TY  - JOUR
AU  - Stevanović, I.D.
AU  - Jovanović, M.D.
AU  - Čolić, M.
AU  - Jelenković, A.
AU  - Mihajlović, R.
AU  - Stojanović, I.
AU  - Ninković, M.
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/270
AB  - The presented experiment was carried out to determine the effectiveness of the inducible nitric oxide synthase inhibitor - aminoguanidine in modulating the toxicity of aluminum chloride on the nitrite levels, malondialdehyde concentration, reduced glutathione content, as well as cytochrome c oxidase activity of Wistar rats. The animals were killed 3 h and 30 days after treatment and the hippocampus was removed. The biochemical results show that aluminum acts as a pro-oxidant, while aminoguanidine exerts an antioxidant action in aluminum chloride-treated animals. We have also applied immunohistochemical techniques to identify iNOS expression after the treatment. Our data suggest that aminoguanidine can be effective in the protection of toxicity induced by aluminum chloride.
AB  - U eksperimentu je određivana efikasnost inhibitora inducibilne forme azot oksid sintaze - aminogvanidina, u modulaciji toksičnosti aluminijum hlorida na nivo nitrita, koncentraciju malondialdehida, sadržaj redukovanog glutationa, kao i aktivnost citohrom c oksidaze kod Wistar pacova. Životinje su dekapitovane 3 časa i 30 dana nakon odgovarajućeg tretmana i izolovan je hipokampus. Rezultati dobijeni na biohemijskom nivou pokazuju da aluminijum deluje kao pro-oksidant, dok aminogvanidin pokazuje antioksidativno dejstvo kod životinja tretiranih aluminijum hloridom. Pored toga, korišćene su i imunohistohemijske tehnike za identifikaciju iNOS ekspresije, 3 časa nakon primene odgovarajućeg tretmana. Naši rezultati pokazuju da aminogvanidin može sprečiti toksičnost indukovanu aluminijum hloridom.
T2  - Archives of Biological Sciences
T1  - Efekat aminogvanidina, inhibitora azot oksid sintaze, na toksičnost AlCl3 u hipokampusu pacova
T1  - The effect of aminoguanidine, an inducible nitric oxide synthase inhibitor, on AlCl3 toxicity in the rat hippocampus
IS  - 4
VL  - 62
SP  - 981
EP  - 991
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_270
ER  - 

@article{
author = "Stevanović, I.D. and Jovanović, M.D. and Čolić, M. and Jelenković, A. and Mihajlović, R. and Stojanović, I. and Ninković, M.",
year = "2010, 2010",
abstract = "The presented experiment was carried out to determine the effectiveness of the inducible nitric oxide synthase inhibitor - aminoguanidine in modulating the toxicity of aluminum chloride on the nitrite levels, malondialdehyde concentration, reduced glutathione content, as well as cytochrome c oxidase activity of Wistar rats. The animals were killed 3 h and 30 days after treatment and the hippocampus was removed. The biochemical results show that aluminum acts as a pro-oxidant, while aminoguanidine exerts an antioxidant action in aluminum chloride-treated animals. We have also applied immunohistochemical techniques to identify iNOS expression after the treatment. Our data suggest that aminoguanidine can be effective in the protection of toxicity induced by aluminum chloride., U eksperimentu je određivana efikasnost inhibitora inducibilne forme azot oksid sintaze - aminogvanidina, u modulaciji toksičnosti aluminijum hlorida na nivo nitrita, koncentraciju malondialdehida, sadržaj redukovanog glutationa, kao i aktivnost citohrom c oksidaze kod Wistar pacova. Životinje su dekapitovane 3 časa i 30 dana nakon odgovarajućeg tretmana i izolovan je hipokampus. Rezultati dobijeni na biohemijskom nivou pokazuju da aluminijum deluje kao pro-oksidant, dok aminogvanidin pokazuje antioksidativno dejstvo kod životinja tretiranih aluminijum hloridom. Pored toga, korišćene su i imunohistohemijske tehnike za identifikaciju iNOS ekspresije, 3 časa nakon primene odgovarajućeg tretmana. Naši rezultati pokazuju da aminogvanidin može sprečiti toksičnost indukovanu aluminijum hloridom.",
journal = "Archives of Biological Sciences",
title = "Efekat aminogvanidina, inhibitora azot oksid sintaze, na toksičnost AlCl3 u hipokampusu pacova, The effect of aminoguanidine, an inducible nitric oxide synthase inhibitor, on AlCl3 toxicity in the rat hippocampus",
number = "4",
volume = "62",
pages = "981-991",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_270"
}

