/kg) in anesthetized rats. Camphor oil induced seizure-like activity with single and multiple spiking of high amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions. The FD values of cortical activity after camphor oil administration increased on the average. Only FD values of cortical ECoG sequences were lower than those before camphor oil administration., Cilj naše studije je bilo istraživanje efekta kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova pomoću fraktalne analize. Vrednosti fraktalne dimenzije parijetalne elektrokortikalne aktivnosti su izračunate pre i posle davanja kamforovog esencijalnog ulja (450-675 μl/kg,i.p.) anesteziranim pacovima. Kamforovo esencijalno ulje izazvalo je moždanu aktivnost nalik na napad sa pojedinačnim i višestrukim šiljak-talasima velike amplitude u parijetalnom elektrokortikogramu kao i povremene klonične konvulzije ekstremiteta. Posle davanja kamforovog ulja, srednje vrednosti fraktalne dimenzije kortikalne aktivnosti suse povećale u proseku. Jedino vrednosti fraktalne dimenzije iktalnih sekvenci elektrokortikograma su bile niže nego one pre davanja kamforovog ulja.",
journal = "Archives of Biological Sciences",
title = "Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije, Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes",
number = "4",
volume = "60",
pages = "547-553",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_205"
}

Stojadinović, G., Ćulić, M., Martać, L., Soković, M., Spasić, S.,& Đoković, D.. (2008). Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije. in Archives of Biological Sciences, 60(4), 547-553.
https://hdl.handle.net/21.15107/rcub_ibiss_205

Stojadinović G, Ćulić M, Martać L, Soković M, Spasić S, Đoković D. Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije. in Archives of Biological Sciences. 2008;60(4):547-553.
https://hdl.handle.net/21.15107/rcub_ibiss_205 .

Stojadinović, Gordana, Ćulić, Milka, Martać, Ljiljana, Soković, M., Spasić, S., Đoković, D., "Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije" in Archives of Biological Sciences, 60, no. 4 (2008):547-553,
https://hdl.handle.net/21.15107/rcub_ibiss_205 .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Ćulić, Milka
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Soković, Marina
AU  - Spasić, Slađana
AU  - Đoković, Dejan
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/356
AB  - We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.
AB  - Odlučili smo se za istraživanje pojave epileptičnih napada kod pacova izazvanih kamforovim esencijalnim uljem jer se još uvek pojavljuju slučajevi teške intoksikacije kamforom u ljudi. Eksperimenti su izvedeni na odraslim pacovima muškog pola Wistar soja. Operativni zahvati i akutna registrovanja elektrofizioloških signala su obavljeni pod Nembutal anestezijom. Registrovani su lokalni potencijali polja parijetalnog dela kore velikog mozga. Kamforovo esencijalno ulje je pacovima intraperitonealno ubrizgavano (150-675 μl/kg, t.m. u l ml fiziološkog rastvora, i.p). Pomoću brze Furijeove transformacije analizirali smo elektrokortikalne signale pre i oko 2-3 h posle intraperitonealnog ubrizgavanja kamforovog ulja, pri frekvenciji semplovanja od 256/s. Pojavio se veliki porast ukupne snage i relativno povećanje snage u delta opsegu, a smanjenje u teta i beta opsegu kada se pojavila epileptična aktivnost kore velikog mozga - šiljci i talasi potencijala velike amplitude i to tek pri dozi kamforovog ulja većoj od 300 μl/kg, a 5-30 min po ubrizgavanju ulja. Neophodno je dalje ispitivati doznu zavisnost efekta svake od glavnih terpenskih komponenti kamforovog ulja na aktivnost mozga pacova kako bi se obezbedila relativna sigurnost upotrebe esencijalnih ulja.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Trovanje kamforom - spektralna analiza aktivnosti mozga pacova
T1  - Camphor oil poisoning: Spectral analysis of rat brain activity
IS  - 3
VL  - 42
SP  - 233
EP  - 238
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_356
ER  - 

