TY  - CONF
AU  - Drača, Dijana
AU  - Markelić, Milica
AU  - Mojić, Marija
AU  - Jelača, Sanja
AU  - Mijatović, Sanja
AU  - Jović, Zorana
AU  - Dragičević, Aleksandra
AU  - Koruga, Đuro
AU  - Maksimović-Ivanić, Danijela
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4433
UR  - https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1
AB  - Although paucigranulocytic asthma (PGA) is the most common phenotype of stable asthma, its features are not adequately studied. In this study, we aim to display the characteristics 
of PGA. 116 non‐smoker adult asthma patients (80% female, mean age 39± 12.9) admitted to three tertiary centres were included. Their demographic and clinical features, allergy 
status, biochemical results, Asthma Control Test (ACT) scores, spirometry and exhaled nitric oxide (FeNO) measurements were obtained. Induced sputum cytometry was performed. 
According to induced sputum cell counts, four phenotypes were detected: eosinophilic (EA) (22.4%), mixed (MGA) (6.9%), neutrophilic (NA) (7.8%) and paucigranulocytic (62.9%). In 
sputum, macrophages were higher in the PGA group compared to other groups (PGA vs NA and PGA vs MGA: p<0.001, PGA vs EA: p=0.03). The atopy rate between phenotypes was 
the same. Although forced expiratory flow 1st second (FEV1) was similar in four groups, FEV1/FVC was higher (p=0.013) and FEV1 reversibility was lower in PGA patients than the 
corresponding values in other phenotypes (p=0.015). Low reversibility was comparable in both inhaled corticosteroid naive PGA patients and in those on ICS treatment. Although 
insignificant, FeNO and blood eosinophil counts were higher in MGA and EA groups while these were the lowest in the PGA group. Uncontrolled asthma ratio was low in PGA (16%) 
while it was 11% for NA, 25% for MG and 23% in EA. Macrophages are predominant in sputum of PGA patients. Besides lower uncontrolled asthma ratio, lower FEV1 reversibility is 
a prominent characteristic of this phenotype.
PB  - Wiley‐VCH GmbH
C3  - 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
T1  - Anti‐melanoma effects of Hyper‐harmonized hydroxylated fullerene water complex and hyperpolarized light in vivo
IS  - Suppl 1
VL  - 51
DO  - 10.1002/eji.202170200
SP  - 353
ER  - 

@conference{
author = "Drača, Dijana and Markelić, Milica and Mojić, Marija and Jelača, Sanja and Mijatović, Sanja and Jović, Zorana and Dragičević, Aleksandra and Koruga, Đuro and Maksimović-Ivanić, Danijela",
year = "2021",
abstract = "Although paucigranulocytic asthma (PGA) is the most common phenotype of stable asthma, its features are not adequately studied. In this study, we aim to display the characteristics 
of PGA. 116 non‐smoker adult asthma patients (80% female, mean age 39± 12.9) admitted to three tertiary centres were included. Their demographic and clinical features, allergy 
status, biochemical results, Asthma Control Test (ACT) scores, spirometry and exhaled nitric oxide (FeNO) measurements were obtained. Induced sputum cytometry was performed. 
According to induced sputum cell counts, four phenotypes were detected: eosinophilic (EA) (22.4%), mixed (MGA) (6.9%), neutrophilic (NA) (7.8%) and paucigranulocytic (62.9%). In 
sputum, macrophages were higher in the PGA group compared to other groups (PGA vs NA and PGA vs MGA: p<0.001, PGA vs EA: p=0.03). The atopy rate between phenotypes was 
the same. Although forced expiratory flow 1st second (FEV1) was similar in four groups, FEV1/FVC was higher (p=0.013) and FEV1 reversibility was lower in PGA patients than the 
corresponding values in other phenotypes (p=0.015). Low reversibility was comparable in both inhaled corticosteroid naive PGA patients and in those on ICS treatment. Although 
insignificant, FeNO and blood eosinophil counts were higher in MGA and EA groups while these were the lowest in the PGA group. Uncontrolled asthma ratio was low in PGA (16%) 
while it was 11% for NA, 25% for MG and 23% in EA. Macrophages are predominant in sputum of PGA patients. Besides lower uncontrolled asthma ratio, lower FEV1 reversibility is 
a prominent characteristic of this phenotype.",
publisher = "Wiley‐VCH GmbH",
journal = "6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting",
title = "Anti‐melanoma effects of Hyper‐harmonized hydroxylated fullerene water complex and hyperpolarized light in vivo",
number = "Suppl 1",
volume = "51",
doi = "10.1002/eji.202170200",
pages = "353"
}

Drača, D., Markelić, M., Mojić, M., Jelača, S., Mijatović, S., Jović, Z., Dragičević, A., Koruga, Đ.,& Maksimović-Ivanić, D.. (2021). Anti‐melanoma effects of Hyper‐harmonized hydroxylated fullerene water complex and hyperpolarized light in vivo. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
Wiley‐VCH GmbH., 51(Suppl 1), 353.
https://doi.org/10.1002/eji.202170200

Drača D, Markelić M, Mojić M, Jelača S, Mijatović S, Jović Z, Dragičević A, Koruga Đ, Maksimović-Ivanić D. Anti‐melanoma effects of Hyper‐harmonized hydroxylated fullerene water complex and hyperpolarized light in vivo. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting. 2021;51(Suppl 1):353.
doi:10.1002/eji.202170200 .

Drača, Dijana, Markelić, Milica, Mojić, Marija, Jelača, Sanja, Mijatović, Sanja, Jović, Zorana, Dragičević, Aleksandra, Koruga, Đuro, Maksimović-Ivanić, Danijela, "Anti‐melanoma effects of Hyper‐harmonized hydroxylated fullerene water complex and hyperpolarized light in vivo" in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting, 51, no. Suppl 1 (2021):353,
https://doi.org/10.1002/eji.202170200 . .