Stevanović, I.D., Jovanović, M.D., Čolić, M., Jelenković, A., Mihajlović, R., Stojanović, I.,& Ninković, M.. (2010). Efekat aminogvanidina, inhibitora azot oksid sintaze, na toksičnost AlCl3 u hipokampusu pacova. in Archives of Biological Sciences, 62(4), 981-991.
https://hdl.handle.net/21.15107/rcub_ibiss_270

Stevanović I, Jovanović M, Čolić M, Jelenković A, Mihajlović R, Stojanović I, Ninković M. Efekat aminogvanidina, inhibitora azot oksid sintaze, na toksičnost AlCl3 u hipokampusu pacova. in Archives of Biological Sciences. 2010;62(4):981-991.
https://hdl.handle.net/21.15107/rcub_ibiss_270 .

Stevanović, I.D., Jovanović, M.D., Čolić, M., Jelenković, A., Mihajlović, R., Stojanović, I., Ninković, M., "Efekat aminogvanidina, inhibitora azot oksid sintaze, na toksičnost AlCl3 u hipokampusu pacova" in Archives of Biological Sciences, 62, no. 4 (2010):981-991,
https://hdl.handle.net/21.15107/rcub_ibiss_270 .

TY  - JOUR
AU  - Stevanović, Ivana
AU  - Jovanović, Marina
AU  - Jelenković, Ankica V.
AU  - Bokonjić, D.
AU  - Čolić, M.
AU  - Stojanović, Ivana
AU  - Ninković, Milica
PY  - 2009
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/475
AB  - The present experiment was carried out to determine the effectiveness of nitric oxide synthase (NOS) inhibitor (L-NAME) in elevating the toxicity of AlCl3 on nitrite concentration and acetylcholine esterase activity of Wistar rats. Animals were killed 10 min and 3 days after the treatment and the forebrain cortex and striatum were removed. The results show that AlCl3 exposure promotes oxidative stress in different neural areas. The biochemical changes observed in neuronal tissues show that aluminium acts as a pro-oxidant, while NOS inhibitor exerts as antioxidant action in AlCl3-treated animals. In the present study, active avoidance learning was significantly impaired after AlCl3 injection, while pretreatment with L-NAME prevented the behavioural deficits caused between the 8th and 12th day after intrahippocampal application of neurotoxin. Our data suggest that aluminium may cause learning and memory deficits, while the treatment with L-NAME may decrease the oxidative stress and prevent learning and memory deficits caused by AlCl3.
AB  - U eksperimentu je ispitivana efikasnost inhibitora azot oksid sintaze (NOS)- L-NAME na toksičnost AlCl3 i određivana koncentracija nitrita i aktivnost acetilholin esteraze kod Wistar pacova. Životinje su dekapitovane 10 minuta ili 3 dana nakon tretmana i izolovani su kora prednjeg mozga i strijatum. Rezultati ukazuju da AlCl3 pokreće oksidativni stres u različitim regionima mozga. Biohemijske promene opisane u neuronskom tkivu ukazuju da aluminijum deluje kao prooksidans, dok inhibitor NOS ima antioksidativno dejstvo kod životinja tretiranih AlCl3. Reakcija aktivnog izbegavanja je bila znatno poremećena nakon aplikacije AlCl3, dok se davanjem L-NAME sprečavaju poremećaji ponašanja uzrokovani između 8. i 12. dana posle intrahipokampusne primene neurotoksina. Naši rezultati ukazuju da aluminijum može dovesti do smetnji u procesima učenja i pamćenja, dok tretman sa L-NAME smanjuje oksidativni stres i sprečava promene u učenju i pamćenju uzrokovane AlCl3.
T2  - Acta veterinaria
T1  - Efekat L-NAME na AlCl3-indukovanu toksičnost u mozgu pacova
T1  - Effect of L-NAME on AlCl3-induced toxicity in rat brain
IS  - 2-3
VL  - 59
DO  - 10.2298/AVB0903133S
SP  - 133
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_475
ER  - 