@article{
author = "Stojadinović, Gordana and Ćulić, Milka and Martać, Ljiljana and Kesić, Srđan and Soković, Marina and Spasić, Slađana and Đoković, Dejan",
year = "2006, 2006",
abstract = "We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids., Odlučili smo se za istraživanje pojave epileptičnih napada kod pacova izazvanih kamforovim esencijalnim uljem jer se još uvek pojavljuju slučajevi teške intoksikacije kamforom u ljudi. Eksperimenti su izvedeni na odraslim pacovima muškog pola Wistar soja. Operativni zahvati i akutna registrovanja elektrofizioloških signala su obavljeni pod Nembutal anestezijom. Registrovani su lokalni potencijali polja parijetalnog dela kore velikog mozga. Kamforovo esencijalno ulje je pacovima intraperitonealno ubrizgavano (150-675 μl/kg, t.m. u l ml fiziološkog rastvora, i.p). Pomoću brze Furijeove transformacije analizirali smo elektrokortikalne signale pre i oko 2-3 h posle intraperitonealnog ubrizgavanja kamforovog ulja, pri frekvenciji semplovanja od 256/s. Pojavio se veliki porast ukupne snage i relativno povećanje snage u delta opsegu, a smanjenje u teta i beta opsegu kada se pojavila epileptična aktivnost kore velikog mozga - šiljci i talasi potencijala velike amplitude i to tek pri dozi kamforovog ulja većoj od 300 μl/kg, a 5-30 min po ubrizgavanju ulja. Neophodno je dalje ispitivati doznu zavisnost efekta svake od glavnih terpenskih komponenti kamforovog ulja na aktivnost mozga pacova kako bi se obezbedila relativna sigurnost upotrebe esencijalnih ulja.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova, Camphor oil poisoning: Spectral analysis of rat brain activity",
number = "3",
volume = "42",
pages = "233-238",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_356"
}

Stojadinović, G., Ćulić, M., Martać, L., Kesić, S., Soković, M., Spasić, S.,& Đoković, D.. (2006). Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 233-238.
https://hdl.handle.net/21.15107/rcub_ibiss_356

Stojadinović G, Ćulić M, Martać L, Kesić S, Soković M, Spasić S, Đoković D. Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):233-238.
https://hdl.handle.net/21.15107/rcub_ibiss_356 .

Stojadinović, Gordana, Ćulić, Milka, Martać, Ljiljana, Kesić, Srđan, Soković, Marina, Spasić, Slađana, Đoković, Dejan, "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):233-238,
https://hdl.handle.net/21.15107/rcub_ibiss_356 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Ćulić, Milka
AU  - Stojadinović, Gordana
AU  - Spasić, Slađana
AU  - Sekulić, Slobodan
AU  - Lalošević, Dušan
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/333
AB  - The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.
AB  - Predmet ovog istraživanja je bio da se elektrofiziološki prouče efekti aluminijumske neurotoksičnosti. Animalni model neurodegenerativne demencije postignut je hroničnim tretmanom Wistar pacova sa aluminium hloridom u toku 4 nedelje u dozi od 2 mg/kg aluminijuma dnevno. Elektrofiziološko registrovanje levog i desnog somatosenzornog korteksa pacova tretiranih aluminijumom i kontrolnih pacova je vršeno pod Nembutalskom anestezijom. Analogno-digitalna konverzija registrovanih signala je izvršena pri frekvenciji semplovanja 256Hz. Spektralna analiza elektrokortikalne aktivnosti u trajanju od 120s (podeljena u epohe od 8s) je izvršena Furijeovom transformacijom, a fraktalna dimenzija ovih signala je izračunata Higučijevim algoritmom. Relativni spektri snage cerebralne aktivnosti u delta frekventnom opsegu su bili povećani, a u (8.1-15.0 Hz) frekventnom opsegu su bili smanjeni kod aluminijumom tretiranih životinja u odnosu na kontrolne. Srednja fraktalna dimenzija elektrokortikalne aktivnosti kod tretiranih pacova je manja - 1,290 u odnosu na srednju fraktalnu dimenziju elektrokortikalne aktivnosti kontrolnih pacova - 1,377. Spektralne i fraktalne karakteristike mogu biti elektrofiziološki znak razvitka neurodegenerativnih procesa kao kod Alchajmerove bolesti.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova
T1  - Effect of aluminium neurotoxicity on the rat brain electrocortical activity
IS  - 3
VL  - 42
SP  - 219
EP  - 225
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_333
ER  - 

