TY  - JOUR
AU  - Jelenković, Ankica V.
AU  - Jovanović, Marina D
AU  - Đurđević, Dragan
AU  - Stanimirović, Danica
AU  - Bokonjić, Dubravko R
AU  - Vasiljević, Ivana D
AU  - Mihajlović, Rosa R
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1426
AB  - Certain types of convulsions may lead to multiorgan dysfunction. We investigated whether the chemoconvulsant pentylenetetrazole (PTZ) could influence energy synthesis in the liver besides evoking convulsions in adult male Wistar rats. In 80% of the rats PTZ (100 mg/kg body weight, administered intraperitoneally - i.p.) evoked generalised clonic convulsions (GCCs) and in 60% of the rats generalised clonic-tonic convulsions (GCTCs) within 4 min after its administration. Cytochrome c oxidase activity was simultaneously reduced approximately three-fold compared to 0.9% NaCl-treated (control) rats (p < 0.01). Midazolam administered before PTZ was an excellent anti-convulsant especially against GCCs (p < 0.05). However, it did not protect against the decrease in cytochrome c oxidase activity induced by PTZ. In contrast to midazolam, pretreatment with L-arginine did not prevent PTZ-evoked convulsions. However, it offered some protection against the PTZ-mediated reduction in cytochrome c oxidase activity. Our results open new avenues of research that will focus on the mechanisms of action of PTZ, midazolam and L-arginine with particular reference to their direct and/or indirect effects on liver function.
T2  - Acta Veterinaria Brno
T1  - Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole
IS  - 3
VL  - 78
EP  - 490
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1426
ER  - 

@article{
author = "Jelenković, Ankica V. and Jovanović, Marina D and Đurđević, Dragan and Stanimirović, Danica and Bokonjić, Dubravko R and Vasiljević, Ivana D and Mihajlović, Rosa R",
year = "2009",
abstract = "Certain types of convulsions may lead to multiorgan dysfunction. We investigated whether the chemoconvulsant pentylenetetrazole (PTZ) could influence energy synthesis in the liver besides evoking convulsions in adult male Wistar rats. In 80% of the rats PTZ (100 mg/kg body weight, administered intraperitoneally - i.p.) evoked generalised clonic convulsions (GCCs) and in 60% of the rats generalised clonic-tonic convulsions (GCTCs) within 4 min after its administration. Cytochrome c oxidase activity was simultaneously reduced approximately three-fold compared to 0.9% NaCl-treated (control) rats (p < 0.01). Midazolam administered before PTZ was an excellent anti-convulsant especially against GCCs (p < 0.05). However, it did not protect against the decrease in cytochrome c oxidase activity induced by PTZ. In contrast to midazolam, pretreatment with L-arginine did not prevent PTZ-evoked convulsions. However, it offered some protection against the PTZ-mediated reduction in cytochrome c oxidase activity. Our results open new avenues of research that will focus on the mechanisms of action of PTZ, midazolam and L-arginine with particular reference to their direct and/or indirect effects on liver function.",
journal = "Acta Veterinaria Brno",
title = "Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole",
number = "3",
volume = "78",
pages = "490",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1426"
}

Jelenković, A. V., Jovanović, M. D., Đurđević, D., Stanimirović, D., Bokonjić, D. R., Vasiljević, I. D.,& Mihajlović, R. R.. (2009). Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole. in Acta Veterinaria Brno, 78(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1426

Jelenković AV, Jovanović MD, Đurđević D, Stanimirović D, Bokonjić DR, Vasiljević ID, Mihajlović RR. Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole. in Acta Veterinaria Brno. 2009;78(3):null-490.
https://hdl.handle.net/21.15107/rcub_ibiss_1426 .

Jelenković, Ankica V., Jovanović, Marina D, Đurđević, Dragan, Stanimirović, Danica, Bokonjić, Dubravko R, Vasiljević, Ivana D, Mihajlović, Rosa R, "Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole" in Acta Veterinaria Brno, 78, no. 3 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1426 .

TY  - JOUR
AU  - Jelenković, Ankica V.
AU  - Petković, Branka
AU  - Pešić, Vesna
AU  - Jovanović, Marina D
AU  - Vasiljević, Ivana D
AU  - Prolić, Zlatko M.
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1656
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0361923005003977?via%3Dihub
AB  - An extremely low-frequency magnetic field (50 Hz, 0.5 mT) was used to investigate its possible effect on the brain of adult male Wistar rats following a 7-day exposure. The control rats were sham-exposed. Superoxide dismutase activities and production Of Superoxide radicals, lipid peroxidation, and nitric oxide were examined in the frontal cortex, striatum, basal forebrain, hippocampus, brainstem, and cerebellum. Significantly increased superoxide radical contents were registered in all the structures examined. Production of nitric oxide, which can oppose superoxide radical activities, was significantly increased in some structures: the frontal cortex, basal forebrain, hippocampus, and brainstem. Augmentation of lipid peroxydation was also observed, with significance only in the basal forebrain and frontal cortex, in spite of the significantly increased superoxide dismutase activities and nitric oxide production in the basal forebrain, and increased production of nitric oxide in the frontal cortex. The results obtained indicate that a 7-day exposure to extremely low-frequency magnetic field can be harmful to the brain, especially to the basal forebrain and frontal cortex due to development of lipid peroxidation. Also, high production of superoxide anion in all regions may compromise nitric oxide signaling processes, due to nitric oxide consumption in the reaction with the superoxide radical.
PB  - Pergamon-Elsevier Science Ltd
T2  - Brain Research Bulletin
T1  - Effects of extremely low-frequency magnetic field in the brain of rats
IS  - 5
VL  - 68
DO  - 10.1016/j.brainresbull.2005.09.011
SP  - 355
EP  - 360
ER  - 