@article{
author = "Stevanović, Ivana and Jovanović, Marina and Jelenković, Ankica V. and Bokonjić, D. and Čolić, M. and Stojanović, Ivana and Ninković, Milica",
year = "2009, 2009",
abstract = "The present experiment was carried out to determine the effectiveness of nitric oxide synthase (NOS) inhibitor (L-NAME) in elevating the toxicity of AlCl3 on nitrite concentration and acetylcholine esterase activity of Wistar rats. Animals were killed 10 min and 3 days after the treatment and the forebrain cortex and striatum were removed. The results show that AlCl3 exposure promotes oxidative stress in different neural areas. The biochemical changes observed in neuronal tissues show that aluminium acts as a pro-oxidant, while NOS inhibitor exerts as antioxidant action in AlCl3-treated animals. In the present study, active avoidance learning was significantly impaired after AlCl3 injection, while pretreatment with L-NAME prevented the behavioural deficits caused between the 8th and 12th day after intrahippocampal application of neurotoxin. Our data suggest that aluminium may cause learning and memory deficits, while the treatment with L-NAME may decrease the oxidative stress and prevent learning and memory deficits caused by AlCl3., U eksperimentu je ispitivana efikasnost inhibitora azot oksid sintaze (NOS)- L-NAME na toksičnost AlCl3 i određivana koncentracija nitrita i aktivnost acetilholin esteraze kod Wistar pacova. Životinje su dekapitovane 10 minuta ili 3 dana nakon tretmana i izolovani su kora prednjeg mozga i strijatum. Rezultati ukazuju da AlCl3 pokreće oksidativni stres u različitim regionima mozga. Biohemijske promene opisane u neuronskom tkivu ukazuju da aluminijum deluje kao prooksidans, dok inhibitor NOS ima antioksidativno dejstvo kod životinja tretiranih AlCl3. Reakcija aktivnog izbegavanja je bila znatno poremećena nakon aplikacije AlCl3, dok se davanjem L-NAME sprečavaju poremećaji ponašanja uzrokovani između 8. i 12. dana posle intrahipokampusne primene neurotoksina. Naši rezultati ukazuju da aluminijum može dovesti do smetnji u procesima učenja i pamćenja, dok tretman sa L-NAME smanjuje oksidativni stres i sprečava promene u učenju i pamćenju uzrokovane AlCl3.",
journal = "Acta veterinaria",
title = "Efekat L-NAME na AlCl3-indukovanu toksičnost u mozgu pacova, Effect of L-NAME on AlCl3-induced toxicity in rat brain",
number = "2-3",
volume = "59",
doi = "10.2298/AVB0903133S",
pages = "133-146",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_475"
}

Stevanović, I., Jovanović, M., Jelenković, A. V., Bokonjić, D., Čolić, M., Stojanović, I.,& Ninković, M.. (2009). Efekat L-NAME na AlCl3-indukovanu toksičnost u mozgu pacova. in Acta veterinaria, 59(2-3), 133-146.
https://doi.org/10.2298/AVB0903133S
https://hdl.handle.net/21.15107/rcub_ibiss_475

Stevanović I, Jovanović M, Jelenković AV, Bokonjić D, Čolić M, Stojanović I, Ninković M. Efekat L-NAME na AlCl3-indukovanu toksičnost u mozgu pacova. in Acta veterinaria. 2009;59(2-3):133-146.
doi:10.2298/AVB0903133S
https://hdl.handle.net/21.15107/rcub_ibiss_475 .

Stevanović, Ivana, Jovanović, Marina, Jelenković, Ankica V., Bokonjić, D., Čolić, M., Stojanović, Ivana, Ninković, Milica, "Efekat L-NAME na AlCl3-indukovanu toksičnost u mozgu pacova" in Acta veterinaria, 59, no. 2-3 (2009):133-146,
https://doi.org/10.2298/AVB0903133S .,
https://hdl.handle.net/21.15107/rcub_ibiss_475 .