TY  - JOUR
AU  - Schiller, Daniela
AU  - N C Yu, Alessandra
AU  - Alia-Klein, Nelly
AU  - Becker, Susanne
AU  - C Cromwell, Howard
AU  - Dolcos, Florin
AU  - J Eslinger, Paul
AU  - Frewen, Paul
AU  - H Kemp, Andrew
AU  - F Pace-Schott, Edward
AU  - Raber, Jacob
AU  - L Silton, Rebecca
AU  - Stefanova, Elka
AU  - H G Williams, Justin
AU  - Abe, Nobuhito
AU  - Aghajani, Moji
AU  - Albrecht, Franziska
AU  - Alexander, Rebecca
AU  - Anders, Silke
AU  - R Aragón, Oriana
AU  - A Arias, Juan
AU  - Arzy, Shahar
AU  - Aue, Tatjana
AU  - Baez, Sandra
AU  - Balconi, Michela
AU  - Ballarini, Tommaso
AU  - Bannister, Scott
AU  - C Banta, Marlissa
AU  - Caplovitz Barrett, Karen
AU  - Belzung, Catherine
AU  - Bensafi, Moustafa
AU  - Booij, Linda
AU  - Bookwala, Jamila
AU  - Boulanger-Bertolus, Julie
AU  - Weber Boutros, Sydney
AU  - Bräscher, Anne-Kathrin
AU  - Bruno, Antonio
AU  - Busatto, Geraldo
AU  - M Bylsma, Lauren
AU  - Caldwell-Harris, Catherine
AU  - Raymond, C K Chan
AU  - Cherbuin, Nicolas
AU  - Chiarella, Julian
AU  - Cipresso, Pietro
AU  - Critchley, Hugo
AU  - E Croote, Denise
AU  - A Demaree, Heath
AU  - F Denson, Thomas
AU  - Depue, Brendan
AU  - Derntl, Birgit
AU  - M Dickson, Joanne
AU  - Dolcos, Sanda
AU  - Drach-Zahavy, Anat
AU  - Dubljević, Olga
AU  - Eerola, Tuomas
AU  - Ellingsen, Dan-Mikael
AU  - Fairfield, Beth
AU  - Ferdenzi, Camille
AU  - H Friedman, Bruce
AU  - H Y Fu, Cynthia
AU  - M Gatt, Justine
AU  - deGelder, Beatrice
AU  - H E Gendolla, Guido
AU  - Gilam, Gadi
AU  - Goldblatt, Hadass
AU  - Kotynski Gooding, Anne Elizabeth
AU  - Gosseries, Olivia
AU  - O Hamm, Alfons
AU  - L Hanson, Jamie
AU  - Hendler, Talma
AU  - Cornelia, Herbert
AU  - G Hofmann, Stefan
AU  - Ibanez, Agustin
AU  - Joffily, Mateus
AU  - Jovanovic, Tanja
AU  - J Kahrilas, Ian
AU  - Kangas, Maria
AU  - Katsumi, Yuta
AU  - Kensinger, Elizabeth
AU  - A J Kirby, Lauren
AU  - Koncz, Rebecca
AU  - H W Koster, Ernst
AU  - Kozlowska, Kasia
AU  - Krach, Sören
AU  - E Kret, Mariska
AU  - Krippl, Martin
AU  - Kusi-Mensah, Kwabena
AU  - D Ladouceur, Cecile
AU  - Laureys, Steven
AU  - Lawrence, Alistair
AU  - R Li, Chiang-Shan
AU  - J Liddell, Belinda
AU  - K Lidhar, Navdeep
AU  - A Lowry, Christopher
AU  - Magee, Kelsey
AU  - Marin, Marie-France
AU  - Mariotti, Veronica
AU  - J Martin, Loren
AU  - A Marusak, Hilary
AU  - V Mayer, Annalina
AU  - R Merner, Amanda
AU  - Minnier, Jessica
AU  - Moll, Jorge
AU  - Robert, G Morrison
AU  - Moore, Matthew
AU  - Mouly, Anne-Marie
AU  - C Mueller, Sven
AU  - Andreas, Mühlberger
AU  - Nora, A Murphy
AU  - Muscatello, Maria Rosaria Anna
AU  - D Musser, Erica
AU  - Tamara, L Newton
AU  - Noll-Hussong, Michael
AU  - Norrholm, Seth Davin
AU  - Northoff, Georg
AU  - Nusslock, Robin
AU  - Hadas, Okon-Singer
AU  - M Olino, Thomas
AU  - Ortner, Catherine
AU  - Mayowa, Owolabi
AU  - Padulo, Caterina
AU  - Romina, Palermo
AU  - Palumbo, Rocco
AU  - Palumbo, Sara
AU  - Papadelis, Christos
AU  - J Pegna, Alan
AU  - Pellegrini, Silvia
AU  - Peltonen, Kirsi
AU  - W J H Penninx, Brenda
AU  - Pietrini, Pietro
AU  - Pinna, Graziano
AU  - Pintos Lobo, Rosario
AU  - L Polnaszek, Kelly
AU  - Polyakova, Maryna
AU  - Rabinak, Christine
AU  - Richter, S Helene
AU  - Richter, Thalia
AU  - Giuseppe, Riva
AU  - Rizzo, Amelia
AU  - L Robinson, Jennifer
AU  - Rosa, Pedro
AU  - S Sachdev, Perminder
AU  - Sato, Wataru
AU  - L Schroeter, Matthias
AU  - Schweizer, Susanne
AU  - Shiban, Youssef
AU  - Siddharthan, Advaith
AU  - Siedlecka, Ewa
AU  - C Smith, Robert
AU  - Soreq, Hermona
AU  - P Spangler, Derek
AU  - R Stern, Emily
AU  - Styliadis, Charis
AU  - B Sullivan, Gavin
AU  - E Swain, James
AU  - Urben, Sébastien
AU  - Van den Stock, Jan
AU  - A Vander Kooij, Michael
AU  - van Overveld, Mark
AU  - E Van Rheenen, Tamsyn
AU  - B VanElzakker, Michael
AU  - Ventura-Bort, Carlos
AU  - Verona, Edelyn
AU  - Volk, Tyler
AU  - Wang, Yi
AU  - T Weingast, Leah
AU  - Weymar, Mathias
AU  - Williams, Claire
AU  - L Willis, Megan
AU  - Yamashita, Paula
AU  - Zahn, Roland
AU  - Zupan, Barbra
AU  - Lowe, Leroy
AU  - Gabriela, Gan
AU  - Huggins F, Charlotte
AU  - Loeffler, Leonie
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6417
AB  - Over the last decades, the interdisciplinary field of the affective sciences has seen proliferation rather than integration of theoretical perspectives. This is due to differences in metaphysical and mechanistic assumptions about human affective phenomena (what they are and how they work) which, shaped by academic motivations and values, have determined the affective constructs and operationalizations. An assumption on the purpose of affective phenomena can be used as a teleological principle to guide the construction of a common set of metaphysical and mechanistic assumptions-a framework for human affective research. In this capstone paper for the special issue "Towards an Integrated Understanding of the Human Affectome", we gather the tiered purpose of human affective phenomena to synthesize assumptions that account for human affective phenomena collectively. This teleologically-grounded framework offers a principled agenda and launchpad for both organizing existing perspectives and generating new ones. Ultimately, we hope Human Affectome brings us a step closer to not only an integrated understanding of human affective phenomena, but an integrated field for affective research.
PB  - Elsevier Ltd.
T2  - Neuroscience and Biobehavioral Reviews
T1  - The Human Affectome
VL  - 105450
DO  - 10.1016/j.neubiorev.2023.105450
ER  - 

