TY  - JOUR
AU  - Radovanović, Marina
AU  - Kekić, Dusan
AU  - Gajić, Ina
AU  - Kabić, Jovana
AU  - Jovićević, Miloš
AU  - Kekić, Natalija
AU  - Opavski, Nataša
AU  - Ranin, Lazar
PY  - 2023
UR  - https://www.frontiersin.org/articles/10.3389/fnut.2023.1054555/full
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9928729
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5486
AB  - Antimicrobial resistance (AMR) poses a substantial threat to human health. The commensal bacteria of the gut microbiome were shown to serve as a reservoir of antibiotic resistance genes (ARGs), termed the gut resistome, which has the potential to transfer horizontally to pathogens and contribute to the emergence of drug-resistant bacteria. Namely, AMR traits are generally linked with mobile genetic elements (MGEs), which apart from disseminating vertically to the progeny, may cross horizontally to the distantly related microbial species. On the other hand, while probiotics are generally considered beneficiary to human health, and are therefore widely consumed in recent years most commonly in conjunction with antibiotics, the complexities and extent of their impact on the gut microbiome and resistome have not been elucidated. By reviewing the latest studies on ARG containing commercial probiotic products and common probiotic supplement species with their actual effects on the human gut resistome, this study aims to demonstrate that their contribution to the spread of ARGs along the GI tract merits additional attention, but also indicates the changes in sampling and profiling of the gut microbiome which may allow for the more comprehensive studying of the effects of probiotics in this part of the resistome.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems
VL  - 10
DO  - 10.3389/fnut.2023.1054555
SP  - 1054555
ER  - 

@article{
author = "Radovanović, Marina and Kekić, Dusan and Gajić, Ina and Kabić, Jovana and Jovićević, Miloš and Kekić, Natalija and Opavski, Nataša and Ranin, Lazar",
year = "2023",
abstract = "Antimicrobial resistance (AMR) poses a substantial threat to human health. The commensal bacteria of the gut microbiome were shown to serve as a reservoir of antibiotic resistance genes (ARGs), termed the gut resistome, which has the potential to transfer horizontally to pathogens and contribute to the emergence of drug-resistant bacteria. Namely, AMR traits are generally linked with mobile genetic elements (MGEs), which apart from disseminating vertically to the progeny, may cross horizontally to the distantly related microbial species. On the other hand, while probiotics are generally considered beneficiary to human health, and are therefore widely consumed in recent years most commonly in conjunction with antibiotics, the complexities and extent of their impact on the gut microbiome and resistome have not been elucidated. By reviewing the latest studies on ARG containing commercial probiotic products and common probiotic supplement species with their actual effects on the human gut resistome, this study aims to demonstrate that their contribution to the spread of ARGs along the GI tract merits additional attention, but also indicates the changes in sampling and profiling of the gut microbiome which may allow for the more comprehensive studying of the effects of probiotics in this part of the resistome.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems",
volume = "10",
doi = "10.3389/fnut.2023.1054555",
pages = "1054555"
}

Radovanović, M., Kekić, D., Gajić, I., Kabić, J., Jovićević, M., Kekić, N., Opavski, N.,& Ranin, L.. (2023). Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems. in Frontiers in Nutrition
Frontiers Media S.A.., 10, 1054555.
https://doi.org/10.3389/fnut.2023.1054555

Radovanović M, Kekić D, Gajić I, Kabić J, Jovićević M, Kekić N, Opavski N, Ranin L. Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems. in Frontiers in Nutrition. 2023;10:1054555.
doi:10.3389/fnut.2023.1054555 .

Radovanović, Marina, Kekić, Dusan, Gajić, Ina, Kabić, Jovana, Jovićević, Miloš, Kekić, Natalija, Opavski, Nataša, Ranin, Lazar, "Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems" in Frontiers in Nutrition, 10 (2023):1054555,
https://doi.org/10.3389/fnut.2023.1054555 . .