TY  - CHAP
AU  - Smiljanić, Kosara
AU  - Lončarević-Vasiljković, Nataša
AU  - Kanazir, Selma
AU  - Mladenović, Aleksandra
PY  - 2020
UR  - http://www.eurekaselect.com/node/182407
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3965
AB  - Cholesterol is the molecule essential for life, but also with a possible detrimental role. Apart from being a vital structural constituent of the cells, cholesterol is a factor involved in many important cell processes. However, it has been known that high blood cholesterol is associated with many pathological conditions. An elevated level of cholesterol is linked with cardiovascular disease, diabetes and neurodegenerative disorders. Almost quarter of the total cholesterol in the body resides in the brain. This vast pool is synthesized in situ and it is almost completely isolated and independent from the periphery due to the presence of blood-brain barrier. In the central nervous system, cholesterol plays important role in neural cells structure and functions, including synaptic transmission. Due to this, its content must be precisely maintained in order to keep brain function well. However, cholesterol is critically challenged in the aging brain and disturbed in several of pathological conditions, like Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and Smith-Lemli Opitz syndrome (SLOS), traumatic brain injury, multiple sclerosis (MS) and in Alzheimer’s disease (AD). Altered cholesterol metabolism has been extensively implicated in the pathogenesis of AD. A growing amount of evidence underscores the link between disturbed intracellular trafficking of cholesterol in the brain and the formation of amyloid plaques. The inheritance of the epsilon4 allele of the Apolipoprotein E (ApoE), the main transport protein for cholesterol in the brain represents the main risk factor for late onset form of Alzheimer’s disease. Other genetic polymorphisms associated with critical points in cholesterol metabolism may also contribute to the AD pathogenesis. Hypercholesterolemia has been considered nowadays also as a risk factor, and all of these players are thought to promote the production of beta-amyloid and development of AD. Additional proof towards cholesterol involvement in the pathogenesis of AD gave epidemiological data of the cholesterol-lowering drugs, statins that have been shown to decrease the risk for AD. This chapter is aimed to summarize existing knowledge about the brain cholesterol metabolism, how the homeostasis is changed during aging and in various neurodegenerative diseases, with special emphasis on Alzheimer’s disease. As a final point, we will try to give a full insight into the environmental influences (including dietary restriction and statins therapy) on brain cholesterol homeostasis.
PB  - Bentham Science Publishers
T2  - Frontiers in Clinical Drug Research-Dementia
T1  - Cholesterol in Brain Health and Pathologies: The Role in Alzheimer’s Disease
DO  - 10.2174/9789811410949120010004
SP  - 26
EP  - 77
ER  - 

@inbook{
editor = "Atta-ur-Rahman",
author = "Smiljanić, Kosara and Lončarević-Vasiljković, Nataša and Kanazir, Selma and Mladenović, Aleksandra",
year = "2020",
abstract = "Cholesterol is the molecule essential for life, but also with a possible detrimental role. Apart from being a vital structural constituent of the cells, cholesterol is a factor involved in many important cell processes. However, it has been known that high blood cholesterol is associated with many pathological conditions. An elevated level of cholesterol is linked with cardiovascular disease, diabetes and neurodegenerative disorders. Almost quarter of the total cholesterol in the body resides in the brain. This vast pool is synthesized in situ and it is almost completely isolated and independent from the periphery due to the presence of blood-brain barrier. In the central nervous system, cholesterol plays important role in neural cells structure and functions, including synaptic transmission. Due to this, its content must be precisely maintained in order to keep brain function well. However, cholesterol is critically challenged in the aging brain and disturbed in several of pathological conditions, like Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and Smith-Lemli Opitz syndrome (SLOS), traumatic brain injury, multiple sclerosis (MS) and in Alzheimer’s disease (AD). Altered cholesterol metabolism has been extensively implicated in the pathogenesis of AD. A growing amount of evidence underscores the link between disturbed intracellular trafficking of cholesterol in the brain and the formation of amyloid plaques. The inheritance of the epsilon4 allele of the Apolipoprotein E (ApoE), the main transport protein for cholesterol in the brain represents the main risk factor for late onset form of Alzheimer’s disease. Other genetic polymorphisms associated with critical points in cholesterol metabolism may also contribute to the AD pathogenesis. Hypercholesterolemia has been considered nowadays also as a risk factor, and all of these players are thought to promote the production of beta-amyloid and development of AD. Additional proof towards cholesterol involvement in the pathogenesis of AD gave epidemiological data of the cholesterol-lowering drugs, statins that have been shown to decrease the risk for AD. This chapter is aimed to summarize existing knowledge about the brain cholesterol metabolism, how the homeostasis is changed during aging and in various neurodegenerative diseases, with special emphasis on Alzheimer’s disease. As a final point, we will try to give a full insight into the environmental influences (including dietary restriction and statins therapy) on brain cholesterol homeostasis.",
publisher = "Bentham Science Publishers",
journal = "Frontiers in Clinical Drug Research-Dementia",
booktitle = "Cholesterol in Brain Health and Pathologies: The Role in Alzheimer’s Disease",
doi = "10.2174/9789811410949120010004",
pages = "26-77"
}