@article{
author = "Schiller, Daniela and N C Yu, Alessandra and Alia-Klein, Nelly and Becker, Susanne and C Cromwell, Howard and Dolcos, Florin and J Eslinger, Paul and Frewen, Paul and H Kemp, Andrew and F Pace-Schott, Edward and Raber, Jacob and L Silton, Rebecca and Stefanova, Elka and H G Williams, Justin and Abe, Nobuhito and Aghajani, Moji and Albrecht, Franziska and Alexander, Rebecca and Anders, Silke and R Aragón, Oriana and A Arias, Juan and Arzy, Shahar and Aue, Tatjana and Baez, Sandra and Balconi, Michela and Ballarini, Tommaso and Bannister, Scott and C Banta, Marlissa and Caplovitz Barrett, Karen and Belzung, Catherine and Bensafi, Moustafa and Booij, Linda and Bookwala, Jamila and Boulanger-Bertolus, Julie and Weber Boutros, Sydney and Bräscher, Anne-Kathrin and Bruno, Antonio and Busatto, Geraldo and M Bylsma, Lauren and Caldwell-Harris, Catherine and Raymond, C K Chan and Cherbuin, Nicolas and Chiarella, Julian and Cipresso, Pietro and Critchley, Hugo and E Croote, Denise and A Demaree, Heath and F Denson, Thomas and Depue, Brendan and Derntl, Birgit and M Dickson, Joanne and Dolcos, Sanda and Drach-Zahavy, Anat and Dubljević, Olga and Eerola, Tuomas and Ellingsen, Dan-Mikael and Fairfield, Beth and Ferdenzi, Camille and H Friedman, Bruce and H Y Fu, Cynthia and M Gatt, Justine and deGelder, Beatrice and H E Gendolla, Guido and Gilam, Gadi and Goldblatt, Hadass and Kotynski Gooding, Anne Elizabeth and Gosseries, Olivia and O Hamm, Alfons and L Hanson, Jamie and Hendler, Talma and Cornelia, Herbert and G Hofmann, Stefan and Ibanez, Agustin and Joffily, Mateus and Jovanovic, Tanja and J Kahrilas, Ian and Kangas, Maria and Katsumi, Yuta and Kensinger, Elizabeth and A J Kirby, Lauren and Koncz, Rebecca and H W Koster, Ernst and Kozlowska, Kasia and Krach, Sören and E Kret, Mariska and Krippl, Martin and Kusi-Mensah, Kwabena and D Ladouceur, Cecile and Laureys, Steven and Lawrence, Alistair and R Li, Chiang-Shan and J Liddell, Belinda and K Lidhar, Navdeep and A Lowry, Christopher and Magee, Kelsey and Marin, Marie-France and Mariotti, Veronica and J Martin, Loren and A Marusak, Hilary and V Mayer, Annalina and R Merner, Amanda and Minnier, Jessica and Moll, Jorge and Robert, G Morrison and Moore, Matthew and Mouly, Anne-Marie and C Mueller, Sven and Andreas, Mühlberger and Nora, A Murphy and Muscatello, Maria Rosaria Anna and D Musser, Erica and Tamara, L Newton and Noll-Hussong, Michael and Norrholm, Seth Davin and Northoff, Georg and Nusslock, Robin and Hadas, Okon-Singer and M Olino, Thomas and Ortner, Catherine and Mayowa, Owolabi and Padulo, Caterina and Romina, Palermo and Palumbo, Rocco and Palumbo, Sara and Papadelis, Christos and J Pegna, Alan and Pellegrini, Silvia and Peltonen, Kirsi and W J H Penninx, Brenda and Pietrini, Pietro and Pinna, Graziano and Pintos Lobo, Rosario and L Polnaszek, Kelly and Polyakova, Maryna and Rabinak, Christine and Richter, S Helene and Richter, Thalia and Giuseppe, Riva and Rizzo, Amelia and L Robinson, Jennifer and Rosa, Pedro and S Sachdev, Perminder and Sato, Wataru and L Schroeter, Matthias and Schweizer, Susanne and Shiban, Youssef and Siddharthan, Advaith and Siedlecka, Ewa and C Smith, Robert and Soreq, Hermona and P Spangler, Derek and R Stern, Emily and Styliadis, Charis and B Sullivan, Gavin and E Swain, James and Urben, Sébastien and Van den Stock, Jan and A Vander Kooij, Michael and van Overveld, Mark and E Van Rheenen, Tamsyn and B VanElzakker, Michael and Ventura-Bort, Carlos and Verona, Edelyn and Volk, Tyler and Wang, Yi and T Weingast, Leah and Weymar, Mathias and Williams, Claire and L Willis, Megan and Yamashita, Paula and Zahn, Roland and Zupan, Barbra and Lowe, Leroy and Gabriela, Gan and Huggins F, Charlotte and Loeffler, Leonie",
year = "2023",
abstract = "Over the last decades, the interdisciplinary field of the affective sciences has seen proliferation rather than integration of theoretical perspectives. This is due to differences in metaphysical and mechanistic assumptions about human affective phenomena (what they are and how they work) which, shaped by academic motivations and values, have determined the affective constructs and operationalizations. An assumption on the purpose of affective phenomena can be used as a teleological principle to guide the construction of a common set of metaphysical and mechanistic assumptions-a framework for human affective research. In this capstone paper for the special issue "Towards an Integrated Understanding of the Human Affectome", we gather the tiered purpose of human affective phenomena to synthesize assumptions that account for human affective phenomena collectively. This teleologically-grounded framework offers a principled agenda and launchpad for both organizing existing perspectives and generating new ones. Ultimately, we hope Human Affectome brings us a step closer to not only an integrated understanding of human affective phenomena, but an integrated field for affective research.",
publisher = "Elsevier Ltd.",
journal = "Neuroscience and Biobehavioral Reviews",
title = "The Human Affectome",
volume = "105450",
doi = "10.1016/j.neubiorev.2023.105450"
}