@article{
author = "Jelenković, Ankica V. and Petković, Branka and Pešić, Vesna and Jovanović, Marina D and Vasiljević, Ivana D and Prolić, Zlatko M.",
year = "2006",
abstract = "An extremely low-frequency magnetic field (50 Hz, 0.5 mT) was used to investigate its possible effect on the brain of adult male Wistar rats following a 7-day exposure. The control rats were sham-exposed. Superoxide dismutase activities and production Of Superoxide radicals, lipid peroxidation, and nitric oxide were examined in the frontal cortex, striatum, basal forebrain, hippocampus, brainstem, and cerebellum. Significantly increased superoxide radical contents were registered in all the structures examined. Production of nitric oxide, which can oppose superoxide radical activities, was significantly increased in some structures: the frontal cortex, basal forebrain, hippocampus, and brainstem. Augmentation of lipid peroxydation was also observed, with significance only in the basal forebrain and frontal cortex, in spite of the significantly increased superoxide dismutase activities and nitric oxide production in the basal forebrain, and increased production of nitric oxide in the frontal cortex. The results obtained indicate that a 7-day exposure to extremely low-frequency magnetic field can be harmful to the brain, especially to the basal forebrain and frontal cortex due to development of lipid peroxidation. Also, high production of superoxide anion in all regions may compromise nitric oxide signaling processes, due to nitric oxide consumption in the reaction with the superoxide radical.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Brain Research Bulletin",
title = "Effects of extremely low-frequency magnetic field in the brain of rats",
number = "5",
volume = "68",
doi = "10.1016/j.brainresbull.2005.09.011",
pages = "355-360"
}

Jelenković, A. V., Petković, B., Pešić, V., Jovanović, M. D., Vasiljević, I. D.,& Prolić, Z. M.. (2006). Effects of extremely low-frequency magnetic field in the brain of rats. in Brain Research Bulletin
Pergamon-Elsevier Science Ltd., 68(5), 355-360.
https://doi.org/10.1016/j.brainresbull.2005.09.011

Jelenković AV, Petković B, Pešić V, Jovanović MD, Vasiljević ID, Prolić ZM. Effects of extremely low-frequency magnetic field in the brain of rats. in Brain Research Bulletin. 2006;68(5):355-360.
doi:10.1016/j.brainresbull.2005.09.011 .

Jelenković, Ankica V., Petković, Branka, Pešić, Vesna, Jovanović, Marina D, Vasiljević, Ivana D, Prolić, Zlatko M., "Effects of extremely low-frequency magnetic field in the brain of rats" in Brain Research Bulletin, 68, no. 5 (2006):355-360,
https://doi.org/10.1016/j.brainresbull.2005.09.011 . .

TY  - CONF
AU  - Jelenković, Ankica V.
AU  - Petković, Branka
AU  - Pešić, Vesna
AU  - Jovanović, Marina D
AU  - Vasiljević, Ivana D
AU  - Prolić, Zlatko M.
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1712
UR  - https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1196/annals.1342.044
AB  - Continuous exposure to extremely low-frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) alone and combined with D-amphetamine (1.5 mg/kg) affected the reduced glutathione content in brain regions of rats. Compared to sham-exposed rats, the glutathione content in the forebrain cortex of the ELFMF-exposed rats decreased (P < 0.001), but this reverted after giving amphetamine upon ELF-MF exposure. In this group, the glutathione content was increased in the brain stem and cerebellum (P < 0.05 compared to the shame-exposed, ELM-MF-exposed, and amphetamine-treated groups). It is suggested that biogenic monoamines are involved in the reduced glutathione changes observed. The changes are not uniform in the brain regions examined.
C3  - Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus
T1  - The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain
IS  - null
VL  - 1048
DO  - 10.1196/annals.1342.044
EP  - 380
ER  - 

@conference{
author = "Jelenković, Ankica V. and Petković, Branka and Pešić, Vesna and Jovanović, Marina D and Vasiljević, Ivana D and Prolić, Zlatko M.",
year = "2005",
abstract = "Continuous exposure to extremely low-frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) alone and combined with D-amphetamine (1.5 mg/kg) affected the reduced glutathione content in brain regions of rats. Compared to sham-exposed rats, the glutathione content in the forebrain cortex of the ELFMF-exposed rats decreased (P < 0.001), but this reverted after giving amphetamine upon ELF-MF exposure. In this group, the glutathione content was increased in the brain stem and cerebellum (P < 0.05 compared to the shame-exposed, ELM-MF-exposed, and amphetamine-treated groups). It is suggested that biogenic monoamines are involved in the reduced glutathione changes observed. The changes are not uniform in the brain regions examined.",
journal = "Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus",
title = "The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain",
number = "null",
volume = "1048",
doi = "10.1196/annals.1342.044",
pages = "380"
}

Jelenković, A. V., Petković, B., Pešić, V., Jovanović, M. D., Vasiljević, I. D.,& Prolić, Z. M.. (2005). The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain. in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus, 1048(null).
https://doi.org/10.1196/annals.1342.044

Jelenković AV, Petković B, Pešić V, Jovanović MD, Vasiljević ID, Prolić ZM. The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain. in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus. 2005;1048(null):null-380.
doi:10.1196/annals.1342.044 .

Jelenković, Ankica V., Petković, Branka, Pešić, Vesna, Jovanović, Marina D, Vasiljević, Ivana D, Prolić, Zlatko M., "The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain" in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus, 1048, no. null (2005),
https://doi.org/10.1196/annals.1342.044 . .