Atta-ur-Rahman, Smiljanić, K., Lončarević-Vasiljković, N., Kanazir, S.,& Mladenović, A.. (2020). Cholesterol in Brain Health and Pathologies: The Role in Alzheimer’s Disease. in Frontiers in Clinical Drug Research-Dementia
Bentham Science Publishers., 26-77.
https://doi.org/10.2174/9789811410949120010004

Atta-ur-Rahman, Smiljanić K, Lončarević-Vasiljković N, Kanazir S, Mladenović A. Cholesterol in Brain Health and Pathologies: The Role in Alzheimer’s Disease. in Frontiers in Clinical Drug Research-Dementia. 2020;:26-77.
doi:10.2174/9789811410949120010004 .

Atta-ur-Rahman, Smiljanić, Kosara, Lončarević-Vasiljković, Nataša, Kanazir, Selma, Mladenović, Aleksandra, "Cholesterol in Brain Health and Pathologies: The Role in Alzheimer’s Disease" in Frontiers in Clinical Drug Research-Dementia (2020):26-77,
https://doi.org/10.2174/9789811410949120010004 . .

TY  - CHAP
AU  - Stojković, Dejan
AU  - Živković, Jelena
AU  - Stanisavljević, Danijela
AU  - Ivanov, Marija
AU  - Popović, Jelena
AU  - Stevanović, Milena
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2019
UR  - https://www.eurekaselect.com/176849/chapter/cytotoxicity-through-molecular-targets-involved-in-apoptosis.-where-should-we-further-search-for-mushrooms-functi
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3964
AB  - Apoptosis is considered as a classical way of programmed cell death and important control mechanism of cell homeostasis. Cancer cells acquire different instruments to circumvent programmed cell death. This promotes uncontrolled growth and frequently confers chemoresistance to tumor cells. Activation of apoptotic signaling pathway has been a target of anti-cancer drugs in an induction of cytotoxicity. The mechanism of apoptosis is complex and includes many pathways. This chapter will focus on the current knowledge of apoptosis-triggering approaches in cancer therapy, as well as on mushroom extracts and isolated compounds acting as initiators of apoptosis through regulation of genes expression involved in cancer cell death. Furthermore, we pointed out directions for novel search for mushroom functionalities in this experimental field and discuss the possible further steps for exploration on the in vitro and in vivo levels.
PB  - Bentham Science Publishers
T2  - Frontiers in Natural Product Chemistry
T1  - Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?
VL  - 5
DO  - 10.2174/9789811423772119050007
SP  - 146
EP  - 191
ER  - 