@article{
author = "Martać, Ljiljana and Kesić, Srđan and Ćulić, Milka and Stojadinović, Gordana and Spasić, Slađana and Sekulić, Slobodan and Lalošević, Dušan",
year = "2006, 2006",
abstract = "The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia., Predmet ovog istraživanja je bio da se elektrofiziološki prouče efekti aluminijumske neurotoksičnosti. Animalni model neurodegenerativne demencije postignut je hroničnim tretmanom Wistar pacova sa aluminium hloridom u toku 4 nedelje u dozi od 2 mg/kg aluminijuma dnevno. Elektrofiziološko registrovanje levog i desnog somatosenzornog korteksa pacova tretiranih aluminijumom i kontrolnih pacova je vršeno pod Nembutalskom anestezijom. Analogno-digitalna konverzija registrovanih signala je izvršena pri frekvenciji semplovanja 256Hz. Spektralna analiza elektrokortikalne aktivnosti u trajanju od 120s (podeljena u epohe od 8s) je izvršena Furijeovom transformacijom, a fraktalna dimenzija ovih signala je izračunata Higučijevim algoritmom. Relativni spektri snage cerebralne aktivnosti u delta frekventnom opsegu su bili povećani, a u (8.1-15.0 Hz) frekventnom opsegu su bili smanjeni kod aluminijumom tretiranih životinja u odnosu na kontrolne. Srednja fraktalna dimenzija elektrokortikalne aktivnosti kod tretiranih pacova je manja - 1,290 u odnosu na srednju fraktalnu dimenziju elektrokortikalne aktivnosti kontrolnih pacova - 1,377. Spektralne i fraktalne karakteristike mogu biti elektrofiziološki znak razvitka neurodegenerativnih procesa kao kod Alchajmerove bolesti.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova, Effect of aluminium neurotoxicity on the rat brain electrocortical activity",
number = "3",
volume = "42",
pages = "219-225",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_333"
}

Martać, L., Kesić, S., Ćulić, M., Stojadinović, G., Spasić, S., Sekulić, S.,& Lalošević, D.. (2006). Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 219-225.
https://hdl.handle.net/21.15107/rcub_ibiss_333

Martać L, Kesić S, Ćulić M, Stojadinović G, Spasić S, Sekulić S, Lalošević D. Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):219-225.
https://hdl.handle.net/21.15107/rcub_ibiss_333 .

Martać, Ljiljana, Kesić, Srđan, Ćulić, Milka, Stojadinović, Gordana, Spasić, Slađana, Sekulić, Slobodan, Lalošević, Dušan, "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):219-225,
https://hdl.handle.net/21.15107/rcub_ibiss_333 .

TY  - CONF
AU  - Spasić, Slađana Z.
AU  - Stojadinović, Gordana
AU  - Kalauzi, Aleksandar
AU  - Ćulić, Milka
AU  - Martać, Ljiljana
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1715
AB  - We recorded electrocortical activity in anesthetized rats and constructed kmax new self-similar time series, applying Higuchi's algorithm. The aim of this study was to estimate value of the parameter k(max). in order to obtain fractal dimension values as an optimum measure of biosignal change. After our analysis, electrocortical activity recordings resulted in a family of curves f(k(max)). Three regions could be distinguished 2 <= k(max). < 8, with a U-shape; 8 <= k(max) <= 30, with a steeper quasilinear increase; and k(max) >= 30, with a smaller slope quasilinear increase. We suggest the optimum region for k(max): 8 < k(max) < 18, specifically k(max) = 8.
C3  - Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus
T1  - Estimation of parameter k(max) in fractal analysis of rat brain activity
IS  - null
VL  - 1048
EP  - 429
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1715
ER  - 

