TY  - JOUR
AU  - Radić, I
AU  - Mijović, M
AU  - Tatalović, Nikola
AU  - Mitić, M
AU  - Lukić, V
AU  - Joksimović, B
AU  - Petrović, Z
AU  - Ristić, S
AU  - Veličković, S
AU  - Nestorovic, V
AU  - Corac, A
AU  - Mirić, M
AU  - Adžić, M
AU  - Blagojević, Duško
AU  - Popović, L
AU  - Hudomal, S J
PY  - 2019
UR  - http://journals.sagepub.com/doi/10.1177/0960327119829518
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3281
AB  - In 2012, alcohol liver disease resulted in 3.3 million-5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey ( per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper-zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling.
T2  - Human & Experimental Toxicology
T1  - Protective effects of whey on rat liver damage induced by chronic alcohol intake.
DO  - 10.1177/0960327119829518
ER  - 

@article{
author = "Radić, I and Mijović, M and Tatalović, Nikola and Mitić, M and Lukić, V and Joksimović, B and Petrović, Z and Ristić, S and Veličković, S and Nestorovic, V and Corac, A and Mirić, M and Adžić, M and Blagojević, Duško and Popović, L and Hudomal, S J",
year = "2019",
abstract = "In 2012, alcohol liver disease resulted in 3.3 million-5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey ( per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper-zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling.",
journal = "Human & Experimental Toxicology",
title = "Protective effects of whey on rat liver damage induced by chronic alcohol intake.",
doi = "10.1177/0960327119829518"
}

Radić, I., Mijović, M., Tatalović, N., Mitić, M., Lukić, V., Joksimović, B., Petrović, Z., Ristić, S., Veličković, S., Nestorovic, V., Corac, A., Mirić, M., Adžić, M., Blagojević, D., Popović, L.,& Hudomal, S. J.. (2019). Protective effects of whey on rat liver damage induced by chronic alcohol intake.. in Human & Experimental Toxicology.
https://doi.org/10.1177/0960327119829518

Radić I, Mijović M, Tatalović N, Mitić M, Lukić V, Joksimović B, Petrović Z, Ristić S, Veličković S, Nestorovic V, Corac A, Mirić M, Adžić M, Blagojević D, Popović L, Hudomal SJ. Protective effects of whey on rat liver damage induced by chronic alcohol intake.. in Human & Experimental Toxicology. 2019;.
doi:10.1177/0960327119829518 .

Radić, I, Mijović, M, Tatalović, Nikola, Mitić, M, Lukić, V, Joksimović, B, Petrović, Z, Ristić, S, Veličković, S, Nestorovic, V, Corac, A, Mirić, M, Adžić, M, Blagojević, Duško, Popović, L, Hudomal, S J, "Protective effects of whey on rat liver damage induced by chronic alcohol intake." in Human & Experimental Toxicology (2019),
https://doi.org/10.1177/0960327119829518 . .