@inbook{
editor = "Atta-ur-Rahman",
author = "Stojković, Dejan and Živković, Jelena and Stanisavljević, Danijela and Ivanov, Marija and Popović, Jelena and Stevanović, Milena and Glamočlija, Jasmina and Soković, Marina",
year = "2019",
abstract = "Apoptosis is considered as a classical way of programmed cell death and important control mechanism of cell homeostasis. Cancer cells acquire different instruments to circumvent programmed cell death. This promotes uncontrolled growth and frequently confers chemoresistance to tumor cells. Activation of apoptotic signaling pathway has been a target of anti-cancer drugs in an induction of cytotoxicity. The mechanism of apoptosis is complex and includes many pathways. This chapter will focus on the current knowledge of apoptosis-triggering approaches in cancer therapy, as well as on mushroom extracts and isolated compounds acting as initiators of apoptosis through regulation of genes expression involved in cancer cell death. Furthermore, we pointed out directions for novel search for mushroom functionalities in this experimental field and discuss the possible further steps for exploration on the in vitro and in vivo levels.",
publisher = "Bentham Science Publishers",
journal = "Frontiers in Natural Product Chemistry",
booktitle = "Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?",
volume = "5",
doi = "10.2174/9789811423772119050007",
pages = "146-191"
}

Atta-ur-Rahman, Stojković, D., Živković, J., Stanisavljević, D., Ivanov, M., Popović, J., Stevanović, M., Glamočlija, J.,& Soković, M.. (2019). Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?. in Frontiers in Natural Product Chemistry
Bentham Science Publishers., 5, 146-191.
https://doi.org/10.2174/9789811423772119050007

Atta-ur-Rahman, Stojković D, Živković J, Stanisavljević D, Ivanov M, Popović J, Stevanović M, Glamočlija J, Soković M. Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?. in Frontiers in Natural Product Chemistry. 2019;5:146-191.
doi:10.2174/9789811423772119050007 .

Atta-ur-Rahman, Stojković, Dejan, Živković, Jelena, Stanisavljević, Danijela, Ivanov, Marija, Popović, Jelena, Stevanović, Milena, Glamočlija, Jasmina, Soković, Marina, "Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?" in Frontiers in Natural Product Chemistry, 5 (2019):146-191,
https://doi.org/10.2174/9789811423772119050007 . .

TY  - CHAP
AU  - Šiler, Branislav
AU  - Mišić, Danijela
PY  - 2016
UR  - http://linkinghub.elsevier.com/retrieve/pii/B9780444636010000119
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-84999806577&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3440
AB  - One of the plant genera with the longest tradition in human medicine history is a popular panacea, Centaurium, named according to Pliny because the plant's medicinal properties were reputedly discovered by Chiron the centaur. In 17th century, Culpeper has claimed that its inward or outward usage was so safe that no one could fail in the using of this wholesome plant. Centauries owe this tremendous quality to their secondary metabolites, terpenoid and phenolic compounds. Among them, secoiridoid glycosides are appearing as most abundant class of terpenoids, while pharmaceutically highly appreciated xanthones and flavonoids mostly represent the class of phenolics. A period of momentous exploration of these compounds in the genus Centaurium was the 1960s of the last century. In parallel, vast area of medicinal studies started to apply isolated compounds and herbal extracts, as well to investigate the principles of their positive influence to many human health issues, such as diabetes, digestive and neurological disorders, cancer, and cardiovascular diseases. In modern times, centauries and the compounds they produce still represent the subject of many medicinal and/or pharmacological studies. Their significance is highlighted by the metaanalysis: Google Scholar returns 72 academic titles (without citations), which in the same time contain either the word Centaurium or “centaury” and are dealing with some phytochemical analytics and/or medicinal aspects of herbal extracts. In only last 5 years, totally 15 studies were engaged in elucidation of medicinal or biological activity of centauries, such as antidiabetic activity—five studies; antimicrobial activity—four studies; toxicity (including cytotoxicity)—three studies; and hepatoprotective, gastroprotective, and vasodilatory effects—one study of each. Hence, there is an evident tendency and scientific interest for in-depth research on phytochemistry of the genus Centaurium s.l. and extensive insight into their modes of action to the human health. This study will offer a comprehensive and comparative overview on the secondary metabolites' analytics throughout the genus, with a contextual respect to the biotechnological enhancement of their accumulation. It will also review to-date accomplishments regarding application of various herbal extracts and isolated compounds in (bio)medicinal studies.
PB  - Elsevier B.V.
T2  - Studies in Natural Products Chemistry
T1  - Biologically Active Compounds from the Genus Centaurium s.l. (Gentianaceae)
VL  - 49
DO  - 10.1016/B978-0-444-63601-0.00011-9
SP  - 363
EP  - 397
ER  - 