@conference{
author = "Spasić, Slađana Z. and Stojadinović, Gordana and Kalauzi, Aleksandar and Ćulić, Milka and Martać, Ljiljana",
year = "2005",
abstract = "We recorded electrocortical activity in anesthetized rats and constructed kmax new self-similar time series, applying Higuchi's algorithm. The aim of this study was to estimate value of the parameter k(max). in order to obtain fractal dimension values as an optimum measure of biosignal change. After our analysis, electrocortical activity recordings resulted in a family of curves f(k(max)). Three regions could be distinguished 2 <= k(max). < 8, with a U-shape; 8 <= k(max) <= 30, with a steeper quasilinear increase; and k(max) >= 30, with a smaller slope quasilinear increase. We suggest the optimum region for k(max): 8 < k(max) < 18, specifically k(max) = 8.",
journal = "Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus",
title = "Estimation of parameter k(max) in fractal analysis of rat brain activity",
number = "null",
volume = "1048",
pages = "429",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1715"
}

Spasić, S. Z., Stojadinović, G., Kalauzi, A., Ćulić, M.,& Martać, L.. (2005). Estimation of parameter k(max) in fractal analysis of rat brain activity. in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus, 1048(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1715

Spasić SZ, Stojadinović G, Kalauzi A, Ćulić M, Martać L. Estimation of parameter k(max) in fractal analysis of rat brain activity. in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus. 2005;1048(null):null-429.
https://hdl.handle.net/21.15107/rcub_ibiss_1715 .

Spasić, Slađana Z., Stojadinović, Gordana, Kalauzi, Aleksandar, Ćulić, Milka, Martać, Ljiljana, "Estimation of parameter k(max) in fractal analysis of rat brain activity" in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus, 1048, no. null (2005),
https://hdl.handle.net/21.15107/rcub_ibiss_1715 .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Kalauzi, Aleksandar
AU  - Spasić, Slađana Z.
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1685
AB  - We propose a new method for calculating fractal dimension (DF) of a signal y(t), based on coefficients m(y)((n)), mean absolute values of its nth order derivatives (consecutive finite differences for sampled signals). We found that logarithms of m(y)((n)), = 2, 3,..., n(max), exhibited linear dependence on n: log (m(y)((n))) = (slope)n + Y(int) with stable slopes and Y-intercepts proportional to signal DF values. Using a family of Weierstrass functions, we established a link between Y-intercepts and signal fractal dimension: DF = A(n(max))Y(int) + B(n(max)), and calculated parameters A(n(max)) and B(n(max)) for n(max) = 3,..., 7. Compared to Higuchi's algorithm, advantages of this method include greater speed and eliminating the need to choose value for k(max), since the smallest error was obtained with n(max) = 3.
T2  - Fractals-Complex Geometry Patterns and Scaling in Nature and Society
T1  - Consecutive differences as a method of signal fractal analysis
IS  - 4
VL  - 13
EP  - 292
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1685
ER  - 

@article{
author = "Ćulić, Milka and Kalauzi, Aleksandar and Spasić, Slađana Z. and Stojadinović, Gordana and Martać, Ljiljana",
year = "2005",
abstract = "We propose a new method for calculating fractal dimension (DF) of a signal y(t), based on coefficients m(y)((n)), mean absolute values of its nth order derivatives (consecutive finite differences for sampled signals). We found that logarithms of m(y)((n)), = 2, 3,..., n(max), exhibited linear dependence on n: log (m(y)((n))) = (slope)n + Y(int) with stable slopes and Y-intercepts proportional to signal DF values. Using a family of Weierstrass functions, we established a link between Y-intercepts and signal fractal dimension: DF = A(n(max))Y(int) + B(n(max)), and calculated parameters A(n(max)) and B(n(max)) for n(max) = 3,..., 7. Compared to Higuchi's algorithm, advantages of this method include greater speed and eliminating the need to choose value for k(max), since the smallest error was obtained with n(max) = 3.",
journal = "Fractals-Complex Geometry Patterns and Scaling in Nature and Society",
title = "Consecutive differences as a method of signal fractal analysis",
number = "4",
volume = "13",
pages = "292",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1685"
}

