TY  - JOUR
AU  - Hadi, Najmeh
AU  - Nikolić, Miloš
AU  - Sefidkon, Fatemeh
AU  - Shojaeiyan, Abdolali
AU  - Šiler, Branislav
AU  - Mišić, Danijela
AU  - Yahyazadeh, Mahdi
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6440
AB  - Pathogenic microorganisms are more or less successfully treated by synthetic chemical compounds, whose residues often cause serious health problems. Plant specialized metabolites with antimicrobial properties have for a long time been the focus of both medicine and pharmacology. This study was conducted to evaluate the in vitro antimicrobial activity of methanol extracts of selected endemic and native Iranian Nepeta species against some of the most important pathogenic bacteria and fungi. The results indicated that N. kotschyi leaf extract was the most efficient against the tested bacteria, with Pseudomonas aeruginosa being the most sensitive and fungal species were more susceptible to the extracts than bacterial strains. Nepeta spp. extracts showed a strong antifungal activity against micromycetes, except for quite resistant Aspergillus niger. Antibacterial MIC values (mg.mL-1) ranged from 0.01 (N. kotschyi) to 0.20 (N. crassifolia), while antifungal MIC values ranged from 0.02 (N. crassifolia, N. kotschyi, N. menthoides, and N. cataria) to 0.13 (N. crassifolia and N. menthoides). When compared to positive controls, in most cases the extracts performed much better. The recorded antimicrobial activity candidates the selected 4 endemic and native Iranian Nepeta spp. as prospective and promising antimicrobial agents to be used in both pharmacology and biotechnology.
PB  - CMB Association Publishers
T2  - Cellular and Molecular Biology
T1  - Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents
IS  - 69
VL  - 10
DO  - 10.14715/cmb/2023.69.10.18
SP  - 129
EP  - 135
ER  - 

@article{
author = "Hadi, Najmeh and Nikolić, Miloš and Sefidkon, Fatemeh and Shojaeiyan, Abdolali and Šiler, Branislav and Mišić, Danijela and Yahyazadeh, Mahdi",
year = "2023",
abstract = "Pathogenic microorganisms are more or less successfully treated by synthetic chemical compounds, whose residues often cause serious health problems. Plant specialized metabolites with antimicrobial properties have for a long time been the focus of both medicine and pharmacology. This study was conducted to evaluate the in vitro antimicrobial activity of methanol extracts of selected endemic and native Iranian Nepeta species against some of the most important pathogenic bacteria and fungi. The results indicated that N. kotschyi leaf extract was the most efficient against the tested bacteria, with Pseudomonas aeruginosa being the most sensitive and fungal species were more susceptible to the extracts than bacterial strains. Nepeta spp. extracts showed a strong antifungal activity against micromycetes, except for quite resistant Aspergillus niger. Antibacterial MIC values (mg.mL-1) ranged from 0.01 (N. kotschyi) to 0.20 (N. crassifolia), while antifungal MIC values ranged from 0.02 (N. crassifolia, N. kotschyi, N. menthoides, and N. cataria) to 0.13 (N. crassifolia and N. menthoides). When compared to positive controls, in most cases the extracts performed much better. The recorded antimicrobial activity candidates the selected 4 endemic and native Iranian Nepeta spp. as prospective and promising antimicrobial agents to be used in both pharmacology and biotechnology.",
publisher = "CMB Association Publishers",
journal = "Cellular and Molecular Biology",
title = "Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents",
number = "69",
volume = "10",
doi = "10.14715/cmb/2023.69.10.18",
pages = "129-135"
}

Hadi, N., Nikolić, M., Sefidkon, F., Shojaeiyan, A., Šiler, B., Mišić, D.,& Yahyazadeh, M.. (2023). Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents. in Cellular and Molecular Biology
CMB Association Publishers., 10(69), 129-135.
https://doi.org/10.14715/cmb/2023.69.10.18

Hadi N, Nikolić M, Sefidkon F, Shojaeiyan A, Šiler B, Mišić D, Yahyazadeh M. Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents. in Cellular and Molecular Biology. 2023;10(69):129-135.
doi:10.14715/cmb/2023.69.10.18 .

Hadi, Najmeh, Nikolić, Miloš, Sefidkon, Fatemeh, Shojaeiyan, Abdolali, Šiler, Branislav, Mišić, Danijela, Yahyazadeh, Mahdi, "Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents" in Cellular and Molecular Biology, 10, no. 69 (2023):129-135,
https://doi.org/10.14715/cmb/2023.69.10.18 . .