@inbook{
editor = "Atta-ur-Rahman",
author = "Šiler, Branislav and Mišić, Danijela",
year = "2016",
abstract = "One of the plant genera with the longest tradition in human medicine history is a popular panacea, Centaurium, named according to Pliny because the plant's medicinal properties were reputedly discovered by Chiron the centaur. In 17th century, Culpeper has claimed that its inward or outward usage was so safe that no one could fail in the using of this wholesome plant. Centauries owe this tremendous quality to their secondary metabolites, terpenoid and phenolic compounds. Among them, secoiridoid glycosides are appearing as most abundant class of terpenoids, while pharmaceutically highly appreciated xanthones and flavonoids mostly represent the class of phenolics. A period of momentous exploration of these compounds in the genus Centaurium was the 1960s of the last century. In parallel, vast area of medicinal studies started to apply isolated compounds and herbal extracts, as well to investigate the principles of their positive influence to many human health issues, such as diabetes, digestive and neurological disorders, cancer, and cardiovascular diseases. In modern times, centauries and the compounds they produce still represent the subject of many medicinal and/or pharmacological studies. Their significance is highlighted by the metaanalysis: Google Scholar returns 72 academic titles (without citations), which in the same time contain either the word Centaurium or “centaury” and are dealing with some phytochemical analytics and/or medicinal aspects of herbal extracts. In only last 5 years, totally 15 studies were engaged in elucidation of medicinal or biological activity of centauries, such as antidiabetic activity—five studies; antimicrobial activity—four studies; toxicity (including cytotoxicity)—three studies; and hepatoprotective, gastroprotective, and vasodilatory effects—one study of each. Hence, there is an evident tendency and scientific interest for in-depth research on phytochemistry of the genus Centaurium s.l. and extensive insight into their modes of action to the human health. This study will offer a comprehensive and comparative overview on the secondary metabolites' analytics throughout the genus, with a contextual respect to the biotechnological enhancement of their accumulation. It will also review to-date accomplishments regarding application of various herbal extracts and isolated compounds in (bio)medicinal studies.",
publisher = "Elsevier B.V.",
journal = "Studies in Natural Products Chemistry",
booktitle = "Biologically Active Compounds from the Genus Centaurium s.l. (Gentianaceae)",
volume = "49",
doi = "10.1016/B978-0-444-63601-0.00011-9",
pages = "363-397"
}

Atta-ur-Rahman, Šiler, B.,& Mišić, D.. (2016). Biologically Active Compounds from the Genus Centaurium s.l. (Gentianaceae). in Studies in Natural Products Chemistry
Elsevier B.V.., 49, 363-397.
https://doi.org/10.1016/B978-0-444-63601-0.00011-9

Atta-ur-Rahman, Šiler B, Mišić D. Biologically Active Compounds from the Genus Centaurium s.l. (Gentianaceae). in Studies in Natural Products Chemistry. 2016;49:363-397.
doi:10.1016/B978-0-444-63601-0.00011-9 .

Atta-ur-Rahman, Šiler, Branislav, Mišić, Danijela, "Biologically Active Compounds from the Genus Centaurium s.l. (Gentianaceae)" in Studies in Natural Products Chemistry, 49 (2016):363-397,
https://doi.org/10.1016/B978-0-444-63601-0.00011-9 . .