Schiller, D., N C Yu, A., Alia-Klein, N., Becker, S., C Cromwell, H., Dolcos, F., J Eslinger, P., Frewen, P., H Kemp, A., F Pace-Schott, E., Raber, J., L Silton, R., Stefanova, E., H G Williams, J., Abe, N., Aghajani, M., Albrecht, F., Alexander, R., Anders, S., R Aragón, O., A Arias, J., Arzy, S., Aue, T., Baez, S., Balconi, M., Ballarini, T., Bannister, S., C Banta, M., Caplovitz Barrett, K., Belzung, C., Bensafi, M., Booij, L., Bookwala, J., Boulanger-Bertolus, J., Weber Boutros, S., Bräscher, A., Bruno, A., Busatto, G., M Bylsma, L., Caldwell-Harris, C., Raymond, C. K. C., Cherbuin, N., Chiarella, J., Cipresso, P., Critchley, H., E Croote, D., A Demaree, H., F Denson, T., Depue, B., Derntl, B., M Dickson, J., Dolcos, S., Drach-Zahavy, A., Dubljević, O., Eerola, T., Ellingsen, D., Fairfield, B., Ferdenzi, C., H Friedman, B., H Y Fu, C., M Gatt, J., deGelder, B., H E Gendolla, G., Gilam, G., Goldblatt, H., Kotynski Gooding, A. E., Gosseries, O., O Hamm, A., L Hanson, J., Hendler, T., Cornelia, H., G Hofmann, S., Ibanez, A., Joffily, M., Jovanovic, T., J Kahrilas, I., Kangas, M., Katsumi, Y., Kensinger, E., A J Kirby, L., Koncz, R., H W Koster, E., Kozlowska, K., Krach, S., E Kret, M., Krippl, M., Kusi-Mensah, K., D Ladouceur, C., Laureys, S., Lawrence, A., R Li, C., J Liddell, B., K Lidhar, N., A Lowry, C., Magee, K., Marin, M., Mariotti, V., J Martin, L., A Marusak, H., V Mayer, A., R Merner, A., Minnier, J., Moll, J., Robert, G. M., Moore, M., Mouly, A., C Mueller, S., Andreas, M., Nora, A. M., Muscatello, M. R. A., D Musser, E., Tamara, L. N., Noll-Hussong, M., Norrholm, S. D., Northoff, G., Nusslock, R., Hadas, O., M Olino, T., Ortner, C., Mayowa, O., Padulo, C., Romina, P., Palumbo, R., Palumbo, S., Papadelis, C., J Pegna, A., Pellegrini, S., Peltonen, K., W J H Penninx, B., Pietrini, P., Pinna, G., Pintos Lobo, R., L Polnaszek, K., Polyakova, M., Rabinak, C., Richter, S. H., Richter, T., Giuseppe, R., Rizzo, A., L Robinson, J., Rosa, P., S Sachdev, P., Sato, W., L Schroeter, M., Schweizer, S., Shiban, Y., Siddharthan, A., Siedlecka, E., C Smith, R., Soreq, H., P Spangler, D., R Stern, E., Styliadis, C., B Sullivan, G., E Swain, J., Urben, S., Van den Stock, J., A Vander Kooij, M., van Overveld, M., E Van Rheenen, T., B VanElzakker, M., Ventura-Bort, C., Verona, E., Volk, T., Wang, Y., T Weingast, L., Weymar, M., Williams, C., L Willis, M., Yamashita, P., Zahn, R., Zupan, B., Lowe, L., Gabriela, G., Huggins F, C.,& Loeffler, L.. (2023). The Human Affectome. in Neuroscience and Biobehavioral Reviews
Elsevier Ltd.., 105450.
https://doi.org/10.1016/j.neubiorev.2023.105450

Schiller D, N C Yu A, Alia-Klein N, Becker S, C Cromwell H, Dolcos F, J Eslinger P, Frewen P, H Kemp A, F Pace-Schott E, Raber J, L Silton R, Stefanova E, H G Williams J, Abe N, Aghajani M, Albrecht F, Alexander R, Anders S, R Aragón O, A Arias J, Arzy S, Aue T, Baez S, Balconi M, Ballarini T, Bannister S, C Banta M, Caplovitz Barrett K, Belzung C, Bensafi M, Booij L, Bookwala J, Boulanger-Bertolus J, Weber Boutros S, Bräscher A, Bruno A, Busatto G, M Bylsma L, Caldwell-Harris C, Raymond CKC, Cherbuin N, Chiarella J, Cipresso P, Critchley H, E Croote D, A Demaree H, F Denson T, Depue B, Derntl B, M Dickson J, Dolcos S, Drach-Zahavy A, Dubljević O, Eerola T, Ellingsen D, Fairfield B, Ferdenzi C, H Friedman B, H Y Fu C, M Gatt J, deGelder B, H E Gendolla G, Gilam G, Goldblatt H, Kotynski Gooding AE, Gosseries O, O Hamm A, L Hanson J, Hendler T, Cornelia H, G Hofmann S, Ibanez A, Joffily M, Jovanovic T, J Kahrilas I, Kangas M, Katsumi Y, Kensinger E, A J Kirby L, Koncz R, H W Koster E, Kozlowska K, Krach S, E Kret M, Krippl M, Kusi-Mensah K, D Ladouceur C, Laureys S, Lawrence A, R Li C, J Liddell B, K Lidhar N, A Lowry C, Magee K, Marin M, Mariotti V, J Martin L, A Marusak H, V Mayer A, R Merner A, Minnier J, Moll J, Robert GM, Moore M, Mouly A, C Mueller S, Andreas M, Nora AM, Muscatello MRA, D Musser E, Tamara LN, Noll-Hussong M, Norrholm SD, Northoff G, Nusslock R, Hadas O, M Olino T, Ortner C, Mayowa O, Padulo C, Romina P, Palumbo R, Palumbo S, Papadelis C, J Pegna A, Pellegrini S, Peltonen K, W J H Penninx B, Pietrini P, Pinna G, Pintos Lobo R, L Polnaszek K, Polyakova M, Rabinak C, Richter SH, Richter T, Giuseppe R, Rizzo A, L Robinson J, Rosa P, S Sachdev P, Sato W, L Schroeter M, Schweizer S, Shiban Y, Siddharthan A, Siedlecka E, C Smith R, Soreq H, P Spangler D, R Stern E, Styliadis C, B Sullivan G, E Swain J, Urben S, Van den Stock J, A Vander Kooij M, van Overveld M, E Van Rheenen T, B VanElzakker M, Ventura-Bort C, Verona E, Volk T, Wang Y, T Weingast L, Weymar M, Williams C, L Willis M, Yamashita P, Zahn R, Zupan B, Lowe L, Gabriela G, Huggins F C, Loeffler L. The Human Affectome. in Neuroscience and Biobehavioral Reviews. 2023;105450.
doi:10.1016/j.neubiorev.2023.105450 .

