TY  - JOUR
AU  - Katanić Stanković, Jelena S.
AU  - Đorović Jovanović, Jelena
AU  - Mišić, Danijela
AU  - Gašić, Uroš
AU  - Nikles, Stefanie
AU  - Marković, Zoran
AU  - Bauer, Rudolf
PY  - 2023
UR  - https://www.mdpi.com/1420-3049/28/3/1274
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9921532
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5482
AB  - Rabelera holostea (L.) M. T. Sharples & E. A. Tripp (Greater Stitchwort), formerly known as Stellaria holostea L., is widespread in the warm temperate areas of Europe and Western Asia, the Caucasus region, as well as in some countries of North Africa. Nowadays it is considered as a weed, but earlier it was often used raw in salads or for the treatment of various inflammatory disorders. The goal of this study was to determine the constituents of the methanol extract of R. holostea aerial parts and its biological potential in terms of antioxidant, antimicrobial, and anti-inflammatory properties. Until now, the constituents and biological activities of this plant were not reported in detail. A comprehensive phytochemical profiling of the extract has shown that phenolic acids, such as ferulic, chlorogenic, and p-coumaric acid, flavonoids and flavonoid glucosides, such as chrysoeriol, rutin, and naringin, are the most abundant compounds. The antioxidant activity of R. holostea extract towards DPPH and ABTS radicals, but also the total antioxidant capacity and the inhibition of lipid peroxidation were moderate. The antimicrobial potential was pronounced mostly towards some fungi such as F. oxysporum (MIC 1.25 mg/mL), whereas the capacity of R. holostea to affect the growth of bacteria was much less pronounced. R. holostea extract was most inclined to anti-inflammatory activity. At a concentration of 50 µg/mL, it significantly inhibited both cyclooxygenase enzymes (COX-1 and COX-2) by 71.24% and 72.83%, respectively. Molecular docking studies indicated that chlorogenic acid and chrysoeriol are the main contributors to COX-1 and COX-2 inhibitory activity.
PB  - Basel: MDPI
T2  - Molecules (Basel, Switzerland)
T1  - UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract
IS  - 3
VL  - 28
DO  - 10.3390/molecules28031274
SP  - 1274
ER  - 

@article{
author = "Katanić Stanković, Jelena S. and Đorović Jovanović, Jelena and Mišić, Danijela and Gašić, Uroš and Nikles, Stefanie and Marković, Zoran and Bauer, Rudolf",
year = "2023",
abstract = "Rabelera holostea (L.) M. T. Sharples & E. A. Tripp (Greater Stitchwort), formerly known as Stellaria holostea L., is widespread in the warm temperate areas of Europe and Western Asia, the Caucasus region, as well as in some countries of North Africa. Nowadays it is considered as a weed, but earlier it was often used raw in salads or for the treatment of various inflammatory disorders. The goal of this study was to determine the constituents of the methanol extract of R. holostea aerial parts and its biological potential in terms of antioxidant, antimicrobial, and anti-inflammatory properties. Until now, the constituents and biological activities of this plant were not reported in detail. A comprehensive phytochemical profiling of the extract has shown that phenolic acids, such as ferulic, chlorogenic, and p-coumaric acid, flavonoids and flavonoid glucosides, such as chrysoeriol, rutin, and naringin, are the most abundant compounds. The antioxidant activity of R. holostea extract towards DPPH and ABTS radicals, but also the total antioxidant capacity and the inhibition of lipid peroxidation were moderate. The antimicrobial potential was pronounced mostly towards some fungi such as F. oxysporum (MIC 1.25 mg/mL), whereas the capacity of R. holostea to affect the growth of bacteria was much less pronounced. R. holostea extract was most inclined to anti-inflammatory activity. At a concentration of 50 µg/mL, it significantly inhibited both cyclooxygenase enzymes (COX-1 and COX-2) by 71.24% and 72.83%, respectively. Molecular docking studies indicated that chlorogenic acid and chrysoeriol are the main contributors to COX-1 and COX-2 inhibitory activity.",
publisher = "Basel: MDPI",
journal = "Molecules (Basel, Switzerland)",
title = "UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract",
number = "3",
volume = "28",
doi = "10.3390/molecules28031274",
pages = "1274"
}

Katanić Stanković, J. S., Đorović Jovanović, J., Mišić, D., Gašić, U., Nikles, S., Marković, Z.,& Bauer, R.. (2023). UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract. in Molecules (Basel, Switzerland)
Basel: MDPI., 28(3), 1274.
https://doi.org/10.3390/molecules28031274

Katanić Stanković JS, Đorović Jovanović J, Mišić D, Gašić U, Nikles S, Marković Z, Bauer R. UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract. in Molecules (Basel, Switzerland). 2023;28(3):1274.
doi:10.3390/molecules28031274 .

Katanić Stanković, Jelena S., Đorović Jovanović, Jelena, Mišić, Danijela, Gašić, Uroš, Nikles, Stefanie, Marković, Zoran, Bauer, Rudolf, "UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract" in Molecules (Basel, Switzerland), 28, no. 3 (2023):1274,
https://doi.org/10.3390/molecules28031274 . .