Ćulić, M., Kalauzi, A., Spasić, S. Z., Stojadinović, G.,& Martać, L.. (2005). Consecutive differences as a method of signal fractal analysis. in Fractals-Complex Geometry Patterns and Scaling in Nature and Society, 13(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1685

Ćulić M, Kalauzi A, Spasić SZ, Stojadinović G, Martać L. Consecutive differences as a method of signal fractal analysis. in Fractals-Complex Geometry Patterns and Scaling in Nature and Society. 2005;13(4):null-292.
https://hdl.handle.net/21.15107/rcub_ibiss_1685 .

Ćulić, Milka, Kalauzi, Aleksandar, Spasić, Slađana Z., Stojadinović, Gordana, Martać, Ljiljana, "Consecutive differences as a method of signal fractal analysis" in Fractals-Complex Geometry Patterns and Scaling in Nature and Society, 13, no. 4 (2005),
https://hdl.handle.net/21.15107/rcub_ibiss_1685 .

TY  - JOUR
AU  - Milenković, Ivanka M.
AU  - Filipović, R
AU  - Nedeljković, Nadezda N
AU  - Peković, Sanja
AU  - Ćulić, Milka
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana B
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1731
AB  - 1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2 - 30 days following unilateral injection of kainic acid (KA) or physiological saline (SC). 2. Analysis of the staining intensity and pattern demonstrated that injection of both KA and physiological saline elicited significant and long-lasting increase of pNFP and npNFP immunoreactivity, at the ipsilateral, and to lesser extent at the contralateral side of lesion. 3. Kainate intoxication induced abundant expression of pNFP and npNFP in cerebellar white matter, as well as in all layers of perilesioned cortex. Higher pNFP expression was evidenced in the Purkinje cell layer, particularly at cell bodies, initial segments, and proximal dendrites, which normally do not contain pNFP. In addition, synaptophysin immunocytochemistry was used as a marker of synaptogenesis and plasticity. 4. Spatio-temporal pattern of NFP and synaptophysin expression suggests that perilesioned cortex undergoes dynamic changes following brain demage and possess a reparative capacity to abridge the consequences of brain trauma.
T2  - Cellular and Molecular Neurobiology
T1  - Spatio-temporal changes in neurofilament proteins immunoreactivity following kainate-induced cerebellar lesion in rats
IS  - 3
VL  - 24
EP  - 378
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1731
ER  - 

@article{
author = "Milenković, Ivanka M. and Filipović, R and Nedeljković, Nadezda N and Peković, Sanja and Ćulić, Milka and Rakić, Ljubisav and Stojiljković, Mirjana B",
year = "2004",
abstract = "1. Spatio-temporal changes in phosphorylated (pNFP) and nonphosphorylated (npNFP) neurofilament proteins were assessed immunocytochemicaly in adult rat cerebellum, 2 - 30 days following unilateral injection of kainic acid (KA) or physiological saline (SC). 2. Analysis of the staining intensity and pattern demonstrated that injection of both KA and physiological saline elicited significant and long-lasting increase of pNFP and npNFP immunoreactivity, at the ipsilateral, and to lesser extent at the contralateral side of lesion. 3. Kainate intoxication induced abundant expression of pNFP and npNFP in cerebellar white matter, as well as in all layers of perilesioned cortex. Higher pNFP expression was evidenced in the Purkinje cell layer, particularly at cell bodies, initial segments, and proximal dendrites, which normally do not contain pNFP. In addition, synaptophysin immunocytochemistry was used as a marker of synaptogenesis and plasticity. 4. Spatio-temporal pattern of NFP and synaptophysin expression suggests that perilesioned cortex undergoes dynamic changes following brain demage and possess a reparative capacity to abridge the consequences of brain trauma.",
journal = "Cellular and Molecular Neurobiology",
title = "Spatio-temporal changes in neurofilament proteins immunoreactivity following kainate-induced cerebellar lesion in rats",
number = "3",
volume = "24",
pages = "378",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1731"
}

