TY  - JOUR
AU  - Ristić, Biljana
AU  - Harhaji-Trajković, Ljubica
AU  - Bošnjak, Mihajlo
AU  - Dakić, Ivana
AU  - Mijatović, Srđan
AU  - Trajković, Vladimir
PY  - 2021
UR  - https://www.mdpi.com/2072-6694/13/16/4145
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4431
AB  - Graphene-based nanomaterials (GNM) are plausible candidates for cancer therapeutics
and drug delivery systems. Pure graphene and graphene oxide nanoparticles, as well as graphene
quantum dots and graphene nanofibers, were all able to trigger autophagy in cancer cells through both
transcriptional and post-transcriptional mechanisms involving oxidative/endoplasmic reticulum
stress, AMP-activated protein kinase, mechanistic target of rapamycin, mitogen-activated protein
kinase, and Toll-like receptor signaling. This was often coupled with lysosomal dysfunction and
subsequent blockade of autophagic flux, which additionally increased the accumulation of autophagy
mediators that participated in apoptotic, necrotic, or necroptotic death of cancer cells and influenced
the immune response against the tumor. In this review, we analyze molecular mechanisms and
structure–activity relationships of GNM-mediated autophagy modulation, its consequences for
cancer cell survival/death and anti-tumor immune response, and the possible implications for the
use of GNM in cancer therapy.
PB  - Basel : MDPI
T2  - Cancers
T1  - Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications
IS  - 16
VL  - 13
DO  - 10.3390/cancers13164145
SP  - 4145
ER  - 

@article{
author = "Ristić, Biljana and Harhaji-Trajković, Ljubica and Bošnjak, Mihajlo and Dakić, Ivana and Mijatović, Srđan and Trajković, Vladimir",
year = "2021",
abstract = "Graphene-based nanomaterials (GNM) are plausible candidates for cancer therapeutics
and drug delivery systems. Pure graphene and graphene oxide nanoparticles, as well as graphene
quantum dots and graphene nanofibers, were all able to trigger autophagy in cancer cells through both
transcriptional and post-transcriptional mechanisms involving oxidative/endoplasmic reticulum
stress, AMP-activated protein kinase, mechanistic target of rapamycin, mitogen-activated protein
kinase, and Toll-like receptor signaling. This was often coupled with lysosomal dysfunction and
subsequent blockade of autophagic flux, which additionally increased the accumulation of autophagy
mediators that participated in apoptotic, necrotic, or necroptotic death of cancer cells and influenced
the immune response against the tumor. In this review, we analyze molecular mechanisms and
structure–activity relationships of GNM-mediated autophagy modulation, its consequences for
cancer cell survival/death and anti-tumor immune response, and the possible implications for the
use of GNM in cancer therapy.",
publisher = "Basel : MDPI",
journal = "Cancers",
title = "Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications",
number = "16",
volume = "13",
doi = "10.3390/cancers13164145",
pages = "4145"
}

Ristić, B., Harhaji-Trajković, L., Bošnjak, M., Dakić, I., Mijatović, S.,& Trajković, V.. (2021). Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications. in Cancers
Basel : MDPI., 13(16), 4145.
https://doi.org/10.3390/cancers13164145

Ristić B, Harhaji-Trajković L, Bošnjak M, Dakić I, Mijatović S, Trajković V. Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications. in Cancers. 2021;13(16):4145.
doi:10.3390/cancers13164145 .

Ristić, Biljana, Harhaji-Trajković, Ljubica, Bošnjak, Mihajlo, Dakić, Ivana, Mijatović, Srđan, Trajković, Vladimir, "Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications" in Cancers, 13, no. 16 (2021):4145,
https://doi.org/10.3390/cancers13164145 . .