Schiller, Daniela, N C Yu, Alessandra, Alia-Klein, Nelly, Becker, Susanne, C Cromwell, Howard, Dolcos, Florin, J Eslinger, Paul, Frewen, Paul, H Kemp, Andrew, F Pace-Schott, Edward, Raber, Jacob, L Silton, Rebecca, Stefanova, Elka, H G Williams, Justin, Abe, Nobuhito, Aghajani, Moji, Albrecht, Franziska, Alexander, Rebecca, Anders, Silke, R Aragón, Oriana, A Arias, Juan, Arzy, Shahar, Aue, Tatjana, Baez, Sandra, Balconi, Michela, Ballarini, Tommaso, Bannister, Scott, C Banta, Marlissa, Caplovitz Barrett, Karen, Belzung, Catherine, Bensafi, Moustafa, Booij, Linda, Bookwala, Jamila, Boulanger-Bertolus, Julie, Weber Boutros, Sydney, Bräscher, Anne-Kathrin, Bruno, Antonio, Busatto, Geraldo, M Bylsma, Lauren, Caldwell-Harris, Catherine, Raymond, C K Chan, Cherbuin, Nicolas, Chiarella, Julian, Cipresso, Pietro, Critchley, Hugo, E Croote, Denise, A Demaree, Heath, F Denson, Thomas, Depue, Brendan, Derntl, Birgit, M Dickson, Joanne, Dolcos, Sanda, Drach-Zahavy, Anat, Dubljević, Olga, Eerola, Tuomas, Ellingsen, Dan-Mikael, Fairfield, Beth, Ferdenzi, Camille, H Friedman, Bruce, H Y Fu, Cynthia, M Gatt, Justine, deGelder, Beatrice, H E Gendolla, Guido, Gilam, Gadi, Goldblatt, Hadass, Kotynski Gooding, Anne Elizabeth, Gosseries, Olivia, O Hamm, Alfons, L Hanson, Jamie, Hendler, Talma, Cornelia, Herbert, G Hofmann, Stefan, Ibanez, Agustin, Joffily, Mateus, Jovanovic, Tanja, J Kahrilas, Ian, Kangas, Maria, Katsumi, Yuta, Kensinger, Elizabeth, A J Kirby, Lauren, Koncz, Rebecca, H W Koster, Ernst, Kozlowska, Kasia, Krach, Sören, E Kret, Mariska, Krippl, Martin, Kusi-Mensah, Kwabena, D Ladouceur, Cecile, Laureys, Steven, Lawrence, Alistair, R Li, Chiang-Shan, J Liddell, Belinda, K Lidhar, Navdeep, A Lowry, Christopher, Magee, Kelsey, Marin, Marie-France, Mariotti, Veronica, J Martin, Loren, A Marusak, Hilary, V Mayer, Annalina, R Merner, Amanda, Minnier, Jessica, Moll, Jorge, Robert, G Morrison, Moore, Matthew, Mouly, Anne-Marie, C Mueller, Sven, Andreas, Mühlberger, Nora, A Murphy, Muscatello, Maria Rosaria Anna, D Musser, Erica, Tamara, L Newton, Noll-Hussong, Michael, Norrholm, Seth Davin, Northoff, Georg, Nusslock, Robin, Hadas, Okon-Singer, M Olino, Thomas, Ortner, Catherine, Mayowa, Owolabi, Padulo, Caterina, Romina, Palermo, Palumbo, Rocco, Palumbo, Sara, Papadelis, Christos, J Pegna, Alan, Pellegrini, Silvia, Peltonen, Kirsi, W J H Penninx, Brenda, Pietrini, Pietro, Pinna, Graziano, Pintos Lobo, Rosario, L Polnaszek, Kelly, Polyakova, Maryna, Rabinak, Christine, Richter, S Helene, Richter, Thalia, Giuseppe, Riva, Rizzo, Amelia, L Robinson, Jennifer, Rosa, Pedro, S Sachdev, Perminder, Sato, Wataru, L Schroeter, Matthias, Schweizer, Susanne, Shiban, Youssef, Siddharthan, Advaith, Siedlecka, Ewa, C Smith, Robert, Soreq, Hermona, P Spangler, Derek, R Stern, Emily, Styliadis, Charis, B Sullivan, Gavin, E Swain, James, Urben, Sébastien, Van den Stock, Jan, A Vander Kooij, Michael, van Overveld, Mark, E Van Rheenen, Tamsyn, B VanElzakker, Michael, Ventura-Bort, Carlos, Verona, Edelyn, Volk, Tyler, Wang, Yi, T Weingast, Leah, Weymar, Mathias, Williams, Claire, L Willis, Megan, Yamashita, Paula, Zahn, Roland, Zupan, Barbra, Lowe, Leroy, Gabriela, Gan, Huggins F, Charlotte, Loeffler, Leonie, "The Human Affectome" in Neuroscience and Biobehavioral Reviews, 105450 (2023),
https://doi.org/10.1016/j.neubiorev.2023.105450 . .

TY  - CONF
AU  - Dubljević, Olga
AU  - Pavković, Željko
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5845
AB  - The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.
PB  - Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade
C3  - FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
T1  - Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5845
ER  - 

@conference{
author = "Dubljević, Olga and Pavković, Željko and Pešić, Vesna",
year = "2023",
abstract = "The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.",
publisher = "Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade",
journal = "FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria",
title = "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5845"
}

Dubljević, O., Pavković, Ž.,& Pešić, V.. (2023). Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade..
https://hdl.handle.net/21.15107/rcub_ibiss_5845

Dubljević O, Pavković Ž, Pešić V. Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria. 2023;.
https://hdl.handle.net/21.15107/rcub_ibiss_5845 .

Dubljević, Olga, Pavković, Željko, Pešić, Vesna, "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model" in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria (2023),
https://hdl.handle.net/21.15107/rcub_ibiss_5845 .

TY  - CONF
AU  - Dubljević, Olga
AU  - Pavković, Željko
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5844
AB  - The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.
PB  - Federation of European Neuroscience Societies
C3  - FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
T1  - Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model
SP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5844
ER  - 

@conference{
author = "Dubljević, Olga and Pavković, Željko and Pešić, Vesna",
year = "2023",
abstract = "The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.",
publisher = "Federation of European Neuroscience Societies",
journal = "FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria",
title = "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model",
pages = "32",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5844"
}

Dubljević, O., Pavković, Ž.,& Pešić, V.. (2023). Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
Federation of European Neuroscience Societies., 32.
https://hdl.handle.net/21.15107/rcub_ibiss_5844

Dubljević O, Pavković Ž, Pešić V. Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria. 2023;:32.
https://hdl.handle.net/21.15107/rcub_ibiss_5844 .

Dubljević, Olga, Pavković, Željko, Pešić, Vesna, "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model" in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria (2023):32,
https://hdl.handle.net/21.15107/rcub_ibiss_5844 .

TY  - CONF
AU  - Pavković, Željko
AU  - Potrebić, Milica
AU  - Dubljević, Olga
AU  - Srbovan, Maja
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5832
AB  - Adolescence is a period when alcohol abuse is more likely to occur. Use of isoflurane
(a volatile anesthetic) in adolescence has been experimentally shown to alter
responses to ethanol, implying that general exposure to anesthetics during adolescence
may be an environmental risk factor contributing to increased susceptibility to alcohol
use disorder (AUD). Our previous work showed that propofol (intravenous anesthetic)
anesthesia exposure (PAE) in adolescence favors risk-taking and preference for
novel/intense stimuli. However, its influence on alcohol consumption hasn’t been
examined. Therefore, we aimed to investigate whether PAE in adolescence alters
alcohol consumption in alcohol-naïve rats.
Male Wistar rats aged 35 and 50 postnatal days (early-to-mid and mid-to-late
adolescence, respectively) were injected with anesthetic dose of propofol emulsion
(75mg/kg) or saline, separated into individual cages and exposed to two-bottle choice
paradigm (allowing free access to food and two bottles, one containing 2,5% ethanol
in 1% sucrose solution and the other containing tap water). Liquid consumption was
measured for 4 constitutive days. Obtained data showed no preference for alcohol in
all analyzed experimental groups. Moreover, the tendency for alcohol intake was
significantly reduced during first 24h after PAE in early-to-mid adolescent rats.
Overall, our study shows that PAE doesn’t increase voluntary alcohol intake in
peripubertal rats used as a rodent model of adolescence. The obtained findings do not
support the view that exposure to general anesthetics in adolescence is a risk factor for
AUD and suggest that a detailed analysis of the range of anesthetics is needed before
generalizing the data.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Propofol reduces the tendency for alcohol consumption in adolescent rats
SP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5832
ER  - 

@conference{
author = "Pavković, Željko and Potrebić, Milica and Dubljević, Olga and Srbovan, Maja and Pešić, Vesna",
year = "2023",
abstract = "Adolescence is a period when alcohol abuse is more likely to occur. Use of isoflurane
(a volatile anesthetic) in adolescence has been experimentally shown to alter
responses to ethanol, implying that general exposure to anesthetics during adolescence
may be an environmental risk factor contributing to increased susceptibility to alcohol
use disorder (AUD). Our previous work showed that propofol (intravenous anesthetic)
anesthesia exposure (PAE) in adolescence favors risk-taking and preference for
novel/intense stimuli. However, its influence on alcohol consumption hasn’t been
examined. Therefore, we aimed to investigate whether PAE in adolescence alters
alcohol consumption in alcohol-naïve rats.
Male Wistar rats aged 35 and 50 postnatal days (early-to-mid and mid-to-late
adolescence, respectively) were injected with anesthetic dose of propofol emulsion
(75mg/kg) or saline, separated into individual cages and exposed to two-bottle choice
paradigm (allowing free access to food and two bottles, one containing 2,5% ethanol
in 1% sucrose solution and the other containing tap water). Liquid consumption was
measured for 4 constitutive days. Obtained data showed no preference for alcohol in
all analyzed experimental groups. Moreover, the tendency for alcohol intake was
significantly reduced during first 24h after PAE in early-to-mid adolescent rats.
Overall, our study shows that PAE doesn’t increase voluntary alcohol intake in
peripubertal rats used as a rodent model of adolescence. The obtained findings do not
support the view that exposure to general anesthetics in adolescence is a risk factor for
AUD and suggest that a detailed analysis of the range of anesthetics is needed before
generalizing the data.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Propofol reduces the tendency for alcohol consumption in adolescent rats",
pages = "70",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5832"
}

Pavković, Ž., Potrebić, M., Dubljević, O., Srbovan, M.,& Pešić, V.. (2023). Propofol reduces the tendency for alcohol consumption in adolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 70.
https://hdl.handle.net/21.15107/rcub_ibiss_5832

Pavković Ž, Potrebić M, Dubljević O, Srbovan M, Pešić V. Propofol reduces the tendency for alcohol consumption in adolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:70.
https://hdl.handle.net/21.15107/rcub_ibiss_5832 .