Milenković, I. M., Filipović, R., Nedeljković, N. N., Peković, S., Ćulić, M., Rakić, L.,& Stojiljković, M. B.. (2004). Spatio-temporal changes in neurofilament proteins immunoreactivity following kainate-induced cerebellar lesion in rats. in Cellular and Molecular Neurobiology, 24(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1731

Milenković IM, Filipović R, Nedeljković NN, Peković S, Ćulić M, Rakić L, Stojiljković MB. Spatio-temporal changes in neurofilament proteins immunoreactivity following kainate-induced cerebellar lesion in rats. in Cellular and Molecular Neurobiology. 2004;24(3):null-378.
https://hdl.handle.net/21.15107/rcub_ibiss_1731 .

Milenković, Ivanka M., Filipović, R, Nedeljković, Nadezda N, Peković, Sanja, Ćulić, Milka, Rakić, Ljubisav, Stojiljković, Mirjana B, "Spatio-temporal changes in neurofilament proteins immunoreactivity following kainate-induced cerebellar lesion in rats" in Cellular and Molecular Neurobiology, 24, no. 3 (2004),
https://hdl.handle.net/21.15107/rcub_ibiss_1731 .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Kalauzi, Aleksandar
AU  - Spasić, Slađana Z.
PY  - 2003
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/95
AB  - Simple, complex action potentials (AP) and interspike recorded background activity (RBA) were detected and extracted from 12 rat cerebellar cortical recordings. For each recording, an averaged simple action potential (SAP) was formed. Fourier amplitude spectra of SAP and RBA were similar in all recordings. For one of the recordings, a series of RBA simulations (SBA) was generated, superimposing random SAPs, varying the superposition frequency (fsup). Average Fourier amplitude, Amp(SBA), was calculated, in order to use Amp(SBA)=f(fsup) as a calibration line for reading fsup of RBA, which is a measure of the population activity. A probability distribution for SAP intensities was derived and a family of calibration lines constructed. As all lines were linear and parallel (slope S) in log-log plots, a population activity change could be calculated as fsup2/fsup1=[Amp2(RBA)/Amp(RBA)]1/S.
AB  - Jednostavni, složeni akcioni potencijali (AR) i međuspajkovna osnovna aktivnost (MOA) detektovani su i izdvojeni iz 12 registrovanih signala kore malog mozga pacova. Za svaku registraciju, formiran je usrednjeni jednostavni AR (JAR). Spektri Furijeovih amplituda JAR i MOA signala bili su slični kod svih registracija. Za jednu od registracija, superponiranjem slučajnih usrednjenih jednostavnih akcionih potencijala formiran je niz simulacija međuspajkovne osnovne aktivnosti (SOA), pri čemu je varirana frekvencija superpozicije (fsup). Izračunavana je srednja Furijeova amplituda, Amp(SBA), u cilju korišćenja Amp(SBA)=f(fsup) kao kalibracione linije za očitavanje fsup od MOA, što je mera za aktivnost populacije. Izvedena je raspodela verovatnoća za intenzitete JAR, pomoću koje je konstruisana familija kalibracionih linija. Kako su sve linije linearne i paralelne u log-log dijagramu, sa nagibom S, promena aktivnosti populacije može se izračunati kao fsup2/fsup1 =[Amp2(RBA)/Amp(RBA)]1/S.
T2  - Archives of Biological Sciences
T1  - Neki detalji metode za merenje promena aktivnosti neuronskih populacija
T1  - Some details on the method for measuring activity changes of neuronal populations
IS  - 3-4
VL  - 55
SP  - 71
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_95
ER  - 

