@article{
author = "Milošević, Verica and Ajdžanović, Vladimir and Šošić-Jurjević, Branka and Filipović, Branko and Brkić, Marjana P. and Nestorović, Nataša and Sekulić, Milka I.",
year = "2009",
abstract = "The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases. The aim of this study was to examine the morphofunctional characteristics of adrenocorticotrophic (ACTH) cells and blood concentrations of ACTH in sham-operated, orchidectomized and genistein-treated orchidectomized, 16-month-old Wistar male rats. Genistein (10 mg/kg/day) was administered subcutaneously for three weeks, while the control groups received the vehicle alone. Orchidectomy and genistein treatment decreased the volume density of ACTH cells and reduced (p < 0.05) circulating ACTH concentrations in comparison with control groups. In conclusion, genistein modulated the morphofunctional features of ACTH cells and decreased blood ACTH levels.",
publisher = "Bratislava: Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences",
journal = "General Physiology and Biophysics",
title = "Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein",
number = "1",
volume = "28",
doi = "10.4149/gpb_2009_01_94",
pages = "94-97",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1462"
}