TY  - JOUR
AU  - Mojić, Marija
AU  - Savic, Aleksandar
AU  - Arion, Vladimir B.
AU  - Bulatović, Mirna Z.
AU  - Poljarevic, Jelena M.
AU  - Miljković, Đorđe
AU  - Sabo, Tibor J.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Grguric-Sipka, Sanja
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2310
AB  - Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and
   isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl)
   propanoic acid as ligands were prepared from p-cymene ruthenium
   dichloride dimer and corresponding ester. All compounds have been
   characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR
   spectroscopy. Single crystal X-ray structure diffraction analysis of C1
   shows the usual piano-stool geometry of complexes, with coordination of
   ester ligand via nitrogen donor atoms. Ligands exhibit moderate
   anticancer activity (IC50 > 50 mu M), while the complexes were
   significantly more cytotoxic towards various cancer cell lines,
   including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0
   mu M). We stress that cisplatin resistant HCT116 cell line was highly
   sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M
   versus IC50 > 120 mu M for cisplatin). In parallel, primary
   fibroblasts-MRC-5 were remarkably less affected by these compounds. (C)
   2013 Elsevier B. V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes
VL  - 749
DO  - 10.1016/j.jorganchem.2013.08.041
SP  - 142
EP  - 149
ER  - 

@article{
author = "Mojić, Marija and Savic, Aleksandar and Arion, Vladimir B. and Bulatović, Mirna Z. and Poljarevic, Jelena M. and Miljković, Đorđe and Sabo, Tibor J. and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Grguric-Sipka, Sanja",
year = "2014",
abstract = "Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and
   isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl)
   propanoic acid as ligands were prepared from p-cymene ruthenium
   dichloride dimer and corresponding ester. All compounds have been
   characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR
   spectroscopy. Single crystal X-ray structure diffraction analysis of C1
   shows the usual piano-stool geometry of complexes, with coordination of
   ester ligand via nitrogen donor atoms. Ligands exhibit moderate
   anticancer activity (IC50 > 50 mu M), while the complexes were
   significantly more cytotoxic towards various cancer cell lines,
   including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0
   mu M). We stress that cisplatin resistant HCT116 cell line was highly
   sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M
   versus IC50 > 120 mu M for cisplatin). In parallel, primary
   fibroblasts-MRC-5 were remarkably less affected by these compounds. (C)
   2013 Elsevier B. V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes",
volume = "749",
doi = "10.1016/j.jorganchem.2013.08.041",
pages = "142-149"
}

Mojić, M., Savic, A., Arion, V. B., Bulatović, M. Z., Poljarevic, J. M., Miljković, Đ., Sabo, T. J., Mijatović, S., Maksimović-Ivanić, D.,& Grguric-Sipka, S.. (2014). Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes. in Journal of Organometallic Chemistry, 749, 142-149.
https://doi.org/10.1016/j.jorganchem.2013.08.041

Mojić M, Savic A, Arion VB, Bulatović MZ, Poljarevic JM, Miljković Đ, Sabo TJ, Mijatović S, Maksimović-Ivanić D, Grguric-Sipka S. Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes. in Journal of Organometallic Chemistry. 2014;749:142-149.
doi:10.1016/j.jorganchem.2013.08.041 .

Mojić, Marija, Savic, Aleksandar, Arion, Vladimir B., Bulatović, Mirna Z., Poljarevic, Jelena M., Miljković, Đorđe, Sabo, Tibor J., Mijatović, Sanja, Maksimović-Ivanić, Danijela, Grguric-Sipka, Sanja, "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes" in Journal of Organometallic Chemistry, 749 (2014):142-149,
https://doi.org/10.1016/j.jorganchem.2013.08.041 . .