Pavković, Željko, Potrebić, Milica, Dubljević, Olga, Srbovan, Maja, Pešić, Vesna, "Propofol reduces the tendency for alcohol consumption in adolescent rats" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):70,
https://hdl.handle.net/21.15107/rcub_ibiss_5832 .

TY  - CONF
AU  - Potrebić, Milica
AU  - Pavković, Željko
AU  - Srbovan, Maja
AU  - Dubljević, Olga
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5831
AB  - Aim: Microglia are macrophages of the brain with a fundamental role in neuronal
homeostasis. Stress-induced activation of microglia leads to rapid morphological
changes and it is implicated that these alternations could mediate different aspects of
early-life stress psychopathologies. We aimed to examine morphological response of
hippocampal microglia to social isolation using peripubertal rats as a rodent model of
adolescence.
Methods: Male peripubertal Wistar rats were randomly selected for group-housing
(GH; n=3 per cage) or single-housing (SH; n=1 per cage) at postnatal day 29. After
1st and 2nd week of defined housing animals῾ brains were sampled, and used for
microglia iba-1 fluorescent labelling and morphology analysis: one filed per section
per animal (n=4 animals per group) in hippocampal dentate gyrus (HDG). Data for
microglia cell shape (FracLac plugin, ImageJ) and cell ramification (Analyze Skeleton
plugin, ImageJ) were collected from single cells in photomicrograph visualized with a
confocal microscope (Leica Microsystems).
Results: Compared to GH peers, SH rats had lower microglial cell density in the HDG
after the 1st week of defined housing, which was not evident after the 2nd week. Other
parameters of microglia shape and ramification showed no difference between the
groups in neither of the two time points examined.
Conclusions: Obtained results showed that change in the cell density in the HDG was
the only and transient change in microglia morphology due to the social isolation
during adolescence. Further examination of other stress-related brain regions is
needed to define in depth the relationship between the microglia phenotype and earlylife
stress conditions.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Microglial morphological response to the lack of direct social contact in periadolescent rats
SP  - 108
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5831
ER  - 

@conference{
author = "Potrebić, Milica and Pavković, Željko and Srbovan, Maja and Dubljević, Olga and Pešić, Vesna",
year = "2023",
abstract = "Aim: Microglia are macrophages of the brain with a fundamental role in neuronal
homeostasis. Stress-induced activation of microglia leads to rapid morphological
changes and it is implicated that these alternations could mediate different aspects of
early-life stress psychopathologies. We aimed to examine morphological response of
hippocampal microglia to social isolation using peripubertal rats as a rodent model of
adolescence.
Methods: Male peripubertal Wistar rats were randomly selected for group-housing
(GH; n=3 per cage) or single-housing (SH; n=1 per cage) at postnatal day 29. After
1st and 2nd week of defined housing animals῾ brains were sampled, and used for
microglia iba-1 fluorescent labelling and morphology analysis: one filed per section
per animal (n=4 animals per group) in hippocampal dentate gyrus (HDG). Data for
microglia cell shape (FracLac plugin, ImageJ) and cell ramification (Analyze Skeleton
plugin, ImageJ) were collected from single cells in photomicrograph visualized with a
confocal microscope (Leica Microsystems).
Results: Compared to GH peers, SH rats had lower microglial cell density in the HDG
after the 1st week of defined housing, which was not evident after the 2nd week. Other
parameters of microglia shape and ramification showed no difference between the
groups in neither of the two time points examined.
Conclusions: Obtained results showed that change in the cell density in the HDG was
the only and transient change in microglia morphology due to the social isolation
during adolescence. Further examination of other stress-related brain regions is
needed to define in depth the relationship between the microglia phenotype and earlylife
stress conditions.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Microglial morphological response to the lack of direct social contact in periadolescent rats",
pages = "108",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5831"
}

Potrebić, M., Pavković, Ž., Srbovan, M., Dubljević, O.,& Pešić, V.. (2023). Microglial morphological response to the lack of direct social contact in periadolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 108.
https://hdl.handle.net/21.15107/rcub_ibiss_5831

Potrebić M, Pavković Ž, Srbovan M, Dubljević O, Pešić V. Microglial morphological response to the lack of direct social contact in periadolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:108.
https://hdl.handle.net/21.15107/rcub_ibiss_5831 .

Potrebić, Milica, Pavković, Željko, Srbovan, Maja, Dubljević, Olga, Pešić, Vesna, "Microglial morphological response to the lack of direct social contact in periadolescent rats" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):108,
https://hdl.handle.net/21.15107/rcub_ibiss_5831 .

TY  - CONF
AU  - Dubljević, Olga
AU  - Pavković, Željko
AU  - Srbovan, Maja
AU  - Potrebić, Milica
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5830
AB  - Parkinson's disease (PD) is characterized by both motor and non-motor symptoms.
Current research indicates that neuroinflammation, along with activated glial cells,
represents one of the key factors in the pathogenesis of PD. The aim of this study was
to assess non-motor symptoms of PD as well as the expression of gene markers of
microgliosis, astrogliosis and neuroinflammation in a transgenic A53T mouse model,
which is recommended for studying PD and other synucleinopathies. These transgenic
mice express an A53T missense mutant form of human alpha-synuclein under the
control of the murine prion promoter.
Depression-like symptoms and anhedonia were assessed using Tail Suspension Test
and Sucrose Preference Test respectively, while memory deficits were assessed using
Novel Object Recognition Test along with Object Relocation Test. Gene expression of
ionized calcium-binding adapter molecule (Iba-1), glial fibrillary acidic protein
(GFAP α and δ form) and cytokines associated with the microglial pro-inflammatory
phenotype (TNFα, IL-1β, IL-6) was assessed using RT-PCR. Brain regions of interest
were the prefrontal cortex, hippocampus, and striatum of 6 months old A53T male
mice. Non-transgenic littermates were used as controls. Obtained results suggest that
A53T mice compared to non-transgenic littermates exert 1) the presence of memory
deficits and anhedonia, 2) no difference in the expression of glial activity markers and
pro-inflammatory cytokines in the cortex and striatum, and 3) increased expression of
glial activity markers in the hippocampus, but without significant changes in the
expression of cytokines. Overall, better understanding of the role of active glia in the
model is needed.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease
SP  - 109
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5830
ER  - 