@article{
author = "Ćulić, Milka and Kalauzi, Aleksandar and Spasić, Slađana Z.",
year = "2003, 2003",
abstract = "Simple, complex action potentials (AP) and interspike recorded background activity (RBA) were detected and extracted from 12 rat cerebellar cortical recordings. For each recording, an averaged simple action potential (SAP) was formed. Fourier amplitude spectra of SAP and RBA were similar in all recordings. For one of the recordings, a series of RBA simulations (SBA) was generated, superimposing random SAPs, varying the superposition frequency (fsup). Average Fourier amplitude, Amp(SBA), was calculated, in order to use Amp(SBA)=f(fsup) as a calibration line for reading fsup of RBA, which is a measure of the population activity. A probability distribution for SAP intensities was derived and a family of calibration lines constructed. As all lines were linear and parallel (slope S) in log-log plots, a population activity change could be calculated as fsup2/fsup1=[Amp2(RBA)/Amp(RBA)]1/S., Jednostavni, složeni akcioni potencijali (AR) i međuspajkovna osnovna aktivnost (MOA) detektovani su i izdvojeni iz 12 registrovanih signala kore malog mozga pacova. Za svaku registraciju, formiran je usrednjeni jednostavni AR (JAR). Spektri Furijeovih amplituda JAR i MOA signala bili su slični kod svih registracija. Za jednu od registracija, superponiranjem slučajnih usrednjenih jednostavnih akcionih potencijala formiran je niz simulacija međuspajkovne osnovne aktivnosti (SOA), pri čemu je varirana frekvencija superpozicije (fsup). Izračunavana je srednja Furijeova amplituda, Amp(SBA), u cilju korišćenja Amp(SBA)=f(fsup) kao kalibracione linije za očitavanje fsup od MOA, što je mera za aktivnost populacije. Izvedena je raspodela verovatnoća za intenzitete JAR, pomoću koje je konstruisana familija kalibracionih linija. Kako su sve linije linearne i paralelne u log-log dijagramu, sa nagibom S, promena aktivnosti populacije može se izračunati kao fsup2/fsup1 =[Amp2(RBA)/Amp(RBA)]1/S.",
journal = "Archives of Biological Sciences",
title = "Neki detalji metode za merenje promena aktivnosti neuronskih populacija, Some details on the method for measuring activity changes of neuronal populations",
number = "3-4",
volume = "55",
pages = "71-76",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_95"
}

Ćulić, M., Kalauzi, A.,& Spasić, S. Z.. (2003). Neki detalji metode za merenje promena aktivnosti neuronskih populacija. in Archives of Biological Sciences, 55(3-4), 71-76.
https://hdl.handle.net/21.15107/rcub_ibiss_95

Ćulić M, Kalauzi A, Spasić SZ. Neki detalji metode za merenje promena aktivnosti neuronskih populacija. in Archives of Biological Sciences. 2003;55(3-4):71-76.
https://hdl.handle.net/21.15107/rcub_ibiss_95 .

Ćulić, Milka, Kalauzi, Aleksandar, Spasić, Slađana Z., "Neki detalji metode za merenje promena aktivnosti neuronskih populacija" in Archives of Biological Sciences, 55, no. 3-4 (2003):71-76,
https://hdl.handle.net/21.15107/rcub_ibiss_95 .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Todorović, Vera N.
AU  - Drndarević, Neda Č.
AU  - Nikolić-Judith, Anna
AU  - Kalauzi, Aleksandar
AU  - Spasić, Slađana Z.
PY  - 2002
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/462
AB  - Although there has been extensive research on the effect of IGF-I on muscles and bone tissue, the effect on brain aging has received little attention. We investigated the IGF-I content in brains of differently aged rats. The IGF-I contents in cerebellar and cerebral cortex were found to be higher in immature rats (4-5 days old) compared to young adult (2.5 months old) and middle-aged (7.5-9 months old) rats. However, the decrease of mean IGF-I in middle-aged rats compared to immature animals was statistically significant only in the cerebellar codex. Our results indicate that IGF-I content decreases through the lifespan and maybe selectively in some brain regions.
AB  - Vršena su istraživanja insulinu sličnog faktora rasta (IGF-I) na mišićno i koštano tkivo, ali je posvećena mala pažnja efektu na mozak u toku starenja. Mi smo ispitivali sadržaj IGF-I u moždanom tkivu pacova različite starosti. Nađeno je da su IGF-I koncentracije u kori malog mozga kao i velikog mozga mladih pacova (4-5 dana starih) više u poređenju sa sadržajima grupe tek-odraslih pacova starosti 2,5 meseca i grupe nešto starijih odraslih pacova (7,5-9 meseci starih). Međutim, smanjenje koncentracije IGF-I sadržaja samo u kori malog mozga nešto starijih pacova (7,5-9 meseci) bilo je značajno u odnosu na vrednosti u novorođenih (4-5 dana starih pacova). Naši rezultati ukazuju da IGF-I opada tokom života i moguće - selektivno u određenim moždanim regionima.
T2  - Acta veterinaria
T1  - Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova
T1  - Age-related changes in the content of insulin: Like growth factor-l in rat brain
IS  - 5-6
VL  - 52
SP  - 299
EP  - 304
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_462
ER  - 