TY  - JOUR
AU  - Katanić Stanković, Jelena S.
AU  - Mićanović, Nenad
AU  - Grozdanić, Nađa
AU  - Kostić, Aleksandar Ž.
AU  - Gašić, Uroš
AU  - Stanojković, Tatjana
AU  - Popović-Đorđević, Jelena B.
PY  - 2022
UR  - https://www.mdpi.com/2311-7524/8/11/1053
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5241
AB  - Plant-based food represents an excellent source of different nutrients and bioactive compounds, such as phenolics, carotenoids, vitamins, etc., with proven health benefits for humans. The content of selected phytochemicals, polyphenolic profile, and biological activity (antioxidant potential and α-glucosidase inhibitory activity) of fruit extracts of medlar (Mespilus germanica L.), blackthorn (Prunus spinosa L.), and common hawthorn (Crataegus monogyna Jacq.), the neglected Rosaceae species originated from Serbia were studied. Targeted UHPLC/(−)HESI–MS/MS quantitative analysis of phenolic compounds revealed pinocembrin only in medlar fruit extract, and it is the first report of this flavanone in medlar fruits. Total phenolic content did not differ between extracts, whereas significant differences were observed for the contents of total flavonoids, total phenolic acids, and total gallotannins. Monomeric anthocyanins and total anthocyanins were significantly higher in blackthorn compared to medlar and hawthorn fruit extracts (p < 0.05). DPPH· and ABTS·+ scavenging activities for examined fruits were modest compared to other natural antioxidants and BHT. The most potent inhibitory activity toward α-glucosidase expressed medlar and blackthorn extracts with IC50 values of 129.46 and 199.84 μg/mL, respectively, which was higher compared to the standard drug acarbose.
PB  - Basel: MDPI
T2  - Horticulturae
T1  - Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia
IS  - 11
VL  - 8
DO  - 10.3390/horticulturae8111053
SP  - 1053
ER  - 

@article{
author = "Katanić Stanković, Jelena S. and Mićanović, Nenad and Grozdanić, Nađa and Kostić, Aleksandar Ž. and Gašić, Uroš and Stanojković, Tatjana and Popović-Đorđević, Jelena B.",
year = "2022",
abstract = "Plant-based food represents an excellent source of different nutrients and bioactive compounds, such as phenolics, carotenoids, vitamins, etc., with proven health benefits for humans. The content of selected phytochemicals, polyphenolic profile, and biological activity (antioxidant potential and α-glucosidase inhibitory activity) of fruit extracts of medlar (Mespilus germanica L.), blackthorn (Prunus spinosa L.), and common hawthorn (Crataegus monogyna Jacq.), the neglected Rosaceae species originated from Serbia were studied. Targeted UHPLC/(−)HESI–MS/MS quantitative analysis of phenolic compounds revealed pinocembrin only in medlar fruit extract, and it is the first report of this flavanone in medlar fruits. Total phenolic content did not differ between extracts, whereas significant differences were observed for the contents of total flavonoids, total phenolic acids, and total gallotannins. Monomeric anthocyanins and total anthocyanins were significantly higher in blackthorn compared to medlar and hawthorn fruit extracts (p < 0.05). DPPH· and ABTS·+ scavenging activities for examined fruits were modest compared to other natural antioxidants and BHT. The most potent inhibitory activity toward α-glucosidase expressed medlar and blackthorn extracts with IC50 values of 129.46 and 199.84 μg/mL, respectively, which was higher compared to the standard drug acarbose.",
publisher = "Basel: MDPI",
journal = "Horticulturae",
title = "Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia",
number = "11",
volume = "8",
doi = "10.3390/horticulturae8111053",
pages = "1053"
}

Katanić Stanković, J. S., Mićanović, N., Grozdanić, N., Kostić, A. Ž., Gašić, U., Stanojković, T.,& Popović-Đorđević, J. B.. (2022). Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia. in Horticulturae
Basel: MDPI., 8(11), 1053.
https://doi.org/10.3390/horticulturae8111053

Katanić Stanković JS, Mićanović N, Grozdanić N, Kostić AŽ, Gašić U, Stanojković T, Popović-Đorđević JB. Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia. in Horticulturae. 2022;8(11):1053.
doi:10.3390/horticulturae8111053 .

Katanić Stanković, Jelena S., Mićanović, Nenad, Grozdanić, Nađa, Kostić, Aleksandar Ž., Gašić, Uroš, Stanojković, Tatjana, Popović-Đorđević, Jelena B., "Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia" in Horticulturae, 8, no. 11 (2022):1053,
https://doi.org/10.3390/horticulturae8111053 . .