@conference{
author = "Dubljević, Olga and Pavković, Željko and Srbovan, Maja and Potrebić, Milica and Pešić, Vesna",
year = "2023",
abstract = "Parkinson's disease (PD) is characterized by both motor and non-motor symptoms.
Current research indicates that neuroinflammation, along with activated glial cells,
represents one of the key factors in the pathogenesis of PD. The aim of this study was
to assess non-motor symptoms of PD as well as the expression of gene markers of
microgliosis, astrogliosis and neuroinflammation in a transgenic A53T mouse model,
which is recommended for studying PD and other synucleinopathies. These transgenic
mice express an A53T missense mutant form of human alpha-synuclein under the
control of the murine prion promoter.
Depression-like symptoms and anhedonia were assessed using Tail Suspension Test
and Sucrose Preference Test respectively, while memory deficits were assessed using
Novel Object Recognition Test along with Object Relocation Test. Gene expression of
ionized calcium-binding adapter molecule (Iba-1), glial fibrillary acidic protein
(GFAP α and δ form) and cytokines associated with the microglial pro-inflammatory
phenotype (TNFα, IL-1β, IL-6) was assessed using RT-PCR. Brain regions of interest
were the prefrontal cortex, hippocampus, and striatum of 6 months old A53T male
mice. Non-transgenic littermates were used as controls. Obtained results suggest that
A53T mice compared to non-transgenic littermates exert 1) the presence of memory
deficits and anhedonia, 2) no difference in the expression of glial activity markers and
pro-inflammatory cytokines in the cortex and striatum, and 3) increased expression of
glial activity markers in the hippocampus, but without significant changes in the
expression of cytokines. Overall, better understanding of the role of active glia in the
model is needed.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease",
pages = "109",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5830"
}

Dubljević, O., Pavković, Ž., Srbovan, M., Potrebić, M.,& Pešić, V.. (2023). Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 109.
https://hdl.handle.net/21.15107/rcub_ibiss_5830

Dubljević O, Pavković Ž, Srbovan M, Potrebić M, Pešić V. Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:109.
https://hdl.handle.net/21.15107/rcub_ibiss_5830 .

Dubljević, Olga, Pavković, Željko, Srbovan, Maja, Potrebić, Milica, Pešić, Vesna, "Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):109,
https://hdl.handle.net/21.15107/rcub_ibiss_5830 .

TY  - JOUR
AU  - Dubljević, Olga
AU  - Ković, Vanja
AU  - Pavković, Željko
AU  - Mitić, Miloš
AU  - Pešić, Vesna
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9599889
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5178
AB  - A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2-5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3-5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals' BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.
PB  - Basel: MDPI
T2  - Brain Sciences
T1  - The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model
IS  - 10
VL  - 12
DO  - 10.3390/brainsci12101332
SP  - 1332
ER  - 

@article{
author = "Dubljević, Olga and Ković, Vanja and Pavković, Željko and Mitić, Miloš and Pešić, Vesna",
year = "2022",
abstract = "A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2-5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3-5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals' BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.",
publisher = "Basel: MDPI",
journal = "Brain Sciences",
title = "The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model",
number = "10",
volume = "12",
doi = "10.3390/brainsci12101332",
pages = "1332"
}

Dubljević, O., Ković, V., Pavković, Ž., Mitić, M.,& Pešić, V.. (2022). The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model. in Brain Sciences
Basel: MDPI., 12(10), 1332.
https://doi.org/10.3390/brainsci12101332

Dubljević O, Ković V, Pavković Ž, Mitić M, Pešić V. The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model. in Brain Sciences. 2022;12(10):1332.
doi:10.3390/brainsci12101332 .

Dubljević, Olga, Ković, Vanja, Pavković, Željko, Mitić, Miloš, Pešić, Vesna, "The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model" in Brain Sciences, 12, no. 10 (2022):1332,
https://doi.org/10.3390/brainsci12101332 . .

TY  - CONF
AU  - Pavković, Željko
AU  - Potrebić, Milica
AU  - Dubljević, Olga
AU  - Srbovan, Maja
AU  - Pešić, Vesna
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5614
AB  - Познато је да су анксиозни поремећаји генерално изражени током адолесценције док специфичности везане за интензитет симптома током различитих фаза адолесценције (рана, средња, касна) још увек нису довољно проучене. Aдолесценција је као период матурације присутна код свих сисара, што оправдава коришћење анималних модела у психобиологији. Имајући у виду дефинисане фазе адолесценције глодара, испитивали смо матурацију експлораторног и анксиозног одговора на новину код мужјака Wistar Han пацова старих 35 ± 1 дан (крај ране/почетак средње адолесценције), 49 ± 1 дан (крај средње/почетак касне адолесценције) и 155 ± 1 дан (адултно доба). Коришћени су тестови у којима животиња слободно истражује нову средину (нова правоугаона арена, црно-бела кутија, уздигнути крстасти лавиринт). Адаптабилност на нову средину је процењивана поређењем бихејвиоралних одговора у првих и последњих 5 минута тестирања. Добијени резултати су показали да код пацова 1) матурациона крива експлораторног одговора на нову средину може имати како линеарни тако и U-профил, у зависности од карактеристика новe средине, 2) понашање налик анксиозном има инвертовани U-профил, док се 3) прилагодљивост независно од срединских услова јавља крајем средње/почетком касне адолесценције. Дискутован је потенцијални значај добијених резултата.
AB  - Poznato je da su anksiozni poremećaji generalno izraženi tokom adolescencije dok specifičnosti vezane za intenzitet simptoma tokom različitih faza adolescencije (rana, srednja, kasna) još uvek nisu dovoljno proučene. Adolescencija je kao period maturacije prisutna kod svih sisara, što opravdava korišćenje animalnih modela u psihobiologiji. Imajući u vidu definisane faze adolescencije glodara, ispitivali smo maturaciju eksploratornog i anksioznog odgovora na novinu kod mužjaka Wistar Han pacova starih 35 ± 1 dan (kraj rane/početak srednje adolescencije), 49 ± 1 dan (kraj srednje/početak kasne adolescencije) i 155 ± 1 dan (adultno doba). Korišćeni su testovi u kojima životinja slobodno istražuje novu sredinu (nova pravougaona arena, crno-bela kutija, uzdignuti krstasti lavirint). Adaptabilnost na novu sredinu je procenjivana poređenjem bihejvioralnih odgovora u prvih i poslednjih 5 minuta testiranja. Dobijeni rezultati su pokazali da kod pacova 1) maturaciona kriva eksploratornog odgovora na novu sredinu može imati kako linearni tako i U-profil, u zavisnosti od karakteristika nove sredine, 2) ponašanje nalik anksioznom ima invertovani U-profil, dok se 3) prilagodljivost nezavisno od sredinskih uslova javlja krajem srednje/početkom kasne adolescencije. Diskutovan je potencijalni značaj dobijenih rezultata.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова
T1  - Maturacija eksploratornog, anksioznog i adaptivnog odgovora na nove sredine u modelu pacova
SP  - 339
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5614
ER  - 