TY  - JOUR
AU  - Hadi, Najmeh
AU  - Sefidkon, Fatemeh
AU  - Shojaeiyan, Abdolali
AU  - Šiler, Branislav
AU  - Jafari, Ali-Ashraf
AU  - Aničić, Neda
AU  - Mišić, Danijela
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0926669016307440
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2485
AB  - This study was aimed at exploring the possibilities for the exploitation of valuable germplasm of four Iranian Nepeta species, highlighting the opportunities for their economic development as crops. Selection of the most promising species for introducing into cultivation was based on the content of medicinally important phenolic compounds. Twenty nine accessions of four Iranian species, Nepeta kotschyi, N. menthoides, N. crassifolia, and N. cataria, cultivated under western Tehran (Iran) environmental conditions were assessed. Quantitative analysis of five targeted phenolic acids and five targeted flavonoids in methanol extracts was performed using UHPLC/-HESI-MS/MS method. Multivariate analyses of chemometric data (PCA and UPGMA) segregated N. kotschyi as a separate group with unique phenolics composition, characterized by high amounts of phenolic acids, especially chlorogenic acid. As expected, rosmarinic acid has been determined as the dominant phenolic compound in analyzed N. cataria, N. menthoides and N. crassifolia accessions. N. kotschyi is recognized as the most promising candidate species for an alternative crop, and “N16” and “N17” accessions as the most suitable for domestication and cultivation practices under specific environmental conditions provided here.
T2  - Industrial Crops and Products
T1  - Phenolics’ composition in four endemic Nepeta species from Iran cultivated under experimental field conditions: The possibility of the exploitation of Nepeta germplasm
VL  - 95
DO  - 10.1016/j.indcrop.2016.10.059
SP  - 475
EP  - 484
ER  - 

@article{
author = "Hadi, Najmeh and Sefidkon, Fatemeh and Shojaeiyan, Abdolali and Šiler, Branislav and Jafari, Ali-Ashraf and Aničić, Neda and Mišić, Danijela",
year = "2017",
abstract = "This study was aimed at exploring the possibilities for the exploitation of valuable germplasm of four Iranian Nepeta species, highlighting the opportunities for their economic development as crops. Selection of the most promising species for introducing into cultivation was based on the content of medicinally important phenolic compounds. Twenty nine accessions of four Iranian species, Nepeta kotschyi, N. menthoides, N. crassifolia, and N. cataria, cultivated under western Tehran (Iran) environmental conditions were assessed. Quantitative analysis of five targeted phenolic acids and five targeted flavonoids in methanol extracts was performed using UHPLC/-HESI-MS/MS method. Multivariate analyses of chemometric data (PCA and UPGMA) segregated N. kotschyi as a separate group with unique phenolics composition, characterized by high amounts of phenolic acids, especially chlorogenic acid. As expected, rosmarinic acid has been determined as the dominant phenolic compound in analyzed N. cataria, N. menthoides and N. crassifolia accessions. N. kotschyi is recognized as the most promising candidate species for an alternative crop, and “N16” and “N17” accessions as the most suitable for domestication and cultivation practices under specific environmental conditions provided here.",
journal = "Industrial Crops and Products",
title = "Phenolics’ composition in four endemic Nepeta species from Iran cultivated under experimental field conditions: The possibility of the exploitation of Nepeta germplasm",
volume = "95",
doi = "10.1016/j.indcrop.2016.10.059",
pages = "475-484"
}

Hadi, N., Sefidkon, F., Shojaeiyan, A., Šiler, B., Jafari, A., Aničić, N.,& Mišić, D.. (2017). Phenolics’ composition in four endemic Nepeta species from Iran cultivated under experimental field conditions: The possibility of the exploitation of Nepeta germplasm. in Industrial Crops and Products, 95, 475-484.
https://doi.org/10.1016/j.indcrop.2016.10.059

Hadi N, Sefidkon F, Shojaeiyan A, Šiler B, Jafari A, Aničić N, Mišić D. Phenolics’ composition in four endemic Nepeta species from Iran cultivated under experimental field conditions: The possibility of the exploitation of Nepeta germplasm. in Industrial Crops and Products. 2017;95:475-484.
doi:10.1016/j.indcrop.2016.10.059 .

Hadi, Najmeh, Sefidkon, Fatemeh, Shojaeiyan, Abdolali, Šiler, Branislav, Jafari, Ali-Ashraf, Aničić, Neda, Mišić, Danijela, "Phenolics’ composition in four endemic Nepeta species from Iran cultivated under experimental field conditions: The possibility of the exploitation of Nepeta germplasm" in Industrial Crops and Products, 95 (2017):475-484,
https://doi.org/10.1016/j.indcrop.2016.10.059 . .