@article{
author = "Ćulić, Milka and Stojadinović, Gordana and Martać, Ljiljana and Todorović, Vera N. and Drndarević, Neda Č. and Nikolić-Judith, Anna and Kalauzi, Aleksandar and Spasić, Slađana Z.",
year = "2002, 2002",
abstract = "Although there has been extensive research on the effect of IGF-I on muscles and bone tissue, the effect on brain aging has received little attention. We investigated the IGF-I content in brains of differently aged rats. The IGF-I contents in cerebellar and cerebral cortex were found to be higher in immature rats (4-5 days old) compared to young adult (2.5 months old) and middle-aged (7.5-9 months old) rats. However, the decrease of mean IGF-I in middle-aged rats compared to immature animals was statistically significant only in the cerebellar codex. Our results indicate that IGF-I content decreases through the lifespan and maybe selectively in some brain regions., Vršena su istraživanja insulinu sličnog faktora rasta (IGF-I) na mišićno i koštano tkivo, ali je posvećena mala pažnja efektu na mozak u toku starenja. Mi smo ispitivali sadržaj IGF-I u moždanom tkivu pacova različite starosti. Nađeno je da su IGF-I koncentracije u kori malog mozga kao i velikog mozga mladih pacova (4-5 dana starih) više u poređenju sa sadržajima grupe tek-odraslih pacova starosti 2,5 meseca i grupe nešto starijih odraslih pacova (7,5-9 meseci starih). Međutim, smanjenje koncentracije IGF-I sadržaja samo u kori malog mozga nešto starijih pacova (7,5-9 meseci) bilo je značajno u odnosu na vrednosti u novorođenih (4-5 dana starih pacova). Naši rezultati ukazuju da IGF-I opada tokom života i moguće - selektivno u određenim moždanim regionima.",
journal = "Acta veterinaria",
title = "Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova, Age-related changes in the content of insulin: Like growth factor-l in rat brain",
number = "5-6",
volume = "52",
pages = "299-304",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_462"
}

Ćulić, M., Stojadinović, G., Martać, L., Todorović, V. N., Drndarević, N. Č., Nikolić-Judith, A., Kalauzi, A.,& Spasić, S. Z.. (2002). Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova. in Acta veterinaria, 52(5-6), 299-304.
https://hdl.handle.net/21.15107/rcub_ibiss_462

Ćulić M, Stojadinović G, Martać L, Todorović VN, Drndarević NČ, Nikolić-Judith A, Kalauzi A, Spasić SZ. Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova. in Acta veterinaria. 2002;52(5-6):299-304.
https://hdl.handle.net/21.15107/rcub_ibiss_462 .

Ćulić, Milka, Stojadinović, Gordana, Martać, Ljiljana, Todorović, Vera N., Drndarević, Neda Č., Nikolić-Judith, Anna, Kalauzi, Aleksandar, Spasić, Slađana Z., "Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova" in Acta veterinaria, 52, no. 5-6 (2002):299-304,
https://hdl.handle.net/21.15107/rcub_ibiss_462 .