@conference{
author = "Pavković, Željko and Potrebić, Milica and Dubljević, Olga and Srbovan, Maja and Pešić, Vesna",
year = "2022",
abstract = "Познато је да су анксиозни поремећаји генерално изражени током адолесценције док специфичности везане за интензитет симптома током различитих фаза адолесценције (рана, средња, касна) још увек нису довољно проучене. Aдолесценција је као период матурације присутна код свих сисара, што оправдава коришћење анималних модела у психобиологији. Имајући у виду дефинисане фазе адолесценције глодара, испитивали смо матурацију експлораторног и анксиозног одговора на новину код мужјака Wistar Han пацова старих 35 ± 1 дан (крај ране/почетак средње адолесценције), 49 ± 1 дан (крај средње/почетак касне адолесценције) и 155 ± 1 дан (адултно доба). Коришћени су тестови у којима животиња слободно истражује нову средину (нова правоугаона арена, црно-бела кутија, уздигнути крстасти лавиринт). Адаптабилност на нову средину је процењивана поређењем бихејвиоралних одговора у првих и последњих 5 минута тестирања. Добијени резултати су показали да код пацова 1) матурациона крива експлораторног одговора на нову средину може имати како линеарни тако и U-профил, у зависности од карактеристика новe средине, 2) понашање налик анксиозном има инвертовани U-профил, док се 3) прилагодљивост независно од срединских услова јавља крајем средње/почетком касне адолесценције. Дискутован је потенцијални значај добијених резултата., Poznato je da su anksiozni poremećaji generalno izraženi tokom adolescencije dok specifičnosti vezane za intenzitet simptoma tokom različitih faza adolescencije (rana, srednja, kasna) još uvek nisu dovoljno proučene. Adolescencija je kao period maturacije prisutna kod svih sisara, što opravdava korišćenje animalnih modela u psihobiologiji. Imajući u vidu definisane faze adolescencije glodara, ispitivali smo maturaciju eksploratornog i anksioznog odgovora na novinu kod mužjaka Wistar Han pacova starih 35 ± 1 dan (kraj rane/početak srednje adolescencije), 49 ± 1 dan (kraj srednje/početak kasne adolescencije) i 155 ± 1 dan (adultno doba). Korišćeni su testovi u kojima životinja slobodno istražuje novu sredinu (nova pravougaona arena, crno-bela kutija, uzdignuti krstasti lavirint). Adaptabilnost na novu sredinu je procenjivana poređenjem bihejvioralnih odgovora u prvih i poslednjih 5 minuta testiranja. Dobijeni rezultati su pokazali da kod pacova 1) maturaciona kriva eksploratornog odgovora na novu sredinu može imati kako linearni tako i U-profil, u zavisnosti od karakteristika nove sredine, 2) ponašanje nalik anksioznom ima invertovani U-profil, dok se 3) prilagodljivost nezavisno od sredinskih uslova javlja krajem srednje/početkom kasne adolescencije. Diskutovan je potencijalni značaj dobijenih rezultata.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова, Maturacija eksploratornog, anksioznog i adaptivnog odgovora na nove sredine u modelu pacova",
pages = "339",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5614"
}

Pavković, Ž., Potrebić, M., Dubljević, O., Srbovan, M.,& Pešić, V.. (2022). Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 339.
https://hdl.handle.net/21.15107/rcub_ibiss_5614

Pavković Ž, Potrebić M, Dubljević O, Srbovan M, Pešić V. Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:339.
https://hdl.handle.net/21.15107/rcub_ibiss_5614 .

Pavković, Željko, Potrebić, Milica, Dubljević, Olga, Srbovan, Maja, Pešić, Vesna, "Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):339,
https://hdl.handle.net/21.15107/rcub_ibiss_5614 .

TY  - CONF
AU  - Dubljević, Olga
AU  - Ković, Vanja
AU  - Pavković, Željko
AU  - Mitić, Miloš
AU  - Pešić, Vesna
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5617
AB  - Већина доступних животињских модела зависности од шећера не укључује компоненту само-администрирања супстанце, а познато је да се код људи конзумирање шећера одвија у ad libitum условима. Како би превазишли овај проблем, у овој студији испитани су конзуматорни и бихевиорални исходи неограниченог уноса шећера, као и накнадног смањења доступности шећера код адултних мужјака C57BL/6J мишева применом модификоване парадигме „Конзуматорни сукцесивни негативни контраст“ (cSNC).1,2 Две групе животиња имале су неограничен приступ 32% раствору сахарозе 10 дана (у виду тзв. Two- Bottle-Choice протокола); 11. дана једна група добила је раствор са мањом концентрацијом сахарозе (32%→4%), док је друга група добила уобичајени 32% раствор. Контролна група је имала ad libitum приступ води. Дванаестог дана стандардизованим тестовима понашања (Тест отвореног поља, Крстасти лавиринт и Туба тест социјалне конфронтације) испитани су социјална доминација, као и новином-изазвано експлораторно и понашање слично анксиозности. Добијени резултати указују на централни утицај неограниченог уноса шећера с обзиром да је код C57BL/6J мужјака уочен анксиолитички ефекат на понашање који вероватно одражава физиолошку дисрегулацију и склоност тражењу сензација. Потенцијални простор за примену нове модификоване парадигме у испитивању патолошких последица неограниченог уноса шећера даље је размотрен.
AB  - Većina dostupnih životinjskih modela zavisnosti od šećera ne uključuje komponentu samo-administriranja supstance, a poznato je da se kod ljudi konzumiranje šećera odvija u ad libitum uslovima. Kako bi prevazišli ovaj problem, u ovoj studiji ispitani su konzumatorni i bihevioralni ishodi neograničenog unosa šećera, kao i naknadnog smanjenja dostupnosti šećera kod adultnih mužjaka C57BL/6J miševa primenom modifikovane paradigme „Konzumatorni sukcesivni negativni kontrast“ (cSNC).1,2 Dve grupe životinja imale su neograničen pristup 32% rastvoru saharoze 10 dana (u vidu tzv. Two- Bottle-Choice protokola); 11. dana jedna grupa dobila je rastvor sa manjom koncentracijom saharoze (32%→4%), dok je druga grupa dobila uobičajeni 32% rastvor. Kontrolna grupa je imala ad libitum pristup vodi. Dvanaestog dana standardizovanim testovima ponašanja (Test otvorenog polja, Krstasti lavirint i Tuba test socijalne konfrontacije) ispitani su socijalna dominacija, kao i novinom-izazvano eksploratorno i ponašanje slično anksioznosti. Dobijeni rezultati ukazuju na centralni uticaj neograničenog unosa šećera s obzirom da je kod C57BL/6J mužjaka uočen anksiolitički efekat na ponašanje koji verovatno odražava fiziološku disregulaciju i sklonost traženju senzacija. Potencijalni prostor za primenu nove modifikovane paradigme u ispitivanju patoloških posledica neograničenog unosa šećera dalje je razmotren.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера
T1  - Konzumatorne i bihevioralne posledice neograničenog unosa šećera i naknadnog smanjenja dostupnosti šećera
SP  - 384
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5617
ER  - 