TY  - JOUR
AU  - Srećković, Nikola
AU  - Mišić, Danijela
AU  - Gašić, Uroš
AU  - Matić, Sanja Lj.
AU  - Katanić Stanković, Jelena S.
AU  - Mihailović, Nevena R.
AU  - Monti, Daria Maria
AU  - D’Elia, Luigi
AU  - Mihailović, Vladimir
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0926669022013243
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5177
AB  - The genus Salvia is well-known for its use in food as aromatic and spicy herbs, as well as in the pharmaceutical and fragrance industries. Regardless of their importance, some Salvia species have not been thoroughly examined and chemically characterized, including Salvia pratensis L. In the present study, the detailed phenolic composition using LC/MS analysis, some bioactivities, and in vitro digestion stability of S. pratensis aerial part (SPA) and root (SPR) methanol extracts were determined. The results showed that both extracts possess high phenolic content, while SPR was richer in rosmarinic (11065.56 µg/g) and caffeic (509.00 µg/g) acids, as well as salvianolic acid A (519.22 µg/g) and B (291.60 µg/g) amounts quantified by UHPLC-DAD/(-)HESI-MS/MS analysis than SPA. The extracts demonstrated considerable antioxidant activity, particularly radical scavenger activity with IC50 values ranging between 24 and 90 µg/mL. The high inhibitory effect of extracts against DNA oxidative damage induced by peroxyl and hydroxyl radicals was noticed. The root extract was the most effective in inhibiting bacterial growth with MIC < 0.156 mg/mL for some G+ bacterial species. SPR extract was substantially more cytotoxic than SPA against all examined cell lines, particularly on cancer cells. The IC50 values of SPR for two cancerogenic cell lines A431 and SVT2 were 24.3 and 49.6 µg/mL, respectively. S. pratensis, especially its root, possess valuable phenolic compounds and biological properties for potential application as a substitute for some commonly used Salvia species.
T2  - Industrial Crops and Products
T1  - Meadow sage (Salvia pratensis L.): A neglected sage species with valuable phenolic compounds and biological potential
VL  - 189
DO  - 10.1016/j.indcrop.2022.115841
SP  - 115841
ER  - 

@article{
author = "Srećković, Nikola and Mišić, Danijela and Gašić, Uroš and Matić, Sanja Lj. and Katanić Stanković, Jelena S. and Mihailović, Nevena R. and Monti, Daria Maria and D’Elia, Luigi and Mihailović, Vladimir",
year = "2022",
abstract = "The genus Salvia is well-known for its use in food as aromatic and spicy herbs, as well as in the pharmaceutical and fragrance industries. Regardless of their importance, some Salvia species have not been thoroughly examined and chemically characterized, including Salvia pratensis L. In the present study, the detailed phenolic composition using LC/MS analysis, some bioactivities, and in vitro digestion stability of S. pratensis aerial part (SPA) and root (SPR) methanol extracts were determined. The results showed that both extracts possess high phenolic content, while SPR was richer in rosmarinic (11065.56 µg/g) and caffeic (509.00 µg/g) acids, as well as salvianolic acid A (519.22 µg/g) and B (291.60 µg/g) amounts quantified by UHPLC-DAD/(-)HESI-MS/MS analysis than SPA. The extracts demonstrated considerable antioxidant activity, particularly radical scavenger activity with IC50 values ranging between 24 and 90 µg/mL. The high inhibitory effect of extracts against DNA oxidative damage induced by peroxyl and hydroxyl radicals was noticed. The root extract was the most effective in inhibiting bacterial growth with MIC < 0.156 mg/mL for some G+ bacterial species. SPR extract was substantially more cytotoxic than SPA against all examined cell lines, particularly on cancer cells. The IC50 values of SPR for two cancerogenic cell lines A431 and SVT2 were 24.3 and 49.6 µg/mL, respectively. S. pratensis, especially its root, possess valuable phenolic compounds and biological properties for potential application as a substitute for some commonly used Salvia species.",
journal = "Industrial Crops and Products",
title = "Meadow sage (Salvia pratensis L.): A neglected sage species with valuable phenolic compounds and biological potential",
volume = "189",
doi = "10.1016/j.indcrop.2022.115841",
pages = "115841"
}

Srećković, N., Mišić, D., Gašić, U., Matić, S. Lj., Katanić Stanković, J. S., Mihailović, N. R., Monti, D. M., D’Elia, L.,& Mihailović, V.. (2022). Meadow sage (Salvia pratensis L.): A neglected sage species with valuable phenolic compounds and biological potential. in Industrial Crops and Products, 189, 115841.
https://doi.org/10.1016/j.indcrop.2022.115841

Srećković N, Mišić D, Gašić U, Matić SL, Katanić Stanković JS, Mihailović NR, Monti DM, D’Elia L, Mihailović V. Meadow sage (Salvia pratensis L.): A neglected sage species with valuable phenolic compounds and biological potential. in Industrial Crops and Products. 2022;189:115841.
doi:10.1016/j.indcrop.2022.115841 .

Srećković, Nikola, Mišić, Danijela, Gašić, Uroš, Matić, Sanja Lj., Katanić Stanković, Jelena S., Mihailović, Nevena R., Monti, Daria Maria, D’Elia, Luigi, Mihailović, Vladimir, "Meadow sage (Salvia pratensis L.): A neglected sage species with valuable phenolic compounds and biological potential" in Industrial Crops and Products, 189 (2022):115841,
https://doi.org/10.1016/j.indcrop.2022.115841 . .