TY  - JOUR
AU  - Arlt, Sören
AU  - Petković, Vladana
AU  - Ludwig, Gerd
AU  - Eichhorn, Thomas
AU  - Lang, Heinrich
AU  - Rüffer, Tobias
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Kaluđerović, Goran
PY  - 2021
UR  - https://www.mdpi.com/1420-3049/26/7/1860
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4220
AB  - Neutral [Ru(η6-arene)Cl2{Ph2P(CH2)3SPh-κP}] (arene = benzene, indane, 1,2,3,4-tetrahydronaphthalene: 2a, 2c and 2d) and cationic [Ru(η6-arene)Cl(Ph2P(CH2)3SPh-κP,κS)]X complexes (arene = mesitylene, 1,4-dihydronaphthalene; X = Cl: 3b, 3e; arene = benzene, mesitylene, indane, 1,2,3,4-tetrahydronaphthalene, and 1,4-dihydronaphthalene; X = PF6: 4a–4e) complexes were prepared and characterized by elemental analysis, IR, 1H, 13C and 31P NMR spectroscopy and also by single-crystal X-ray diffraction analyses. The stability of the complexes has been investigated in DMSO. Complexes have been assessed for their cytotoxic activity against 518A2, 8505C, A253, MCF-7 and SW480 cell lines. Generally, complexes exhibited activity in the lower micromolar range; moreover, they are found to be more active than cisplatin. For the most active ruthenium(II) complex, 4b, bearing mesitylene as ligand, the mechanism of action against 8505C cisplatin resistant cell line was determined. Complex 4b induced apoptosis accompanied by caspase activation.
PB  - MDPI
T2  - Molecules
T1  - Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand
IS  - 7
VL  - 26
DO  - 10.3390/molecules26071860
SP  - 1860
ER  - 

@article{
author = "Arlt, Sören and Petković, Vladana and Ludwig, Gerd and Eichhorn, Thomas and Lang, Heinrich and Rüffer, Tobias and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Kaluđerović, Goran",
year = "2021",
abstract = "Neutral [Ru(η6-arene)Cl2{Ph2P(CH2)3SPh-κP}] (arene = benzene, indane, 1,2,3,4-tetrahydronaphthalene: 2a, 2c and 2d) and cationic [Ru(η6-arene)Cl(Ph2P(CH2)3SPh-κP,κS)]X complexes (arene = mesitylene, 1,4-dihydronaphthalene; X = Cl: 3b, 3e; arene = benzene, mesitylene, indane, 1,2,3,4-tetrahydronaphthalene, and 1,4-dihydronaphthalene; X = PF6: 4a–4e) complexes were prepared and characterized by elemental analysis, IR, 1H, 13C and 31P NMR spectroscopy and also by single-crystal X-ray diffraction analyses. The stability of the complexes has been investigated in DMSO. Complexes have been assessed for their cytotoxic activity against 518A2, 8505C, A253, MCF-7 and SW480 cell lines. Generally, complexes exhibited activity in the lower micromolar range; moreover, they are found to be more active than cisplatin. For the most active ruthenium(II) complex, 4b, bearing mesitylene as ligand, the mechanism of action against 8505C cisplatin resistant cell line was determined. Complex 4b induced apoptosis accompanied by caspase activation.",
publisher = "MDPI",
journal = "Molecules",
title = "Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand",
number = "7",
volume = "26",
doi = "10.3390/molecules26071860",
pages = "1860"
}

Arlt, S., Petković, V., Ludwig, G., Eichhorn, T., Lang, H., Rüffer, T., Mijatović, S., Maksimović-Ivanić, D.,& Kaluđerović, G.. (2021). Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand. in Molecules
MDPI., 26(7), 1860.
https://doi.org/10.3390/molecules26071860

Arlt S, Petković V, Ludwig G, Eichhorn T, Lang H, Rüffer T, Mijatović S, Maksimović-Ivanić D, Kaluđerović G. Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand. in Molecules. 2021;26(7):1860.
doi:10.3390/molecules26071860 .

Arlt, Sören, Petković, Vladana, Ludwig, Gerd, Eichhorn, Thomas, Lang, Heinrich, Rüffer, Tobias, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Kaluđerović, Goran, "Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand" in Molecules, 26, no. 7 (2021):1860,
https://doi.org/10.3390/molecules26071860 . .

TY  - JOUR
AU  - Edeler, David
AU  - Arlt, Sören
AU  - Petković, Vladana
AU  - Ludwig, Gerd
AU  - Drača, Dijana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0162013417306165
UR  - http://www.ncbi.nlm.nih.gov/pubmed/29288894
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2954
AB  - SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential. According to the loaded amount of the [Ru] in SBA-15|[Ru] and SBA-15~SH|[Ru] the IC50 values are 1-2μM depending on the test used, thus in comparison to [Ru] alone the activity of nanomaterials containing [Ru] are elevated 3-6 times in vitro. However, the mechanism of apoptosis induction differs for these two mesoporous silica. Unlike reference [Ru] compound and SBA-15~SH|[Ru], SBA-15|[Ru] induces high caspase activation. Discrepancy in mechanism of drugs action at intracellular level points towards an influence of functionalization as well as availability of the drug. Moreover, both SBA-15|[Ru] and SBA-15~SH|[Ru] similarly to [Ru] are declining autophagy in B16 cell line.
T2  - Journal of Inorganic Biochemistry
T1  - Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.
VL  - 180
DO  - 10.1016/j.jinorgbio.2017.12.011
SP  - 155
EP  - 162
ER  - 

@article{
author = "Edeler, David and Arlt, Sören and Petković, Vladana and Ludwig, Gerd and Drača, Dijana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2018",
abstract = "SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential. According to the loaded amount of the [Ru] in SBA-15|[Ru] and SBA-15~SH|[Ru] the IC50 values are 1-2μM depending on the test used, thus in comparison to [Ru] alone the activity of nanomaterials containing [Ru] are elevated 3-6 times in vitro. However, the mechanism of apoptosis induction differs for these two mesoporous silica. Unlike reference [Ru] compound and SBA-15~SH|[Ru], SBA-15|[Ru] induces high caspase activation. Discrepancy in mechanism of drugs action at intracellular level points towards an influence of functionalization as well as availability of the drug. Moreover, both SBA-15|[Ru] and SBA-15~SH|[Ru] similarly to [Ru] are declining autophagy in B16 cell line.",
journal = "Journal of Inorganic Biochemistry",
title = "Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.",
volume = "180",
doi = "10.1016/j.jinorgbio.2017.12.011",
pages = "155-162"
}

Edeler, D., Arlt, S., Petković, V., Ludwig, G., Drača, D., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2018). Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.. in Journal of Inorganic Biochemistry, 180, 155-162.
https://doi.org/10.1016/j.jinorgbio.2017.12.011

Edeler D, Arlt S, Petković V, Ludwig G, Drača D, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.. in Journal of Inorganic Biochemistry. 2018;180:155-162.
doi:10.1016/j.jinorgbio.2017.12.011 .

Edeler, David, Arlt, Sören, Petković, Vladana, Ludwig, Gerd, Drača, Dijana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study." in Journal of Inorganic Biochemistry, 180 (2018):155-162,
https://doi.org/10.1016/j.jinorgbio.2017.12.011 . .