@conference{
author = "Dubljević, Olga and Ković, Vanja and Pavković, Željko and Mitić, Miloš and Pešić, Vesna",
year = "2022",
abstract = "Већина доступних животињских модела зависности од шећера не укључује компоненту само-администрирања супстанце, а познато је да се код људи конзумирање шећера одвија у ad libitum условима. Како би превазишли овај проблем, у овој студији испитани су конзуматорни и бихевиорални исходи неограниченог уноса шећера, као и накнадног смањења доступности шећера код адултних мужјака C57BL/6J мишева применом модификоване парадигме „Конзуматорни сукцесивни негативни контраст“ (cSNC).1,2 Две групе животиња имале су неограничен приступ 32% раствору сахарозе 10 дана (у виду тзв. Two- Bottle-Choice протокола); 11. дана једна група добила је раствор са мањом концентрацијом сахарозе (32%→4%), док је друга група добила уобичајени 32% раствор. Контролна група је имала ad libitum приступ води. Дванаестог дана стандардизованим тестовима понашања (Тест отвореног поља, Крстасти лавиринт и Туба тест социјалне конфронтације) испитани су социјална доминација, као и новином-изазвано експлораторно и понашање слично анксиозности. Добијени резултати указују на централни утицај неограниченог уноса шећера с обзиром да је код C57BL/6J мужјака уочен анксиолитички ефекат на понашање који вероватно одражава физиолошку дисрегулацију и склоност тражењу сензација. Потенцијални простор за примену нове модификоване парадигме у испитивању патолошких последица неограниченог уноса шећера даље је размотрен., Većina dostupnih životinjskih modela zavisnosti od šećera ne uključuje komponentu samo-administriranja supstance, a poznato je da se kod ljudi konzumiranje šećera odvija u ad libitum uslovima. Kako bi prevazišli ovaj problem, u ovoj studiji ispitani su konzumatorni i bihevioralni ishodi neograničenog unosa šećera, kao i naknadnog smanjenja dostupnosti šećera kod adultnih mužjaka C57BL/6J miševa primenom modifikovane paradigme „Konzumatorni sukcesivni negativni kontrast“ (cSNC).1,2 Dve grupe životinja imale su neograničen pristup 32% rastvoru saharoze 10 dana (u vidu tzv. Two- Bottle-Choice protokola); 11. dana jedna grupa dobila je rastvor sa manjom koncentracijom saharoze (32%→4%), dok je druga grupa dobila uobičajeni 32% rastvor. Kontrolna grupa je imala ad libitum pristup vodi. Dvanaestog dana standardizovanim testovima ponašanja (Test otvorenog polja, Krstasti lavirint i Tuba test socijalne konfrontacije) ispitani su socijalna dominacija, kao i novinom-izazvano eksploratorno i ponašanje slično anksioznosti. Dobijeni rezultati ukazuju na centralni uticaj neograničenog unosa šećera s obzirom da je kod C57BL/6J mužjaka uočen anksiolitički efekat na ponašanje koji verovatno odražava fiziološku disregulaciju i sklonost traženju senzacija. Potencijalni prostor za primenu nove modifikovane paradigme u ispitivanju patoloških posledica neograničenog unosa šećera dalje je razmotren.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера, Konzumatorne i bihevioralne posledice neograničenog unosa šećera i naknadnog smanjenja dostupnosti šećera",
pages = "384",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5617"
}

Dubljević, O., Ković, V., Pavković, Ž., Mitić, M.,& Pešić, V.. (2022). Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 384.
https://hdl.handle.net/21.15107/rcub_ibiss_5617

Dubljević O, Ković V, Pavković Ž, Mitić M, Pešić V. Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:384.
https://hdl.handle.net/21.15107/rcub_ibiss_5617 .

Dubljević, Olga, Ković, Vanja, Pavković, Željko, Mitić, Miloš, Pešić, Vesna, "Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):384,
https://hdl.handle.net/21.15107/rcub_ibiss_5617 .

TY  - CONF
AU  - Dubljević, Olga
AU  - Bjegojević, Bojana
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5825
AB  - Adolescence marks the beginning of rapid biological changes in brain structure and connectivity, however, these developmental changes do not happen simultaneously. The neurons of the prefrontal region of the brain seem to develop slowly, as they undergo a delicate process of synaptic pruning and myelinization of axons. Findings regarding the prolonged development of this region are in line with growing evidence from literature and “everyday” experience which suggests that adolescents are more prone to risk-taking, faulty decision making, and cognitive biases. Due to the incomplete process of myelination in the immature frontal lobes, the efficiency of information processing might be limited in adolescents compared to adults, which could lead to evident differences in cognitive abilities associated with this region i.e. planning, executive functions, and inference abilities. The purpose of this study was to determine whether adolescents’ performance in tasks employing these cognitive abilities differs from that of adult subjects. Reasoning and inference abilities were assessed via Wason Selection Test (WST). Executive functions including inhibitory control and attention shifting performance were estimated through reaction time on Stroop Color-Word Test and Trail-Making-Test respectively. The possibility of predicting the performance in the reasoning task based on the achievement in the tests of executive functions was explored as well. The sample consisted of 20 adult subjects and 20 healthy adolescents (gender ratio balanced). Logical reasoning ability was assessed through Significant differences were found between the groups in both WST achievement and executive functions tests’ performance, the latter not being a significant predictor of successfulness in the reasoning task. These results suggest that although the assessed executive functions are not an underlying process of logical reasoning, both are significantly impaired in adolescents compared to adult subjects. The implications of these findings for education programs and initiatives aimed at lowering risk-taking tendencies in adolescents are discussed.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade
C3  - ISDN 2021: 23rd Biennial Meeting of the International Society for Developmental Neuroscience: 'Advancing understanding of nervous system development and neurodevelopmental disorders; 2021 May 25-27; Online
T1  - Healthy adolescents differ from adults in cognitive abilities associated with the prefrontal cortical region
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5825
ER  - 

@conference{
author = "Dubljević, Olga and Bjegojević, Bojana",
year = "2021",
abstract = "Adolescence marks the beginning of rapid biological changes in brain structure and connectivity, however, these developmental changes do not happen simultaneously. The neurons of the prefrontal region of the brain seem to develop slowly, as they undergo a delicate process of synaptic pruning and myelinization of axons. Findings regarding the prolonged development of this region are in line with growing evidence from literature and “everyday” experience which suggests that adolescents are more prone to risk-taking, faulty decision making, and cognitive biases. Due to the incomplete process of myelination in the immature frontal lobes, the efficiency of information processing might be limited in adolescents compared to adults, which could lead to evident differences in cognitive abilities associated with this region i.e. planning, executive functions, and inference abilities. The purpose of this study was to determine whether adolescents’ performance in tasks employing these cognitive abilities differs from that of adult subjects. Reasoning and inference abilities were assessed via Wason Selection Test (WST). Executive functions including inhibitory control and attention shifting performance were estimated through reaction time on Stroop Color-Word Test and Trail-Making-Test respectively. The possibility of predicting the performance in the reasoning task based on the achievement in the tests of executive functions was explored as well. The sample consisted of 20 adult subjects and 20 healthy adolescents (gender ratio balanced). Logical reasoning ability was assessed through Significant differences were found between the groups in both WST achievement and executive functions tests’ performance, the latter not being a significant predictor of successfulness in the reasoning task. These results suggest that although the assessed executive functions are not an underlying process of logical reasoning, both are significantly impaired in adolescents compared to adult subjects. The implications of these findings for education programs and initiatives aimed at lowering risk-taking tendencies in adolescents are discussed.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade",
journal = "ISDN 2021: 23rd Biennial Meeting of the International Society for Developmental Neuroscience: 'Advancing understanding of nervous system development and neurodevelopmental disorders; 2021 May 25-27; Online",
title = "Healthy adolescents differ from adults in cognitive abilities associated with the prefrontal cortical region",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5825"
}

Dubljević, O.,& Bjegojević, B.. (2021). Healthy adolescents differ from adults in cognitive abilities associated with the prefrontal cortical region. in ISDN 2021: 23rd Biennial Meeting of the International Society for Developmental Neuroscience: 'Advancing understanding of nervous system development and neurodevelopmental disorders; 2021 May 25-27; Online
Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade..
https://hdl.handle.net/21.15107/rcub_ibiss_5825

Dubljević O, Bjegojević B. Healthy adolescents differ from adults in cognitive abilities associated with the prefrontal cortical region. in ISDN 2021: 23rd Biennial Meeting of the International Society for Developmental Neuroscience: 'Advancing understanding of nervous system development and neurodevelopmental disorders; 2021 May 25-27; Online. 2021;.
https://hdl.handle.net/21.15107/rcub_ibiss_5825 .

Dubljević, Olga, Bjegojević, Bojana, "Healthy adolescents differ from adults in cognitive abilities associated with the prefrontal cortical region" in ISDN 2021: 23rd Biennial Meeting of the International Society for Developmental Neuroscience: 'Advancing understanding of nervous system development and neurodevelopmental disorders; 2021 May 25-27; Online (2021),
https://hdl.handle.net/21.15107/rcub_ibiss_5825 .